SitesBLAST
Comparing WP_038200760.1 NCBI__GCF_000745855.1:WP_038200760.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4nbuB Crystal structure of fabg from bacillus sp (see paper)
46% identity, 96% coverage: 7:249/252 of query aligns to 5:242/244 of 4nbuB
- active site: G18 (= G20), N111 (≠ H117), S139 (= S145), Q149 (= Q155), Y152 (= Y158), K156 (= K162)
- binding acetoacetyl-coenzyme a: D93 (≠ T99), K98 (= K104), S139 (= S145), N146 (≠ T152), V147 (≠ I153), Q149 (= Q155), Y152 (= Y158), F184 (≠ M194), M189 (vs. gap), K200 (≠ R207)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G16), N17 (≠ Q19), G18 (= G20), I19 (= I21), D38 (= D40), F39 (≠ W41), V59 (≠ C65), D60 (= D66), V61 (= V67), N87 (= N93), A88 (= A94), G89 (= G95), I90 (= I96), T137 (= T143), S139 (= S145), Y152 (= Y158), K156 (= K162), P182 (= P188), F184 (≠ M194), T185 (= T195), T187 (= T197), M189 (vs. gap)
1edoA The x-ray structure of beta-keto acyl carrier protein reductase from brassica napus complexed with NADP+ (see paper)
47% identity, 96% coverage: 11:251/252 of query aligns to 3:244/244 of 1edoA
- active site: G12 (= G20), S138 (= S145), Y151 (= Y158), K155 (= K162)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G16), S10 (≠ G18), R11 (≠ Q19), I13 (= I21), N31 (≠ D40), Y32 (≠ W41), A33 (vs. gap), R34 (vs. gap), S35 (≠ N42), D59 (= D66), V60 (= V67), N86 (= N93), A87 (= A94), S138 (= S145), Y151 (= Y158), K155 (= K162), P181 (= P188), G182 (= G189), I184 (≠ A190), S186 (≠ T192), M188 (= M194)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
47% identity, 95% coverage: 10:249/252 of query aligns to 5:244/246 of 3osuA
7tzpG Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
44% identity, 96% coverage: 7:249/252 of query aligns to 6:245/247 of 7tzpG
- binding 1,4-dihydronicotinamide adenine dinucleotide: G15 (= G16), R18 (≠ Q19), G19 (= G20), I20 (= I21), D39 (= D40), R40 (≠ W41), C63 (= C65), I65 (≠ V67), N91 (= N93), G93 (= G95), I94 (= I96), V114 (= V116), Y155 (= Y158), K159 (= K162), I188 (≠ A190), T190 (= T192), T193 (= T195)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
44% identity, 96% coverage: 7:249/252 of query aligns to 3:245/247 of 4jroC
- active site: G16 (= G20), S142 (= S145), Q152 (= Q155), Y155 (= Y158), K159 (= K162)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), S14 (≠ G18), R15 (≠ Q19), G16 (= G20), I17 (= I21), N35 (≠ D40), Y36 (≠ W41), N37 (= N42), G38 (vs. gap), S39 (vs. gap), N63 (≠ D66), V64 (= V67), N90 (= N93), A91 (= A94), I93 (= I96), I113 (≠ V116), S142 (= S145), Y155 (= Y158), K159 (= K162), P185 (= P188), I188 (≠ A190), T190 (= T192)
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
46% identity, 95% coverage: 10:249/252 of query aligns to 2:237/239 of 3sj7A
- active site: G12 (= G20), S138 (= S145), Q148 (= Q155), Y151 (= Y158), K155 (= K162)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G16), S10 (≠ G18), R11 (≠ Q19), I13 (= I21), N31 (vs. gap), Y32 (≠ V39), A33 (≠ D40), G34 (≠ W41), S35 (≠ N42), A58 (≠ C65), N59 (≠ D66), V60 (= V67), N86 (= N93), A87 (= A94), T109 (≠ V116), S138 (= S145), Y151 (= Y158), K155 (= K162), P181 (= P188), G182 (= G189)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
44% identity, 96% coverage: 7:249/252 of query aligns to 6:244/247 of 3op4A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G16), S17 (≠ G18), R18 (≠ Q19), I20 (= I21), T40 (= T45), N62 (≠ D66), V63 (= V67), N89 (= N93), A90 (= A94), I92 (= I96), V139 (≠ T143), S141 (= S145), Y154 (= Y158), K158 (= K162), P184 (= P188), G185 (= G189), I187 (≠ A190), T189 (= T192), M191 (= M194)
P73574 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-acyl carrier protein reductase; EC 1.1.1.100 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
46% identity, 97% coverage: 6:249/252 of query aligns to 3:244/247 of P73574
- A14 (= A17) mutation to G: 4.2-fold increase in activity on acetoacetyl-CoA.
- P151 (≠ I153) mutation to F: 2.7-fold increase in activity on acetoacetyl-CoA.; mutation to V: 5.7-fold increase in activity on acetoacetyl-CoA.
- K160 (= K162) mutation to A: Almost no activity on acetoacetyl-CoA.
- F188 (vs. gap) mutation to Y: 3.3-fold increase in activity on acetoacetyl-CoA.
- N198 (≠ R199) mutation to R: 3.5-fold increase in activity on acetoacetyl-CoA.
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
44% identity, 96% coverage: 7:249/252 of query aligns to 6:240/243 of 4i08A
- active site: G19 (= G20), N113 (≠ H117), S141 (= S145), Q151 (= Q155), Y154 (= Y158), K158 (= K162)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G16), S17 (≠ G18), R18 (≠ Q19), I20 (= I21), T40 (= T45), N62 (≠ D66), V63 (= V67), N89 (= N93), A90 (= A94), G140 (≠ I144), S141 (= S145), Y154 (= Y158), K158 (= K162), P184 (= P188), G185 (= G189), T189 (= T200)
6t77A Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
45% identity, 97% coverage: 6:249/252 of query aligns to 2:241/244 of 6t77A
- active site: G16 (= G20), S138 (= S145), Y151 (= Y158)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), S14 (≠ G18), R15 (≠ Q19), T37 (= T45), L58 (≠ C65), N59 (≠ D66), V60 (= V67), A87 (= A94), G88 (= G95), I89 (= I96)
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+ (see paper)
43% identity, 96% coverage: 7:249/252 of query aligns to 2:240/243 of 1q7bA
- active site: G15 (= G20), E101 (≠ Q109), S137 (= S145), Q147 (= Q155), Y150 (= Y158), K154 (= K162)
- binding calcium ion: E232 (≠ Q241), T233 (≠ L242)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G16), S13 (≠ G18), R14 (≠ Q19), T36 (= T45), N58 (≠ D66), V59 (= V67), N85 (= N93), A86 (= A94), G87 (= G95), I88 (= I96), S137 (= S145), Y150 (= Y158), K154 (= K162), P180 (= P188), G181 (= G189), I183 (≠ A190)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 2 papers)
43% identity, 96% coverage: 7:249/252 of query aligns to 3:241/244 of P0AEK2
- GASR 12:15 (≠ GAGQ 16:19) binding NADP(+)
- T37 (= T45) binding NADP(+)
- NV 59:60 (≠ DV 66:67) binding NADP(+)
- N86 (= N93) binding NADP(+)
- Y151 (= Y158) mutation to F: Defect in the affinity for NADPH.
- YAAAK 151:155 (≠ YGSAK 158:162) binding NADP(+)
- A154 (= A161) mutation to T: Decreases in the thermolability of the reductase; when associated with K-233.
- K155 (= K162) mutation to A: Defect in the affinity for NADPH.
- I184 (≠ A190) binding NADP(+)
- E233 (≠ Q241) mutation to K: Decreases in the thermolability of the reductase; when associated with T-154.
7emgB Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
42% identity, 97% coverage: 6:249/252 of query aligns to 1:240/243 of 7emgB
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment (see paper)
42% identity, 96% coverage: 7:249/252 of query aligns to 2:240/243 of 1q7cA
- active site: G15 (= G20), S137 (= S145), Q147 (= Q155), F150 (≠ Y158), K154 (= K162)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G11 (= G16), S13 (≠ G18), R14 (≠ Q19), A35 (≠ E44), T36 (= T45), L57 (≠ C65), N58 (≠ D66), V59 (= V67), G87 (= G95), I88 (= I96)
P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
43% identity, 97% coverage: 6:249/252 of query aligns to 2:241/244 of P0A2C9
- M125 (= M132) mutation to I: Loss of the temperature-sensitive phenotype; when associated with T-223.
- A223 (= A231) mutation to T: Loss of the temperature-sensitive phenotype; when associated with I-125.
- S224 (= S232) mutation to F: Distorts the local conformation and prevent stacking around Phe-221. The S224F mutation would additionally disrupt the hydrogen bond formed between Ser-224 and Glu-226.
4nbtA Crystal structure of fabg from acholeplasma laidlawii (see paper)
42% identity, 98% coverage: 5:251/252 of query aligns to 1:239/239 of 4nbtA
- active site: G16 (= G20), S132 (= S145), Y145 (= Y158), K149 (= K162)
- binding nicotinamide-adenine-dinucleotide: G12 (= G16), K15 (≠ Q19), G16 (= G20), L17 (≠ I21), D36 (= D40), L37 (≠ W41), L52 (≠ C65), N53 (≠ D66), V54 (= V67), N80 (= N93), A81 (= A94), G82 (= G95), I130 (≠ T143), S132 (= S145), Y145 (= Y158), K149 (= K162), P177 (= P188), G178 (= G189), I180 (≠ A191), T182 (= T195)
Q9KJF1 (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase subunit BbsD; (S,R)-2-(alpha-hydroxybenzyl)succinyl-CoA dehydrogenase subunit BbsD; EC 1.1.1.429 from Thauera aromatica (see 2 papers)
40% identity, 97% coverage: 7:251/252 of query aligns to 3:245/248 of Q9KJF1
- S15 (≠ Q19) binding NAD(+)
- D36 (= D40) binding NAD(+)
- D62 (= D66) binding NAD(+)
- I63 (≠ V67) binding NAD(+)
- N89 (= N93) binding NAD(+)
- Y153 (= Y158) binding NAD(+)
- K157 (= K162) binding NAD(+)
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
7pcsB Structure of the heterotetrameric sdr family member bbscd (see paper)
40% identity, 97% coverage: 7:251/252 of query aligns to 2:244/247 of 7pcsB
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), M16 (≠ I21), D35 (= D40), I36 (≠ W41), I62 (≠ V67), N88 (= N93), G90 (= G95), I138 (= I144), S140 (≠ T146), Y152 (= Y158), K156 (= K162), I185 (vs. gap)
4dmmB 3-oxoacyl-[acyl-carrier-protein] reductase from synechococcus elongatus pcc 7942 in complex with NADP
45% identity, 96% coverage: 7:249/252 of query aligns to 3:237/240 of 4dmmB
- active site: G16 (= G20), S142 (= S145), Q152 (= Q155), Y155 (= Y158), K159 (= K162)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), S14 (≠ G18), R15 (≠ Q19), G16 (= G20), I17 (= I21), A37 (≠ E44), S38 (≠ T45), S39 (≠ A46), A62 (≠ C65), D63 (= D66), V64 (= V67), N90 (= N93), A91 (= A94), L113 (≠ V116), I140 (≠ T143), S142 (= S145), Y155 (= Y158), K159 (= K162), P185 (= P188), G186 (= G189), I188 (≠ A190), T190 (= T192), M192 (= M194)
7x5jC Acp-dependent oxoacyl reductase
40% identity, 98% coverage: 6:251/252 of query aligns to 1:253/256 of 7x5jC
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G16), S13 (≠ G18), G15 (= G20), L16 (≠ I21), N36 (≠ D40), R37 (≠ W41), N38 (= N42), D62 (= D66), V63 (= V67), N89 (= N93), A90 (= A94), A91 (vs. gap), V114 (= V116), I141 (≠ T143), Y156 (= Y158), K160 (= K162), L186 (vs. gap), G187 (vs. gap), V188 (= V186), R194 (≠ T192), S197 (≠ T195), S198 (≠ E196)
Query Sequence
>WP_038200760.1 NCBI__GCF_000745855.1:WP_038200760.1
MFSGKALENKVAIVTGAGQGIGAGIARAYGAQAAKVAVVDWNLETAEQVAQSIRDAGGQA
AAFKCDVADRAAVDAMVAAVVAKFGPVDVLVNNAGITRTAMLHKMSAHQWQQVIDVHLTG
SFNCLQAVVDGMMERQRGWIINTISTAGILGTIGQINYGSAKAGLIGFTKSAARELARYN
IIVNCVAPGAATPMTETIRTDERFKQRTLDRIPLGRWAEPEEIAPVWVFLASEGASYVTG
QLIGVDGGMSIH
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory