SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_038200266.1 NCBI__GCF_000745855.1:WP_038200266.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1wdlA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form ii (native4) (see paper)
47% identity, 99% coverage: 1:711/715 of query aligns to 2:714/715 of 1wdlA

query
sites
1wdlA

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active site: A69 (= A69), N89 (≠ V89), N93 (= N93), G117 (= G117), E120 (= E120), P139 (= P139), E140 (= E140), P147 (= P147), G148 (= G148), S430 (= S427), H451 (= H448), E463 (= E460), N501 (= N498)
binding nicotinamide-adenine-dinucleotide: A322 (= A319), I324 (= I321), M325 (= M322), D344 (= D341), I345 (= I342), A400 (= A397), V401 (= V398), E403 (= E400), N428 (= N425), T429 (= T426), S430 (= S427)

P28793 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Pseudomonas fragi (see paper)
47% identity, 99% coverage: 1:711/715 of query aligns to 2:714/715 of P28793

query
sites
P28793

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M

S

A

A

E

G

G

Y

F

P

P

Q

D

R

R

M

M

H

K

P

D

G

D

E

R

R

R

N

S

V

A

I

I

R

D

A

A

F

L

A

Y

E

E

A

A

G

K

R

R

L

L

G

G

Q

Q

K

K

S

N

G

G

A

K

G

G

F

F

Y

Y

D

A

Y

Y

D

E

A

A

-

D

A

K

G

K

G

G

R

K

P

Q

K

K

R

K

-

L

-

V

-

D

S

S

S

S

S

V

A

L

E

E

A

V

R

L

A

K

L

P

V

I

R

V

Q

Y

M

E

Q

Q

R

R

G

D

A

V

V

T

C

-

G

-

L

-

D

-

D

D

A

E

Q

D

I

I

V

I

E

N

R

W

M

M

M

M

L

I

P

P

M

L

L

C

L

L

E

E

A

T

I

V

R

R

C

C

L

L

E

E

E

D

G

G

V

I

V

V

R

E

T

T

A

A

A

A

E

E

L

A

D

D

Q

M

A

G

M

L

L

V

L
x
Y

G

G

V

I

G

G

F

F

P

P

A

L

Y

F

L

R

G

G

G

G

P

A

L

L

Q

R

Y

Y

A

I

D

D

W

S

L

I

G

G

L

V

P

A

R

E

L

F

A

V

A

A

R

L

C

A

A

D

S

Q

L

Y

A

A

A

E

C

L

G

G

P

A

M

L

F

Y

E

H

A

P

P

T

A

A

L

K

L

L

S

R

E

E

M

M

A

A

A

K

Q

N

G

G

G

Q

S

S

F

F

Y

F

D297 (≠ E294) binding substrate
M325 (= M322) binding NAD(+)
D344 (= D341) binding NAD(+)
VVE 401:403 (= VVE 398:400) binding NAD(+)
K408 (= K405) binding NAD(+)
S430 (= S427) binding NAD(+)
N454 (= N451) binding NAD(+)
N501 (= N498) binding substrate
Y660 (≠ L657) binding substrate

1wdmA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native3) (see paper)
46% identity, 99% coverage: 1:711/715 of query aligns to 2:706/707 of 1wdmA

query
sites
1wdmA

M

I

F

Y

A

E

S

G

D

K

T

A

V

I

Q

T

V

V

R

T

P

A

L

L

E

E

G

S

G

G

L

I

V

V

E

E

L

L

C

K

F

F

D

D

R

L

R

K

G

G

E

E

A

S

I

V

N

N

K

K

L

F

D

N

D

R

K

L

A

T

V

L

A

N

E

E

F

L

D

R

Q

Q

A

A

V

V

R

D

A

A

I

I

A

K

A

A

A

-

G

D

G

A

G

S

V

V

R

K

G

G

V

V

L

I

V

V

T

S

S

S

A

G

K

K

D

D

V

V

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F

F

G

V

R

E

K

N

F

F

R

K

R

L

G

P

G

D

E

A

Q

E

V

L

A

I

R

A

E

G

V
x
N

L

L

E

E

A

A

N
|
N

Q

K

V

I

F

F

V

S

R

D

F

F

E

E

D

D

L

L

D

N

V

V

P

P

A

T

V

V

V

A

A

A

I

I

N

N

G

G

F

I

A

A

L

L

G

G

G
|
G

G

G

L

L

E
|
E

L

M

A

C

L

L

C

A

A

A

S

D

H

F

R

R

V

V

M

M

S

A

E

D

H

S

A

A

R

K

I

I

G

G

V

L

P
|
P

E
|
E

V

V

K
|
K

L

L

G

G

L

I

F

Y

P
|
P

G
|
G

F

F

G

G

G

G

T

T

V

V

R

R

L

L

A

P

R

R

V

L

G

I

G

G

P

V

Q

D

A

N

A

A

V

V

D

E

W

W

V

I

A

A

S

S

G

G

R

K

S

E

I

N

K

R

A

A

D

E

E

D

A

A

L

L

R

K

A

V

G

S

V

A

V

V

D

D

A

A

V

V

A

V

A

T

P

A

E

D

R

K

L

L

R

G

D

A

E

A

A

A

L

L

A

D

V

L

L

I

W

K

Q

R

C

A

V

I

E

S

G

G

R

E

L

L

D

D

W

Y

R

K

A

A

A

K

Q

R

Q

Q

K

P

K

K

-

L

-

E

R

K

A

L

A

K

V

L

P

N

A

A

A

I

D

E

R

Q

R

M

V

M

-

A

F

F

D

E

D

T

A

A

L

K

A

G

Q

F

L

V

A

A

R

G

H

Q

A

A

S

G

R

P

H

N

Q

Y

P

P

A

A

A

P

E

V

M

E

A

A

V

I

H

K

M

T

M

I

R

Q

A

K

A

A

A

A

G

N

E

F

D

G

R

R

A

D

R

K

A

A

L

L

A

E

M

V

E

E

A

A

E

A

A

G

F

F

G

A

A

K

V

L

T

A

Q

K

T

T

Q

S

A

A

A

S

R

N

S

C

M

L

V

I

Q

G

A

L

F

F

L

L

N

N

E
x
D

Q

Q

A

E

V

L

K

K

K

K

R

K

A

A

R

K

S

V

Q

Y

A

D

E

K

G

I

G

A

R

K

T

D

V

V

R

K

Q

Q

A

A

A

A

V

V

I

L

G
|
G

A
|
A

G

G

I
|
I

M
|
M

G

G

G

G

G

G

I

I

A

A

Y

Y

T

Q

T

S

A

A

L

S

R

K

G

G

T

T

A

P

V

I

R

L

L

M

K

K

D
|
D

I

I

A

N

P

E

A

H

A

G

L

I

E

E

L

Q

G

G

V

L

N

A

E

E

A

A

R

A

R

K

Q

L

L

L

A

V

K

G

Q

R

V

V

Q

D

Q

K

G

G

R

R

L

M

T

T

Q

P

E

A

K

K

A

M

D

A

R

E

I

V

A

L

G

N

A

G

I

I

T

R

P

P

Q

T

L

L

D

S

D

Y

A

G

G

D

L

F

D

G

A

N

V

V

D

D

I

L

V

V

V

V

E

E

A

A

V
|
V

V

V

E
|
E

S

N

L

P

P

K

V

V

K

K

H

Q

R

A

V

V

L

L

T

A

A

E

L

V

E

E

E

N

H

H

V

V

R

R

P

E

G

D

T

A

V

I

L

L

A

A

S

S

N
|
N

T

T

S
|
S

S

T

L

I

R

S

I

I

D

S

D

L

I

L

A

A

A

K

P

A

L

L

A

K

R

R

P

P

E

E

D

N

V

F

V

V

G

G

L

M

H
|
H

F

F

F

F

N
|
N

P

P

V

V

P

H

V

M

M
|
M

P

P

L

L

V

V

E
|
E

V

V

V

I

R

R

G

G

T

E

R

K

S

S

S

S

D

D

A

L

A

A

V

V

A

A

T

T

A

T

T

V

A

A

H

Y

V

A

I

K

G

K

L

M

G

G

K

K

T

N

P

P

I

I

V

V

V

V

K

N

D

D

C

C

P

P

G

G

F

F

L

L

V

V

N
|
N

R

R

I

V

L

L

T

F

P

P

Y

Y

V

F

L

G

S

G

F

F

C

A

D

K

L

L

V

V

A

S

Q

A

G

G

A

V

D

D

H

F

E

V

R

R

I

I

D

D

R

K

A

V

L

M

E

E

A

K

F

F

G

G

W

W

P
|
P

M

M

G

G

P

P

A

A

Y

Y

L

L

E

M

D

D

V

V

V

V

G

G

L

I

D

D

T

T

G

G

S

H

H

H

V

G

I

R

D

D

V

V

I

M

S

A

A

E

G

G

Y

F

P

P

Q

D

R

R

M

M

H

K

P

D

G

D

E

R

R

R

N

S

V

A

I

I

R

D

A

A

F

L

A

Y

E

E

A

A

G

K

R

R

L

L

G

G

Q

Q

K

K

S

N

G

G

A

K

G

G

F

F

Y

Y

D

A

Y

Y

D

K

A

-

A

-

G

-

G

-

R

K

P

L

K

V

R

D

S

S

S

S

S

V

A

L

E

E

A

V

R

L

A

K

L

P

V

I

R

V

Q

Y

M

E

Q

Q

R

R

G

-

A

-

V

-

C

-

G

D

L

V

D

T

D

D

A

E

Q

D

I

I

V

I

E

N

R

W

M

M

M

M

L

I

P

P

M

L

L

C

L

L

E

E

A

T

I

V

R

R

C

C

L

L

E

E

E

D

G

G

V

I

V

V

R

E

T

T

A

A

A

A

E

E

L

A

D

D

Q

M

A

G

M

L

L

V

L
x
Y

G

G

V

I

G

G

F

F

P

P

A
x
L

Y

F

L

R

G

G

G

G

P

A

L

L

Q

R

Y

Y

A

I

D

D

W

S

L

I

G

G

L

V

P

A

R

E

L

F

A

V

A

A

R

L

C

A

A

D

S

Q

L

Y

A

A

A

E

C

L

G

G

P

A

M

L

F

Y

E

H

A

P

P

T

A

A

L

K

L

L

S

R

E

E

M

M

A

A

A

K

Q

N

G

G

G

Q

S

S

F

F

Y

F

active site: A69 (= A69), N89 (≠ V89), N93 (= N93), G117 (= G117), E120 (= E120), P139 (= P139), E140 (= E140), P147 (= P147), G148 (= G148), S430 (= S427), H451 (= H448), E463 (= E460), N501 (= N498)
binding acetyl coenzyme *a: K142 (= K142), D297 (≠ E294), M459 (= M456), N501 (= N498), P534 (= P531), Y652 (≠ L657), L658 (≠ A663)
binding nicotinamide-adenine-dinucleotide: G321 (= G318), A322 (= A319), I324 (= I321), M325 (= M322), D344 (= D341), V401 (= V398), E403 (= E400), N428 (= N425), S430 (= S427), N454 (= N451)

6tnmA E. Coli aerobic trifunctional enzyme subunit-alpha (see paper)
44% identity, 100% coverage: 1:712/715 of query aligns to 2:715/719 of 6tnmA

query
sites
6tnmA

M

L

F

Y

A

K

S

G

D

D

T

T

V

L

Q

Y

V

L

R

D

P

W

L

L

E

E

G

D

G

G

L

I

V

A

E

E

L

L

C

V

F

F

D

D

R

A

R

P

G

G

E

-

A

S

I

V

N

N

K

K

L

L

D

D

D

T

K

A

A

T

V

V

A

A

E

S

F

L

D

G

Q

E

A

A

V

I

R

-

A

G

I

V

A

L

A

E

A

Q

G

Q

G

S

G

D

V

L

R

K

G

G

V

L

L

L

V

L

T

R

S

S

A

N

K

K

D

A

V

A

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F
|
F

G

L

R

S

K

L

F

F

R

L

R

V

G

P

G

E

E

E

Q

Q

V

L

A

S

R

Q

E

W

V

L

L

H

E

F

A

A

N

N

Q

S

V

V

F

F

V

N

R

R

F

L

E

E

D

D

L

L

D

P

V

V

P

P

A

T

V

I

V

A

A

A

I

V

N

N

G

G

F

Y

A

A

L

L

G

G

G
|
G

G

G

L

C

E
|
E

L

C

A

V

L

L

C

A

A

T

S

D

H

Y

R

R

V

L

M

A

S

T

E

P

H

D

A

L

R

R

I

I

G

G

V

L

P
|
P

E
|
E

V

T

K

K

L

L

G

G

L

I

F

M

P

P

G
|
G

F

F

G

G

G

G

T

S

V

V

R

R

L

M

A

P

R

R

V

M

G

L

G

G

P

A

Q

D

A

S

A

A

V

L

D

E

W

I

V

I

A

A

S

A

G

G

R

K

S

D

I

V

K

G

A

A

D

D

E

Q

A

A

L

L

R

K

A

I

G

G

V

L

V

V

D

D

A

G

V

V

A

V

A

K

P

A

E

E

R

K

L

L

R

V

D

E

E

G

A

A

L

K

A

A

V

V

L

L

W

R

Q

Q

C

A

V

I

E

N

G

G

R

D

L

L

D

D

W

W

R

K

A

A

A

K

Q

R

Q

Q

K

P

K

K

R

L

A

E

A

P

V

L

P

K

A

L

A

S

D

K

-

I

-

E

-

A

R

T

R

M

V

S

F

F

D

T

D

I

A

A

L

K

A

G

Q

M

L

V

A

A

R

Q

H

T

A

A

S

G

R

K

H

H

Q

Y

P

P

A

A

A

P

E

I

M

T

A

A

V

V

H

K

M

T

M

I

R

E

A

A

A

A

A

A

G

R

E

F

D

G

R

R

A

E

R

E

A

A

L

L

A
x
N

M

L

E

E

A

N

E

K

A

S

F

F

G

V

A

P

V

L

T

A

Q

H

T

T

Q

N

A

E

A

A

R

R

S

A

M

L

V

V

Q

G

A

I

F

F

L

L

N

N

E

D

Q

Q

A

Y

V

V

K

K

K

G

R

K

A

A

R

K

S

K

Q

L

A

T

E

K

G

D

G

V

R

E

T

T

V

P

R

K

Q

Q

A

A

A

A

V

V

I

L

G

G

A

A

G

G

I

I

M

M

G

G

G

G

G

G

I

I

A

A

Y

Y

T

Q

T

S

A

A

L

W

R

K

G

G

T

V

A

P

V

V

R

V

L

M

K

K

D
|
D

I
|
I

A

N

P

D

A

K

A

S

L

L

E

T

L

L

G

G

V

M

N

T

E

E

A

A

R

A

R

K

Q

L

L

L

A

N

K

K

Q

Q

V

L

Q

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Q

R

G

G

R

K

L

I

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D

Q

G

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L

K

K

A

L

D

A

R

G

I

V

A

I

G

S

A

T

I

I

T

H

P

P

Q

T

L

L

D

D

D

Y

A

A

G

G

L

F

D

D

A

R

V

V

D

D

I

I

V

V

V

V

E

E

A

A

V
|
V

V
|
V

E

E

S

N

L

P

P

K

V
|
V

K

K

H

K

R

A

V

V

L

L

T

A

A

E

L

T

E

E

E

Q

H

K

V

V

R

R

P

Q

G

D

T

T

V

V

L

L

A

A

S

S

N

N

T

T

S
|
S

S

T

L

I

R

P

I

I

D

S

D

E

I

L

A

A

A

N

P

A

L

L

A

E

R

R

P

P

E

E

D

N

V

F

V

C

G

G

L

M

H
|
H

F

F

F

F

N

N

P

P

V

V

P

H

V

R

M

M

P

P

L

L

V

V

E
|
E

V

I

V

I

R

R

G

G

T

E

R

K

S

S

S

S

D

D

A

E

A

T

V

I

A

A

T

K

A

V

T

V

A

A

H

W

V

A

I

S

G

K

L

M

G

G

K

K

T

T

P

P

I

I

V

V

V

V

K

N

D

D

C

C

P

P

G

G

F

F

L

F

V

V

N
|
N

R

R

I

V

L

L

T

F

P

P

Y

Y

V

F

L

A

S

G

F

F

C

S

D

Q

L

L

V

L

A

R

Q

D

G

G

A

A

D

D

H

F

E

R

R

K

I

I

D

D

R

K

A

V

L

M

E

E

A

K

-

Q

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

Y

Y

L

L

E

L

D

D

V

V

V

V

G

G

L

I

D

D

T

T

G

A

S

H

H

H

V

A

I

Q

D

A

V

V

I

M

S

A

A

A

G

G

Y

F

P

P

Q

Q

R

R

M

M

H

Q

P

K

G

D

E

Y

R

R

N

D

V

A

I

I

R

D

A

A

F

L

A

F

E

D

A

A

G

N

R

R

L

F

G

G

Q

Q

K
|
K

S

N

G

G

A

L

G

G

F

F

Y

W

D

R

Y

Y

-

K

D

E

A

D

A

S

G

K

G

G

R

K

P

P

K

K

R

K

S

E

S

E

S

D

A

A

E

A

A

V

R

E

A

D

L

L

V

L

R

A

Q

E

M

V

Q

S

R

Q

G

P

A

K

V

-

C

R

G

D

L

F

D

S

D

E

A

E

Q

E

I

I

V

I

E

A

R

R

M

M

M

M

L

I

P

P

M

M

L

V

L

N

E

E

A

V

I

V

R

R

C

C

L

L

E

E

E

E

G

G

V

I

V

I

R

A

T

T

A

P

A

A

E

E

L

A

D

D

Q

M

A

A

M

L

L

V

L

Y

G

G

V

L

G

G

F

F

P

P

A

P

Y

F

L

H

G

G

G

G

P

A

L

F

Q

R

Y

W

A

L

D

D

W

T

L

L

G

G

L

S

P

A

R

K

L

Y

A

L

A

D

R

M

C

A

A

Q

S

Q

L

Y

A

Q

A

H

C

L

G

G

P

P

M

L

F

Y

E

E

A

V

P

P

A

E

L

G

L

L

S

R

E

N

M

K

A

A

A

R

Q

H

G

N

G

E

S

P

F

Y

Y

Y

P

P

active site: A68 (= A69), F73 (= F74), G116 (= G117), E119 (= E120), P138 (= P139), E139 (= E140), G147 (= G148), N271 (≠ A269), S429 (= S427), H450 (= H448), E462 (= E460), N500 (= N498)
binding adenosine-5'-triphosphate: D343 (= D341), I344 (= I342), V400 (= V398), V401 (= V399), V406 (= V404), K584 (= K581)

P21177 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Escherichia coli (strain K12) (see 2 papers)
44% identity, 100% coverage: 1:712/715 of query aligns to 2:715/729 of P21177

query
sites
P21177

M

L

F

Y

A

K

S

G

D

D

T

T

V

L

Q

Y

V

L

R

D

P

W

L

L

E

E

G

D

G

G

L

I

V

A

E

E

L

L

C

V

F

F

D

D

R

A

R

P

G

G

E

-

A

S

I

V

N

N

K

K

L

L

D

D

D

T

K

A

A

T

V

V

A

A

E

S

F

L

D

G

Q

E

A

A

V

I

R

-

A

G

I

V

A

L

A

E

A

Q

G

Q

G

S

G

D

V

L

R

K

G

G

V

L

L

L

V

L

T

R

S

S

A

N

K

K

D

A

V

A

F

F

I

I

V

V

G

G

A

A

D

D

I

I

T

T

E

E

F

F

G

L

R

S

K

L

F

F

R

L

R

V

G

P

G

E

E

E

Q

Q

V

L

A

S

R

Q

E

W

V

L

L

H

E

F

A

A

N

N

Q

S

V

V

F

F

V

N

R

R

F

L

E

E

D

D

L

L

D

P

V

V

P

P

A

T

V

I

V

A

A

A

I

V

N

N

G

G

F

Y

A

A

L

L

G

G

G
|
G

G

G

L

C

E

E

L

C

A

V

L

L

C

A

A

T

S

D

H

Y

R

R

V

L

M

A

S

T

E

P

H

D

A

L

R

R

I

I

G

G

V

L

P

P

E

E

V

T

K

K

L

L

G

G

L

I

F

M

P

P

G

G

F

F

G

G

G

G

T

S

V

V

R

R

L

M

A

P

R

R

V

M

G

L

G

G

P

A

Q

D

A

S

A

A

V

L

D

E

W

I

V

I

A

A

S

A

G

G

R

K

S

D

I

V

K

G

A

A

D

D

E

Q

A

A

L

L

R

K

A

I

G

G

V

L

V

V

D

D

A

G

V

V

A

V

A

K

P

A

E

E

R

K

L

L

R

V

D

E

E

G

A

A

L

K

A

A

V

V

L

L

W

R

Q

Q

C

A

V

I

E

N

G

G

R

D

L

L

D

D

W

W

R

K

A

A

A

K

Q

R

Q

Q

K

P

K

K

R

L

A

E

A

P

V

L

P

K

A

L

A

S

D

K

-

I

-

E

-

A

R

T

R

M

V

S

F

F

D

T

D

I

A

A

L

K

A

G

Q

M

L

V

A

A

R

Q

H

T

A

A

S

G

R

K

H

H

Q

Y

P

P

A

A

A

P

E

I

M

T

A

A

V

V

H

K

M

T

M

I

R

E

A

A

A

A

A

A

G

R

E

F

D

G

R

R

A

E

R

E

A

A

L

L

A

N

M

L

E

E

A

N

E

K

A

S

F

F

G

V

A

P

V

L

T

A

Q

H

T

T

Q

N

A

E

A

A

R

R

S

A

M

L

V

V

Q

G

A

I

F

F

L

L

N

N

E

D

Q

Q

A

Y

V

V

K

K

K

G

R

K

A

A

R

K

S

K

Q

L

A

T

E

K

G

D

G

V

R

E

T

T

V

P

R

K

Q

Q

A

A

A

A

V

V

I

L

G

G

A

A

G
|
G

I

I

M

M

G

G

G

G

G

G

I

I

A

A

Y

Y

T

Q

T

S

A

A

L

W

R

K

G

G

T

V

A

P

V

V

R

V

L

M

K

K

D

D

I

I

A

N

P

D

A

K

A

S

L

L

E

T

L

L

G

G

V

M

N

T

E

E

A

A

R

A

R

K

Q

L

L

L

A

N

K

K

Q

Q

V

L

Q

E

Q

R

G

G

R

K

L

I

T

D

Q

G

E

L

K

K

A

L

D

A

R

G

I

V

A

I

G

S

A

T

I

I

T

H

P

P

Q

T

L

L

D

D

D

Y

A

A

G

G

L

F

D

D

A

R

V

V

D

D

I

I

V

V

V

V

E

E

A

A

V

V

V

V

E

E

S

N

L

P

P

K

V

V

K

K

H

K

R

A

V

V

L

L

T

A

A

E

L

T

E

E

E

Q

H

K

V

V

R

R

P

Q

G

D

T

T

V

V

L

L

A

A

S

S

N

N

T

T

S

S

S

T

L

I

R

P

I

I

D

S

D

E

I

L

A

A

A

N

P

A

L

L

A

E

R

R

P

P

E

E

D

N

V

F

V

C

G

G

L

M

H
|
H

F

F

F

F

N

N

P

P

V

V

P

H

V

R

M

M

P

P

L

L

V

V

E

E

V

I

V

I

R

R

G

G

T

E

R

K

S

S

S

S

D

D

A

E

A

T

V

I

A

A

T

K

A

V

T

V

A

A

H

W

V

A

I

S

G

K

L

M

G

G

K

K

T

T

P

P

I

I

V

V

V

V

K

N

D

D

C

C

P

P

G

G

F

F

L

F

V

V

N

N

R

R

I

V

L

L

T

F

P

P

Y

Y

V

F

L

A

S

G

F

F

C

S

D

Q

L

L

V

L

A

R

Q

D

G

G

A

A

D

D

H

F

E

R

R

K

I

I

D

D

R

K

A

V

L

M

E

E

A

K

-

Q

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

Y

Y

L

L

E

L

D

D

V

V

V

V

G

G

L

I

D

D

T

T

G

A

S

H

H

H

V

A

I

Q

D

A

V

V

I

M

S

A

A

A

G

G

Y

F

P

P

Q

Q

R

R

M

M

H

Q

P

K

G

D

E

Y

R

R

N

D

V

A

I

I

R

D

A

A

F

L

A

F

E

D

A

A

G

N

R

R

L

F

G

G

Q

Q

K

K

S

N

G

G

A

L

G

G

F

F

Y

W

D

R

Y

Y

-

K

D

E

A

D

A

S

G

K

G

G

R

K

P

P

K

K

R

K

S

E

S

E

S

D

A

A

E

A

A

V

R

E

A

D

L

L

V

L

R

A

Q

E

M

V

Q

S

R

Q

G

P

A

K

V

-

C

R

G

D

L

F

D

S

D

E

A

E

Q

E

I

I

V

I

E

A

R

R

M

M

M

M

L

I

P

P

M

M

L

V

L

N

E

E

A

V

I

V

R

R

C

C

L

L

E

E

E

E

G

G

V

I

V

I

R

A

T

T

A

P

A

A

E

E

L

A

D

D

Q

M

A

A

M

L

L

V

L

Y

G

G

V

L

G

G

F

F

P

P

A

P

Y

F

L

H

G

G

G

G

P

A

L

F

Q

R

Y

W

A

L

D

D

W

T

L

L

G

G

L

S

P

A

R

K

L

Y

A

L

A

D

R

M

C

A

A

Q

S

Q

L

Y

A

Q

A

H

C

L

G

G

P

P

M

L

F

Y

E

E

A

V

P

P

A

E

L

G

L

L

S

R

E

N

M

K

A

A

A

R

Q

H

G

N

G

E

S

P

F

Y

Y

Y

P

P

G116 (= G117) mutation to F: Absence of both enoyl-CoA hydratase and 3-hydroxyacyl-CoA epimerase activities. Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase is only slightly affected.
G322 (= G320) mutation to A: 10-fold increase in KM for NADH.
H450 (= H448) active site, For 3-hydroxyacyl-CoA dehydrogenase activity; mutation H->A,Q: Almost complete loss of 3-hydroxyacyl-CoA dehydrogenase activity.

6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
36% identity, 97% coverage: 19:711/715 of query aligns to 16:703/707 of 6yswA

query
sites
6yswA

L

I

C

T

F

I

D

D

R

V

R

P

G

G

E
|
E

A

K

I
x
M

N

N

K

T

L

L

D

K

D

-

K

-

A

-

V

-

A

A

E

E

F

F

D

A

Q

S

A

Q

V

V

R

R

A

A

I

I

A

I

A

K

A

Q

-

L

-

R

-

E

G

N

G

K

G

E

V

L

R

R

G

G

V

V

L

V

V

F

T

V

S

S

A

A

K

K

-

P

D

D

V

N

F

F

I

I

V

A

G

G

A
|
A

D
|
D

I
|
I

T

N

E

M

F
x
I

G

G

R

N

-

C

K

K

F

T

R

A

R

Q

G

E

G

A

E

E

Q

A

V

L

A
|
A

R

R

E

Q

V

-

L

-

E

-

A

G

N
x
Q

Q

Q

V

L

F

M

V

A

R

E

F

I

E

H

D

A

L

L

D

P

V

I

P

Q

A

V

V

I

V

A

A

A

I

I

N

H

G

G

F

A

A

C

L

L

G

G

G
|
G

G

G

L

L

E
|
E

L

L

A

A

L

L

C

A

A

C

S

H

H

G

R

R

V

V

M

C

S

T

E

D

H

D

A

P

R

K

-

T

-

V

I

L

G

G

V

L

P
|
P

E
|
E

V

V

K

Q

L
|
L

G

G

L

L

F

L

P

P

G
|
G

F

S

G

G

G

G

T

T

V

Q

R

R

L

L

A

P

R

R

V

L

G

I

G

G

P

V

Q

S

A

T

A

A

V

L

D

E

W

M

V

I

A

L

S

T

G

G

R

K

S

Q

I

L

K

R

A

A

D

K

E

Q

A

A

L

L

R

K

A

L

G

G

V

L

V

V

D

D

A

D

V

V

A

V

A

-

P

P

E

H

R

S

L

I

R

L

D

L

E

E

A

A

L

A

A

V

V

E

L

L

W

A

Q

K

C

-

V

-

E

K

G

E

R

R

L

P

D

S

W

S

R

R

A

P

A

L

Q

P

Q

V

K

R

K

E

R

R

A

I

A

L

V

A

P

G

A

P

A

L

D

G

R

R

R

A

V

L

F

L

D

F

D

K

A

M

L

V

A

G

Q

K

L

K

A

T

R

E

H

H

A

K

S

T

R

Q

-

G

H

N

Q

Y

P

P

A

A

A

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active site: A66 (= A69), I71 (≠ F74), A84 (= A86), Q88 (≠ N93), G112 (= G117), E115 (= E120), P136 (= P139), E137 (= E140), G145 (= G148), D264 (≠ A269), S422 (= S427), H443 (= H448), E455 (= E460), N493 (= N498)
binding coenzyme a: E23 (= E26), M25 (≠ I28), A66 (= A69), D67 (= D70), I68 (= I71), P136 (= P139), E137 (= E140), L140 (= L143), T290 (≠ Q295), K293 (= K298)

P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
31% identity, 96% coverage: 28:711/715 of query aligns to 61:762/763 of P40939

query
sites
P40939

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