SitesBLAST
Comparing WP_041277947.1 NCBI__GCF_000025945.1:WP_041277947.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2jg7A Crystal structure of seabream antiquitin and elucidation of its substrate specificity (see paper)
51% identity, 99% coverage: 4:508/510 of query aligns to 13:509/509 of 2jg7A
- active site: N166 (= N160), K189 (= K183), E267 (= E262), C301 (= C296), E398 (= E396), E478 (= E477)
- binding nicotinamide-adenine-dinucleotide: I162 (= I156), T163 (= T157), A164 (= A158), F165 (= F159), N166 (= N160), K189 (= K183), P192 (≠ S186), A226 (≠ K221), G229 (= G224), T230 (≠ D225), F243 (= F238), T244 (= T239), G245 (= G240), S246 (= S241), V249 (≠ T244), E267 (= E262), L268 (= L263), C301 (= C296), E398 (= E396), F400 (= F398)
4pxnA Structure of zm aldh7 in complex with NAD (see paper)
53% identity, 93% coverage: 31:503/510 of query aligns to 32:498/498 of 4pxnA
- active site: N161 (= N160), K184 (= K183), E262 (= E262), C296 (= C296), E392 (= E396), E472 (= E477)
- binding nicotinamide-adenine-dinucleotide: I157 (= I156), T158 (= T157), A159 (= A158), F160 (= F159), N161 (= N160), K184 (= K183), T221 (≠ K221), G224 (= G224), Q225 (≠ D225), F238 (= F238), T239 (= T239), G240 (= G240), S241 (= S241), A244 (≠ T244), V248 (≠ A248), E262 (= E262), L263 (= L263), S264 (≠ G264), C296 (= C296), E392 (= E396), F394 (= F398), F461 (= F466)
4zulA Structure aldh7a1 complexed with alpha-aminoadipate (see paper)
51% identity, 99% coverage: 4:508/510 of query aligns to 12:508/509 of 4zulA
- active site: N165 (= N160), K188 (= K183), E266 (= E262), C300 (= C296), E397 (= E396), E477 (= E477)
- binding 2-aminohexanedioic acid: E119 (= E114), F166 (= F161), R299 (= R295), C300 (= C296), T301 (= T297), G459 (= G459), A460 (= A460), F466 (= F466)
4x0tA Structure aldh7a1 inactivated by 4-diethylaminobenzaldehyde and complexed with NAD+ (see paper)
51% identity, 99% coverage: 4:508/510 of query aligns to 12:508/509 of 4x0tA
- active site: N165 (= N160), K188 (= K183), E266 (= E262), C300 (= C296), E397 (= E396), E477 (= E477)
- binding 4-(diethylamino)benzaldehyde: F166 (= F161), V170 (= V165), W173 (= W168), C300 (= C296), F466 (= F466)
- binding nicotinamide-adenine-dinucleotide: T162 (= T157), A163 (= A158), F164 (= F159), N165 (= N160), K188 (= K183), G189 (≠ P184), A190 (≠ S185), A225 (≠ K221), G228 (= G224), T229 (≠ D225), F242 (= F238), T243 (= T239), G244 (= G240), S245 (= S241), V248 (≠ T244), E266 (= E262), L267 (= L263), C300 (= C296), E397 (= E396), F399 (= F398)
P49419 Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31; EC 1.2.1.3; EC 1.2.1.8 from Homo sapiens (Human) (see 5 papers)
51% identity, 99% coverage: 4:508/510 of query aligns to 42:538/539 of P49419
- TAF 192:194 (= TAF 157:159) binding NAD(+)
- A199 (= A164) to V: in EPEO4; loss of alpha-AASA dehydrogenase activity; dbSNP:rs121912709
- K218 (= K183) binding NAD(+)
- GT 258:259 (≠ GD 224:225) binding NAD(+)
- GS 274:275 (= GS 240:241) binding NAD(+)
- EL 296:297 (= EL 262:263) binding NAD(+)
- C330 (= C296) active site, Nucleophile
- E427 (= E396) binding NAD(+); to Q: in EPEO4; loss of alpha-AASA dehydrogenase activity; dbSNP:rs121912707
- K439 (≠ S408) to Q: in dbSNP:rs12514417
Sites not aligning to the query:
- 110:539 natural variant: Missing (in EPEO4; loss of alpha-AASA dehydrogenase activity)
6dbbA Crystal structure of a putative aldehyde dehydrogenase family protein burkholderia cenocepacia j2315 in complex with partially reduced nadh
51% identity, 93% coverage: 35:510/510 of query aligns to 27:504/504 of 6dbbA
- active site: N152 (= N160), E259 (= E262), C293 (= C296), E471 (= E477)
- binding nicotinamide-adenine-dinucleotide: I148 (= I156), S149 (≠ T157), A150 (= A158), F151 (= F159), N152 (= N160), K175 (= K183), S177 (= S185), R218 (≠ K221), T236 (= T239), G237 (= G240), S238 (= S241), M241 (≠ T244), E259 (= E262), L260 (= L263), G261 (= G264), C293 (= C296), E391 (= E396), F393 (= F398)
- binding beta-6-hydroxy-1,4,5,6-tetrhydronicotinamide adenine dinucleotide: I148 (= I156), S149 (≠ T157), A150 (= A158), F151 (= F159), N152 (= N160), K175 (= K183), S177 (= S185), R218 (≠ K221), T236 (= T239), G237 (= G240), S238 (= S241), M241 (≠ T244), E259 (= E262), L260 (= L263), G261 (= G264), C293 (= C296), E391 (= E396), F393 (= F398)
6o4dB Structure of aldh7a1 mutant w175a complexed with l-pipecolic acid (see paper)
50% identity, 99% coverage: 4:508/510 of query aligns to 13:509/510 of 6o4dB
2j6lA Structure of aminoadipate-semialdehyde dehydrogenase (see paper)
50% identity, 97% coverage: 4:496/510 of query aligns to 12:496/497 of 2j6lA
- active site: N165 (= N160), K188 (= K183), E266 (= E262), C300 (= C296), E397 (= E396), E477 (= E477)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I161 (= I156), T162 (= T157), A163 (= A158), F164 (= F159), N165 (= N160), K188 (= K183), A225 (≠ K221), G228 (= G224), T229 (≠ D225), F242 (= F238), T243 (= T239), G244 (= G240), S245 (= S241), V248 (≠ T244), E266 (= E262), L267 (= L263), C300 (= C296), E397 (= E396), F399 (= F398)
4x0uD Structure aldh7a1 inactivated by 4-diethylaminobenzaldehyde (see paper)
49% identity, 97% coverage: 4:496/510 of query aligns to 12:486/487 of 4x0uD
- active site: N165 (= N160), K188 (= K183), E266 (= E262), C300 (= C296), E397 (= E396), E467 (= E477)
- binding 4-(diethylamino)benzaldehyde: F166 (= F161), A169 (= A164), V170 (= V165), C300 (= C296), F456 (= F466), H461 (≠ D471)
- binding magnesium ion: E119 (= E114), D122 (= D117)
6rtsA Piperideine-6-carboxylate dehydrogenase from streptomyces clavuligerus complexed with NAD+ (see paper)
50% identity, 93% coverage: 35:509/510 of query aligns to 37:509/509 of 6rtsA
- active site: N162 (= N160), E263 (= E262), C297 (= C296), E477 (= E477)
- binding nicotinamide-adenine-dinucleotide: I158 (= I156), S159 (≠ T157), A160 (= A158), F161 (= F159), N162 (= N160), K185 (= K183), S187 (= S185), E188 (≠ S186), A222 (≠ G220), G225 (= G224), T240 (= T239), G241 (= G240), S242 (= S241), M245 (≠ T244), E263 (= E262), L264 (= L263), C297 (= C296), E397 (= E396), F399 (= F398)
6rttA Piperideine-6-carboxylate dehydrogenase from streptomyces clavuligerus complexed with picolinic acid (see paper)
50% identity, 93% coverage: 35:509/510 of query aligns to 36:508/508 of 6rttA
- active site: N161 (= N160), E262 (= E262), C296 (= C296), E476 (= E477)
- binding pyridine-2-carboxylic acid: A159 (= A158), F162 (= F161), V166 (= V165), W169 (= W168), G240 (= G240), S241 (= S241), R295 (= R295), C296 (= C296), T297 (= T297), E396 (= E396), F398 (= F398), P421 (≠ H422), K469 (= K470), E470 (≠ D471)
6rtuA Piperideine-6-carboxylate dehydrogenase from streptomyces clavuligerus complexed with alpha-aminoadipic acid (see paper)
50% identity, 93% coverage: 35:509/510 of query aligns to 36:505/505 of 6rtuA
- active site: N161 (= N160), E259 (= E262), C293 (= C296), E473 (= E477)
- binding 2-aminohexanedioic acid: E115 (= E114), F162 (= F161), R292 (= R295), C293 (= C296), T294 (= T297), S454 (= S458), G455 (= G459), A456 (= A460), F462 (= F466)
6fkuA Structure and function of aldehyde dehydrogenase from thermus thermophilus: an enzyme with an evolutionarily-distinct c-terminal arm (recombinant protein with shortened c-terminal, in complex with NADP) (see paper)
32% identity, 93% coverage: 30:504/510 of query aligns to 28:510/511 of 6fkuA
- active site: N159 (= N160), E261 (= E262), C295 (= C296), E483 (= E477)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I155 (= I156), T156 (= T157), N159 (= N160), K182 (= K183), S184 (= S185), E185 (≠ S186), G214 (≠ S219), G215 (= G220), K216 (= K221), G220 (= G224), Q221 (≠ D225), F237 (= F238), T238 (= T239), G239 (= G240), S240 (= S241), V243 (≠ T244), E261 (= E262), L262 (= L263), C295 (= C296), R342 (≠ D342), F343 (≠ A343), E404 (= E396), F406 (= F398)
6j76A Structure of 3,6-anhydro-l-galactose dehydrogenase in complex with nap (see paper)
29% identity, 94% coverage: 16:496/510 of query aligns to 4:477/477 of 6j76A
- active site: N148 (= N160), E246 (= E262), C280 (= C296), E458 (= E477)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I144 (= I156), T145 (= T157), A146 (= A158), W147 (≠ F159), N148 (= N160), K171 (= K183), T173 (≠ S185), S174 (= S186), G204 (= G220), G208 (= G224), T223 (= T239), G224 (= G240), S225 (= S241), A228 (≠ T244), S231 (≠ H247), I232 (≠ A248), E246 (= E262), L247 (= L263), C280 (= C296), E381 (= E396), F383 (= F398), H447 (≠ F466)
3jz4A Crystal structure of e. Coli NADP dependent enzyme (see paper)
29% identity, 93% coverage: 21:494/510 of query aligns to 17:479/481 of 3jz4A
- active site: N156 (= N160), K179 (= K183), E254 (= E262), C288 (= C296), E385 (= E396), E462 (= E477)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: P154 (≠ A158), W155 (≠ F159), K179 (= K183), A181 (≠ S185), S182 (= S186), A212 (≠ G220), G216 (= G224), G232 (= G240), S233 (= S241), I236 (≠ T244), C288 (= C296), K338 (≠ N346), E385 (= E396), F387 (= F398)
P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12) (see paper)
29% identity, 93% coverage: 21:494/510 of query aligns to 18:480/482 of P25526
8vr1A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (ctp bound)
30% identity, 94% coverage: 21:497/510 of query aligns to 12:482/488 of 8vr1A
8vr0A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (gmp bound)
30% identity, 94% coverage: 21:497/510 of query aligns to 12:482/488 of 8vr0A
8vqzA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (cmp bound)
30% identity, 94% coverage: 21:497/510 of query aligns to 12:482/488 of 8vqzA
8vqwC Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (coa bound)
30% identity, 94% coverage: 21:497/510 of query aligns to 12:482/488 of 8vqwC
- binding coenzyme a: I147 (= I156), W150 (≠ F159), K174 (= K183), S176 (= S185), E177 (≠ S186), G207 (= G220), G211 (= G224), F225 (= F238), G227 (= G240), G228 (≠ S241), S231 (≠ T244), H331 (≠ A343), F387 (= F398)
Query Sequence
>WP_041277947.1 NCBI__GCF_000025945.1:WP_041277947.1
MESIKKLHIKKANSGICTGTEWISPAGSKVIESISPVDGRIIAKIQAGGAPEYKRIITQA
QKAFPLWRKIPAPERGEIVRQIGEALRKDKENLGRMICLEMGKSLQEGYGEVQEMIDVCD
FAVGQSRMLYGATMPSERPSHRLYDQYHPLGVVGIITAFNFPAAVWAWNAMLSTVCGNVL
VWKPSSQVGLTAIAIQHIIARVLKKNKLPEGIFSLICGSGKDIGDLMLADTRLPLISFTG
SVRTGRHAAQIIAGRLGKSLLELGGNNSIIISPEADLAIAIPAVVFGAVGTAGQRCTTTR
RLIIHESIYDKVRDGLTKAYKSLRIGSPLNQDNHMGPLVNQDAVANYLAAVETIKDQGGE
ILCGGHALQGEGFESGCYVAPTLVEVKSDIPIIKEETFAPILYLIRYSGDINQAIEINNS
AHEGLSSAIFSNNLREAETFLSPWGSDCGIANVNIGTSGAEIGGAFGGEKDTGGGRESGS
DAWKAYMRRQTVTINYGHELPLAQGINFTI
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory