SitesBLAST
Comparing WP_041416449.1 NCBI__GCF_000019185.1:WP_041416449.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
57% identity, 99% coverage: 5:705/706 of query aligns to 4:703/707 of 6yswA
- active site: A66 (= A67), I71 (≠ L72), A84 (≠ S85), Q88 (≠ H89), G112 (= G113), E115 (= E116), P136 (= P137), E137 (= E138), G145 (= G146), D264 (≠ E268), S422 (= S427), H443 (= H448), E455 (= E460), N493 (= N498)
- binding coenzyme a: E23 (= E24), M25 (= M26), A66 (= A67), D67 (= D68), I68 (= I69), P136 (= P137), E137 (= E138), L140 (= L141), T290 (= T294), K293 (= K297)
P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
43% identity, 98% coverage: 14:705/706 of query aligns to 49:761/763 of P40939
- V282 (≠ I229) to D: in MTPD1; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852773
- I305 (= I252) to N: in MTPD1; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852774
- L342 (≠ V289) to P: in LCHAD deficiency; dbSNP:rs137852772
- E510 (= E460) active site, For hydroxyacyl-coenzyme A dehydrogenase activity; to Q: in AFLP and LCHAD deficiency; loss of long-chain-3-hydroxyacyl-CoA dehydrogenase activity; dbSNP:rs137852769
1wdlA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form ii (native4) (see paper)
39% identity, 100% coverage: 3:705/706 of query aligns to 6:714/715 of 1wdlA
- active site: A69 (= A67), N89 (vs. gap), N93 (≠ H89), G117 (= G113), E120 (= E116), P139 (= P137), E140 (= E138), P147 (= P145), G148 (= G146), S430 (= S427), H451 (= H448), E463 (= E460), N501 (= N498)
- binding nicotinamide-adenine-dinucleotide: A322 (≠ G318), I324 (≠ L320), M325 (= M321), D344 (= D341), I345 (= I342), A400 (= A397), V401 (= V398), E403 (= E400), N428 (= N425), T429 (= T426), S430 (= S427)
P28793 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Pseudomonas fragi (see paper)
39% identity, 100% coverage: 3:705/706 of query aligns to 6:714/715 of P28793
- D297 (≠ T293) binding substrate
- M325 (= M321) binding NAD(+)
- D344 (= D341) binding NAD(+)
- VVE 401:403 (≠ VFE 398:400) binding NAD(+)
- K408 (= K405) binding NAD(+)
- S430 (= S427) binding NAD(+)
- N454 (≠ S451) binding NAD(+)
- N501 (= N498) binding substrate
- Y660 (≠ F650) binding substrate
1wdmA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native3) (see paper)
39% identity, 100% coverage: 3:705/706 of query aligns to 6:706/707 of 1wdmA
- active site: A69 (= A67), N89 (vs. gap), N93 (≠ H89), G117 (= G113), E120 (= E116), P139 (= P137), E140 (= E138), P147 (= P145), G148 (= G146), S430 (= S427), H451 (= H448), E463 (= E460), N501 (= N498)
- binding acetyl coenzyme *a: K142 (≠ Q140), D297 (≠ T293), M459 (= M456), N501 (= N498), P534 (= P531), Y652 (≠ F650), L658 (≠ P656)
- binding nicotinamide-adenine-dinucleotide: G321 (= G317), A322 (≠ G318), I324 (≠ L320), M325 (= M321), D344 (= D341), V401 (= V398), E403 (= E400), N428 (= N425), S430 (= S427), N454 (≠ S451)
6tnmA E. Coli aerobic trifunctional enzyme subunit-alpha (see paper)
36% identity, 99% coverage: 4:705/706 of query aligns to 7:714/719 of 6tnmA
- active site: A68 (= A67), F73 (≠ L72), G116 (= G113), E119 (= E116), P138 (= P137), E139 (= E138), G147 (= G146), N271 (≠ E268), S429 (= S427), H450 (= H448), E462 (= E460), N500 (= N498)
- binding adenosine-5'-triphosphate: D343 (= D341), I344 (= I342), V400 (= V398), V401 (≠ F399), V406 (≠ L404), K584 (= K579)
P21177 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Escherichia coli (strain K12) (see 2 papers)
36% identity, 99% coverage: 4:705/706 of query aligns to 7:714/729 of P21177