SitesBLAST
Comparing WP_041100439.1 NCBI__GCF_000828635.1:WP_041100439.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3m4rA Structure of the n-terminal class ii aldolase domain of a conserved protein from thermoplasma acidophilum
42% identity, 31% coverage: 16:221/659 of query aligns to 14:213/213 of 3m4rA
5fffA Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and piperonal (see paper)
34% identity, 38% coverage: 405:654/659 of query aligns to 5:252/257 of 5fffA
- active site: K206 (≠ R603)
- binding 1,3-benzodioxole-5-carbaldehyde: Y100 (≠ F493), H158 (≠ A553)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G18 (= G418), T20 (≠ A420), G22 (= G422), I23 (= I423), R43 (≠ L443), C67 (= C461), D68 (= D462), V69 (= V463), N96 (= N489), I146 (= I541), Y161 (= Y556), K165 (= K560), P191 (= P586), A193 (= A588), I194 (≠ V589), T196 (≠ D591), G198 (= G593), T199 (= T596)
5ff9B Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and tyramine (see paper)
34% identity, 38% coverage: 405:654/659 of query aligns to 5:252/257 of 5ff9B
- active site: K206 (≠ R603)
- binding 4-(2-aminoethyl)phenol: Y100 (≠ F493), I155 (≠ G550), H158 (≠ A553)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G18 (= G418), T20 (≠ A420), K21 (≠ S421), I23 (= I423), S42 (≠ D442), R43 (≠ L443), C67 (= C461), D68 (= D462), V69 (= V463), N96 (= N489), I146 (= I541), S148 (= S543), Y161 (= Y556), K165 (= K560), P191 (= P586), A193 (= A588), I194 (≠ V589), T196 (≠ D591), G198 (= G593), T199 (= T596)
A0A1A9TAK5 Noroxomaritidine/norcraugsodine reductase; NorRed; EC 1.1.1.- from Narcissus pseudonarcissus (Daffodil) (see paper)
34% identity, 38% coverage: 405:654/659 of query aligns to 5:252/257 of A0A1A9TAK5
6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate (see paper)
33% identity, 37% coverage: 411:654/659 of query aligns to 6:256/260 of 6zzqA
- active site: G17 (= G422), S142 (= S543), Y155 (= Y556)
- binding acetoacetic acid: Q94 (≠ P494), S142 (= S543), K152 (≠ A553), Y155 (= Y556), Q196 (≠ E598)
- binding nicotinamide-adenine-dinucleotide: G13 (= G418), S16 (= S421), G17 (= G422), I18 (= I423), D37 (= D442), M38 (≠ L443), D63 (= D462), V64 (= V463), N90 (= N489), A91 (= A490), G92 (= G491), M140 (≠ I541), A141 (≠ G542), S142 (= S543), Y155 (= Y556), K159 (= K560), Y187 (≠ A588), V188 (= V589), T190 (= T592)
6zzsD Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
33% identity, 37% coverage: 411:654/659 of query aligns to 7:257/261 of 6zzsD
- active site: G18 (= G422), S143 (= S543), Y156 (= Y556)
- binding nicotinamide-adenine-dinucleotide: G14 (= G418), S17 (= S421), I19 (= I423), D38 (= D442), M39 (≠ L443), D64 (= D462), V65 (= V463), N91 (= N489), A92 (= A490), G93 (= G491), M141 (≠ I541), A142 (≠ G542), S143 (= S543), Y156 (= Y556), K160 (= K560), P186 (= P586), G187 (≠ N587), V189 (= V589), T191 (= T592), L193 (= L594)
- binding 3-oxidanylidenepentanoic acid: Q95 (≠ P494), S143 (= S543), N145 (= N545), K153 (≠ A553), Y156 (= Y556), Q197 (≠ E598)
Q73SC8 Uncharacterized NAD-dependent oxidoreductase MAP_4146; EC 1.-.-.- from Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) (Mycobacterium paratuberculosis)
30% identity, 38% coverage: 404:654/659 of query aligns to 3:271/275 of Q73SC8
3pgxA Crystal structure of a putative carveol dehydrogenase from mycobacterium paratuberculosis bound to nicotinamide adenine dinucleotide (see paper)
30% identity, 37% coverage: 408:654/659 of query aligns to 2:266/270 of 3pgxA
- active site: G16 (= G422), S155 (= S543), Y168 (= Y556), K172 (= K560)
- binding nicotinamide-adenine-dinucleotide: G12 (= G418), R15 (≠ S421), G16 (= G422), Q17 (≠ I423), D36 (= D442), I37 (≠ L443), A50 (vs. gap), D75 (= D478), V76 (≠ A479), N102 (= N489), A103 (= A490), G104 (= G491), V105 (≠ I492), V125 (= V513), V153 (≠ I541), Y168 (= Y556), K172 (= K560), P198 (= P586), V201 (= V589), T203 (≠ D591), M205 (≠ G593), I206 (≠ L594)
P50162 Tropinone reductase 1; Tropine dehydrogenase; Tropinone reductase I; TR-I; EC 1.1.1.206 from Datura stramonium (Jimsonweed) (Common thornapple) (see paper)
31% identity, 37% coverage: 408:654/659 of query aligns to 18:266/273 of P50162
- 25:49 (vs. 415:439, 52% identical) binding NADP(+)
- S158 (= S543) binding substrate
- Y171 (= Y556) active site, Proton acceptor
1ae1B Tropinone reductase-i complex with NADP (see paper)
31% identity, 37% coverage: 408:654/659 of query aligns to 3:251/258 of 1ae1B
- active site: G17 (= G422), S143 (= S543), V153 (≠ A553), Y156 (= Y556), K160 (= K560)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G418), S15 (≠ A420), K16 (≠ S421), G17 (= G422), I18 (= I423), S37 (≠ D442), R38 (≠ L443), C62 (= C461), D63 (= D462), L64 (≠ V463), N91 (= N489), A92 (= A490), S143 (= S543), Y156 (= Y556), K160 (= K560), P186 (= P586), I189 (≠ V589), T191 (≠ D591), L193 (≠ G593), V194 (≠ L594)
3rwbA Crystal structure of complex of 4pal (4-pyridoxolactone) and pldh (tetrameric pyridoxal 4-dehydrogenase) from mesorhizobium loti
36% identity, 28% coverage: 409:594/659 of query aligns to 4:191/247 of 3rwbA
- active site: G17 (= G422), S140 (= S543), Y153 (= Y556), K157 (= K560)
- binding 7-hydroxy-6-methylfuro[3,4-c]pyridin-1(3H)-one: S140 (= S543), N141 (≠ K544), T142 (≠ N545), M150 (≠ A553), Y153 (= Y556), L185 (≠ A588)
- binding nicotinamide-adenine-dinucleotide: G13 (= G418), Q16 (≠ S421), G17 (= G422), I18 (= I423), D37 (= D442), I38 (≠ L443), D60 (= D462), I61 (≠ V463), N87 (= N489), A88 (= A490), S89 (≠ G491), I138 (= I541), S140 (= S543), Y153 (= Y556), K157 (= K560), P183 (= P586), L185 (≠ A588), I186 (≠ V589), S188 (≠ D591), G190 (= G593), V191 (≠ L594)
Sites not aligning to the query:
3ndrA Crystal structure of tetrameric pyridoxal 4-dehydrogenase from mesorhizobium loti
36% identity, 28% coverage: 409:594/659 of query aligns to 4:191/247 of 3ndrA
- active site: G17 (= G422), S140 (= S543), Y153 (= Y556), K157 (= K560)
- binding nicotinamide-adenine-dinucleotide: G13 (= G418), Q16 (≠ S421), G17 (= G422), I18 (= I423), D37 (= D442), I38 (≠ L443), D60 (= D462), I61 (≠ V463), N87 (= N489), A88 (= A490), S89 (≠ G491), V110 (= V513), I138 (= I541), S140 (= S543), Y153 (= Y556), K157 (= K560), P183 (= P586), L185 (≠ A588), I186 (≠ V589), S188 (≠ D591), G190 (= G593), V191 (≠ L594)
6zzpA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and 3-oxovalerate (see paper)
34% identity, 34% coverage: 409:633/659 of query aligns to 8:240/265 of 6zzpA
- binding nicotinamide-adenine-dinucleotide: G17 (= G418), S20 (= S421), G21 (= G422), I22 (= I423), D41 (= D442), I42 (≠ L443), M66 (≠ C461), D67 (= D462), V68 (= V463), N94 (= N489), A95 (= A490), G96 (= G491), M145 (≠ I541), S147 (= S543), Y160 (= Y556), K164 (= K560), P190 (= P586), F192 (= F590), V193 (≠ D591), T195 (≠ G593), L197 (≠ W595), V198 (≠ T596)
- binding 3-oxidanylidenepentanoic acid: Q98 (≠ F493), S147 (= S543), H149 (≠ N545), K157 (≠ A553), Y160 (= Y556), F192 (= F590), Q201 (≠ V599)
6zzoC Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and acetoacetate (see paper)
34% identity, 34% coverage: 409:633/659 of query aligns to 8:240/265 of 6zzoC
- binding acetoacetic acid: Q98 (≠ F493), H149 (≠ N545), K157 (≠ A553), F192 (= F590), Q201 (≠ V599)
- binding nicotinamide-adenine-dinucleotide: G17 (= G418), S20 (= S421), G21 (= G422), I22 (= I423), D41 (= D442), I42 (≠ L443), M66 (≠ C461), D67 (= D462), V68 (= V463), N94 (= N489), A95 (= A490), G96 (= G491), M145 (≠ I541), Y160 (= Y556), K164 (= K560), P190 (= P586), F192 (= F590), V193 (≠ D591), T195 (≠ G593), L197 (≠ W595), V198 (≠ T596)
2ekpA Structure of tt0495 protein from thermus thermophilus (see paper)
34% identity, 37% coverage: 414:654/659 of query aligns to 4:234/238 of 2ekpA
- active site: G12 (= G422), S128 (= S543), Y143 (= Y556), K147 (= K560)
- binding nicotinamide-adenine-dinucleotide: G8 (= G418), S10 (≠ A420), G12 (= G422), I13 (= I423), S32 (≠ D442), T49 (≠ C461), D50 (= D462), L51 (≠ V463), A76 (≠ N489), A78 (≠ G491), I126 (= I541), G127 (= G542), Y143 (= Y556), K147 (= K560), P173 (= P586), G174 (≠ N587), V176 (= V589), T178 (vs. gap), F180 (= F590), T181 (≠ D591)
4cr6A Crystal structure of the n-acetyl-d-mannosamine dehydrogenase without substrates (see paper)
36% identity, 28% coverage: 409:593/659 of query aligns to 3:187/255 of 4cr6A
Sites not aligning to the query:
5ojiA Crystal structure of the dehydrogenase/reductase sdr family member 4 (dhrs4) from caenorhabditis elegans (see paper)
34% identity, 27% coverage: 409:589/659 of query aligns to 8:194/260 of 5ojiA