SitesBLAST
Comparing WP_036257391.1 NCBI__GCF_000746085.1:WP_036257391.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6tg9A Cryo-em structure of nadh reduced form of NAD+-dependent formate dehydrogenase from rhodobacter capsulatus (see paper)
72% identity, 98% coverage: 8:940/948 of query aligns to 8:948/949 of 6tg9A
- active site: K289 (= K281), C380 (= C372), H381 (= H373), L545 (= L537), G582 (= G574), Q583 (= Q575)
- binding fe2/s2 (inorganic) cluster: C51 (= C52), V59 (≠ F60), G60 (= G61), C62 (= C63), C65 (= C66), C79 (= C80)
- binding 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraaza-anthracen-4-one guanosine dinucleotide: C255 (= C247), K289 (= K281), R351 (= R343), C352 (= C344), C380 (= C372), G414 (= G406), A415 (= A407), D419 (= D411), G420 (= G412), H421 (= H413), P443 (= P435), R444 (= R436), P464 (= P456), N467 (= N459), L545 (= L537), G546 (= G538), H550 (= H542), G582 (= G574), Q583 (= Q575), Q583 (= Q575), G649 (= G641), E650 (= E642), S655 (= S647), N680 (= N672), S693 (= S685), K698 (= K690), D724 (= D716), T820 (= T812), T821 (= T813), R823 (= R815), R823 (= R815), I824 (= I816), L825 (= L817), N829 (= N821), V830 (= V822), Q833 (= Q825), N902 (= N894), Y918 (≠ F910), K919 (= K911)
- binding iron/sulfur cluster: H111 (= H112), C115 (= C116), C118 (= C119), A120 (= A121), C124 (= C125), C176 (= C167), I177 (= I168), V178 (= V169), C179 (= C170), M180 (≠ N171), C182 (= C173), C186 (= C177), I206 (≠ V197), C218 (= C210), S220 (= S212), C221 (= C213), G222 (= G214), C224 (= C216), C228 (= C220), T230 (= T222), A231 (= A223), C252 (= C244), Y254 (= Y246), C255 (= C247), V257 (= V249), C259 (= C251), F261 (= F253), C287 (= C279), K289 (= K281), V423 (= V415)
7vw6A Cryo-em structure of formate dehydrogenase 1 from methylorubrum extorquens am1 (see paper)
37% identity, 95% coverage: 20:917/948 of query aligns to 2:910/913 of 7vw6A
- binding fe2/s2 (inorganic) cluster: H32 (≠ K50), C34 (= C52), H35 (vs. gap), G45 (= G61), C47 (= C63), R48 (= R64), C50 (= C66), C64 (= C80)
- binding 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraaza-anthracen-4-one guanosine dinucleotide: K263 (= K281), K339 (≠ R343), C364 (= C368), C368 (= C372), G402 (= G406), N404 (= N408), N408 (≠ G412), D431 (= D434), P432 (= P435), R433 (= R436), F447 (≠ L454), G450 (= G457), D452 (≠ N459), G525 (= G536), M526 (≠ L537), G527 (= G538), Q530 (≠ E541), H531 (= H542), G563 (= G574), Q564 (= Q575), G630 (= G641), N632 (≠ D643), S636 (= S647), Q656 (= Q667), D657 (= D668), L658 (= L669), T805 (= T813), R807 (= R815), R807 (= R815), V808 (≠ I816), L809 (= L817), H811 (= H819), W812 (≠ Y820), H813 (≠ N821), H813 (≠ N821), T814 (≠ V822), M817 (≠ Q825), F879 (= F886), N887 (= N894), F903 (= F910), K904 (= K911)
- binding iron/sulfur cluster: C145 (= C167), I146 (= I168), Q147 (≠ V169), C148 (= C170), N149 (= N171), C151 (= C173), C155 (= C177), N161 (≠ T183), V163 (≠ A185), I164 (≠ L186), V175 (= V197), C188 (= C210), V189 (= V211), A190 (≠ S212), C191 (= C213), G192 (= G214), C194 (= C216), C198 (= C220), P199 (= P221), T200 (= T222), A202 (≠ T224), L203 (= L225), C227 (= C244), C230 (= C247), C234 (= C251), C261 (= C279), K263 (= K281), G264 (= G282), V411 (= V415)
1fdiA Oxidized form of formate dehydrogenase h from e. Coli complexed with the inhibitor nitrite (see paper)
37% identity, 71% coverage: 241:917/948 of query aligns to 5:685/715 of 1fdiA
- active site: C11 (= C247), L41 (≠ S278), C42 (= C279), K44 (= K281), S108 (= S341), R110 (= R343), D134 (= D366), C140 (= C372), H141 (= H373), S180 (≠ G412), M297 (≠ L537), R333 (= R573), G334 (= G574), Q335 (= Q575)
- binding 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraaza-anthracen-4-one guanosine dinucleotide: K44 (= K281), R110 (= R343), G111 (≠ C344), V139 (= V371), C140 (= C372), F173 (≠ V405), G174 (= G406), Y175 (≠ A407), N176 (= N408), D179 (= D411), S180 (≠ G412), C201 (≠ I433), D202 (= D434), P203 (= P435), R204 (= R436), L218 (= L454), G221 (= G457), N223 (= N459), G296 (= G536), M297 (≠ L537), G298 (= G538), F302 (≠ H542), G334 (= G574), Q335 (= Q575), Q335 (= Q575), G402 (= G641), E403 (= E642), T408 (≠ S647), Q428 (= Q667), D429 (= D668), I430 (≠ L669), S445 (≠ G684), D478 (= D716), T579 (= T813), V580 (≠ G814), R581 (= R815), R581 (= R815), E582 (≠ I816), H585 (= H819), Y586 (= Y820), S587 (≠ N821), C588 (≠ V822), Y654 (≠ F886), N662 (= N894), Y678 (≠ F910), K679 (= K911)
- binding nitrite ion: C140 (= C372), H141 (= H373), R333 (= R573), G334 (= G574), V338 (= V578)
- binding iron/sulfur cluster: C8 (= C244), Y10 (= Y246), C11 (= C247), S13 (≠ V249), C15 (= C251), L41 (≠ S278), C42 (= C279), K44 (= K281), P182 (= P414), I183 (≠ V415)
P07658 Formate dehydrogenase H; Formate dehydrogenase-H subunit alpha; FDH-H; Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide; EC 1.17.98.4 from Escherichia coli (strain K12) (see 2 papers)
37% identity, 71% coverage: 241:917/948 of query aligns to 5:685/715 of P07658
- C8 (= C244) binding [4Fe-4S] cluster
- C11 (= C247) binding [4Fe-4S] cluster
- C15 (= C251) binding [4Fe-4S] cluster
- C42 (= C279) binding [4Fe-4S] cluster
- R110 (= R343) binding Mo-bis(molybdopterin guanine dinucleotide)
- U140 (≠ C372) binding Mo-bis(molybdopterin guanine dinucleotide); modified: nonstandard, Selenocysteine
- N176 (= N408) binding Mo-bis(molybdopterin guanine dinucleotide)
- D179 (= D411) binding Mo-bis(molybdopterin guanine dinucleotide)
- S180 (≠ G412) binding Mo-bis(molybdopterin guanine dinucleotide)
- C201 (≠ I433) binding Mo-bis(molybdopterin guanine dinucleotide)
- D202 (= D434) binding Mo-bis(molybdopterin guanine dinucleotide)
- R204 (= R436) binding Mo-bis(molybdopterin guanine dinucleotide)
- G221 (= G457) binding Mo-bis(molybdopterin guanine dinucleotide)
- N223 (= N459) binding Mo-bis(molybdopterin guanine dinucleotide)
- M297 (≠ L537) binding Mo-bis(molybdopterin guanine dinucleotide)
- Q335 (= Q575) binding Mo-bis(molybdopterin guanine dinucleotide)
- D404 (= D643) binding Mo-bis(molybdopterin guanine dinucleotide)
- T408 (≠ S647) binding Mo-bis(molybdopterin guanine dinucleotide)
- Q428 (= Q667) binding Mo-bis(molybdopterin guanine dinucleotide)
- D429 (= D668) binding Mo-bis(molybdopterin guanine dinucleotide)
- S445 (≠ G684) binding Mo-bis(molybdopterin guanine dinucleotide)
- D478 (= D716) binding Mo-bis(molybdopterin guanine dinucleotide)
- R581 (= R815) binding Mo-bis(molybdopterin guanine dinucleotide)
- E582 (≠ I816) binding Mo-bis(molybdopterin guanine dinucleotide)
- H585 (= H819) binding Mo-bis(molybdopterin guanine dinucleotide)
- S587 (≠ N821) binding Mo-bis(molybdopterin guanine dinucleotide)
- Y678 (≠ F910) binding Mo-bis(molybdopterin guanine dinucleotide)
- K679 (= K911) binding Mo-bis(molybdopterin guanine dinucleotide)
2iv2X Reinterpretation of reduced form of formate dehydrogenase h from e. Coli (see paper)
37% identity, 71% coverage: 241:917/948 of query aligns to 5:667/697 of 2iv2X
- active site: C11 (= C247), L41 (≠ S278), C42 (= C279), K44 (= K281), S108 (= S341), C140 (= C372), H141 (= H373), S180 (≠ G412), M297 (≠ L537), R333 (= R573), G334 (= G574), Q335 (= Q575)
- binding guanylate-o'-phosphoric acidmono-(2-amino-5,6-dimercapto-4-oxo-3,5,6,7,8a,9,10,10a-octahydro-4h-8-oxa-1,3,9,10-tetraaza-anthracen-7-ylmethyl) ester: R110 (= R343), G111 (≠ C344), T112 (= T345), A137 (= A369), Q335 (= Q575), G402 (= G641), E403 (= E642), D404 (= D643), T408 (≠ S647), A410 (≠ P649), Q428 (= Q667), D429 (= D668), I430 (≠ L669), S445 (≠ G684), D478 (= D716), C588 (≠ V822), Y660 (≠ F910)
- binding 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraaza-anthracen-4-one guanosine dinucleotide: K44 (= K281), F173 (≠ V405), G174 (= G406), Y175 (≠ A407), N176 (= N408), D179 (= D411), S180 (≠ G412), D202 (= D434), P203 (= P435), R204 (= R436), N223 (= N459), G296 (= G536), M297 (≠ L537), F302 (≠ H542), G334 (= G574), R581 (= R815), E582 (≠ I816), V583 (≠ L817), H585 (= H819), Y586 (= Y820), S587 (≠ N821), K661 (= K911)
- binding iron/sulfur cluster: C8 (= C244), C11 (= C247), S13 (≠ V249), C15 (= C251), L41 (≠ S278), C42 (= C279), K44 (= K281), G45 (= G282), I183 (≠ V415)
7qv7S Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
40% identity, 58% coverage: 237:786/948 of query aligns to 1:539/571 of 7qv7S