SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_041100966.1 NCBI__GCF_000828635.1:WP_041100966.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5i92F Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase (gsa) from pseudomonas aeruginosa
63% identity, 100% coverage: 1:424/425 of query aligns to 1:420/420 of 5i92F

query
sites
5i92F

M

M

T

S

R

R

N

S

E

E

E

T

L

L

F

F

S

N

R

N

A

A

Q

Q

K

K

T

H

I

I

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

R

K

S

S

V

V

G

G

G

G

A

T

P

P

C

L

F

F

F

F

A

K

S

H

G

A

S

E

G

G

A

A

R

Y

V

V

R

L

D

D

A

E

D

D

G

D

K

K

E

R

Y

Y

I

V

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

L

M

I

I

L

L

G

G

H

H

A

S

D

H

A

P

D

D

T

V

V

L

R

D

A

A

V

V

Q

R

E

R

A

Q

A

L

M

D

K

H

G

G

L

L

S

S

F

Y

G

G

A

A

P

P

T

T

E

A

A

L

E

E

I

V

E

E

L

M

A

A

E

D

L

L

L

V

V

C

R

S

R

M

V

V

P

P

S

S

M

M

E

E

M

M

V

V

R

R

L

M

V

V

S

S

S

S

G

G

T

T

E

E

A

A

T

T

M

M

S

S

A

A

I

I

R

R

L

L

A

A

R

R

G

G

F

Y

T

T

G

G

R

R

D

D

A

S

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

G

S

D

D

S

S

L

L

L

L

V

V

K

K

A

A

G

G

S

S

G

-

L

-

L

-

T

T

F

F

G

G

N

V

P

P

S

N

S

S

A

P

G

G

V

V

P

P

A

A

D

A

L

F

A

A

Q

K

H

H

T

T

L

L

V

T

L

L

D

P

Y

F

N

N

D

D

A

I

Q

E

G

A

L

V

R

R

D

K

A

T

F

L

A

G

K

E

H

V

G

G

K

K

T

E

I

V

A

A

C

C

V

I

I

I

V

V

E
|
E

P

P

V

V

A

A

G

G

N

N

M

M

N

N

L

C

I

V

A

P

P

P

K

A

P

P

E

G

F

F

L

L

A

E

A

G

M

L

R

R

E

E

L

A

C

C

T

D

Q

E

H

H

G

G

S

V

V

V

L

L

I

I

F

F

D
|
D

E

E

V

V

M
|
M

T

T

G

G

F

F

R

R

V

V

G

A

P

L

G

G

S

G

A

A

Q

Q

G

A

L

Y

Y

Y

G

G

I

V

T

T

P

P

D

D

L

L

S

S

T

T

F

F

G

G

K
|
K

V

I

V

I

G

G

G

G

G

G

M

M

P

P

L

V

G

G

A

A

F

F

G

G

G

G

R

K

R

R

D

E

I

I

M

M

E

Q

K

Q

I

I

A

S

P

P

L

L

G

G

P

P

V

V

Y

Y

Q

Q

A

A

G

G

T

T

L

-

S

-

G

G

N

N

P

P

L

L

S

A

V

M

A

A

A

A

G

G

L

L

V

T

T

T

L

L

K

R

K

L

V

I

G

S

A

R

P

P

G

G

F

F

Y

H

D

D

A

E

L

L

T

T

A

A

K

Y

T

T

R

T

T

R

L

M

V

L

D

D

G

G

L

L

A

Q

A

Q

A

R

A

A

K

D

K

A

R

A

G

G

V

I

K

P

F

F

S

V

A

T

Q

T

S

Q

V

A

G

G

G

G

M

M

F

F

G

G

V

L

Y

Y

F

F

A

S

-

G

A

A

T

D

P

A

P

I

T

V

S

T

Y

F

A

E

E

D

V

V

M

M

A

A

S

S

D

D

K

V

E

E

A

R

F

F

N

K

R

R

F

F

F

F

H

H

A

L

M

M

L

L

D

D

A

G

G

G

F

V

Y

Y

L

L

A

A

P

P

S

S

A

A

F

F

E

E

A
|
A

G

G

F

F

V

T

S

S

A

I

A

A

H

H

S

G

D

D

A

K

D

E

I

L

A

E

A

I

T

T

I

L

A

N

A

A

A

A

D

E

A

K

I
x
A

F
|
F

A

A

A
|
A

active site: V19 (= V19), Y142 (= Y142), E201 (= E204), D234 (= D237), M237 (= M240), K262 (= K265), A395 (= A399)
binding leucine: A417 (≠ I421), F418 (= F422), A420 (= A424)

P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see paper)
61% identity, 100% coverage: 1:423/425 of query aligns to 1:424/426 of P23893

query
sites
P23893

M

M

T

S

R

K

N

S

E

E

E

N

L

L

F

Y

S

S

R

A

A

A

Q

R

K

E

T

L

I

I

P

P

G

G

G

G

V

V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

R

T

S

G

V

V

G

G

G

G

A

T

P

P

C

L

F

F

F

I

A

E

S

K

G

A

S

D

G

G

A

A

R

Y

V

L

R

Y

D

D

A

V

D

D

G

G

K

K

E

A

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

L

M

I

V

L

L

G

G

H

H

A

N

D

H

A

P

D

A

T

I

V

R

R

N

A

A

V

V

Q

I

E

E

A

A

A

A

M

E

K

R

G

G

L

L

S

S

F

F

G

G

A

A

P

P

T

T

E

E

A

M

E

E

I

V

E

K

L

M

A

A

E

Q

L

L

L

V

V

T

R

E

R

L

V

V

P

P

S

T

M

M

E

D

M

M

V

V

R

R

L

M

V

V

S

N

S

S

G

G

T

T

E

E

A

A

T

T

M

M

S

S

A

A

I

I

R

R

L

L

A

A

R

R

G

G

F

F

T

T

G

G

R

R

D

D

A

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y

Y

H

H

G

G

H

H

G

A

D

D

S

C

L

L

L

L

V

V

K

K

A

A

G

G

S

S

G

G

L

A

L

L

T

T

F

L

G

G

N

Q

P

P

S

N

S

S

A

P

G

G

V

V

P

P

A

A

D

D

L

F

A

A

Q

K

H

Y

T

T

L

L

V

T

L

C

D

T

Y

Y

N

N

D

D

A

L

Q

A

G

S

L

V

R

R

D

A

A

A

F

F

A

E

K

Q

H

Y

G

P

K

Q

T

E

I

I

A

A

C

C

V

I

I

I

V

V

E

E

P

P

V

V

A

A

G

G

N

N

M

M

N

N

L

C

I

V

A

P

P

P

K

L

P

P

E

E

F

F

L

L

A

P

A

G

M

L

R

R

E

A

L

L

C

C

T

D

Q

E

H

F

G

G

S

A

V

L

L

L

I

I

F

I

D

D

E

E

V

V

M

M

T

T

G

G

F

F

R

R

V

V

G

A

P

L

G

A

S

G

A

A

Q

Q

G

D

L

Y

Y

Y

G

G

I

V

T

V

P

P

D

D

L

L

S

T

T

C

F

L

G

G

K
|
K

V

I

V

I

G

G

G

G

G

G

M

M

P

P

L

V

G

G

A

A

F

F

G

G

G

G

R

R

R

R

D

D

I

V

M

M

E

D

K

A

I

L

A

A

P

P

L

T

G

G

P

P

V

V

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

I

S

A

V

M

A

A

A

A

G

G

L

F

V

A

T

C

L

L

K

N

K

E

V

V

G

A

A

Q

P

P

G

G

F

V

Y

H

D

E

A

T

L

L

T

D

A

E

K

L

T

T

R

T

T

R

L

L

V

A

D

E

G

G

L

L

A

L

A

E

A

A

A

A

K

E

K

E

R

A

G

G

V

I

K

P

F

L

S

V

A

V

Q

N

S

H

V

V

G

G

G

G

M

M

F

F

G

G

V

I

Y

F

F

F

A

T

-

D

A

A

T

E

P

S

P

V

T

T

S

C

Y

Y

A

Q

E

D

V

V

M

M

A

A

S

C

D

D

K

V

E

E

A

R

F

F

N

K

R

R

F

F

F

F

H

H

A

M

M

M

L

L

D

D

A

E

G

G

F

V

Y

Y

L

L

A

A

P

P

S

S

A

A

F

F

E

E

A

A

G

G

F

F

V

M

S

S

A

V

A

A

H

H

S

S

D

M

A

E

D

D

I

I

A

N

A

N

T

T

I

I

A

D

A

A

A

A

D

R

A

R

I

V

F

F

A

A

K265 (= K265) mutation to R: 2% of wild-type activity.

6w80A Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from stenotrophomonas maltophilia k279a in complex with plp
59% identity, 97% coverage: 3:415/425 of query aligns to 10:419/430 of 6w80A

query
sites
6w80A

R

Q

N

S

E

H

E

A

L

L

F

F

S

S

R

R

A

A

Q

Q

K

Q

T

L

I

L

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

R

K

S

S

V

V

G

G

G

G

A

E

P

P

C

F

F

F

F

V

A

E

S

R

G

A

S

D

G

G

A

A

R

Y

V

L

R

Y

D

D

A

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

L

M

I

I

L

V

G

G

H

H

A

N

D

H

A

P

D

A

T

V

V

R

R

Q

A

A

V

V

Q

K

E

K

A

A

A

I

M

D

K

N

G

G

L

L

S

S

F

F

G

G

A

A

P

P

T

C

E

A

A

G

E

E

I

V

E

T

L

M

A

A

E

E

L

T

L

I

V

T

R

R

R

L

V

V

P

P

S

S

M

C

E

E

M

M

V

V

R

R

L

M

V

V

S

N

S
|
S

G
|
G

T
|
T

E

E

A

A

T

T

M

L

S

S

A

A

I

I

R

R

L

L

A

A

R

R

G

G

F

A

T

T

G

G

R

R

D

N

A

R

I

I

I

V

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

G

G

D

D

S

S

L

F

L

L

V

V

K

K

A

A

G

-

S

-

G

-

L

M

L

L

T

T

F

L

G

G

N

V

P

P

S

T

S

S

A

P

G

G

V

V

P

P

A

A

D

G

L

L

A

S

Q

E

H

L

T

T

L

L

V

T

L

L

D

P

Y

Y

N

N

D

D

A

F

Q

E

G

A

L

A

R

T

D

A

A

L

F

F

A

E

K

Q

H

Q

G

G

K

D

T

D

I

I

A

A

C

G

V

L

I

I

V

I

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

A

N

N

L

C

I

I

A

P

P

P

K

R

P

E

E

G

F

Y

L

L

A

Q

A

H

M

L

R

R

E

A

L

L

C

C

T

T

Q

K

H

H

G

G

S

A

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M

M

T

T

G

G

F

F

R

R

V

V

G

A

P

L

G

G

S

G

A

A

Q

Q

G

A

L

H

Y

Y

G

G

I

I

T

T

P

P

D

D

L

L

S

T

T

T

F

F

G

G

K
|
K

V

I

V

I

G

G

G

G

G

G

M

M

P

P

L

V

G

G

A

A

F

Y

G

G

G

G

R

R

R

R

D

E

I

L

M

M

E

Q

K

Q

I

I

A

A

P

P

L

A

G

G

P

P

V

I

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

V

S

A

V

M

A

A

A

A

G

G

L

L

V

A

T

M

L

L

K

E

K

L

V

V

G

Q

A

Q

P

P

G

G

F

F

Y

H

D

A

A

D

L

L

T

A

A

E

K

R

T

T

R

A

T

R

L

L

V

C

D

A

G

G

L

L

A

E

A

A

A

A

A

A

K

A

K

D

R

A

G

G

V

V

K

A

F

V

S

T

A

T

Q

T

S

R

V

V

G

G

G

A

M

M

F

F

G

G

V

L

Y

F

F

F

A

T

A

S

T

E

P

K

P

V

T

E

S

T

Y

Y

A

A

E

Q

V

A

M

T

A

A

S

C

D

D

K

I

E

P

A

A

F

F

N

N

R

R

F

F

F

F

H

H

A

A

M

M

L

L

D

E

A

Q

G

G

F

V

Y

F

L

L

A

A

P

P

S

S

A

A

F

Y

E

E

A

A

G

G

F

F

V

L

S

S

A

S

A

A

H

H

S

D

D

D

A

A

D

V

I

I

A

E

A

A

T

T

I

L

active site: V26 (= V19), Y149 (= Y142), D241 (= D237), K269 (= K265)
binding pyridoxal-5'-phosphate: S121 (= S114), G122 (= G115), T123 (= T116), Y149 (= Y142), H150 (= H143), E208 (= E204), N213 (= N209), D241 (= D237), V243 (= V239), K269 (= K265)

3bs8A Crystal structure of glutamate 1-semialdehyde aminotransferase complexed with pyridoxamine-5'-phosphate from bacillus subtilis (see paper)
54% identity, 99% coverage: 3:423/425 of query aligns to 6:425/430 of 3bs8A

query
sites
3bs8A

R

K

N

S

E

K

E

T

L

A

F

F

S

K

R

E

A

A

Q

Q

K

K

T

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

R

K

S

S

V

V

G

D

G

M

A

D

P

P

C

I

F

F

F

M

A

E

S

R

G

G

S

K

G

G

A

S

R

K

V

I

R

F

D

D

A

I

D

D

G

G

K

N

E

E

Y

Y

I

I

D

D

Y

Y

V

V

G

L

S

S

W

W

G

G

P

P

L

L

I

I

L

L

G

G

H

H

A

T

D

N

A

D

D

R

T

V

V

V

R

E

A

S

V

L

Q

K

E

K

A

V

A

A

M

E

K

Y

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

T

E

E

A

V

E

E

I

N

E

E

L

L

A

A

E

K

L

L

L

V

V

I

R

D

R

R

V

V

P

P

S

S

M

V

E

E

M

I

V

V

R

R

L

M

V

V

S

S

S

S

G
|
G

T
|
T

E

E

A

A

T

T

M

M

S

S

A

A

I

L

R

R

L

L

A

A

R

R

G

G

F

Y

T

T

G

G

R

R

D

N

A

K

I

I

I

L

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

G

G

D

D

S

S

L

L

L

L

V

I

K

K

A

A

G

G

S

S

G

G

L

V

L

A

T

T

F

L

G

G

N

L

P

P

S

D

S

S

A

P

G

G

V

V

P

P

A

E

D

G

L

I

A

A

Q

K

H

N

T

T

L

I

V

T

L

V

D

P

Y

Y

N

N

D

D

A

L

Q

E

G

S

L

V

R

K

D

L

A

A

F

F

A

Q

K

Q

H

F

G

G

K

E

T

D

I

I

A

A

C

G

V

V

I

I

V

V

E
|
E

P

P

V

V

A

A

G

G

N
|
N

M

M

N

G

L

V

I

V

A

P

P

P

K

Q

P

E

E

G

F

F

L

L

A

Q

A

G

M

L

R

R

E

D

L

I

C

T

T

E

Q

Q

H

Y

G

G

S

S

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

V

G

D

P

Y

G

N

S

C

A

A

Q

Q

G

G

L

Y

Y

F

G

G

I

V

T

T

P

P

D

D

L

L

S

T

T

C

F

L

G

G

K
|
K

V

V

V

I

G

G

G

G

G

G

M

L

P

P

L

V

G

G

A

A

F

Y

G

G

G

G

R

K

R

A

D

E

I

I

M

M

E

E

K

Q

I

I

A

A

P

P

L

S

G

G

P

P

V

I

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

S

A

V

M

A

T

A

A

G

G

L

L

V

E

T

T

L

L

K

K

K

Q

V

L

G

-

A

T

P

P

G

D

F

S

Y

Y

D

K

A

N

L

F

T

I

A

K

K

K

T

G

R

D

T

R

L

L

V

E

D

E

G

G

L

I

A

S

A

K

A

A

A

A

K

E

K

A

R

H

G

G

V

I

K

P

F

H

S

T

A

F

Q

N

S

R

V

A

G

G

G

S

M

M

F

I

G

G

V

F

Y

F

F

F

A

T

A

N

T

E

P

P

P

V

T

I

S

N

Y

Y

A

E

E

T

V

A

M

K

A

A

S

S

D

D

K

L

E

K

A

L

F

F

N

A

R

S

F

Y

F

Y

H

K

A

G

M

M

L

A

D

N

A

E

G

G

F

V

Y

F

L

L

A

P

P

P

S

S

A

Q

F

F

E

E

A
x
G

G

L

F

F

V

L

S

S

A

T

A

A

H

H

S

T

D

D

A

E

D

D

I

I

A

E

A

N

T

T

I

I

A

Q

A

A

A

A

D

E

A

K

I

V

F

F

A

A

active site: V22 (= V19), Y145 (= Y142), E207 (= E204), D240 (= D237), M243 (= M240), K268 (= K265), G401 (≠ A399)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G115), T119 (= T116), Y145 (= Y142), H146 (= H143), E207 (= E204), N212 (= N209), D240 (= D237), V242 (= V239), K268 (= K265)

Q42522 Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic; GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
54% identity, 100% coverage: 1:423/425 of query aligns to 48:470/472 of Q42522

query
sites
Q42522

M

L

T

Q

R

K

N

S

E

E

E

E

L

A

F

F

S

N

R

A

A

A

Q

K

K

N

T

L

I

M

P

P

G

G

G

G

V

V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

R

K

S

S

V

V

G

G

G

G

A

Q

P

P

C

V

F

V

F

M

A

D

S

S

G

A

S

K

G

G

A

S

R

R

V

I

R
|
R

D

D

A

I

D

D

G

G

K

N

E

E

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

L

A

I

I

L

I

G

G

H

H

A

A

D

D

A

D

D

E

T

V

V

L

R

A

A

A

V

L

Q

A

E

E

A

T

A

M

M

K

K

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

A

L

E

E

I

N

E

V

L

L

A

A

E

E

L

M

L

V

V

I

R

S

R

A

V

V

P

P

S

S

M

I

E

E

M

M

V

V

R

R

L

F

V

V

S

N

S

S

G
|
G

T

T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

F

F

T

T

G

G

R

K

D

Q

A

K

I

F

I

I

K

K

F

F

E

E

G

G

C

C

Y

Y

H

H

G

G

H

H

G

A

D

N

S

S

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

L

V

L

A

T

T

F

L

G

G

N

L

P

P

S

D

S

S

A

P

G

G

V

V

P

P

A

K

D

A

L

A

A

T

Q

S

H

D

T

T

L

L

V

T

L

A

D

P

Y

Y

N

N

D

D

A

I

Q

A

G

A

L

V

R

E

D

K

A

L

F

F

A

E

K

A

H

N

G

K

K

G

T

E

I

I

A

A

C

A

V

I

I

I

V

L

E

E

P

P

V

V

A

V

G

G

N

N

M

S

N

G

L

F

I

I

A

T

P

P

K

K

P

P

E

E

F

F

L

I

A

E

A

G

M

I

R

R

E

R

L

I

C

T

T

K

Q

D

H

N

G

G

S

A

V

L

L

L

I

I

F

F

D

D

E

E

V

V

M

M

T

T

G

G

F

F

R

R

V

L

G

A

P

Y

G

G

S

G

A

A

Q

Q

G

E

L

Y

Y

F

G

G

I

I

T

T

P

P

D

D

L

L

S

T

T

T

F

L

G

G

K

K

V

I

V

I

G

G

G

G

G

G

M

L

P

P

L

V

G

G

A

A

F

Y

G

G

G

G

R

R

R

R

D

D

I

I

M

M

E

E

K

M

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

S

A

V

M

A

T

A

A

G

G

L

I

V

H

T

T

L

L

K

K

K

R

V

L

G

S

A

Q

P

P

G

G

F

T

Y

Y

D

E

A

Y

L

L

T

D

A

K

K

I

T

T

R

K

T

E

L

L

V

T

D

N

G

G

L

I

A

L

A

E

A

A

A

G

K

K

K

K

R

T

G

G

V

H

K

A

F

M

S

C

A

G

Q

G

S

Y

V

I

G

S

G

G

M

M

F

F

G

G

V

F

Y

F

F

F

A

T

A

E

T

G

P

P

P

V

T

Y

S

D

Y

F

A

S

E

D

V

A

M

K

A

K

S

S

D

D

K

T

E

E

A

K

F

F

N

G

R

K

F

F

F

F

H

R

A

G

M

M

L

L

D

E

A

E

G

G

F

V

Y

Y

L

L

A

A

P

P

S

S

A

Q

F

F

E

E

A

A

G

G

F

F

V

T

S

S

A

L

A

A

H

H

S

T

D

S

A

E

D

D

I

I

A

Q

A

F

T

T

I

I

A

A

A

A

A

A

D

E

A

K

I

V

F

L

A

S

R92 (= R45) mutation to K: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with S-162.
G162 (= G115) mutation to S: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with K-92.

P42799 Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic; AtGSA1; GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
53% identity, 100% coverage: 1:423/425 of query aligns to 50:472/474 of P42799

query
sites
P42799

M

L

T

Q

R

K

N

S

E

E

E

E

L

A

F

F

S

N

R

A

A

A

Q

K

K

N

T

L

I

M

P

P

G

G

G

G

V

V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

R

K

S

S

V

V

G

G

G

G

A

Q

P

P

C

V

F

L

F

I

A

D

S

S

G

V

S

K

G

G

A

S

R

K

V

M

R

W

D

D

A

I

D

D

G

G

K

N

E

E

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

L

A

I

I

L

I

G

G

H

H

A

A

D

D

A

D

D

E

T

V

V

L

R

A

A

A

V

L

Q

A

E

E

A

T

A

M

M

K

K

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

A

L

E

E

I

N

E

V

L

L

A

A

E

E

L

M

L

V

V

I

R

S

R

A

V

V

P

P

S

S

M

I

E

E

M

M

V

V

R

R

L

F

V

V

S

N

S

S

G

G

T

T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

F

F

T

T

G

N

R

K

D

E

A

K

I

F

I

I

K

K

F

F

E

E

G

G

C

C

Y

Y

H

H

G

G

H

H

G

A

D

N

S

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

L

V

L

A

T

T

F

L

G

G

N

L

P

P

S

D

S

S

A

P

G

G

V

V

P

P

A

K

D

A

L

A

A

T

Q

S

H

D

T

T

L

L

V

T

L

A

D

P

Y

Y

N

N

D

D

A

L

Q

E

G

A

L

V

R

E

D

K

A

L

F

F

A

A

K

A

H

H

G

K

K

G

T

E

I

I

A

S

C

A

V

V

I

I

V

L

E

E

P

P

V

V

A

V

G

G

N

N

M

S

N

G

L

F

I

I

A

P

P

P

K

T

P

P

E

E

F

F

L

I

A

N

A

G

M

L

R

R

E

Q

L

L

C

T

T

K

Q

D

H

N

G

G

S

V

V

L

L

L

I

I

F

F

D

D

E

E

V

V

M

M

T

T

G

G

F

F

R

R

V

L

G

A

P

Y

G

G

S

G

A

A

Q

Q

G

E

L

Y

Y

F

G

G

I

I

T

T

P

P

D

D

L

L

S

T

T

T

F

L

G

G

K
|
K

V

I

V

I

G

G

G

G

G

G

M

L

P

P

L

V

G

G

A

A

F

Y

G

G

G

G

R

R

R

R

D

D

I

I

M

M

E

E

K

M

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

S

A

V

M

A

T

A

A

G

G

L

I

V

H

T

T

L

L

K

K

K

R

V

L

G

K

A

Q

P

A

G

G

F

T

Y

Y

D

E

A

Y

L

L

T

D

A

K

K

I

T

T

R

K

T

E

L

L

V

T

D

N

G

G

L

I

A

L

A

E

A

A

A

G

K

K

K

K

R

T

G

G

V

H

K

P

F

M

S

C

A

G

Q

G

S

Y

V

I

G

S

G

G

M

M

F

F

G

G

V

F

Y

F

F

F

A

A

A

E

T

G

P

P

P

V

T

Y

S

N

Y

F

A

A

E

D

V

S

M

K

A

K

S

S

D

D

K

T

E

E

A

K

F

F

N

G

R

R

F

F

F

F

H

R

A

G

M

M

L

L

D

E

A

E

G

G

F

V

Y

Y

L

F

A

A

P

P

S

S

A

Q

F

F

E

E

A

A

G

G

F

F

V

T

S

S

A

L

A

A

H

H

S

T

D

P

A

E

D

D

I

I

A

Q

A

L

T

T

I

I

A

A

A

A

A

A

D

E

A

R

I

V

F

L

A

S

K314 (= K265) modified: N6-(pyridoxal phosphate)lysine

5hdmB Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
53% identity, 100% coverage: 1:423/425 of query aligns to 4:426/428 of 5hdmB

query
sites
5hdmB

M

L

T

Q

R

K

N

S

E

E

E

E

L

A

F

F

S

N

R

A

A

A

Q

K

K

N

T

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

R

K

S

S

V

V

G

G

G

G

A

Q

P

P

C

V

F

L

F

I

A

D

S

S

G

V

S

K

G

G

A

S

R

K

V

M

R

W

D

D

A

I

D

D

G

G

K

N

E

E

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

L

A

I

I

L

I

G

G

H

H

A

A

D

D

A

D

D

E

T

V

V

L

R

A

A

A

V

L

Q

A

E

E

A

T

A

M

M

K

K

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

A

L

E

E

I

N

E

V

L

L

A

A

E

E

L

M

L

V

V

I

R

S

R

A

V

V

P

P

S

S

M

I

E

E

M

M

V

V

R

R

L

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

F

F

T

T

G

N

R

K

D

E

A

K

I

F

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

G

A

D

N

S

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

L

V

L

A

T

T

F

L

G

G

N

L

P

P

S

D

S

S

A

P

G

G

V

V

P

P

A

K

D

A

L

A

A

T

Q

S

H

D

T

T

L

L

V

T

L

A

D

P

Y

Y

N

N

D

D

A

L

Q

E

G

A

L

V

R

E

D

K

A

L

F

F

A

A

K

A

H

H

G

K

K

G

T

E

I

I

A

S

C

A

V

V

I

I

V

L

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

S

N

G

L

F

I

I

A

P

P

P

K

T

P

P

E

E

F

F

L

I

A

N

A

G

M

L

R

R

E

Q

L

L

C

T

T

K

Q

D

H

N

G

G

S

V

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

L

G

A

P

Y

G

G

S

G

A

A

Q

Q

G

E

L

Y

Y

F

G

G

I

I

T

T

P

P

D

D

L

L

S

T

T

T

F

L

G

G

K
|
K

V

I

V

I

G

G

G

G

G

G

M

L

P

P

L

V

G

G

A

A

F

Y

G

G

G

G

R

R

R

R

D

D

I

I

M

M

E

E

K

M

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

S

A

V

M

A

T

A

A

G

G

L

I

V

H

T

T

L

L

K

K

K

R

V

L

G

K

A

Q

P

A

G

G

F

T

Y

Y

D

E

A

Y

L

L

T

D

A

K

K

I

T

T

R

K

T

E

L

L

V

T

D

N

G

G

L

I

A

L

A

E

A

A

A

G

K

K

K

K

R

T

G

G

V

H

K

P

F

M

S

C

A

G

Q

G

S

Y

V

I

G

S

G

G

M

M

F

F

G

G

V

F

Y

F

F

F

A

A

A

E

T

G

P

P

P

V

T

Y

S

N

Y

F

A

A

E

D

V

S

M

K

A

K

S

S

D

D

K

T

E

E

A

K

F

F

N

G

R

R

F

F

F

F

H

R

A

G

M

M

L

L

D

E

A

E

G

G

F

V

Y

Y

L

F

A

A

P

P

S

S

A

Q

F

F

E

E

A
|
A

G

G

F

F

V

T

S

S

A

L

A

A

H

H

S

T

D

P

A

E

D

D

I

I

A

Q

A

L

T

T

I

I

A

A

A

A

A

A

D

E

A

R

I

V

F

L

A

S

active site: V22 (= V19), Y145 (= Y142), E207 (= E204), D240 (= D237), M243 (= M240), K268 (= K265), A402 (= A399)
binding pyridoxal-5'-phosphate: G118 (= G115), T119 (= T116), Y145 (= Y142), E207 (= E204), N212 (= N209), D240 (= D237), V242 (= V239), M243 (= M240), K268 (= K265)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G115), T119 (= T116), Y145 (= Y142), E207 (= E204), N212 (= N209), D240 (= D237), V242 (= V239), M243 (= M240), K268 (= K265)

5hdmA Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
53% identity, 100% coverage: 1:423/425 of query aligns to 4:426/428 of 5hdmA

query
sites
5hdmA

M

L

T

Q

R

K

N

S

E

E

E

E

L

A

F

F

S

N

R

A

A

A

Q

K

K

N

T

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

R

K

S

S

V

V

G

G

G

G

A

Q

P

P

C

V

F

L

F

I

A

D

S

S

G

V

S

K

G

G

A

S

R

K

V

M

R

W

D

D

A

I

D

D

G

G

K

N

E

E

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

L

A

I

I

L

I

G

G

H

H

A

A

D

D

A

D

D

E

T

V

V

L

R

A

A

A

V

L

Q

A

E

E

A

T

A

M

M

K

K

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

A

L

E

E

I

N

E

V

L

L

A

A

E

E

L

M

L

V

V

I

R

S

R

A

V

V

P

P

S

S

M

I

E

E

M

M

V

V

R

R

L

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

F

F

T

T

G

N

R

K

D

E

A

K

I

F

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G
|
G

H

H

G

A

D

N

S

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

L

V

L

A

T

T

F

L

G

G

N

L

P

P

S

D

S

S

A

P

G

G

V

V

P

P

A

K

D

A

L

A

A

T

Q

S

H

D

T

T

L

L

V

T

L

A

D

P

Y

Y

N

N

D

D

A

L

Q

E

G

A

L

V

R

E

D

K

A

L

F

F

A

A

K

A

H

H

G

K

K

G

T

E

I

I

A

S

C

A

V

V

I

I

V

L

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

S

N

G

L

F

I

I

A

P

P

P

K

T

P

P

E

E

F

F

L

I

A

N

A

G

M

L

R

R

E

Q

L

L

C

T

T

K

Q

D

H

N

G

G

S

V

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

L

G

A

P

Y

G

G

S

G

A

A

Q

Q

G

E

L

Y

Y

F

G

G

I

I

T

T

P

P

D

D

L

L

S

T

T

T

F

L

G

G

K
|
K

V

I

V

I

G

G

G

G

G

G

M

L

P

P

L

V

G

G

A

A

F

Y

G

G

G

G

R

R

R

R

D

D

I

I

M

M

E

E

K

M

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

S

A

V

M

A

T

A

A

G

G

L

I

V

H

T

T

L

L

K

K

K

R

V

L

G

K

A

Q

P

A

G

G

F

T

Y

Y

D

E

A

Y

L

L

T

D

A

K

K

I

T

T

R

K

T

E

L

L

V

T

D

N

G

G

L

I

A

L

A

E

A

A

A

G

K

K

K

K

R

T

G

G

V

H

K

P

F

M

S

C

A

G

Q

G

S

Y

V

I

G

S

G

G

M

M

F

F

G

G

V

F

Y

F

F

F

A

A

A

E

T

G

P

P

P

V

T

Y

S

N

Y

F

A

A

E

D

V

S

M

K

A

K

S

S

D

D

K

T

E

E

A

K

F

F

N

G

R

R

F

F

F

F

H

R

A

G

M

M

L

L

D

E

A

E

G

G

F

V

Y

Y

L

F

A

A

P

P

S

S

A

Q

F

F

E

E

A
|
A

G

G

F

F

V

T

S

S

A

L

A

A

H

H

S

T

D

P

A

E

D

D

I

I

A

Q

A

L

T

T

I

I

A

A

A

A

A

A

D

E

A

R

I

V

F

L

A

S

active site: V22 (= V19), Y145 (= Y142), E207 (= E204), D240 (= D237), M243 (= M240), K268 (= K265), A402 (= A399)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G115), T119 (= T116), Y145 (= Y142), G147 (= G144), E207 (= E204), N212 (= N209), D240 (= D237), V242 (= V239), K268 (= K265)

2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
52% identity, 99% coverage: 3:424/425 of query aligns to 5:426/427 of 2gsaB

query
sites
2gsaB

R

K

N

S

E

D

E

E

L

I

F

F

S

A

R

A

A

A

Q

Q

K

K

T

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

R

K

S

S

V

V

G

G

G

G

A

Q

P

P

C

I

F

V

F

F

A

D

S

R

G

V

S

K

G

D

A

A

R

Y

V

A

R

W

D

D

A

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

L

A

I

I

L

C

G

G

H

H

A

A

D

H

A

P

D

E

T

V

V

I

R

E

A

A

V

L

Q

K

E

V

A

A

A

M

M

E

K

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

A

L

E

E

I

N

E

V

L

L

A

A

E

E

L

M

L

V

V

N

R

D

R

A

V

V

P

P

S

S

M

I

E

E

M

M

V

V

R

R

L

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

F

Y

T

T

G

G

R

R

D

D

A

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

G

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

L

V

L

A

T

T

F

L

G

G

N

L

P

P

S

S

S

S

A

P

G

G

V

V

P

P

A

K

D

K

L

T

A

T

Q

A

H

N

T

T

L

L

V

T

L

T

D

P

Y

Y

N

N

D

D

A

L

Q

E

G

A

L

V

R

K

D

A

A

L

F

F

A

A

K

E

H

N

G

P

K

G

T

E

I

I

A

A

C

G

V

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

N

G

L

F

I

I

A

V

P

P

K

D

P

A

E

G

F

F

L

L

A

E

A

G

M

L

R

R

E

E

L

I

C

T

T

L

Q

E

H

H

G

D

S

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

I

G

A

P

Y

G

G

S

G

A

V

Q

Q

G

E

L

K

Y

F

G

G

I

V

T

T

P

P

D

D

L

L

S

T

T

T

F

L

G

G

K
|
K

V

I

V

I

G

G

G

G

G

G

M

L

P

P

L

V

G

G

A

A

F

Y

G

G

G

G

R

K

R

R

D

E

I

I

M

M

E

Q

K

L

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

S

A

V

M

A

T

A

A

G

G

L

I

V

K

T

T

L

L

K

E

K

L

V

L

G

R

A

Q

P

P

G

G

F

T

Y

Y

D

E

A

Y

L

L

T

D

A

Q

K

I

T

T

R

K

T

R

L

L

V

S

D

D

G

G

L

L

A

L

A

A

A

I

A

A

K

Q

K

E

R

T

G

G

V

H

K

A

F

A

S

C

A

G

Q

G

S

Q

V

V

G

S

G

G

M

M

F

F

G

G

V

F

Y

F

F

F

A

T

A

E

T

G

P

P

P

V

T

H

S

N

Y

Y

A

E

E

D

V

A

M

K

A

K

S

S

D

D

K

L

E

Q

A

K

F

F

N

S

R

R

F

F

F

H

H

R

A

G

M

M

L

L

D

E

A

Q

G

G

F

I

Y

Y

L

L

A

A

P

P

S

S

A

Q

F

F

E

E

A
|
A

G

G

F

F

V

T

S

S

A

L

A

A

H

H

S

T

D

E

A

E

D

D

I

I

A

D

A

A

T

T

I

L

A

A

A

A

A

A

D

R

A

T

I

V

F

M

A

S

A

A

active site: V21 (= V19), Y144 (= Y142), E206 (= E204), D239 (= D237), M242 (= M240), K267 (= K265), A401 (= A399)
binding pyridoxal-5'-phosphate: G117 (= G115), T118 (= T116), Y144 (= Y142), E206 (= E204), N211 (= N209), D239 (= D237), V241 (= V239), M242 (= M240), K267 (= K265)

2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
52% identity, 99% coverage: 3:424/425 of query aligns to 5:426/427 of 2gsaA

query
sites
2gsaA

R

K

N

S

E

D

E

E

L

I

F

F

S

A

R

A

A

A

Q

Q

K

K

T

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

R

K

S

S

V

V

G

G

G

G

A

Q

P

P

C

I

F

V

F

F

A

D

S

R

G

V

S

K

G

D

A

A

R

Y

V

A

R

W

D

D

A

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

L

A

I

I

L

C

G

G

H

H

A

A

D

H

A

P

D

E

T

V

V

I

R

E

A

A

V

L

Q

K

E

V

A

A

A

M

M

E

K

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

A

L

E

E

I

N

E

V

L

L

A

A

E

E

L

M

L

V

V

N

R

D

R

A

V

V

P

P

S

S

M

I

E

E

M

M

V

V

R

R

L

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

F

Y

T

T

G

G

R

R

D

D

A

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

G

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

L

V

L

A

T

T

F

L

G

G

N

L

P

P

S

S

S

S

A

P

G

G

V

V

P

P

A

K

D

K

L

T

A

T

Q

A

H

N

T

T

L

L

V

T

L

T

D

P

Y

Y

N

N

D

D

A

L

Q

E

G

A

L

V

R

K

D

A

A

L

F

F

A

A

K

E

H

N

G

P

K

G

T

E

I

I

A

A

C

G

V

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

N

G

L

F

I

I

A

V

P

P

K

D

P

A

E

G

F

F

L

L

A

E

A

G

M

L

R

R

E

E

L

I

C

T

T

L

Q

E

H

H

G

D

S

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

I

G

A

P

Y

G

G

S

G

A

V

Q

Q

G

E

L

K

Y

F

G

G

I

V

T

T

P

P

D

D

L

L

S

T

T

T

F

L

G

G

K
|
K

V

I

V

I

G

G

G

G

G

G

M

L

P

P

L

V

G

G

A

A

F

Y

G

G

G

G

R

K

R

R

D

E

I

I

M

M

E

Q

K

L

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

S

A

V

M

A

T

A

A

G

G

L

I

V

K

T

T

L

L

K

E

K

L

V

L

G

R

A

Q

P

P

G

G

F

T

Y

Y

D

E

A

Y

L

L

T

D

A

Q

K

I

T

T

R

K

T

R

L

L

V

S

D

D

G

G

L

L

A

L

A

A

A

I

A

A

K

Q

K

E

R

T

G

G

V

H

K

A

F

A

S

C

A

G

Q

G

S

Q

V

V

G

S

G

G

M

M

F

F

G

G

V

F

Y

F

F

F

A

T

A

E

T

G

P

P

P

V

T

H

S

N

Y

Y

A

E

E

D

V

A

M

K

A

K

S

S

D

D

K

L

E

Q

A

K

F

F

N

S

R

R

F

F

F

H

H

R

A

G

M

M

L

L

D

E

A

Q

G

G

F

I

Y

Y

L

L

A

A

P

P

S

S

A

Q

F

F

E

E

A
|
A

G

G

F

F

V

T

S

S

A

L

A

A

H

H

S

T

D

E

A

E

D

D

I

I

A

D

A

A

T

T

I

L

A

A

A

A

A

A

D

R

A

T

I

V

F

M

A

S

A

A

active site: V21 (= V19), Y144 (= Y142), E206 (= E204), D239 (= D237), M242 (= M240), K267 (= K265), A401 (= A399)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G115), T118 (= T116), Y144 (= Y142), H145 (= H143), G146 (= G144), N211 (= N209), D239 (= D237), V241 (= V239), K267 (= K265)

3usfA Crystal structure of dava-4
52% identity, 99% coverage: 3:424/425 of query aligns to 5:426/427 of 3usfA

query
sites
3usfA

R

K

N

S

E

D

E

E

L

I

F

F

S

A

R

A

A

A

Q

Q

K

K

T

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

R

K

S

S

V

V

G

G

G

G

A

Q

P

P

C

I

F

V

F

F

A

D

S

R

G

V

S

K

G

D

A

A

R

Y

V

A

R

W

D

D

A

V

D

D

G

G

K

N

E

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

L

A

I

I

L

C

G

G

H

H

A

A

D

H

A

P

D

E

T

V

V

I

R

E

A

A

V

L

Q

K

E

V

A

A

A

M

M

E

K

K

G

G

L

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

A

L

E

E

I

N

E

V

L

L

A

A

E

E

L

M

L

V

V

N

R

D

R

A

V

V

P

P

S

S

M

I

E

E

M

M

V

V

R

R

L

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

F

Y

T

T

G

G

R

R

D

D

A

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

G

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S
|
S

G

G

L

V

L

A

T

T

F

L

G

G

N

L

P

P

S

S

S

S

A

P

G

G

V

V

P

P

A

K

D

K

L

T

A

T

Q

A

H

N

T

T

L

L

V

T

L

T

D

P

Y

Y

N

N

D

D

A

L

Q

E

G

A

L

V

R

K

D

A

A

L

F

F

A

A

K

E

H

N

G

P

K

G

T

E

I

I

A

A

C

G

V

V

I

I

V

L

E

E

P

P

V

I

A

V

G

G

N
|
N

M

S

N

G

L

F

I

I

A

V

P

P

K

D

P

A

E

G

F

F

L

L

A

E

A

G

M

L

R

R

E

E

L

I

C

T

T

L

Q

E

H

H

G

D

S

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

T

T

G

G

F

F

R

R

V

I

G

A

P

Y

G

G

S

G

A

V

Q

Q

G

E

L

K

Y

F

G

G

I

V

T

T

P

P

D

D

L

L

S

T

T

T

F

L

G

G

K
|
K

V

I

V

I

G

G

G

G

G

G

M

L

P

P

L

V

G

G

A

A

F

Y

G

G

G

G

R

K

R

R

D

E

I

I

M

M

E

Q

K

L

I

V

A

A

P

P

L

A

G

G

P

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

S

A

V

M

A

T

A

A

G

G

L

I

V

K

T

T

L

L

K

E

K

L

V

L

G

R

A

Q

P

P

G

G

F

T

Y

Y

D