SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_041278049.1 NCBI__GCF_000025945.1:WP_041278049.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
48% identity, 99% coverage: 6:565/567 of query aligns to 96:658/667 of P09342

query
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P09342

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C161 (≠ A71) modified: Disulfide link with 307
P194 (= P104) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
C307 (≠ V215) modified: Disulfide link with 161

P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
49% identity, 99% coverage: 6:565/567 of query aligns to 93:655/664 of P09114

query
sites
P09114

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P191 (= P104) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
W568 (= W485) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.

3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
47% identity, 98% coverage: 6:558/567 of query aligns to 13:568/582 of 3ea4A

query
sites
3ea4A

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K
|
K

D

D

I

I

L

Q

A

Q

T

Q

L

L

I

A

D

I

Y

P

P

N

Q

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I

E

A

Q

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A

I

M

K

R

L

L

D

P

S

G

Y

Y

Q

M

P

S

N

R

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M

-

P

-

K

K

P

P

P

H

E

Q

D

G

S

Q

H

I

L

T

E

K

Q

A

I

C

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K

R

L

L

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Q

E

A

S

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K

P

P

V

V

L

L

Y

Y

V

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G
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G

V

C

I

L

L

-

S

-

N

N

S

S

H

S

K

D

E

E

L

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S

G

A

R

L

F

A

V

E

E

K

L

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I

P

P

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T

T
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T

L
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L

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M

G

G

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L

G

G

A

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F

Y

P

P

G

C

S

D

H

D

D

E

L

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S

S

M

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M

M

L
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L

G
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G

M
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M

H
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H

G

G

S

T

Y

V

T

Y

A

A

N

N

M

Y

A

A

V

V

A

E

E

H

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S

D

D

L

L

I

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A

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G

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R

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F

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D

R
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R

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V

T

T

G

G

K

K

L

L

E

E

D

A

F

F

A

A

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S

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R

A

A

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I

I

I

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V

I

D
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D

I
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I

D

D

P

S

T

A

S

E

I

I

S

G

K

K

N

N

V

K

K

T

V

P

D

H

V

V

P

S

I

V

V

C

A
x
G

D
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D

C
x
V

L

K

A

L

A

A

L

L

T

Q

A

G

I

M

N

N

D

K

W

V

L

L

E

E

K

N

C

R

P

A

E

E

E

-

I

-

A

-

E

E

R

L

R

K

D

L

A

D

H

F

K

G

P

V

W

W

I

R

D

N

T

E

V

L

H

N

N

V

W

Q

T

K

K

Q

E

K

H

F

P

P

M

L

R

S

Y

F

N

K

S

T

N

F

G

G

S

E

E

A

I

I

K

P

P

P

Q

Q

F

Y

V

A

V

I

E

K

T

V

I

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D

D

R

E

L

L

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K

D

G

G

E

K

A

A

I

I

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S

T

T

E

G

V
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V

G
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G

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Q

N
x
H

Q

Q

M
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M

W

W

A

A

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Q

F

F

Y

Y

K

N

F

Y

N

K

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W

V

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G
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G

G

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G
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G

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M

G

G

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F

G

G

L

L

P

P

A

A

I

I

G

G

A

A

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M

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A

A

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N

P

P

D

D

K

A

I

I

V

V

I

V

D

D

I

I

A

D

G
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G

D
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D

G
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G

S
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S

I

F

Q

I

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M

N

N

I

V

Q

Q

E

E

L

L

A

A

T

T

A

I

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R

Q

V

N

E

N

N

C

L

N

P

V

V

K

K

I

V

V

L

I

L

L

L

N

N

N
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x
H

L
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L

G
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G

M
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M

V
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V

R

M

Q

Q

W
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W

Q

E

E

D

L

R

F

F

Y

Y

D

K

K

A

R

N

Y

R

A

A

S

H

T

T

V

F

M

L

-

G

-

D

-

P

-

A

-

Q

-

E

-

D

D

E

V

I

A

F

P

P

D

N

F

M

V

L

K

L

L

F

A

A

E

A

A

A

Y

C

G

G

A

I

V

P

G

A

L

A

R

R

A

V

T

T

K

K

E

A

E

D

V

L

E

R

S

E

V

A

L

I

A

Q

E

T

G

M

L

L

A

D

T

T

D

P

N

G

V

P

V

Y

I

L

M

L

E

D

F

V

L

I

V

C

A

P

P
x
H

E

Q

E

E

G

H

V

V

Y

L

P

P

M

M

V

I

P

P

A
x
S

G

G

active site: Y32 (= Y25), G34 (= G27), G35 (= G28), A36 (= A29), S37 (≠ V30), E58 (= E51), T81 (= T74), F120 (= F113), Q121 (= Q114), E122 (= E115), K170 (= K163), M265 (= M258), V292 (= V285), V399 (= V396), G425 (= G422), M427 (= M424), D452 (= D449), N479 (= N476), H481 (≠ Y478), L482 (= L479), M484 (= M481), V485 (= V482), W488 (= W485), H557 (≠ P547)
binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D283), R291 (= R284), W488 (= W485), S567 (≠ A557)
binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R153), G221 (= G212), G222 (= G213), G223 (= G214), T245 (= T238), L246 (= L239), M247 (= M240), L263 (= L256), G264 (= G257), M265 (= M258), H266 (= H259), G285 (= G278), R287 (= R280), D289 (= D282), R291 (= R284), D309 (= D302), I310 (= I303), G327 (≠ A320), D328 (= D321), V329 (≠ C322), M404 (= M401), G422 (= G419)
binding magnesium ion: D452 (= D449), N479 (= N476), H481 (≠ Y478)
binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V396), G400 (= G397), Q401 (= Q398), H402 (≠ N399), M427 (= M424), G451 (= G448), D452 (= D449), G453 (= G450), S454 (= S451), N479 (= N476), H481 (≠ Y478), L482 (= L479), G483 (= G480), M484 (= M481), V485 (= V482)

3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
47% identity, 98% coverage: 6:558/567 of query aligns to 13:568/582 of 3e9yA

query
sites
3e9yA

G

G

S

A

R

D

A

I

I

L

V

V

Q

E

C

A

L

L

K

E

E

R

E

Q

G

G

V

V

Q

E

T

T

I

V

F

F

G

A

Y
|
Y

P

P

G
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G

A
|
A

V
x
S

I

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D

E

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I

Y

H

D

Q

A

A

L

L

M

T

D

R

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S

T

S

D

S

I

I

E

R

H

N

V

V

L

L

V

P

R

R

H

H

E
|
E

Q

Q

G

G

A

G

V

V

H

F

A

A

D

E

A

G

F

Y

A

A

R

R

V

S

T

S

G

G

E

K

V

P

G

G

V

I

A

C

L

I

L

A

T
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T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

G

L

V

V

T

S

G

G

I

L

A

A

T

D

A

A

Y

L

L

L

D

D

S

S

I

V

P

P

L

L

V

V

V

A

L

I

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T

G

G

Q

Q

V

V

P

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R

R

A

R

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I

I

G

G

N

T

D

D

A

A

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F

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Q

E
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E

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D

P

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I

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V

G

E

I

V

T

T

R

R

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T

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K

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Y

L

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K

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E

E

D

D

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I

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E

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E

A

A

F

F

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F

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A

A

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R

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L

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K

D

D

I

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A

D

I

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A

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L

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Y

Y

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-

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V

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L

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G

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L

-

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-

N

N

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S

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E

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A

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T

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M

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L

G

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M

H

H

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Y

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T

Y

A

A

N

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M

Y

A

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G

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D

I
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I

D

D

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A

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E

I

I

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G

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K

N

N

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G

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D

C
x
V

L

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A

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A

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A

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I

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N

N

D

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A

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-

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-

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-

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E

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L

A

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H

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W

I

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N

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Q

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F

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F

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S

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A

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D

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E

L

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D

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A

A

I

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T

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E

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V
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V

G
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G

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Q

N
x
H

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M

W

W

A

A

Q

Q

F

F

Y

Y

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N

F

Y

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G

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F

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A

A

I

I

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G

A

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A

A

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D

D

K

A

I

I

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I

V

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D

I

I

A

D

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G

D
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D

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S
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S

I

F

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I

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M

N

N

I

V

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E

E

L

L

A

A

T

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A

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E

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C

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P

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V

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K

I

V

V

L

I

L

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L

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x
H

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L

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M
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M

V
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V

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M

Q

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W

Q

E

E

D

L

R

F

F

Y

Y

D

K

K

A

R

N

Y

R

A

A

S

H

T

T

V

F

M

L

-

G

-

D

-

P

-

A

-

Q

-

E

-

D

D

E

V

I

A

F

P

P

D

N

F

M

V

L

K

L

L

F

A

A

E

A

A

A

Y

C

G

G

A

I

V

P

G

A

L

A

R

R

A

V

T

T

K

K

E

A

E

D

V

L

E

R

S

E

V

A

L

I

A

Q

E

T

G

M

L

L

A

D

T

T

D

P

N

G

V

P

V

Y

I

L

M

L

E

D

F

V

L

I

V

C

A

P

P
x
H

E

Q

E

E

G

H

V

V

Y

L

P

P

M

M

V

I

P

P

A
x
S

G

G

active site: Y32 (= Y25), G34 (= G27), G35 (= G28), A36 (= A29), S37 (≠ V30), E58 (= E51), T81 (= T74), F120 (= F113), Q121 (= Q114), E122 (= E115), K170 (= K163), M265 (= M258), V292 (= V285), V399 (= V396), G425 (= G422), M427 (= M424), D452 (= D449), N479 (= N476), H481 (≠ Y478), L482 (= L479), M484 (= M481), V485 (= V482), W488 (= W485), H557 (≠ P547)
binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D283), R291 (= R284), W488 (= W485), S567 (≠ A557)
binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R153), G221 (= G212), G222 (= G213), G223 (= G214), T245 (= T238), L246 (= L239), M247 (= M240), L263 (= L256), G285 (= G278), R287 (= R280), D289 (= D282), R291 (= R284), D309 (= D302), I310 (= I303), G327 (≠ A320), D328 (= D321), V329 (≠ C322), M404 (= M401), G422 (= G419)
binding magnesium ion: D452 (= D449), N479 (= N476), H481 (≠ Y478)
binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V396), G400 (= G397), Q401 (= Q398), H402 (≠ N399), M427 (= M424), G451 (= G448), G453 (= G450), S454 (= S451), N479 (= N476), H481 (≠ Y478), L482 (= L479), G483 (= G480), M484 (= M481), V485 (= V482)

5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
47% identity, 98% coverage: 6:558/567 of query aligns to 14:569/583 of 5k3sA

query
sites
5k3sA

G

G

S

A

R

D

A

I

I

L

V

V

Q

E

C

A

L

L

K

E

E

R

E

Q

G

G

V

V

Q

E

T

T

I

V

F

F

G

A

Y
|
Y

P

P

G
|
G

A
|
A

V
x
S

I

M

D

E

L

I

Y

H

D

Q

A

A

L

L

M

T

D

R

S

S

T

S

D

S

I

I

E

R

H

N

V

V

L

L

V

P

R

R

H

H

E
|
E

Q

Q

G

G

A

G

V

V

H

F

A

A

D

E

A

G

F

Y

A

A

R

R

V

S

T

S

G

G

E

K

V

P

G

G

V

I

A

C

L

I

L

A

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

G

L

V

V

T

S

G

G

I

L

A

A

T

D

A

A

Y

L

L

L

D

D

S

S

I

V

P

P

L

L

V

V

V

A

L

I

T

T

G

G

Q

Q

V

V

P

P

R

R

A

R

L

M

I

I

G

G

N

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

P

S

C

I

T

T

K

K

H

H

N

N

Y

Y

L

L

V

V

S

M

K

D

P

V

E

E

D

D

L

I

V

P

P

R

V

I

L

I

R

E

E

E

A

A

F

F

H

F

V

L

A

A

K

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

L

V

P

P

K
|
K

D

D

I

I

L

Q

A

Q

T

Q

L

L

I

A

D

I

Y

P

P

N

Q

W

I

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A

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A

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Y

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-

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M

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V

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-

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M

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N

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N

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K

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Y

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-

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-

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N

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G

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x
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G

active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), S38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M258), V293 (= V285), V400 (= V396), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ Y478), L483 (= L479), M485 (= M481), V486 (= V482), W489 (= W485), H558 (≠ P547)
binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R284), M485 (= M481), W489 (= W485), G569 (= G558)
binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G212), G223 (= G213), G224 (= G214), T246 (= T238), L247 (= L239), M248 (= M240), L264 (= L256), M266 (= M258), G286 (= G278), R288 (= R280), D290 (= D282), V293 (= V285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ C322), M405 (= M401), G423 (= G419)
binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ Y478)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V396), G401 (= G397), Q402 (= Q398), H403 (≠ N399), G426 (= G422), M428 (= M424), D453 (= D449), G454 (= G450), S455 (= S451), N480 (= N476), H482 (≠ Y478), L483 (= L479), G484 (= G480), M485 (= M481), V486 (= V482)

8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
47% identity, 98% coverage: 6:558/567 of query aligns to 14:569/582 of 8et4A

query
sites
8et4A

G

G

S

A

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L

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F

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D

K

K

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R

N

Y

R

A

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S

H

T

T

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F

M

L

-

G

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D

-

P

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A

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-

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A

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D

N

F

M

V

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K

L

L

F

A

A

E

A

A

A

Y

C

G

G

A

I

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P

G

A

L

A

R

R

A

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T

T

K

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K
|
K

E

A

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D

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R

S

E

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A

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I

A

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A

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T

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N

G

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M

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C

A

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Q

E

E

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H

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V

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M

M

V

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A
x
S

G

G

binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V396), G401 (= G397), Q402 (= Q398), H403 (≠ N399), G426 (= G422), M428 (= M424), G452 (= G448), D453 (= D449), G454 (= G450), S455 (= S451), M458 (= M454), N480 (= N476), H482 (≠ Y478), L483 (= L479), G484 (= G480), M485 (= M481), V486 (= V482)
binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G212), G223 (= G213), G224 (= G214), T246 (= T238), L247 (= L239), M248 (= M240), L264 (= L256), M266 (= M258), H267 (= H259), G286 (= G278), V287 (≠ A279), R288 (= R280), D290 (= D282), R292 (= R284), V293 (= V285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ C322), M405 (= M401), G423 (= G419)
binding magnesium ion: F370 (≠ Y366), D453 (= D449), M458 (= M454), Q461 (= Q457), N480 (= N476), H482 (≠ Y478), K533 (= K522)
binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M258), R292 (= R284), M485 (= M481), W489 (= W485), S568 (≠ A557)

5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
47% identity, 98% coverage: 6:558/567 of query aligns to 14:569/582 of 5wj1A

query
sites
5wj1A

G

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E

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R

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active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (= A29), S38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M258), V293 (= V285), V400 (= V396), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ Y478), L483 (= L479), M485 (= M481), V486 (= V482), W489 (= W485), H558 (≠ P547)
binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G212), G223 (= G213), G224 (= G214), T246 (= T238), L247 (= L239), M248 (= M240), M263 (= M255), L264 (= L256), G286 (= G278), R288 (= R280), V293 (= V285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ C322), M405 (= M401), G423 (= G419), G424 (= G420)
binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ Y478)
binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M258), D291 (= D283), R292 (= R284), M485 (= M481), W489 (= W485), S568 (≠ A557)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V396), G401 (= G397), Q402 (= Q398), H403 (≠ N399), M428 (= M424), D453 (= D449), G454 (= G450), S455 (= S451), M458 (= M454), N480 (= N476), H482 (≠ Y478), L483 (= L479), G484 (= G480), M485 (= M481), V486 (= V482)

5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
47% identity, 98% coverage: 6:558/567 of query aligns to 14:569/582 of 5k6tA

query
sites
5k6tA

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