SitesBLAST
Comparing WP_041278539.1 NCBI__GCF_000025945.1:WP_041278539.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4yi7A Anthranilate bound at active site of anthranilate phosphoribosyl transferase from acinetobacter (anprt; trpd)
41% identity, 99% coverage: 2:338/339 of query aligns to 3:325/331 of 4yi7A
4zojA Methylsulfanyl-containing inhibitor bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
44% identity, 99% coverage: 5:338/339 of query aligns to 5:338/341 of 4zojA
- active site: V82 (= V83)
- binding 4-methyl-2-{[2-methyl-6-(methylsulfanyl)phenyl]amino}benzoic acid: N114 (= N115), A155 (= A156), P156 (= P157), H159 (= H160), Y162 (≠ M163), R169 (= R170), G182 (= G183)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G84), G85 (= G86), G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), R115 (= R116), A116 (= A117), A117 (≠ V118), S119 (= S120)
4zokA Methylsulfonyl-containing inhibitor bound in the substrate capture site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
44% identity, 99% coverage: 5:338/339 of query aligns to 5:339/342 of 4zokA
- active site: V82 (= V83)
- binding 4-methyl-2-{[2-methyl-6-(methylsulfonyl)phenyl]amino}benzoic acid: P156 (= P157), R163 (≠ K164), A166 (≠ I167), A167 (≠ V168)
- binding magnesium ion: S95 (= S96), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), A116 (= A117), A117 (≠ V118), S119 (= S120), G122 (= G123)
4zofA Lobenzarit-like inhibitor bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
44% identity, 99% coverage: 5:338/339 of query aligns to 5:339/342 of 4zofA
- active site: V82 (= V83)
- binding 2-[(2-carboxy-5-nitrophenyl)amino]-3-methylbenzoic acid: G113 (= G114), N114 (= N115), A155 (= A156), H159 (= H160), Y162 (≠ M163), R169 (= R170), G182 (= G183)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G84), G85 (= G86), G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), A116 (= A117), A117 (≠ V118), S119 (= S120), G122 (= G123)
4owmA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 3-fluoroanthranilate, prpp and magnesium (see paper)
43% identity, 99% coverage: 5:338/339 of query aligns to 5:342/346 of 4owmA
- active site: V82 (= V83)
- binding 2-azanyl-3-fluoranyl-benzoic acid: P156 (= P157), H159 (= H160), Y162 (≠ M163), R163 (≠ K164), A166 (≠ I167), R170 (= R171)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G84), G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), A117 (≠ V118), S118 (= S119), S119 (= S120), G122 (= G123)
4gkmA Bianthranilate-like analogue bound in the outer site of anthranilate phosphoribosyltransferase (anprt; trpd) (see paper)
43% identity, 99% coverage: 5:338/339 of query aligns to 5:342/346 of 4gkmA
- active site: V82 (= V83)
- binding 2-[(2-carboxyphenyl)amino]-5-methylbenzoic acid: N114 (= N115), A155 (= A156), P156 (= P157), Y162 (≠ M163), R163 (≠ K164), A166 (≠ I167), R169 (= R170), R170 (= R171)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), A117 (≠ V118), S118 (= S119), S119 (= S120), G122 (= G123)
3r6cA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs179) (see paper)
43% identity, 99% coverage: 5:338/339 of query aligns to 5:342/346 of 3r6cA
- active site: V82 (= V83)
- binding 8-methoxyphenanthro[3,4-d][1,3]dioxole-5,6-dicarboxylic acid: M62 (= M62), N114 (= N115), A155 (= A156), P156 (= P157), H159 (= H160), Y162 (≠ M163), A166 (≠ I167), R169 (= R170), G182 (= G183), T185 (= T186), R239 (≠ D241), A241 (≠ H243), D246 (≠ T248), V301 (≠ L304), A310 (≠ V309), W312 (≠ T311)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G84), G85 (= G86), G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), N114 (= N115), R115 (= R116), A116 (= A117), A117 (≠ V118), S118 (= S119), S119 (= S120), G122 (= G123), G123 (≠ S124)
3qsaA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor tamu-a7)
43% identity, 99% coverage: 5:338/339 of query aligns to 5:342/346 of 3qsaA
- active site: V82 (= V83)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G84), G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), A117 (≠ V118), S118 (= S119), S119 (= S120), G122 (= G123)
- binding 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione: M62 (= M62), N114 (= N115), A155 (= A156), P156 (= P157), H159 (= H160), Y162 (≠ M163), R163 (≠ K164), A166 (≠ I167), G182 (= G183)
3qs8A Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs174) (see paper)
43% identity, 99% coverage: 5:338/339 of query aligns to 5:342/346 of 3qs8A
- active site: V82 (= V83)
- binding 2-benzylbenzoic acid: M62 (= M62), G83 (= G84), N114 (= N115), N114 (= N115), A155 (= A156), A155 (= A156), P156 (= P157), Y162 (≠ M163), Y162 (≠ M163), A166 (≠ I167), R169 (= R170), R169 (= R170), R170 (= R171), L181 (= L182), G182 (= G183)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G84), G85 (= G86), G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), N114 (= N115), A116 (= A117), A117 (≠ V118), S118 (= S119), S119 (= S120), G122 (= G123), E228 (= E230)
3qqsA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs172) (see paper)
43% identity, 99% coverage: 5:338/339 of query aligns to 5:342/346 of 3qqsA
- active site: V82 (= V83)
- binding 2,2'-iminodibenzoic acid: P156 (= P157), H159 (= H160), Y162 (≠ M163), R163 (≠ K164), A166 (≠ I167), R169 (= R170), R170 (= R171)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V82 (= V83), G85 (= G86), G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), R115 (= R116), A117 (≠ V118), S118 (= S119), S119 (= S120), G122 (= G123)
1zvwA The crystal structure of trpd (rv2192c) from mycobacterium tuberculosis in complex with prpp and magnesium (see paper)
43% identity, 99% coverage: 5:338/339 of query aligns to 5:342/346 of 1zvwA
- active site: V82 (= V83)
- binding benzamidine: T46 (≠ R46), M47 (= M47), K48 (= K48), P50 (≠ E50), D201 (≠ S202)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G84), N93 (= N94), S95 (= S96), T96 (= T97), A117 (≠ V118), S118 (= S119), S119 (= S120)
P9WFX5 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
43% identity, 99% coverage: 5:338/339 of query aligns to 29:366/370 of P9WFX5
- G107 (= G84) binding 5-phospho-alpha-D-ribose 1-diphosphate
- T115 (= T92) binding 5-phospho-alpha-D-ribose 1-diphosphate
- G147 (≠ S124) binding 5-phospho-alpha-D-ribose 1-diphosphate
4giuA Bianthranilate-like analogue bound in inner site of anthranilate phosphoribosyltransferase (anprt; trpd). (see paper)
43% identity, 99% coverage: 5:338/339 of query aligns to 6:343/346 of 4giuA