Comparing WP_038217426.1 NCBI__GCF_000745855.1:WP_038217426.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1umdD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate (see paper)
42% identity, 97% coverage: 10:328/330 of query aligns to 3:321/323 of 1umdD
1umcD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate (see paper)
42% identity, 97% coverage: 10:328/330 of query aligns to 3:321/323 of 1umcD
1umbD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
42% identity, 97% coverage: 10:328/330 of query aligns to 3:321/323 of 1umbD
Q5SLR3 2-oxoisovalerate dehydrogenase subunit beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
42% identity, 97% coverage: 10:328/330 of query aligns to 4:322/324 of Q5SLR3
3dv0D Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
40% identity, 88% coverage: 10:299/330 of query aligns to 3:294/324 of 3dv0D
3dv0B Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
40% identity, 88% coverage: 10:299/330 of query aligns to 3:294/324 of 3dv0B
3dufD Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
40% identity, 88% coverage: 10:299/330 of query aligns to 3:294/324 of 3dufD
1w85B The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2 (see paper)
40% identity, 88% coverage: 10:299/330 of query aligns to 3:294/324 of 1w85B
6cfoB Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate (see paper)
35% identity, 98% coverage: 7:329/330 of query aligns to 1:329/330 of 6cfoB
6cerD Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
35% identity, 98% coverage: 7:329/330 of query aligns to 2:330/331 of 6cerD
P11177 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Homo sapiens (Human) (see 6 papers)
35% identity, 98% coverage: 8:329/330 of query aligns to 31:358/359 of P11177
Sites not aligning to the query:
1qs0B Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
39% identity, 85% coverage: 7:288/330 of query aligns to 2:294/338 of 1qs0B
2j9fD Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase e1b (see paper)
34% identity, 98% coverage: 7:329/330 of query aligns to 5:328/329 of 2j9fD
1dtwB Human branched-chain alpha-keto acid dehydrogenase (see paper)
34% identity, 98% coverage: 7:329/330 of query aligns to 2:325/326 of 1dtwB
P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Homo sapiens (Human) (see 2 papers)
34% identity, 98% coverage: 7:329/330 of query aligns to 68:391/392 of P21953
6yakDDD C-terminal component of the split chain transketolase (see paper)
26% identity, 95% coverage: 14:328/330 of query aligns to 7:307/311 of 6yakDDD
2o1sA 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from escherichia coli (see paper)
23% identity, 76% coverage: 54:304/330 of query aligns to 271:511/536 of 2o1sA
Sites not aligning to the query:
P77488 1-deoxy-D-xylulose-5-phosphate synthase; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS; EC 2.2.1.7 from Escherichia coli (strain K12) (see 2 papers)
23% identity, 76% coverage: 54:304/330 of query aligns to 355:595/620 of P77488
Sites not aligning to the query:
2o1sB 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from escherichia coli (see paper)
23% identity, 76% coverage: 54:304/330 of query aligns to 227:467/493 of 2o1sB
Sites not aligning to the query:
6ouwA 1-deoxy-d-xylulose 5-phosphate synthase (dxps) from deinococcus radiodurans with enamine intermediate bound (see paper)
27% identity, 72% coverage: 61:299/330 of query aligns to 282:509/544 of 6ouwA
Sites not aligning to the query:
>WP_038217426.1 NCBI__GCF_000745855.1:WP_038217426.1
MNRVVDTLDLSYAQAAALALAEAMEADPNVVALGEDLGRGGVFGQYRDPDGAPLARRFGG
HRIVDTPISESTIVGAAVGMALAGVRPVVELRVVDFALCAIDELVNQAAKNRFMFGGQGR
VPLVARMPIGLWGNSAAQHSQSLEAWFAHIPGLVVAAPATPADNYGLLHAALACGDPVIY
MEHKELWGVAGAVAPGAHVPLGKARLAHPGNDLTIVSWSRQVHACVAAAEALARESIGAE
VIDLRTLWPWDREAVLGSAERTRRVLVVHEAVQVAGFGAEVAATVAEHSPARVARLGAPR
IPVGYAAVLEDEARITAGKVVDAARRLLQR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory