SitesBLAST
Comparing WP_041101149.1 NCBI__GCF_000828635.1:WP_041101149.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 11 hits to proteins with known functional sites (download)
3dmeA Crystal structure of conserved exported protein from bordetella pertussis. Northeast structural genomics target ber141
63% identity, 99% coverage: 4:367/369 of query aligns to 3:366/366 of 3dmeA
- binding flavin-adenine dinucleotide: I8 (= I9), G9 (= G10), G11 (= G12), V12 (= V13), V13 (≠ I14), E32 (= E33), A33 (≠ S34), T41 (≠ I42), S42 (= S43), R44 (= R45), N45 (= N46), S46 (= S47), V48 (= V49), H50 (= H51), P170 (= P171), L171 (≠ V172), A203 (= A204), I313 (= I314), R314 (= R315), I346 (= I347), E347 (= E348), S348 (= S349), P349 (= P350), G350 (= G351), L351 (= L352), T352 (= T353)
8w7fB Structure of drosophila melanogaster l-2-hydroxyglutarate dehydrogenase bound with fad and a sulfate ion (see paper)
33% identity, 66% coverage: 28:272/369 of query aligns to 29:274/412 of 8w7fB
- binding flavin-adenine dinucleotide: E34 (= E33), K35 (≠ S34), H42 (≠ G41), Q43 (≠ I42), S44 (= S43), H46 (≠ R45), N47 (= N46), S48 (= S47), V50 (= V49), H52 (= H51), V173 (= V172), G205 (≠ A204), G206 (= G205), Q208 (≠ G207), Y231 (= Y233)
Sites not aligning to the query:
8w78A Structure of drosophila melanogaster l-2-hydroxyglutarate dehydrogenase in complex with fad and 2-oxoglutarate (see paper)
33% identity, 66% coverage: 28:272/369 of query aligns to 29:272/410 of 8w78A
- binding 2-oxoglutaric acid: S48 (= S47), H52 (= H51), Y245 (= Y247), F254 (≠ G254), L255 (= L255), H258 (= H258)
- binding flavin-adenine dinucleotide: E34 (= E33), K35 (≠ S34), H42 (≠ G41), Q43 (≠ I42), S44 (= S43), N47 (= N46), S48 (= S47), V50 (= V49), H52 (= H51), V173 (= V172), G203 (≠ A204), G204 (= G205), Q206 (≠ G207)
Sites not aligning to the query:
4x9mA Oxidized l-alpha-glycerophosphate oxidase from mycoplasma pneumoniae with fad bound (see paper)
26% identity, 99% coverage: 1:367/369 of query aligns to 1:366/384 of 4x9mA
- binding flavin-adenine dinucleotide: G10 (= G10), G12 (= G12), I14 (= I14), E33 (= E33), K34 (≠ S34), E41 (≠ G41), T42 (≠ I42), S43 (= S43), A45 (≠ R45), N46 (= N46), S47 (= S47), V49 (= V49), H51 (= H51), E176 (≠ P171), V177 (= V172), A209 (= A204), G210 (= G205), Y212 (≠ G207), Y234 (= Y233), S319 (≠ I314), R320 (= R315), M346 (≠ I347), K347 (≠ E348), S348 (= S349), P349 (= P350), G350 (= G351), L351 (= L352), T352 (= T353)
- binding sn-glycerol-3-phosphate: S47 (= S47), H51 (= H51), K258 (≠ L255), G259 (= G256), R320 (= R315), S348 (= S349)
P75063 Glycerol 3-phosphate oxidase; GlpO; L-alpha-glycerophosphate oxidase; EC 1.1.3.21 from Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae) (see paper)
26% identity, 99% coverage: 1:367/369 of query aligns to 1:366/384 of P75063
Q63342 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Rattus norvegicus (Rat) (see 2 papers)
26% identity, 61% coverage: 2:227/369 of query aligns to 41:263/857 of Q63342
- CV 52:53 (≠ VI 13:14) binding FAD
- EK 73:74 (≠ ES 33:34) binding FAD
- 80:88 (vs. 38:46, 22% identical) binding FAD
- H84 (≠ I42) modified: Tele-8alpha-FAD histidine
- V212 (= V172) binding FAD
- W244 (≠ G207) binding FAD
Sites not aligning to the query:
- 390:395 binding FAD
- 573:575 binding (6S)-5,6,7,8-tetrahydrofolate
- 669 binding (6S)-5,6,7,8-tetrahydrofolate
- 676:678 binding (6S)-5,6,7,8-tetrahydrofolate
- 737 binding (6S)-5,6,7,8-tetrahydrofolate
4pabB Crystal structure of the precursor form of rat dmgdh complexed with tetrahydrofolate (see paper)
26% identity, 61% coverage: 2:227/369 of query aligns to 4:226/824 of 4pabB
- active site: T53 (≠ E48), E102 (≠ R101), H226 (= H227)
- binding flavin-adenine dinucleotide: I11 (= I9), G12 (= G10), G14 (= G12), C15 (≠ V13), V16 (≠ I14), L35 (= L32), E36 (= E33), K37 (≠ S34), G43 (≠ F38), S44 (≠ G39), T45 (= T40), H47 (≠ I42), A48 (≠ S43), A49 (= A44), G50 (≠ R45), L51 (≠ N46), V175 (= V172), A204 (= A204), G205 (= G205), W207 (≠ G207), H226 (= H227)
Sites not aligning to the query:
- active site: 255, 536
- binding flavin-adenine dinucleotide: 228, 326, 328, 353, 355, 356, 357, 358
- binding (6s)-5,6,7,8-tetrahydrofolate: 523, 536, 538, 550, 612, 613, 632, 639, 680, 700
Q9UI17 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Homo sapiens (Human) (see 4 papers)
26% identity, 61% coverage: 2:227/369 of query aligns to 48:270/866 of Q9UI17
- CV 59:60 (≠ VI 13:14) binding FAD
- EK 80:81 (≠ ES 33:34) binding FAD
- 87:95 (vs. 38:46, 22% identical) binding FAD
- H91 (≠ I42) modified: Tele-8alpha-FAD histidine
- H109 (≠ C66) to R: in DMGDHD; shows 10 fold lower catalytic efficiency due to lower cofactor saturation and reduced thermal stability; dbSNP:rs121908331
- V219 (= V172) binding FAD
Sites not aligning to the query:
- 279 S → P: in dbSNP:rs532964
- 397:402 binding FAD
- 530 A → G: in dbSNP:rs1805073
- 646 S → P: in dbSNP:rs1805074
7cyxA Crystal strcuture of glycine oxidase from bacillus cereus atcc 14579 (see paper)
24% identity, 85% coverage: 3:317/369 of query aligns to 1:302/363 of 7cyxA
- binding flavin-adenine dinucleotide: I7 (= I9), G8 (= G10), G10 (= G12), V11 (= V13), I12 (= I14), V30 (≠ L32), E31 (= E33), K32 (≠ S34), E38 (≠ R45), A39 (≠ N46), S40 (= S47), A43 (≠ I50), G45 (≠ A52), L46 (vs. gap), V171 (= V172), G200 (= G210), G201 (≠ I211), W203 (≠ R213), G298 (= G313), R300 (= R315), P301 (= P316)
Sites not aligning to the query:
6j39A Crystal structure of cmis2 with inhibitor (see paper)
28% identity, 63% coverage: 14:244/369 of query aligns to 11:239/368 of 6j39A
- binding (3R)-3-[(carboxymethyl)sulfanyl]nonanoic acid: M44 (≠ I54), P46 (≠ Y56), N49 (≠ G59)
- binding flavin-adenine dinucleotide: I11 (= I14), V29 (≠ L32), D30 (≠ E33), P31 (≠ S34), E32 (= E35), K36 (≠ N46), A37 (≠ S47), S38 (≠ E48), V40 (≠ I50), S41 (≠ H51), A42 (= A52), G43 (= G53), M44 (≠ I54), A174 (≠ P171), A203 (= A204), W206 (≠ G207), I228 (≠ Y233)
Sites not aligning to the query:
- binding (3R)-3-[(carboxymethyl)sulfanyl]nonanoic acid: 243, 252, 267, 308, 334, 335
- binding flavin-adenine dinucleotide: 7, 9, 10, 252, 308, 333, 334, 335, 336, 337, 338
6j38A Crystal structure of cmis2 (see paper)
28% identity, 63% coverage: 14:244/369 of query aligns to 11:239/368 of 6j38A
- binding flavin-adenine dinucleotide: I11 (= I14), V29 (≠ L32), D30 (≠ E33), P31 (≠ S34), K36 (≠ N46), A37 (≠ S47), S38 (≠ E48), S41 (≠ H51), A42 (= A52), G43 (= G53), M44 (≠ I54), A174 (≠ P171), A203 (= A204), W206 (≠ G207), G226 (= G231)
Sites not aligning to the query:
Query Sequence
>WP_041101149.1 NCBI__GCF_000828635.1:WP_041101149.1
MDKIDCAVIGAGVIGLAVARKLAAAGREVLILESENAFGTGISARNSEVIHAGIYYAAGS
LKARLCVAGRRMLYAYCAERGIGHRRCGKLIVATRDDQLARLDGIAAAARSNGVDDLQFL
SRNEARALEPALECTAALLSPSTGIIDSHALMLSLLGDAERDGAVLALNSPVRGGRVDRD
GIMLEAGVGAGETAILAQSVVNCAGLGAQGIARALRGLSPASVPPLHYAKGNYYSLAGRA
PFSRLIYPVPEAAGLGVHLTLDLGGQARFGPDVEWIENIDYAVAPERADAFYAEVRRYWP
QLPDGALLPAYAGIRPKPHAPGAPACDFLVSGPAEHGVPGLVNLYGIESPGLTASLALAD
HAVASLSGP
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory