Comparing WP_041675895.1 NCBI__GCF_000021545.1:WP_041675895.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P11177 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Homo sapiens (Human) (see 6 papers)
42% identity, 96% coverage: 4:316/325 of query aligns to 36:353/359 of P11177
Sites not aligning to the query:
6cerD Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
42% identity, 96% coverage: 4:316/325 of query aligns to 8:325/331 of 6cerD
6cfoB Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate (see paper)
42% identity, 96% coverage: 4:316/325 of query aligns to 7:324/330 of 6cfoB
1umdD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate (see paper)
45% identity, 95% coverage: 5:312/325 of query aligns to 7:313/323 of 1umdD
1umcD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate (see paper)
45% identity, 95% coverage: 5:312/325 of query aligns to 7:313/323 of 1umcD
1umbD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
45% identity, 95% coverage: 5:312/325 of query aligns to 7:313/323 of 1umbD
Q5SLR3 2-oxoisovalerate dehydrogenase subunit beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
45% identity, 95% coverage: 5:312/325 of query aligns to 8:314/324 of Q5SLR3
1qs0B Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
40% identity, 95% coverage: 5:312/325 of query aligns to 9:328/338 of 1qs0B
3dv0D Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
41% identity, 91% coverage: 5:299/325 of query aligns to 7:302/324 of 3dv0D
3dv0B Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
41% identity, 91% coverage: 5:299/325 of query aligns to 7:302/324 of 3dv0B
3dufD Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
41% identity, 91% coverage: 5:299/325 of query aligns to 7:302/324 of 3dufD
1w85B The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2 (see paper)
41% identity, 91% coverage: 5:299/325 of query aligns to 7:302/324 of 1w85B
P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Homo sapiens (Human) (see 2 papers)
39% identity, 95% coverage: 5:313/325 of query aligns to 75:383/392 of P21953
1dtwB Human branched-chain alpha-keto acid dehydrogenase (see paper)
39% identity, 95% coverage: 5:313/325 of query aligns to 9:317/326 of 1dtwB
2j9fD Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase e1b (see paper)
39% identity, 95% coverage: 5:313/325 of query aligns to 12:320/329 of 2j9fD
6yakDDD C-terminal component of the split chain transketolase (see paper)
25% identity, 84% coverage: 4:276/325 of query aligns to 6:265/311 of 6yakDDD
2o1sA 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from escherichia coli (see paper)
25% identity, 78% coverage: 49:303/325 of query aligns to 278:516/536 of 2o1sA
Sites not aligning to the query:
2o1sB 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from escherichia coli (see paper)
25% identity, 78% coverage: 49:303/325 of query aligns to 234:472/493 of 2o1sB
Sites not aligning to the query:
8a9cB Structure of truncated 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from klebsiella pneumoniae in complex with cofactor tpp
23% identity, 81% coverage: 42:303/325 of query aligns to 256:501/520 of 8a9cB
Sites not aligning to the query:
8bzxA 1-deoxy-d-xylulose 5-phosphate synthase from klebsiella pneumoniae (kpdxps),co-crystal with thiamine monophosphate analog (see paper)
23% identity, 81% coverage: 42:303/325 of query aligns to 281:526/546 of 8bzxA
Sites not aligning to the query:
>WP_041675895.1 NCBI__GCF_000021545.1:WP_041675895.1
MFYREALNLAIDEMMEIDESVVILGEDVGFYGGNYKVTEGLYAKYGEKRVIDTPIAENSI
VGIAIGMALGGLRPIAEIMTANFAMLAMDQIVNNMAKLRYMSGGKIVLPMVVRMPQGVVK
QLASQHSQSLESLFAGIPGLRVFTASDCITAYHGLKTAIKLDDPVVFLEHTLLYFEKFDL
PKDSFYNPFKARVLKEGKDLTIFSYLKMVHDVLKVVDKIESTLNVSVEVIDVGPLNPLDL
ETLTNSVKKTKRFVIVEENPKHGGFGAQIVSSILEECFYNLDAPPLRIAGEDVPIPYNRK
LELLSIPTPEKIYLKIVEWGKQNGL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory