SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_037375641.1 NCBI__GCF_000428045.1:WP_037375641.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 14 hits to proteins with known functional sites (download)

7plmA Cryoem reconstruction of pyruvate ferredoxin oxidoreductase (pfor) in anaerobic conditions (see paper)
25% identity, 80% coverage: 9:168/200 of query aligns to 414:582/1177 of 7plmA

query
sites
7plmA

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binding iron/sulfur cluster: K458 (vs. gap)

Sites not aligning to the query:

binding calcium ion: 950, 952, 1026, 1028
binding magnesium ion: 930, 958, 960, 962
binding iron/sulfur cluster: 657, 659, 664, 665, 666, 667, 668, 670, 674, 675, 679, 708, 715, 716, 717, 718, 719, 721, 725, 726, 731, 732, 781, 782, 785, 787, 810, 962, 1038, 1039
binding thiamine diphosphate: 27, 28, 29, 63, 787, 808, 809, 810, 839, 929, 930, 931, 960, 961, 962, 963, 964

6ciqA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with coenzyme a bound (see paper)
24% identity, 96% coverage: 9:199/200 of query aligns to 411:617/1169 of 6ciqA

query
sites
6ciqA

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binding coenzyme a: S423 (≠ G21), D424 (≠ Q22), V427 (= V25), G428 (≠ L26), R553 (≠ I140), Y586 (≠ A173)

Sites not aligning to the query:

active site: 28, 61, 111, 999
binding coenzyme a: 28, 999
binding magnesium ion: 966, 994, 996
binding iron/sulfur cluster: 678, 680, 685, 686, 688, 689, 691, 695, 696, 700, 734, 741, 742, 743, 744, 745, 747, 751, 757, 807, 808, 811, 813, 836, 998, 1074, 1075
binding thiamine diphosphate: 26, 27, 61, 85, 813, 835, 836, 865, 965, 966, 967, 996, 997, 998, 999, 1000

6cinB Crystal structure of pyruvate:ferredoxin oxidoreductase from moorella thermoacetica (see paper)
24% identity, 96% coverage: 9:199/200 of query aligns to 411:617/1169 of 6cinB

query
sites
6cinB

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binding iron/sulfur cluster: K455 (≠ R52)

Sites not aligning to the query:

active site: 28, 61, 111, 999
binding magnesium ion: 966, 994, 996
binding iron/sulfur cluster: 678, 685, 686, 687, 688, 689, 691, 695, 700, 741, 742, 743, 744, 745, 746, 747, 751, 752, 757, 758, 807, 808, 811, 813, 836, 998, 1074, 1075
binding thiamine diphosphate: 26, 27, 61, 834, 835, 836, 865, 965, 966, 967, 996, 997, 998, 999, 1000

6cioA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with lactyl-tpp bound (see paper)
24% identity, 96% coverage: 9:199/200 of query aligns to 411:617/1164 of 6cioA

query
sites
6cioA

K

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binding iron/sulfur cluster: K455 (≠ R52)

Sites not aligning to the query:

active site: 28, 61, 111, 999
binding magnesium ion: 966, 994, 996
binding iron/sulfur cluster: 678, 680, 685, 686, 688, 689, 691, 695, 699, 700, 734, 741, 742, 744, 745, 747, 751, 757, 758, 807, 808, 811, 813, 836, 1074, 1075
binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: 26, 27, 28, 61, 85, 111, 813, 834, 835, 836, 865, 965, 966, 967, 996, 997, 998, 999, 1000

Q2RMD6 Pyruvate:ferredoxin oxidoreductase; PFOR; Pyruvate synthase; EC 1.2.7.1 from Moorella thermoacetica (strain ATCC 39073 / JCM 9320) (see paper)
24% identity, 96% coverage: 9:199/200 of query aligns to 412:618/1171 of Q2RMD6

query
sites
Q2RMD6

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SDGTV 424:428 (≠ GQGAV 21:25) binding CoA
K456 (≠ R52) binding CoA
N556 (= N142) binding CoA
N598 (= N178) binding CoA

Sites not aligning to the query:

686 binding [4Fe-4S] cluster
689 binding [4Fe-4S] cluster
692 binding [4Fe-4S] cluster
696 binding [4Fe-4S] cluster
742 binding [4Fe-4S] cluster
745 binding [4Fe-4S] cluster
748 binding [4Fe-4S] cluster
752 binding [4Fe-4S] cluster
809 binding [4Fe-4S] cluster
812 binding [4Fe-4S] cluster
814 binding thiamine diphosphate
837 binding [4Fe-4S] cluster; binding thiamine diphosphate
967 binding Mg(2+)
967:969 binding thiamine diphosphate
995 binding Mg(2+)
995:1000 binding thiamine diphosphate
997 binding Mg(2+)
1075 binding [4Fe-4S] cluster

6cipA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with acetyl-tpp bound (see paper)
24% identity, 96% coverage: 9:199/200 of query aligns to 411:617/1165 of 6cipA

query
sites
6cipA

K

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Y

-

F

-

V

-

Y

-

D

-

S

E

K

R
x
K

R

S

G

G

A

G

P

V

V

T

A

I

A

S

F

H

L

L

R

R

Y

F

S

G

D

K

R

Q

P

P

L

I

R

Q

A

S

V

A

T

Y

N

L

I

I

Y

D

A

Q

P

A

D

D

Y

L

I

I

I

A

C

C

I

H

D

N

P

P

S

S

I

Y

P

V

K

G

A

R

V

Y

D

N

I

L

F

L

A

E

G

G

V

I

Q

K

P

P

N

G

S

G

T

I

L

F

I

L

Q

L

A

N

T

S

R

T

Q

W

S

S

A

A

E

E

S

E

L

M

N

D

C

S

-

R

-

L

P

P

E

A

Q

D

V

M

T

K

R

R

V

T

V

I

L

A

C

T

-

K

-

K

-

L

-

K

-

F

-

Y

-

N

-

I

D

D

A

A

V

V

T

K

I

I

G

A

M

Q

E

E

V

I

F

G

R

L

R

G

P

S

I

R

T

I

N

N

T

V

I

I

M

M

L

Q

G

T

A

A

F

F

A

F

K

K

A

I

T

A

G

N

I

V

V

I

T

P

M

V

E

D

G

E

L

A

R

I

A

K

G

Y

L

I

E

K

S

D

A

S

N

I

F

V

R

K

D

T

A

Y

G

G

-

K

-

K

-

G

-

D

-

K

-

I

L

L

E

N

Q

M

N

N

L

F

I

A

A

A

V

V

E

D

R

R

G

A

F

L

N

-

E

E

S

A

I

L

V

E

K

E

Q

I

R

K

Q

Y

G

P

G

A

E

S

W

W

binding iron/sulfur cluster: K455 (≠ R52)

Sites not aligning to the query:

active site: 28, 61, 111, 999
binding 2-acetyl-thiamine diphosphate: 27, 61, 85, 111, 813, 834, 835, 836, 865, 965, 966, 967, 996, 998, 999
binding magnesium ion: 966, 994, 996
binding iron/sulfur cluster: 678, 680, 685, 686, 688, 689, 691, 695, 699, 700, 734, 741, 742, 744, 745, 747, 751, 757, 758, 807, 808, 811, 813, 836, 998, 1074

2c3uA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus, oxygen inhibited form (see paper)
25% identity, 76% coverage: 9:159/200 of query aligns to 414:576/1231 of 2c3uA

query
sites
2c3uA

K

K

T

G

T

T

H

I

E

Q

V

C

R

Q

L

F

H

W

G

G

R

L

G

G

G

A

Q

D

G

G

A

T

V

V

L

G

A

A

S

N

K

K

I

Q

L

A

A

I

K

K

A

-

I

I

V

I

M

G

S

D

G

N

Q

T

H

D

V

L

T

F

A

A

I

Q

P

G

A

Y

F

F

G

S

F

Y

E

D

R

S

R

K

-
x
K

-

S

G

G

A

G

P

I

V

T

A

I

A

S

F

H

L

L

R

R

Y

F

S

G

D

E

R

K

P

P

L

I

R

Q

A

S

V

T

T

Y

N

L

I

V

Y

N

A

R

P

A

D

D

Y

Y

I

V

I

A

C

C

I

H

D

N

P

P

S

A

I

Y

P

V

K

G

A

I

V

Y

D

D

I

I

F

L

A

E

G

G

V

I

Q

K

P

D

N

G

S

G

T

T

L

F

I

V

-

L

Q

N

A

S

T

P

R

W

Q

S

S

S

A

L

E

E

S

D

L

M

N

D

-

K

-

H

C

L

P

P

E

S

Q

G

V

I

T

K

R

R

V

T

V

I

L

A

-

N

-

K

-

K

-

L

-

K

-

F

-

Y

-

N

C

I

D

D

A

A

V

V

T

K

I

I

G

A

M

T

E

D

V

V

F

G

R

L

R

G

P

G

I

R

T

I

N

N

T

M

I

I

M

M

L

Q

G

T

A

A

F

F

A

F

K

K

A

L

T

A

G

G

I

V

V

L

T

P

M

F

E

E

binding iron/sulfur cluster: K458 (vs. gap)

Sites not aligning to the query:

active site: 30, 63, 113, 995
binding 2-(3-{[4-(hydroxyamino)-2-methylpyrimidin-5-yl]methyl}-4-methyl-2,3-dihydro-1,3-thiazol-5-yl)ethyl trihydrogen diphosphate: 28, 29, 63, 87, 816, 837, 839, 868, 869, 961, 962, 963, 964, 992, 993, 994, 995, 996
binding calcium ion: 982, 984, 1055, 1056, 1058, 1060, 1062
binding magnesium ion: 962, 990, 992
binding pyruvic acid: 30, 113, 122, 995
binding iron/sulfur cluster: 681, 683, 688, 689, 691, 692, 694, 698, 699, 702, 703, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 811, 814, 816, 839, 1070, 1071

2c3pA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
25% identity, 76% coverage: 9:159/200 of query aligns to 414:576/1231 of 2c3pA

query
sites
2c3pA

K

K

T

G

T

T

H

I

E

Q

V

C

R

Q

L

F

H

W

G

G

R

L

G

G

G

A

Q

D

G

G

A

T

V

V

L

G

A

A

S

N

K

K

I

Q

L

A

A

I

K

K

A

-

I

I

V

I

M

G

S

D

G

N

Q

T

H

D

V

L

T

F

A

A

I

Q

P

G

A

Y

F

F

G

S

F

Y

E

D

R

S

R

K

-
x
K

-

S

G

G

A

G

P

I

V

T

A

I

A

S

F

H

L

L

R

R

Y

F

S

G

D

E

R

K

P

P

L

I

R

Q

A

S

V

T

T

Y

N

L

I

V

Y

N

A

R

P

A

D

D

Y

Y

I

V

I

A

C

C

I

H

D

N

P

P

S

A

I

Y

P

V

K

G

A

I

V

Y

D

D

I

I

F

L

A

E

G

G

V

I

Q

K

P

D

N

G

S

G

T

T

L

F

I

V

-

L

Q

N

A

S

T

P

R

W

Q

S

S

S

A

L

E

E

S

D

L

M

N

D

-

K

-

H

C

L

P

P

E

S

Q

G

V

I

T

K

R

R

V

T

V

I

L

A

-

N

-

K

-

K

-

L

-

K

-

F

-

Y

-

N

C

I

D

D

A

A

V

V

T

K

I

I

G

A

M

T

E

D

V

V

F

G

R

L

R

G

P

G

I

R

T

I

N

N

T

M

I

I

M

M

L

Q

G

T

A

A

F

F

A

F

K

K

A

L

T

A

G

G

I

V

V

L

T

P

M

F

E

E

binding iron/sulfur cluster: K458 (vs. gap)

Sites not aligning to the query:

active site: 30, 63, 113, 995
binding 1-(2-{(2s,4r,5r)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1s)-1-carboxy-1-hydroxyethyl]-4-methyl-1,3-thiazolidin-5-yl}ethoxy)-1,1,3,3-tetrahydroxy-1lambda~5~-diphosphox-1-en-2-ium 3-oxide: 28, 29, 30, 63, 87, 113, 816, 837, 838, 839, 868, 869, 961, 962, 963, 992, 993, 994, 995, 996
binding calcium ion: 982, 983, 984, 1055, 1056, 1058, 1060, 1062
binding magnesium ion: 962, 990, 992
binding iron/sulfur cluster: 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 702, 703, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 810, 811, 814, 816, 839, 994, 1070, 1071

2c3oA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
25% identity, 76% coverage: 9:159/200 of query aligns to 414:576/1231 of 2c3oA

query
sites
2c3oA

K

K

T

G

T

T

H

I

E

Q

V

C

R

Q

L

F

H

W

G

G

R

L

G

G

G

A

Q

D

G

G

A

T

V

V

L

G

A

A

S

N

K

K

I

Q

L

A

A

I

K

K

A

-

I

I

V

I

M

G

S

D

G

N

Q

T

H

D

V

L

T

F

A

A

I

Q

P

G

A

Y

F

F

G

S

F

Y

E

D

R

S

R

K

-
x
K

-

S

G

G

A

G

P

I

V

T

A

I

A

S

F

H

L

L

R

R

Y

F

S

G

D

E

R

K

P

P

L

I

R

Q

A

S

V

T

T

Y

N

L

I

V

Y

N

A

R

P

A

D

D

Y

Y

I

V

I

A

C

C

I

H

D

N

P

P

S

A

I

Y

P

V

K

G

A

I

V

Y

D

D

I

I

F

L

A

E

G

G

V

I

Q

K

P

D

N

G

S

G

T

T

L

F

I

V

-

L

Q

N

A

S

T

P

R

W

Q

S

S

S

A

L

E

E

S

D

L

M

N

D

-

K

-

H

C

L

P

P

E

S

Q

G

V

I

T

K

R

R

V

T

V

I

L

A

-

N

-

K

-

K

-

L

-

K

-

F

-

Y

-

N

C

I

D

D

A

A

V

V

T

K

I

I

G

A

M

T

E

D

V

V

F

G

R

L

R

G

P

G

I

R

T

I

N

N

T

M

I

I

M

M

L

Q

G

T

A

A

F

F

A

F

K

K

A

L

T

A

G

G

I

V

V

L

T

P

M

F

E

E

binding iron/sulfur cluster: K458 (vs. gap)

Sites not aligning to the query:

active site: 30, 63, 113, 995
binding calcium ion: 982, 984, 1056, 1058, 1060
binding magnesium ion: 962, 990, 992
binding pyruvic acid: 30, 113, 996
binding iron/sulfur cluster: 681, 688, 689, 691, 692, 694, 698, 699, 702, 703, 744, 746, 747, 748, 749, 750, 754, 760, 761, 810, 811, 814, 816, 839, 1070, 1071
binding thiamine diphosphate: 28, 29, 63, 87, 816, 837, 838, 839, 868, 961, 962, 963, 992, 993, 994, 995, 996

1kekA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase (see paper)
25% identity, 76% coverage: 9:159/200 of query aligns to 414:576/1231 of 1kekA

query
sites
1kekA

K

K

T

G

T

T

H

I

E

Q

V

C

R

Q

L

F

H

W

G

G

R

L

G

G

G

A

Q

D

G

G

A

T

V

V

L

G

A

A

S

N

K

K

I

Q

L

A

A

I

K

K

A

-

I

I

V

I

M

G

S

D

G

N

Q

T

H

D

V

L

T

F

A

A

I

Q

P

G

A

Y

F

F

G

S

F

Y

E

D

R

S

R

K

-
x
K

-

S

G

G

A

G

P

I

V

T

A

I

A

S

F

H

L

L

R

R

Y

F

S

G

D

E

R

K

P

P

L

I

R

Q

A

S

V

T

T

Y

N

L

I

V

Y

N

A

R

P

A

D

D

Y

Y

I

V

I

A

C

C

I

H

D

N

P

P

S

A

I

Y

P

V

K

G

A

I

V

Y

D

D

I

I

F

L

A

E

G

G

V

I

Q

K

P

D

N

G

S

G

T

T

L

F

I

V

-

L

Q

N

A

S

T

P

R

W

Q

S

S

S

A

L

E

E

S

D

L

M

N

D

-

K

-

H

C

L

P

P

E

S

Q

G

V

I

T

K

R

R

V

T

V

I

L

A

-

N

-

K

-

K

-

L

-

K

-

F

-

Y

-

N

C

I

D

D

A

A

V

V

T

K

I

I

G

A

M

T

E

D

V

V

F

G

R

L

R

G

P

G

I

R

T

I

N

N

T

M

I

I

M

M

L

Q

G

T

A

A

F

F

A

F

K

K

A

L

T

A

G

G

I

V

V

L

T

P

M

F

E

E

binding iron/sulfur cluster: K458 (vs. gap)

Sites not aligning to the query:

active site: 30, 63, 113, 995
binding calcium ion: 982, 984, 1055, 1056, 1058, 1062
binding 2-acetyl-thiamine diphosphate: 29, 63, 87, 113, 816, 837, 838, 839, 868, 961, 962, 963, 992, 993, 994, 995, 996
binding magnesium ion: 962, 990, 992
binding iron/sulfur cluster: 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 703, 737, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 810, 811, 814, 816, 839, 1070, 1071

1b0pA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
25% identity, 76% coverage: 9:159/200 of query aligns to 414:576/1231 of 1b0pA

query
sites
1b0pA

K

K

T

G

T

T

H

I

E

Q

V

C

R

Q

L

F

H

W

G

G

R

L

G

G

G

A

Q

D

G

G

A

T

V

V

L

G

A

A

S

N

K

K

I

Q

L

A

A

I

K

K

A

-

I

I

V

I

M

G

S

D

G

N

Q

T

H

D

V

L

T

F

A

A

I

Q

P

G

A

Y

F

F

G

S

F

Y

E

D

R

S

R

K

-
x
K

-

S

G

G

A

G

P

I

V

T

A

I

A

S

F

H

L

L

R

R

Y

F

S

G

D

E

R

K

P

P

L

I

R

Q

A

S

V

T

T

Y

N

L

I

V

Y

N

A

R

P

A

D

D

Y

Y

I

V

I

A

C

C

I

H

D

N

P

P

S

A

I

Y

P

V

K

G

A

I

V

Y

D

D

I

I

F

L

A

E

G

G

V

I

Q

K

P

D

N

G

S

G

T

T

L

F

I

V

-

L

Q

N

A

S

T

P

R

W

Q

S

S

S

A

L

E

E

S

D

L

M

N

D

-

K

-

H

C

L

P

P

E

S

Q

G

V

I

T

K

R

R

V

T

V

I

L

A

-

N

-

K

-

K

-

L

-

K

-

F

-

Y

-

N

C

I

D

D

A

A

V

V

T

K

I

I

G

A

M

T

E

D

V

V

F

G

R

L

R

G

P

G

I

R

T

I

N

N

T

M

I

I

M

M

L

Q

G

T

A

A

F

F

A

F

K

K

A

L

T

A

G

G

I

V

V

L

T

P

M

F

E

E

binding iron/sulfur cluster: K458 (vs. gap)

Sites not aligning to the query:

active site: 30, 63, 113, 995
binding calcium ion: 982, 984, 1055, 1056, 1058, 1060
binding magnesium ion: 962, 990, 992
binding iron/sulfur cluster: 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 702, 703, 737, 744, 745, 747, 748, 750, 754, 755, 760, 811, 814, 816, 839, 994, 1070, 1071
binding thiamine diphosphate: 28, 29, 63, 816, 837, 838, 839, 868, 961, 962, 963, 992, 993, 994, 995, 996

P94692 Pyruvate:ferredoxin oxidoreductase; PFOR; POR; Pyruvate synthase; EC 1.2.7.1 from Desulfocurvibacter africanus (Desulfovibrio africanus) (see 3 papers)
25% identity, 76% coverage: 9:159/200 of query aligns to 415:577/1232 of P94692

query
sites
P94692

K

K

T

G

T

T

H

I

E

Q

V

C

R

Q

L

F

H

W

G

G

R

L

G

G

G

A

Q

D

G

G

A

T

V

V

L

G

A

A

S

N

K

K

I

Q

L

A

A

I

K

K

A

-

I

I

V

I

M

G

S

D

G

N

Q

T

H

D

V

L

T

F

A

A

I

Q

P

G

A

Y

F

F

G

S

F

Y

E

D

R

S

R

K

-

K

-

S

G

G

A

G

P

I

V

T

A

I

A

S

F

H

L

L

R

R

Y

F

S

G

D

E

R

K

P

P

L

I

R

Q

A

S

V

T

T

Y

N

L

I

V

Y

N

A

R

P

A

D

D

Y

Y

I

V

I

A

C

C

I

H

D

N

P

P

S

A

I

Y

P

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K

G

A

I

V

Y

D

D

I

I

F

L

A

E

G

G

V

I

Q

K

P

D

N

G

S

G

T

T

L

F

I

V

-

L

Q

N

A

S

T

P

R

W

Q

S

S

S

A

L

E

E

S

D

L

M

N

D

-

K

-

H

C

L

P

P

E

S

Q

G

V

I

T

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R

R

V

T

V

I

L

A

-

N

-

K

-

K

-

L

-

K

-

F

-

Y

-

N

C

I

D

D

A

A

V

V

T

K

I

I

G

A

M

T

E

D

V

V

F

G

R

L

R

G

P

G

I

R

T

I

N

N

T

M

I

I

M

M

L

Q

G

T

A

A

F

F

A

F

K

K

A

L

T

A

G

G

I

V

V

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T

P

M

F

E

E

Sites not aligning to the query:

31 binding pyruvate
64 binding thiamine diphosphate
114 binding pyruvate
689 binding [4Fe-4S] cluster
692 binding [4Fe-4S] cluster
695 binding [4Fe-4S] cluster
699 binding [4Fe-4S] cluster
745 binding [4Fe-4S] cluster
748 binding [4Fe-4S] cluster
751 binding [4Fe-4S] cluster
755 binding [4Fe-4S] cluster
812 binding [4Fe-4S] cluster
815 binding [4Fe-4S] cluster
817 binding thiamine diphosphate
840 binding [4Fe-4S] cluster; binding thiamine diphosphate
962:965 binding thiamine diphosphate
963 binding Mg(2+)
983 binding Ca(2+)
985 binding Ca(2+)
991 binding Mg(2+)
991:996 binding thiamine diphosphate
993 binding Mg(2+)
1056 binding Ca(2+)
1059 binding Ca(2+)
1061 binding Ca(2+)
1063 binding Ca(2+)
1071 binding [4Fe-4S] cluster

5exdH Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-di-oxido-methyl-tpp (coom-tpp) intermediate (see paper)
28% identity, 82% coverage: 31:193/200 of query aligns to 31:183/291 of 5exdH

query
sites
5exdH

L

L

A

T

K

E

A

A

I

A

V

A

M

K

S

E

G

G

Q

K

H

Y

V

V

T

Q

A

A

I

W

P

E

A

N

F

Y

G

V

F

D

-

L

-

P

E

D

R

R

R

I

G

Y

A

V

P

P

V

V

A

R

A

A

F

Y

L

A

R

R

Y

I

S

S

D

S

R

D

P

P

L

I

R

E

A

S

V

-

T

K

N

Y

I

I

Y

Y

-

E

-

N

-

E

A

T

P

P

D

D

Y

I

I

V

I

V

C

L

I

V

D

E

P

E

S

S

I

L

P

I

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K

A

G

V

V

D

P

I

I

F

L

A

K

G

G

V

I

Q

R

P

P

N

G

S

S

T

T

L

L

I

V

Q

V

A

N

T

T

R

K

Q

R

S

S

A

I

E

D

S

T

-

I

-

L

-

E

-

F

L

L

N

G

C

D

P

T

E

G

Q

N

V

L

T

A

R

Q

V

I

V

V

L

T

C

V

D

D

A

A

V

N

T

S

I

M

G

A

M

G

E

-

V

-

F

-

R

-

R

-

P

-

I

-

T

I

N

A

T

A

I

P

M

I

L

A

G

G

A

A

F

V

A

V

K

K

A

A

T

T

G

G

I

I

V

V

T

D

M

V

E

E

G

N

L

L

R

-

A

-

G

-

L

-

E

-

S

-

A

-

N

-

F

-

R

-

D

-

A

A

G

A

L

V

E

V

Q

K

N

N

L

P

I

A

A

A

V

M

E

R

R

R

G

G

F

Y

N

A

E

E

S

A

I

Q

V

V

K

R

Q

Q

Sites not aligning to the query:

binding iron/sulfur cluster: 230, 237, 238, 239, 240, 241, 243, 247, 259, 266, 267, 268, 269, 270, 272, 276, 278, 281

5c4iE Structure of an oxalate oxidoreductase (see paper)
27% identity, 82% coverage: 31:193/200 of query aligns to 34:206/312 of 5c4iE

query
sites
5c4iE

L

L

A

T

K

E

A

A

I

A

V

A

M

K

S

E

G

G

Q

K

H

Y

V

V

T

Q

A

A

I

W

P

E

A

N

F

Y

G

V

F

D

-

L

-

P

E

D

R

R

R

I

G

Y

A

V

P

P

V

V

A

R

A

A

F

Y

L

A

R

R

Y

I

S

S

D

S

R

D

P

P

L

I

R

E

A

S

V

-

T

K

N

Y

I

I

Y

Y

-

E

-

N

-

E

A

T

P

P

D

D

Y

I

I

V

I

V

C

L

I

V

D

E

P

E

S

S

I

L

P

I

K

K

A

G

V

V

D

P

I

I

F

L

A

K

G

G

V

I

Q

R

P

P

N

G

S

S

T

T

L

L

I

V

Q

V

A

N

T

T

R

K

Q

R

S

S

A

I

E

D

S

T

-

I

-

L

-

E

-

F

L

L

N

G

C

D

P

T

E

G

Q

N

V

L

T

A

R

Q

V

I

V

V

L

T

C

V

D

D

A

A

V

N

T

S

I

M

G

A

M

E

E

A

V

V

F

M

-

T

-

L

-

S

-

G

-

A

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E

-

G

-

A

-

T

-

D

-

A

-

T

-

G

R

I

R

G

P

A

I

G

T

I

N

A

T

A

I

P

M

I

L

A

G

G

A

A

F

V

A

V

K

K

A

A

T

T

G

G

I

I

V

V

T

D

M

V

E

E

G

N

L

L

R

-

A

-

G

-

L

-

E

-

S

-

A

-

N

-

F

-

R

-

D

-

A

A

G

A

L

V

E

V

Q

K

N

N

L

P

I

A

A

A

V

M

E

R

R

R

G

G

F

Y

N

A

E

E

S

A

I

Q

V

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R

Q

Q

Sites not aligning to the query:

binding iron/sulfur cluster: 258, 259, 260, 261, 262, 264, 268, 272, 287, 288, 289, 290, 291, 293, 297, 298, 299, 302

Query Sequence

>WP_037375641.1 NCBI__GCF_000428045.1:WP_037375641.1
MTITAVEQKTTHEVRLHGRGGQGAVLASKILAKAIVMSGQHVTAIPAFGFERRGAPVAAF
LRYSDRPLRAVTNIYAPDYIICIDPSIPKAVDIFAGVQPNSTLIQATRQSAESLNCPEQV
TRVVLCDAVTIGMEVFRRPITNTIMLGAFAKATGIVTMEGLRAGLESANFRDAGLEQNLI
AVERGFNESIVKQRQGGEWV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory