SitesBLAST
Comparing WP_038857019.1 NCBI__GCF_001277175.1:WP_038857019.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5u4qA 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
74% identity, 99% coverage: 1:335/337 of query aligns to 2:321/321 of 5u4qA
- binding nicotinamide-adenine-dinucleotide: G8 (= G7), G11 (= G10), F12 (= F11), I13 (= I12), D32 (= D31), N33 (= N32), N35 (= N34), Y38 (= Y37), K43 (= K42), D61 (= D61), L62 (= L62), L83 (= L83), A84 (= A84), A85 (= A85), A118 (= A125), Y145 (= Y152), K149 (= K156), F172 (= F179), F173 (= F180), T174 (= T181), V175 (= V182), R181 (= R188)
5u4qB 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
72% identity, 99% coverage: 1:333/337 of query aligns to 2:303/304 of 5u4qB
- binding nicotinamide-adenine-dinucleotide: G8 (= G7), G11 (= G10), F12 (= F11), I13 (= I12), D32 (= D31), N33 (= N32), N35 (= N34), Y38 (= Y37), K43 (= K42), D61 (= D61), L62 (= L62), L83 (= L83), A84 (= A84), A85 (= A85), A123 (= A125), Y150 (= Y152), K154 (= K156), F177 (= F179), V180 (= V182), R186 (= R188), M189 (= M191)
6zllA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-galacturonic acid and NAD (see paper)
32% identity, 99% coverage: 1:334/337 of query aligns to 1:315/321 of 6zllA
- active site: T126 (≠ S127), S127 (= S128), S128 (= S129), Y149 (= Y152), K153 (= K156)
- binding nicotinamide-adenine-dinucleotide: G7 (= G7), G10 (= G10), F11 (= F11), I12 (= I12), D32 (= D31), H33 (≠ N32), F34 (≠ L33), I35 (≠ N34), K43 (= K42), D62 (= D61), I63 (≠ L62), L81 (= L83), A82 (= A84), A83 (= A85), I124 (≠ A125), T126 (≠ S127), Y149 (= Y152), K153 (= K156), Y176 (≠ F179), V179 (= V182), R185 (= R188), M188 (= M191)
- binding (2S,3R,4S,5R,6R)-6-[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-3,4,5-trihydroxy-oxane-2-carboxylic acid: P85 (≠ A87), V87 (= V89), R88 (= R90), T126 (≠ S127), S127 (= S128), Y149 (= Y152), T178 (= T181), R185 (= R188), A189 (= A192), R192 (≠ K195), T204 (≠ D207), F206 (≠ Y209), Q211 (≠ M214), R213 (= R216), I250 (≠ L269), E276 (≠ D295)
6zldA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-glucuronic acid and NAD (see paper)
33% identity, 99% coverage: 1:333/337 of query aligns to 1:314/314 of 6zldA
- active site: T126 (≠ S127), S127 (= S128), S128 (= S129), Y149 (= Y152), K153 (= K156)
- binding nicotinamide-adenine-dinucleotide: G7 (= G7), G10 (= G10), F11 (= F11), I12 (= I12), D32 (= D31), H33 (≠ N32), F34 (≠ L33), I35 (≠ N34), K43 (= K42), D62 (= D61), I63 (≠ L62), L81 (= L83), A82 (= A84), A83 (= A85), I124 (≠ A125), T126 (≠ S127), K153 (= K156), Y176 (≠ F179), T178 (= T181), R185 (= R188), M188 (= M191)
- binding uridine-5'-diphosphate-glucuronic acid: P85 (≠ A87), R88 (= R90), T126 (≠ S127), S127 (= S128), S128 (= S129), Y149 (= Y152), F177 (= F180), T178 (= T181), R185 (= R188), M188 (= M191), A189 (= A192), R192 (≠ K195), T204 (≠ D207), F206 (≠ Y209), Q211 (≠ M214), R213 (= R216), I250 (≠ L269), E276 (≠ D295)
6zl6A Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp and NAD (see paper)
33% identity, 99% coverage: 1:333/337 of query aligns to 1:314/314 of 6zl6A
- active site: T126 (≠ S127), S127 (= S128), S128 (= S129), Y149 (= Y152), K153 (= K156)
- binding nicotinamide-adenine-dinucleotide: G7 (= G7), G10 (= G10), F11 (= F11), I12 (= I12), D32 (= D31), H33 (≠ N32), F34 (≠ L33), I35 (≠ N34), K43 (= K42), D62 (= D61), I63 (≠ L62), L81 (= L83), A82 (= A84), A83 (= A85), I124 (≠ A125), T126 (≠ S127), K153 (= K156), Y176 (≠ F179), T178 (= T181), V179 (= V182), R185 (= R188), M188 (= M191)
- binding uridine-5'-diphosphate: T178 (= T181), A189 (= A192), R192 (≠ K195), T204 (≠ D207), F206 (≠ Y209), Q211 (≠ M214), R213 (= R216), I250 (≠ L269), E276 (≠ D295)
6zljA Crystal structure of udp-glucuronic acid 4-epimerase y149f mutant from bacillus cereus in complex with udp-4-deoxy-4-fluoro-glucuronic acid and NAD (see paper)
32% identity, 99% coverage: 1:333/337 of query aligns to 1:314/314 of 6zljA
- active site: T126 (≠ S127), S127 (= S128), S128 (= S129), F149 (≠ Y152), K153 (= K156)
- binding nicotinamide-adenine-dinucleotide: G7 (= G7), G10 (= G10), F11 (= F11), I12 (= I12), D32 (= D31), H33 (≠ N32), F34 (≠ L33), I35 (≠ N34), K43 (= K42), D62 (= D61), I63 (≠ L62), L81 (= L83), A82 (= A84), A83 (= A85), I124 (≠ A125), T126 (≠ S127), K153 (= K156), Y176 (≠ F179), T178 (= T181), V179 (= V182), R185 (= R188), M188 (= M191)
- binding (2~{R},3~{S},4~{R},5~{R},6~{R})-6-[[[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3-fluoranyl-4,5-bis(oxidanyl)oxane-2-carboxylic acid: P85 (≠ A87), R88 (= R90), T126 (≠ S127), S127 (= S128), S128 (= S129), F149 (≠ Y152), F177 (= F180), T178 (= T181), R185 (= R188), M188 (= M191), A189 (= A192), R192 (≠ K195), T204 (≠ D207), F206 (≠ Y209), Q211 (≠ M214), R213 (= R216), I250 (≠ L269), E276 (≠ D295)
4zrnA Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
29% identity, 98% coverage: 1:330/337 of query aligns to 1:305/309 of 4zrnA
- active site: T117 (≠ S127), G119 (≠ S128), A120 (≠ S129), Y143 (= Y152), K147 (= K156), Y181 (≠ W186), G185 (≠ D190)
- binding nicotinamide-adenine-dinucleotide: G7 (= G7), G10 (= G10), F11 (= F11), I12 (= I12), D31 (= D31), N32 (= N32), S34 (≠ N34), S35 (≠ D35), G36 (≠ A44), S51 (≠ K59), I52 (= I60), L73 (= L83), A74 (= A84), A75 (= A85), T92 (≠ A102), S115 (≠ A125), S116 (= S126), Y143 (= Y152), K147 (= K156), Y170 (≠ F179), V173 (= V182)
- binding uridine-5'-diphosphate-glucose: T117 (≠ S127), G119 (≠ S128), A120 (≠ S129), Y143 (= Y152), N172 (≠ T181), G185 (≠ D190), V186 (≠ M191), H201 (≠ D207), F203 (≠ Y209), Y208 (≠ M214), R210 (= R216), V244 (≠ L269), R267 (≠ Q292), D270 (= D295)
1sb9A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-glucose (see paper)
31% identity, 98% coverage: 3:332/337 of query aligns to 18:338/340 of 1sb9A
- active site: S141 (= S127), S142 (= S128), S143 (= S129), Y165 (= Y152), K169 (= K156), N203 (≠ D190)
- binding nicotinamide-adenine-dinucleotide: G22 (= G7), G25 (= G10), F26 (= F11), I27 (= I12), D46 (= D31), N47 (= N32), F48 (≠ L33), T50 (≠ D35), G51 (≠ Y36), D77 (= D61), I78 (≠ L62), Q97 (≠ L83), A99 (= A85), T116 (≠ A102), A139 (= A125), A140 (≠ S126), Y165 (= Y152), K169 (= K156), Y192 (≠ F179), N194 (≠ T181), V195 (= V182)
- binding uridine-5'-diphosphate-glucose: S141 (= S127), Y165 (= Y152), N194 (≠ T181), A208 (vs. gap), V209 (vs. gap), W213 (≠ F196), Y224 (≠ D207), I225 (≠ V208), N226 (≠ Y209), L270 (= L269), R298 (≠ Q292), D301 (= D295)
1sb8A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-n-acetylgalactosamine (see paper)
31% identity, 98% coverage: 3:332/337 of query aligns to 19:339/341 of 1sb8A
- active site: S142 (= S127), S143 (= S128), S144 (= S129), Y166 (= Y152), K170 (= K156), N204 (≠ D190)
- binding nicotinamide-adenine-dinucleotide: G23 (= G7), G26 (= G10), F27 (= F11), I28 (= I12), D47 (= D31), N48 (= N32), F49 (≠ L33), T51 (≠ D35), G52 (≠ Y36), D78 (= D61), I79 (≠ L62), Q98 (≠ L83), A100 (= A85), T117 (≠ A102), A140 (= A125), A141 (≠ S126), Y166 (= Y152), K170 (= K156), Y193 (≠ F179), N195 (≠ T181), V196 (= V182)
- binding uridine-diphosphate-n-acetylgalactosamine: S103 (≠ G88), S142 (= S127), S143 (= S128), S144 (= S129), Y166 (= Y152), N195 (≠ T181), A209 (vs. gap), V210 (vs. gap), W214 (≠ F196), Y225 (≠ D207), I226 (≠ V208), N227 (≠ Y209), R234 (= R216), L271 (= L269), R299 (≠ Q292), D302 (= D295), S306 (≠ T299)
3ruhA Alternative analogs as viable substrates of udp-hexose 4-epimerases
29% identity, 98% coverage: 3:332/337 of query aligns to 19:334/336 of 3ruhA
- active site: S142 (= S127), S143 (= S128), S144 (= S129), Y166 (= Y152), K170 (= K156), N204 (≠ D190)
- binding nicotinamide-adenine-dinucleotide: G23 (= G7), G26 (= G10), F27 (= F11), I28 (= I12), D47 (= D31), N48 (= N32), S50 (≠ N34), T51 (≠ D35), G52 (≠ Y36), D78 (= D61), I79 (≠ L62), Q98 (≠ L83), A99 (= A84), A100 (= A85), T117 (≠ A102), A140 (= A125), A141 (≠ S126), S142 (= S127), Y166 (= Y152), K170 (= K156), Y193 (≠ F179), V196 (= V182)
- binding [[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl][(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-4,5-bis(oxidanyl)-3-(2-oxidanylidenepropyl)oxan-2-yl] hydrogen phosphate: G102 (≠ A87), S103 (≠ G88), S142 (= S127), S143 (= S128), S144 (= S129), Y166 (= Y152), Y193 (≠ F179), N195 (≠ T181), A209 (vs. gap), V210 (vs. gap), K213 (= K195), W214 (≠ F196), Y225 (≠ D207), I226 (≠ V208), N227 (≠ Y209), R234 (= R216), L271 (= L269), R294 (≠ Q292), D297 (= D295), V298 (= V296), S301 (≠ T299)
3rufA Alternative analogs as viable substrates of udp-hexose 4-epimerases
29% identity, 98% coverage: 3:332/337 of query aligns to 19:334/336 of 3rufA
- active site: S142 (= S127), S143 (= S128), S144 (= S129), Y166 (= Y152), K170 (= K156), N204 (≠ D190)
- binding nicotinamide-adenine-dinucleotide: G23 (= G7), G26 (= G10), F27 (= F11), I28 (= I12), D47 (= D31), N48 (= N32), S50 (≠ N34), T51 (≠ D35), G52 (≠ Y36), D78 (= D61), I79 (≠ L62), Q98 (≠ L83), A99 (= A84), A100 (= A85), T117 (≠ A102), A140 (= A125), Y166 (= Y152), K170 (= K156), Y193 (≠ F179), V196 (= V182)
- binding uridine-5'-diphosphate: N195 (≠ T181), A209 (vs. gap), V210 (vs. gap), K213 (= K195), W214 (≠ F196), Y225 (≠ D207), I226 (≠ V208), N227 (≠ Y209), R234 (= R216), L271 (= L269), R294 (≠ Q292), D297 (= D295)
3lu1A Crystal structure analysis of wbgu: a udp-galnac 4-epimerase (see paper)
29% identity, 98% coverage: 3:332/337 of query aligns to 19:334/336 of 3lu1A