SitesBLAST
Comparing WP_041099023.1 NCBI__GCF_000828635.1:WP_041099023.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5xf9B Crystal structure of NAD+-reducing [nife]-hydrogenase in the air- oxidized state (see paper)
56% identity, 95% coverage: 3:227/237 of query aligns to 1:223/234 of 5xf9B
- binding fe2/s2 (inorganic) cluster: C35 (= C37), G44 (= G46), C46 (= C48), R47 (≠ K49), C49 (= C51), C61 (= C63)
- binding iron/sulfur cluster: F90 (= F92), H95 (= H97), F96 (= F98), C97 (= C99), C100 (= C102), S103 (= S105), C106 (= C108), C145 (= C147), I146 (= I148), L147 (≠ M149), C148 (= C150), G149 (≠ S151), C151 (= C153), L174 (≠ V178), C198 (= C202), G201 (= G205), A202 (≠ V206)
7t30A Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn/NAD(h) bound state (see paper)
37% identity, 85% coverage: 6:207/237 of query aligns to 5:207/666 of 7t30A
- binding fe2/s2 (inorganic) cluster: C36 (= C37), G45 (= G46), C47 (= C48), R48 (≠ K49), C50 (= C51), C64 (= C63)
- binding iron/sulfur cluster: F93 (= F92), H98 (= H97), F99 (= F98), C100 (= C99), C103 (= C102), Q105 (≠ K104), C109 (= C108), L141 (≠ I140), R147 (= R146), C148 (= C147), L150 (≠ M149), C151 (= C150), Q152 (≠ S151), C154 (= C153), C158 (≠ S157), C192 (≠ A193), V193 (= V194), N194 (≠ T195), C195 (≠ D196), G196 (≠ R197), A197 (= A198), C198 (vs. gap), C202 (= C202), P203 (= P203), T204 (≠ V204), G205 (= G205), T206 (≠ V206), I207 (= I207)
Sites not aligning to the query:
7p8na Tmhydabc- t. Maritima hydrogenase with bridge closed (see paper)
27% identity, 85% coverage: 7:207/237 of query aligns to 3:201/642 of 7p8na
- binding fe2/s2 (inorganic) cluster: N32 (≠ H35), C34 (= C37), Y42 (≠ N45), G43 (= G46), C45 (= C48), R46 (≠ K49), C48 (= C51), C60 (= C63)
- binding iron/sulfur cluster: H92 (≠ G95), D95 (≠ F98), C96 (= C99), C99 (= C102), C105 (= C108), Q108 (= Q111), C143 (= C147), I144 (= I148), L145 (≠ M149), C146 (= C150), G147 (≠ S151), D148 (≠ L152), C149 (= C153), C153 (≠ S157), V161 (≠ I165), C186 (≠ F192), V187 (≠ A193), L188 (≠ V194), C189 (≠ T195), G190 (≠ D196), C192 (≠ A198), C196 (= C202), P197 (= P203), T198 (≠ V204), A200 (≠ V206), L201 (≠ I207)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 575, 577, 579, 580, 612, 613, 615, 616
- binding iron/sulfur cluster: 295, 350, 480, 481, 482, 486
8a5eA Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from acetobacterium woodii in the reduced state (see paper)
29% identity, 86% coverage: 6:210/237 of query aligns to 5:209/583 of 8a5eA
- binding fe2/s2 (inorganic) cluster: T34 (≠ H35), C36 (= C37), G45 (= G46), C47 (= C48), C50 (= C51), C64 (= C63)
- binding iron/sulfur cluster: H96 (≠ G95), N97 (= N96), C100 (= C99), C103 (= C102), S106 (= S105), C109 (= C108), C148 (= C147), C151 (= C150), K152 (≠ S151), C154 (= C153), C158 (≠ S157), V166 (≠ I165), C191 (≠ F192), C194 (≠ T195), G195 (≠ D196), C197 (≠ A198), C201 (= C202), P202 (= P203), V203 (= V204)
Sites not aligning to the query:
8a6tA Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from thermoanaerobacter kivui in the reduced state (see paper)
31% identity, 85% coverage: 9:210/237 of query aligns to 8:207/571 of 8a6tA
- binding fe2/s2 (inorganic) cluster: C36 (= C37), D37 (≠ W38), C47 (= C48), R48 (≠ K49), C50 (= C51), C63 (= C63)
- binding iron/sulfur cluster: H95 (≠ G95), C99 (= C99), C102 (= C102), C108 (= C108), C146 (= C147), C149 (= C150), G150 (≠ S151), K151 (≠ L152), C152 (= C153), C156 (≠ S157), C189 (≠ F192), C192 (≠ T195), C195 (≠ A198), C199 (= C202), G202 (= G205)
Sites not aligning to the query:
- binding 2 iron/2 sulfur/5 carbonyl/2 water inorganic cluster: 229, 230, 231, 298, 323, 352, 353, 357, 412, 500
- binding iron/sulfur cluster: 299, 354, 496, 500
7q5yA Structure of nadh:ubichinon oxidoreductase (complex i) of the hyperthermophilic eubacterium aquifex aeolicus
31% identity, 86% coverage: 7:210/237 of query aligns to 4:211/626 of 7q5yA
- binding fe2/s2 (inorganic) cluster: C34 (= C37), Y35 (≠ W38), G43 (= G46), C45 (= C48), R46 (≠ K49), C48 (= C51), C62 (= C63)
- binding iron/sulfur cluster: H96 (≠ G95), D99 (≠ F98), C100 (= C99), C103 (= C102), A106 (≠ S105), C109 (= C108), Q112 (= Q111), C151 (= C147), V152 (≠ I148), V153 (≠ M149), C154 (= C150), Y155 (≠ S151), C157 (= C153), C161 (≠ S157), T167 (≠ K163), C193 (≠ F192), M195 (≠ V194), C196 (≠ T195), G197 (≠ D196), C199 (≠ A198), C203 (= C202), P204 (= P203), A207 (≠ V206), I208 (= I207)
Sites not aligning to the query:
6tg9A Cryo-em structure of nadh reduced form of NAD+-dependent formate dehydrogenase from rhodobacter capsulatus (see paper)
29% identity, 85% coverage: 9:210/237 of query aligns to 23:236/949 of 6tg9A
- binding fe2/s2 (inorganic) cluster: C51 (= C37), V59 (≠ N45), G60 (= G46), C62 (= C48), C65 (= C51), C79 (= C63)
- binding iron/sulfur cluster: H111 (≠ G95), C115 (= C99), C118 (= C102), A120 (≠ K104), C124 (= C108), C176 (= C147), I177 (= I148), V178 (≠ M149), C179 (= C150), M180 (≠ S151), C182 (= C153), C186 (≠ S157), I206 (≠ V180), C218 (≠ F192), S220 (≠ V194), C221 (≠ T195), G222 (≠ D196), C224 (≠ A198), C228 (= C202), T230 (≠ V204), A231 (≠ G205)
Sites not aligning to the query:
- active site: 289, 380, 381, 545, 582, 583
- binding 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraaza-anthracen-4-one guanosine dinucleotide: 255, 289, 351, 352, 380, 414, 415, 419, 420, 421, 443, 444, 464, 467, 545, 546, 550, 582, 583, 583, 649, 650, 655, 680, 693, 698, 724, 820, 821, 823, 823, 824, 825, 829, 830, 833, 902, 918, 919
- binding iron/sulfur cluster: 252, 254, 255, 257, 259, 261, 287, 289, 423
7arcG Cryo-em structure of polytomella complex-i (peripheral arm) (see paper)
28% identity, 87% coverage: 9:214/237 of query aligns to 10:212/682 of 7arcG
- binding fe2/s2 (inorganic) cluster: R36 (≠ H35), C38 (= C37), Y39 (≠ W38), G47 (= G46), C49 (= C48), R50 (≠ K49), C52 (= C51), C66 (= C63)
- binding iron/sulfur cluster: H98 (≠ G95), D101 (≠ F98), C102 (= C99), C105 (= C102), Q107 (≠ K104), C111 (= C108), Q114 (= Q111), C150 (= C147), I151 (= I148), C153 (= C150), C156 (= C153), C200 (= C202), V202 (= V204), A204 (≠ V206), L205 (≠ I207)
Sites not aligning to the query:
7zm7A Cryoem structure of mitochondrial complex i from chaetomium thermophilum (inhibited by ddm) (see paper)
28% identity, 87% coverage: 9:214/237 of query aligns to 7:211/711 of 7zm7A
- binding fe2/s2 (inorganic) cluster: R33 (≠ H35), C35 (= C37), Y36 (≠ W38), G44 (= G46), C46 (= C48), R47 (≠ K49), C49 (= C51), C63 (= C63)
- binding iron/sulfur cluster: H95 (≠ G95), D98 (≠ F98), C99 (= C99), C102 (= C102), Q104 (≠ K104), G105 (≠ S105), C108 (= C108), Q111 (= Q111), C149 (= C147), I150 (= I148), C152 (= C150), T153 (≠ S151), C155 (= C153), I179 (≠ V180), C199 (= C202), V201 (= V204), L204 (≠ I207)
7awtG E. Coli nadh quinone oxidoreductase hydrophilic arm (see paper)
29% identity, 86% coverage: 6:210/237 of query aligns to 2:208/907 of 7awtG
- binding fe2/s2 (inorganic) cluster: Y31 (≠ H35), C33 (= C37), W34 (= W38), G42 (= G46), C44 (= C48), R45 (≠ K49), C47 (= C51), C66 (= C63)
- binding magnesium ion: V197 (≠ A199), C200 (= C202), T202 (≠ V204)
- binding iron/sulfur cluster: H98 (≠ G95), D101 (≠ F98), C102 (= C99), C105 (= C102), C111 (= C108), Q114 (= Q111), C150 (= C147), I151 (= I148), A152 (≠ M149), C153 (= C150), Y154 (≠ S151), C156 (= C153), F180 (≠ S182), C200 (= C202), P201 (= P203), T202 (≠ V204), T202 (≠ V204), G203 (= G205), V204 (= V206)
Sites not aligning to the query:
7nyrG Respiratory complex i from escherichia coli - conformation 1 (see paper)
29% identity, 86% coverage: 6:210/237 of query aligns to 3:209/907 of 7nyrG
- binding fe2/s2 (inorganic) cluster: C34 (= C37), W35 (= W38), C45 (= C48), R46 (≠ K49), C48 (= C51), M65 (≠ S61), C67 (= C63)
- binding iron/sulfur cluster: H99 (≠ G95), D102 (≠ F98), C103 (= C99), C106 (= C102), G109 (≠ S105), C112 (= C108), Q115 (= Q111), C151 (= C147), I152 (= I148), A153 (≠ M149), C154 (= C150), Y155 (≠ S151), C157 (= C153), F181 (≠ S182), C201 (= C202), G204 (= G205), V205 (= V206), F206 (≠ I207)
Sites not aligning to the query:
7vw6A Cryo-em structure of formate dehydrogenase 1 from methylorubrum extorquens am1 (see paper)
28% identity, 86% coverage: 4:208/237 of query aligns to 1:204/913 of 7vw6A
- binding fe2/s2 (inorganic) cluster: H32 (= H35), C34 (= C37), H35 (≠ W38), G45 (= G46), C47 (= C48), R48 (≠ K49), C50 (= C51), C64 (= C63)
- binding iron/sulfur cluster: C145 (= C147), I146 (= I148), Q147 (≠ M149), C148 (= C150), N149 (≠ S151), C151 (= C153), C155 (≠ S157), N161 (≠ K163), V163 (≠ I165), I164 (≠ F166), V175 (= V178), C188 (≠ F192), V189 (≠ A193), A190 (≠ V194), C191 (≠ T195), G192 (≠ D196), C194 (≠ A198), C198 (= C202), P199 (= P203), T200 (≠ V204), A202 (≠ V206), L203 (≠ I207)
Sites not aligning to the query:
- binding 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraaza-anthracen-4-one guanosine dinucleotide: 263, 339, 364, 368, 402, 404, 408, 431, 432, 433, 447, 450, 452, 525, 526, 527, 530, 531, 563, 564, 630, 632, 636, 656, 657, 658, 805, 807, 807, 808, 809, 811, 812, 813, 813, 814, 817, 879, 887, 903, 904
- binding iron/sulfur cluster: 227, 230, 234, 261, 263, 264, 411
7b0nG 3.7-angstrom structure of Yarrowia lipolytica complex I with an R121M mutation in NUCM. (see paper)
26% identity, 87% coverage: 9:214/237 of query aligns to 7:211/694 of 7b0nG
- binding fe2/s2 (inorganic) cluster: C35 (= C37), G44 (= G46), C46 (= C48), R47 (≠ K49), C49 (= C51), C63 (= C63)
- binding iron/sulfur cluster: H95 (≠ G95), C99 (= C99), C102 (= C102), C108 (= C108), Q111 (= Q111), C149 (= C147), H151 (≠ M149), C152 (= C150), T153 (≠ S151), C155 (= C153), C199 (= C202), V201 (= V204)
8e9hG Mycobacterial respiratory complex i, fully-inserted quinone (see paper)
29% identity, 85% coverage: 6:207/237 of query aligns to 6:207/782 of 8e9hG
- binding fe2/s2 (inorganic) cluster: R35 (≠ H35), C37 (= C37), D38 (≠ W38), G46 (= G46), C48 (= C48), R49 (≠ K49), C51 (= C51), A63 (≠ S61), C65 (= C63)
- binding iron/sulfur cluster: H99 (≠ G95), D102 (≠ F98), C103 (= C99), C106 (= C102), G109 (≠ S105), C112 (= C108), Q115 (= Q111), C152 (= C147), V153 (≠ I148), L154 (≠ M149), C155 (= C150), A156 (≠ S151), R157 (≠ L152), C158 (= C153), C202 (= C202), P203 (= P203), V204 (= V204), A206 (≠ V206), L207 (≠ I207)
Sites not aligning to the query:
- binding guanosine-5'-triphosphate: 320, 486, 487, 554, 556, 559, 579, 580, 582, 627, 689, 695, 696, 697
- binding iron/sulfur cluster: 228, 231, 233, 235, 262, 263, 266, 391, 392
6x89S1 radiata mitochondrial complex I* (see paper)
28% identity, 87% coverage: 9:214/237 of query aligns to 23:225/688 of 6x89S1
- binding fe2/s2 (inorganic) cluster: C51 (= C37), G60 (= G46), C62 (= C48), R63 (≠ K49), C65 (= C51), C79 (= C63)
- binding iron/sulfur cluster: H111 (≠ G95), C115 (= C99), C118 (= C102), C124 (= C108), L126 (= L110), R162 (= R146), C163 (= C147), I164 (= I148), Q165 (≠ M149), C166 (= C150), C169 (= C153), C213 (= C202), P214 (= P203), V215 (= V204), V215 (= V204), G216 (= G205)
Sites not aligning to the query:
- binding : 306, 307, 590, 591, 596, 597, 600, 603, 604, 607, 612
7a23C Plant mitochondrial respiratory complex i (see paper)
27% identity, 87% coverage: 9:214/237 of query aligns to 29:231/693 of 7a23C
- binding fe2/s2 (inorganic) cluster: R55 (≠ H35), C57 (= C37), Y58 (≠ W38), C68 (= C48), C71 (= C51), C85 (= C63)
- binding iron/sulfur cluster: H117 (≠ G95), D120 (≠ F98), C121 (= C99), C124 (= C102), G127 (≠ S105), C130 (= C108), L132 (= L110), Q133 (= Q111), C169 (= C147), I170 (= I148), Q171 (≠ M149), C172 (= C150), T173 (≠ S151), R174 (≠ L152), C175 (= C153), I199 (≠ V178), C219 (= C202), P220 (= P203), V221 (= V204), G222 (= G205)
8gyms1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (see paper)
25% identity, 87% coverage: 9:214/237 of query aligns to 8:210/689 of 8gyms1
- binding fe2/s2 (inorganic) cluster: R34 (≠ H35), C36 (= C37), Y37 (≠ W38), C47 (= C48), C50 (= C51), C64 (= C63)
- binding iron/sulfur cluster: H96 (≠ G95), C100 (= C99), C103 (= C102), Q105 (≠ K104), G106 (≠ S105), C109 (= C108), Q112 (= Q111), R147 (= R146), C148 (= C147), I149 (= I148), H150 (≠ M149), C151 (= C150), T152 (≠ S151), R153 (≠ L152), C154 (= C153), C198 (= C202), P199 (= P203), V200 (= V204), G201 (= G205), A202 (≠ V206)
8bedG Cryo-em structure of the arabidopsis thaliana i+iii2 supercomplex (ci peripheral tip) (see paper)
27% identity, 87% coverage: 9:214/237 of query aligns to 22:224/687 of 8bedG
- binding fe2/s2 (inorganic) cluster: R48 (≠ H35), C50 (= C37), Y51 (≠ W38), G59 (= G46), C61 (= C48), R62 (≠ K49), C64 (= C51), C78 (= C63)
- binding iron/sulfur cluster: H110 (≠ G95), D113 (≠ F98), C114 (= C99), C117 (= C102), Q119 (≠ K104), G120 (≠ S105), C123 (= C108), L125 (= L110), Q126 (= Q111), C162 (= C147), I163 (= I148), Q164 (≠ M149), C165 (= C150), T166 (≠ S151), C168 (= C153), I192 (≠ V178), C212 (= C202), V214 (= V204), A216 (≠ V206), L217 (≠ I207)
- binding : I116 (≠ S101), F224 (= F214)
Sites not aligning to the query:
- binding : 305, 306, 589, 590, 595, 596, 599, 600, 602, 603, 606
7qsoG Bovine complex i in lipid nanodisc, state 3 (slack) (see paper)
25% identity, 87% coverage: 9:214/237 of query aligns to 9:211/700 of 7qsoG
- binding fe2/s2 (inorganic) cluster: R35 (≠ H35), C37 (= C37), Y38 (≠ W38), G46 (= G46), C48 (= C48), R49 (≠ K49), C51 (= C51), C65 (= C63)
- binding iron/sulfur cluster: H97 (≠ G95), D100 (≠ F98), C101 (= C99), C104 (= C102), Q106 (≠ K104), G107 (≠ S105), C110 (= C108), Q113 (= Q111), C149 (= C147), I150 (= I148), Q151 (≠ M149), C152 (= C150), T153 (≠ S151), R154 (≠ L152), C155 (= C153), C199 (= C202), P200 (= P203), V201 (= V204), G202 (= G205), A203 (≠ V206)
8eszS1 NADH-ubiquinone oxidoreductase chain 1 (see paper)
27% identity, 87% coverage: 9:214/237 of query aligns to 8:214/683 of 8eszS1
- binding fe2/s2 (inorganic) cluster: C36 (= C37), Y37 (≠ W38), A44 (≠ N45), G45 (= G46), C47 (= C48), R48 (≠ K49), C50 (= C51), C64 (= C63)
- binding iron/sulfur cluster: H96 (≠ G95), D99 (≠ F98), C100 (= C99), C103 (= C102), C109 (= C108), Q112 (= Q111), C152 (= C147), I153 (= I148), H154 (≠ M149), C155 (= C150), T156 (≠ S151), R157 (≠ L152), C158 (= C153), I182 (≠ V180), C202 (= C202), P203 (= P203), V204 (= V204)
Query Sequence
>WP_041099023.1 NCBI__GCF_000828635.1:WP_041099023.1
MTATNTFHIDGKEVPFTPGQTVIQAATANGTWIPHLCWHPDFQVNGSCKLCTVKVNGRFG
SSCTMEAQAGMEVENRTAELDDKRRTLLQMLFVEGNHFCPSCEKSGDCALQATAYELKMM
SPHFDMFYPDRPVDASHPDILLDFNRCIMCSLCVSASRDVDGKSIFYMGGRGILGRRVHV
SSESGKLGDTDFAVTDRAASVCPVGVILKKRRGFAVPIGERTYDKAPISGQVKETTS
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory