SitesBLAST

P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 3 papers)
25% identity, 90% coverage: 3:181/198 of query aligns to 33:183/203 of P07464

query
sites
P07464

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S71 (≠ W47) binding substrate
N85 (≠ K68) binding in other chain; binding in other chain
D93 (≠ C91) binding substrate
H115 (= H116) mutation to A: Results in an 1800-fold decrease in catalytic activity.
S142 (≠ A140) binding in other chain
A160 (= A158) binding in other chain
TK 165:166 (≠ FK 163:164) binding acetyl-CoA
R180 (= R178) binding acetyl-CoA
R183 (≠ K181) binding in other chain

Sites not aligning to the query:

1 modified: Initiator methionine, Removed; Partial
17 binding substrate

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal (see paper)
25% identity, 90% coverage: 3:181/198 of query aligns to 32:182/201 of 1krvA

query
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1krvA

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binding 4-nitrophenyl beta-D-galactopyranoside: S70 (≠ W47), Y82 (= Y66), N84 (≠ K68), V90 (= V89), D92 (≠ C91), M126 (≠ L125)
binding coenzyme a: A104 (≠ S106), S110 (≠ C112), T112 (≠ G114), W138 (= W137), G140 (≠ A139), S141 (≠ A140), N146 (≠ G145), A159 (= A158), P177 (= P176), R179 (= R178), R182 (≠ K181)

Sites not aligning to the query:

binding 4-nitrophenyl beta-D-galactopyranoside: 16, 25

1kruA Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
25% identity, 90% coverage: 3:181/198 of query aligns to 32:182/201 of 1kruA

query
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1kruA

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binding coenzyme a: H114 (= H116), W138 (= W137), G140 (≠ A139), S141 (≠ A140), G158 (= G157), A159 (= A158), P177 (= P176), R182 (≠ K181)
binding 1-methylethyl 1-thio-beta-D-galactopyranoside: W62 (= W39), S70 (≠ W47), Y82 (= Y66), Y82 (= Y66), N84 (≠ K68), V90 (= V89), D92 (≠ C91), L102 (≠ V104), H114 (= H116), M126 (≠ L125)

Sites not aligning to the query:

binding 1-methylethyl 1-thio-beta-D-galactopyranoside: 16, 22, 25

2xatA Complex of the hexapeptide xenobiotic acetyltransferase with chloramphenicol and desulfo-coenzyme a (see paper)
48% identity, 26% coverage: 132:183/198 of query aligns to 111:162/208 of 2xatA

query
sites
2xatA

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binding desulfo-coenzyme a: G118 (≠ A139), T119 (≠ A140), G136 (= G157), S137 (≠ A158), G152 (≠ V173), G153 (= G174), I159 (= I180)

Sites not aligning to the query:

binding chloramphenicol: 6, 7, 8, 28

3igjC Crystal structure of maltose o-acetyltransferase complexed with acetyl coenzyme a from bacillus anthracis
28% identity, 70% coverage: 45:182/198 of query aligns to 45:185/188 of 3igjC

query
sites
3igjC

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binding acetyl coenzyme *a: F84 (≠ Y82), A106 (≠ S106), Y112 (≠ C112), A114 (≠ G114), H116 (= H116), G142 (≠ A139), N148 (≠ G145), A160 (≠ G157), S161 (≠ A158), T166 (≠ F163), N178 (= N175)

4isxA The crystal structure of maltose o-acetyltransferase from clostridium difficile 630 in complex with acetyl-coa
28% identity, 69% coverage: 45:181/198 of query aligns to 44:182/186 of 4isxA

query
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4isxA

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binding acetyl coenzyme *a: N84 (≠ G88), A104 (≠ S106), W138 (= W137), G140 (≠ A139), G141 (≠ A140), A159 (= A158), V174 (= V173), K182 (= K181)

6u9cA The 2.2 a crystal structure of the type b chloramphenicol acetyltransferase from vibrio cholerae in the complex with acetyl coa
44% identity, 26% coverage: 132:183/198 of query aligns to 111:162/206 of 6u9cA

query
sites
6u9cA

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binding acetyl coenzyme *a: W116 (= W137), A136 (≠ G157), I159 (= I180)

6pubA Crystal structure of the type b chloramphenicol acetyltransferase from vibrio cholerae in the complex with crystal violet
44% identity, 26% coverage: 132:183/198 of query aligns to 114:165/210 of 6pubA

query
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6pubA

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Sites not aligning to the query:

binding crystal violet: 4, 7, 9, 10, 11, 36, 37

3dhoA Structure of streptogramin acetyltransferase in complex with an inhibitor
41% identity, 30% coverage: 124:183/198 of query aligns to 104:167/203 of 3dhoA

query
sites
3dhoA

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binding 6-bromo-N'-[(1Z)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-2-methylquinoline-4-carbohydrazide: I139 (≠ V155), A141 (≠ G157), V147 (≠ F163), L155 (≠ V171), G157 (≠ V173), P160 (= P176), I164 (= I180)

Sites not aligning to the query:

binding 6-bromo-N'-[(1Z)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-2-methylquinoline-4-carbohydrazide: 84

1khrA Crystal structure of vat(d) in complex with virginiamycin and coenzyme a (see paper)
41% identity, 30% coverage: 124:183/198 of query aligns to 104:167/206 of 1khrA

query
sites
1khrA

Q

K

L

L

V

D

Q

Q

K

L

P

P

I

I

A

K

-

G

-

D

-

T

-

I

I

I

G

G

A

N

H

D

A

V

W
|
W

I

I

A

G

A

K

E

D

A

V

F

V

V

I

G

M

P

P

G

G

V

V

T

K

V

I

N

G

E

D

G

G

A

A

V

I

V

V

G
x
A

A
|
A

R

N

A

S

V

V

L

V

F
x
V

K

K

D

D

A

I

E

A

P

P

W

Y

G

M

V
x
L

Y

A

V
x
G

G

G

N

N

P
|
P

A

A

R

N

W

E

I
|
I

K

K

T

Q

R

R

binding coenzyme a: W121 (= W137), A141 (≠ G157), A142 (= A158), V147 (≠ F163), L155 (≠ V171), G157 (≠ V173), P160 (= P176), I164 (= I180)

Sites not aligning to the query:

binding coenzyme a: 82, 84
binding virginiamycin m1: 37, 39, 54, 80, 81, 82, 93

1mrlA Crystal structure of streptogramin a acetyltransferase with dalfopristin (see paper)
41% identity, 30% coverage: 124:183/198 of query aligns to 104:167/204 of 1mrlA

query
sites
1mrlA

Q

K

L

L

V

D

Q

Q

K
x
L

P

P

I

I

A

K

-

G

-

D

-

T

-

I

I

I

G

G

A

N

H

D

A

V

W

W

I

I

A

G

A

K

E

D

A

V

F

V

V

I

G

M

P

P

G

G

V

V

T

K

V

I

N

G

E

D

G

G

A

A

V

I

V

V

G

A

A

A

R

N

A

S

V

V

L

V

F

V

K

K

D

D

A

I

E

A

P

P

W

Y

G

M

V

L

Y

A

V

G

G

G

N

N

P

P

A

A

R

N

W

E

I

I

K

K

T

Q

R

R

binding 5-(2-diethylamino-ethanesulfonyl)-21-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triaza-tricyclo[23.2.1.00,255]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetraone: L108 (≠ K128)

Sites not aligning to the query:

binding 5-(2-diethylamino-ethanesulfonyl)-21-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triaza-tricyclo[23.2.1.00,255]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetraone: 37, 39, 54, 56, 81, 82, 93, 102

3fsbA Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-quinovose (see paper)
34% identity, 53% coverage: 76:180/198 of query aligns to 122:219/260 of 3fsbA

query
sites
3fsbA

H

H

L

V

T

Y

M

I

G

G

A

N

Y

Y

A

V

V

N

L

I

G

-

P

-

G

-

V

-

D

-

C

-

Y

-

C

-

Q
x
H

G

S

R

N

I

V

T

F

I

V

G

G

E

E

K

K

A

S

V

I

S

K

Q

D

G

F

A

V

S

W

L

L

-
x
F

-

P

-

H

C

V

A

V

G

L

T

T

H

N

D

D

I

P

A

T

D

P

P

P

N

S

F

N

Q

E

L

L

V

L

Q

G

K

-

P

-

I

V

A

T

I

I

G

E

A

L

H

F

A

A

W

V

I

I

A
|
A

E

R

A

S

F

V

V

V

G

L

P

P

G

G

V

I

T

H

V

I

N

N

E

E

G

D

A

A

V

L

V

V

G
|
G

A
|
A

R

G

A

A

V

V

L

V

F

T

K

K

D

D

A

V

E

P

P

K

W

E

G

T

V

V

Y

V

V
|
V

G

G

N

N

P

P

A

A

R

R

W

E

I

I

binding coenzyme a: F150 (vs. gap), A178 (= A139), A179 (= A140), G196 (= G157), A197 (= A158), V212 (= V173)
binding [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate: H132 (≠ Q94), F150 (vs. gap)

Sites not aligning to the query:

binding [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate: 78, 114, 241, 243

3fscA Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-fucose (see paper)
34% identity, 53% coverage: 76:180/198 of query aligns to 122:219/259 of 3fscA

query
sites
3fscA

H

H

L

V

T

Y

M

I

G

G

A

N

Y

Y

A

V

V

N

L

I

G

-

P

-

G

-

V

-

D

-

C

-

Y

-

C

-

Q
x
H

G
x
S

R

N

I

V

T

F

I

V

G

G

E

E

K

K

A

S

V

I

S

K

Q

D

G

F

A

V

S

W

L

L

-
x
F

-

P

-

H

C

V

A

V

G

L

T

T

H

N

D

D

I

P

A

T

D

P

P

P

N

S

F

N

Q

E

L

L

V

L

Q

G

K

-

P

-

I

V

A

T

I

I

G

E

A

L

H

F

A

A

W

V

I

I

A
|
A

E

R

A

S

F

V

V

V

G

L

P

P

G

G

V

I

T

H

V

I

N

N

E

E

G

D

A

A

V

L

V

V

G
|
G

A
|
A

R

G

A

A

V

V

L

V

F

T

K

K

D

D

A

V

E

P

P

K

W

E

G

T

V

V

Y

V

V
|
V

G

G

N

N

P

P

A

A

R

R

W

E

I

I

binding coenzyme a: F150 (vs. gap), A178 (= A139), A179 (= A140), G196 (= G157), A197 (= A158), V212 (= V173)
binding (3R,4S,5R,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate: H132 (≠ Q94), S133 (≠ G95)

Sites not aligning to the query:

3fs8A Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with acetyl-coa (see paper)
34% identity, 53% coverage: 76:180/198 of query aligns to 122:219/259 of 3fs8A

query
sites
3fs8A

H

H

L

V

T

Y

M

I

G

G

A

N

Y

Y

A

V

V

N

L

I

G

-

P

-

G

-

V

-

D

-

C

-

Y

-

C

-

Q

H

G

S

R

N

I

V

T

F

I

V

G

G

E

E

K

K

A

S

V

I

S

K

Q

D

G

F

A

V

S

W

L

L

-
x
F

-
x
P

-

H

C

V

A

V

G

L

T

T

H

N

D

D

I

P

A

T

D

P

P

P

N

S

F

N

Q

E

L

L

V

L

Q

G

K

-

P

-

I

V

A

T

I

I

G

E

A

L

H

F

A

A

W

V

I

I

A
|
A

E

R

A

S

F

V

V

V

G

L

P

P

G

G

V

I

T

H

V

I

N

N

E

E

G

D

A

A

V

L

V

V

G
|
G

A
|
A

R

G

A

A

V

V

L

V

F

T

K

K

D

D

A

V

E

P

P

K

W

E

G

T

V

V

Y

V

V
|
V

G

G

N

N

P

P

A

A

R

R

W

E

I

I

binding acetyl coenzyme *a: F150 (vs. gap), P151 (vs. gap), A178 (= A139), A179 (= A140), G196 (= G157), A197 (= A158), V212 (= V173)

Sites not aligning to the query:

1kk4A Crystal structure of vat(d) in complex with acetyl-coa (see paper)
41% identity, 30% coverage: 124:183/198 of query aligns to 104:167/205 of 1kk4A

query
sites
1kk4A

Q

K

L

L

V

D

Q

Q

K

L

P

P

I

I

A
x
K

-

G

-

D

-

T

-

I

I

I

G

G

A

N

H

D

A

V

W
|
W

I

I

A
x
G

A
x
K

E

D

A

V

F

V

V

I

G

M

P

P

G

G

V

V

T

K

V

I

N

G

E

D

G

G

A

A

V

I

V

V

G
x
A

A
|
A

R

N

A

S

V

V

L

V

F
x
V

K
|
K

D

D

A

I

E

A

P

P

W

Y

G

M

V
x
L

Y

A

V
x
G

G
|
G

N

N

P
|
P

A

A

R

N

W

E

I
|
I

K

K

T

Q

R

R

binding acetyl coenzyme *a: K111 (≠ A131), W121 (= W137), G123 (≠ A139), K124 (≠ A140), A141 (≠ G157), A142 (= A158), V147 (≠ F163), K148 (= K164), L155 (≠ V171), G157 (≠ V173), G158 (= G174), P160 (= P176), I164 (= I180)

Sites not aligning to the query:

binding acetyl coenzyme *a: 69, 70

4husA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with virginiamycin m1 (see paper)
37% identity, 27% coverage: 130:183/198 of query aligns to 113:166/212 of 4husA

query
sites
4husA

I

I

A

E

I

I

G

G

A

N

H

D

A

V

W

W

I

I

A

G

A

R

E

D

A

V

F

T

V

I

G

M

P

P

G

G

V

V

T

K

V

I

N

G

E

D

G

G

A

A

V

I

G

A

A

A

R

E

A

A

V

V

L

V

F

T

K

K

D

N

A

V

E

A

P

P

W

Y

G

S

V

I

Y

V

V

G

G

G

N

N

P

P

A

L

R

K

W

F

I

I

K

R

T

K

R

R

Sites not aligning to the query:

binding virginiamycin m1: 17, 36, 38

4hurA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with acetyl coenzyme a (see paper)
37% identity, 27% coverage: 130:183/198 of query aligns to 113:166/211 of 4hurA

query
sites
4hurA

I

I

A

E

I

I

G

G

A

N

H

D

A

V

W
|
W

I
|
I

A
x
G

A
x
R

E

D

A

V

F

T

V

I

G
x
M

P

P

G

G

V

V

T

K

V

I

N

G

E

D

G

G

A

A

V

I

G
x
A

A
|
A

R

E

A

A

V

V

L

V

F
x
T

K

K

D

N

A

V

E

A

P

P

W

Y

G

S

V

I

Y

V

V
x
G

G

G

N

N

P
|
P

A

L

R

K

W

F

I
|
I

K
x
R

T

K

R

R

binding acetyl coenzyme *a: W120 (= W137), I121 (= I138), G122 (≠ A139), R123 (≠ A140), M128 (≠ G145), A140 (≠ G157), A141 (= A158), T146 (≠ F163), G156 (≠ V173), P159 (= P176), I163 (= I180), R164 (≠ K181)

Sites not aligning to the query:

binding acetyl coenzyme *a: 51, 67, 68, 69, 79, 80, 110

Query Sequence

>WP_038212316.1 NCBI__GCF_000745855.1:WP_038212316.1
MSLLDAGRSRPLEGGASYSIGHRLFRALWNLAWLLCAAWTPPPLHRWRGLLLRLFGADVH
PTARVYGKARIWYPPHLTMGAYAVLGPGVDCYCQGRITIGEKAVVSQGASLCAGTHDIAD
PNFQLVQKPIAIGAHAWIAAEAFVGPGVTVNEGAVVGARAVLFKDAEPWGVYVGNPARWI
KTRVLRQPAPHQAQVIGA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory