Comparing WP_038018188.1 NCBI__GCF_000757425.2:WP_038018188.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 7 hits to proteins with known functional sites (download)
P00946 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Escherichia coli (strain K12) (see paper)
59% identity, 98% coverage: 1:384/391 of query aligns to 1:385/391 of P00946
3h1mA Crystal structure of mannose 6-phosphate isomerase (holo; zinc bound)
57% identity, 98% coverage: 1:384/391 of query aligns to 3:386/392 of 3h1mA
3h1yA Crystal structure of mannose 6-phosphate isomerase from salmonella typhimurium bound to substrate (f6p)and metal atom (zn)
56% identity, 100% coverage: 1:390/391 of query aligns to 3:391/391 of 3h1yA
P29952 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
29% identity, 92% coverage: 9:368/391 of query aligns to 13:404/429 of P29952
Sites not aligning to the query:
P34948 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
29% identity, 92% coverage: 9:368/391 of query aligns to 14:410/441 of P34948
5nw7A Crystal structure of candida albicans phosphomannose isomerase in complex with inhibitor (see paper)
29% identity, 92% coverage: 9:368/391 of query aligns to 13:409/440 of 5nw7A
1zx5A The structure of a putative mannosephosphate isomerase from archaeoglobus fulgidus
42% identity, 19% coverage: 33:105/391 of query aligns to 36:108/300 of 1zx5A
Sites not aligning to the query:
>WP_038018188.1 NCBI__GCF_000757425.2:WP_038018188.1
MDKLINTIQHYDWGSKTTLTELYGIENPENLPMAELWMGAHPDAPSRVVVAGQPVSLAEL
IRQQPQQLLGEKVARRFSGLPYLFKVLCAAGPLSVQVHPDKQAAEQGFQRENQAGIPLSS
PLRNYKDNNHKPELVYALTPFRAMNGFRPPQQIAGLLEPLVGAHPQIGAFVARPEMAGLK
ALFAVLLSLQGDEAALALKWLAEVSAGLPGETWQTVRSLQHSYPGDMGQFMPLLLNVVVL
QPGQAMFLFAKTPHAYLQGSGLEIMANSNNVLRAGLTAKHIDIPELLDNVEFVSHPAEQL
LTQPVVSQHEISFPVPVDDFSFAVHQLQPTAQALSWPGPRIILCLEGTARCECSGQQLTL
RPGESAFIPANEGPLTVSGQGRLAGSFCDIN
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory