Comparing WP_041786279.1 NCBI__GCF_000016185.1:WP_041786279.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 7 hits to proteins with known functional sites (download)
P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 5 papers)
62% identity, 98% coverage: 6:352/355 of query aligns to 4:350/1227 of P13009
Sites not aligning to the query:
Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 6 papers)
58% identity, 98% coverage: 9:355/355 of query aligns to 21:368/1265 of Q99707
Sites not aligning to the query:
4cczA Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains
54% identity, 98% coverage: 9:355/355 of query aligns to 5:328/611 of 4cczA
Sites not aligning to the query:
8g3hA Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
38% identity, 91% coverage: 5:327/355 of query aligns to 1:301/841 of 8g3hA
Sites not aligning to the query:
1q8jA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima (cd2+, hcy, methyltetrahydrofolate complex) (see paper)
28% identity, 90% coverage: 13:332/355 of query aligns to 10:292/559 of 1q8jA
Sites not aligning to the query:
3bofA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima complexed with zn2+ and homocysteine (see paper)
28% identity, 90% coverage: 13:332/355 of query aligns to 10:292/560 of 3bofA
5dmmA Crystal structure of the homocysteine methyltransferase mmum from escherichia coli, metallated form (see paper)
28% identity, 86% coverage: 18:323/355 of query aligns to 12:284/288 of 5dmmA
>WP_041786279.1 NCBI__GCF_000016185.1:WP_041786279.1
MTREQRLAKLRGIAARRILVIDGAMGTMIQRHHLDEAGYRGERFKDWPRDVKGNNDLLSL
TRPDIIRDIHAQYLAAGADIIETNTFNSTSISLADYGMEALAYELNVAGAKLAREAADAA
EAADPSRPRYVAGALGPTNRTASISPVVTDPGFRNVDFDELRGAYAEQTRGLIDGGADVL
LVETVFDTLNAKAALFAVEEVLEERGLDLPVMISGTITDRSGRTLSGQTTEAFWNSLRHV
RPFSIGLNCALGADLMRPYVQELARVADVPVSAYPNAGLPNEFGGYDETPAQMAQSLHSW
AADGLVNIVGGCCGTTPDHIRAIAEAVKDVTPRVPPVPDRAMRLSGLEPFTMAAF
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory