SitesBLAST
Comparing WP_041929725.1 NCBI__GCF_000015725.1:WP_041929725.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3gqtC Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment (1,4-dimethyl-1,2,3,4- tetrahydroquinoxalin-6-yl)methylamine (see paper)
82% identity, 99% coverage: 3:390/391 of query aligns to 1:385/385 of 3gqtC
- active site: L135 (= L137), T136 (= T138), A250 (= A249), E365 (= E370), R377 (= R382)
- binding 1-(1,4-dimethyl-1,2,3,4-tetrahydroquinoxalin-6-yl)methanamine: W166 (= W168), K210 (= K209), L213 (= L212), T218 (= T217), Y364 (= Y369)
3eonC 2.55a crystal structure of native glutaryl-coa dehydrogenase from burkholderia pseudomallei in complex with a small molecule (see paper)
82% identity, 99% coverage: 3:389/391 of query aligns to 1:382/382 of 3eonC
3gncA Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment 6421 (see paper)
81% identity, 99% coverage: 2:389/391 of query aligns to 1:380/380 of 3gncA
3d6bC 2.2 a crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei (see paper)
80% identity, 99% coverage: 3:389/391 of query aligns to 1:377/377 of 3d6bC
2r0nA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
66% identity, 99% coverage: 5:390/391 of query aligns to 2:388/390 of 2r0nA
- active site: L133 (= L137), T134 (= T138), A247 (= A249), E368 (= E370), R380 (= R382)
- binding flavin-adenine dinucleotide: F131 (= F135), L133 (= L137), T134 (= T138), G139 (= G143), S140 (= S144), W166 (= W168), I167 (= I169), T168 (= T170), Y367 (= Y369), T370 (= T372), D372 (= D374)
- binding 3-thiaglutaryl-CoA: R92 (= R96), S93 (= S97), V97 (= V101), P142 (= P146), G238 (≠ K240), F241 (= F243), L244 (= L246), N245 (= N247), P318 (≠ V320), Y367 (= Y369), E368 (= E370), I377 (= I379)
1sirA The crystal structure and mechanism of human glutaryl-coa dehydrogenase (see paper)
66% identity, 99% coverage: 5:390/391 of query aligns to 2:388/390 of 1sirA
- active site: L133 (= L137), T134 (= T138), A247 (= A249), E368 (= E370), R380 (= R382)
- binding flavin-adenine dinucleotide: F131 (= F135), L133 (= L137), T134 (= T138), G139 (= G143), S140 (= S144), W166 (= W168), I167 (= I169), T168 (= T170), Y367 (= Y369), T370 (= T372)
- binding s-4-nitrobutyryl-coa: S93 (= S97), S140 (= S144), F241 (= F243), G242 (≠ T244), L244 (= L246), N245 (= N247), R248 (= R250), P318 (≠ V320), Y367 (= Y369), E368 (= E370), R380 (= R382)
2r0mA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
65% identity, 99% coverage: 5:390/391 of query aligns to 2:388/390 of 2r0mA
- active site: L133 (= L137), T134 (= T138), A247 (= A249), D368 (≠ E370), R380 (= R382)
- binding 4-nitrobutanoic acid: L101 (= L105), Y367 (= Y369), D368 (≠ E370)
- binding flavin-adenine dinucleotide: F131 (= F135), L133 (= L137), T134 (= T138), G139 (= G143), S140 (= S144), W166 (= W168), I167 (= I169), T168 (= T170), L210 (= L212), Y367 (= Y369), T370 (= T372)
2ebaA Crystal structure of the putative glutaryl-coa dehydrogenase from thermus thermophilus
49% identity, 97% coverage: 13:390/391 of query aligns to 7:380/380 of 2ebaA
- active site: L131 (= L137), T132 (= T138), A239 (= A249), E360 (= E370), R372 (= R382)
- binding flavin-adenine dinucleotide: L131 (= L137), T132 (= T138), G136 (≠ H142), G137 (= G143), S138 (= S144), W161 (= W168), T163 (= T170), R265 (= R275), L272 (= L282), K275 (≠ N285), D333 (= D343), I334 (≠ M344), G337 (= G347), T355 (≠ V365), T358 (= T368), Y359 (= Y369), T362 (= T372)
3sf6A Crystal structure of glutaryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
47% identity, 98% coverage: 8:390/391 of query aligns to 5:386/387 of 3sf6A
- active site: L134 (= L137), T135 (= T138), A245 (= A249), E366 (= E370), Q378 (≠ R382)
- binding dihydroflavine-adenine dinucleotide: F132 (= F135), L134 (= L137), T135 (= T138), G140 (= G143), S141 (= S144), W165 (= W168), I166 (= I169), T167 (= T170), S361 (≠ V365), T364 (= T368), Y365 (= Y369), T368 (= T372), E370 (≠ D374), M371 (≠ V375)
3swoA Crystal structure of a glutaryl-coa dehydrogenase from mycobacterium smegmatis in complex with fadh2 (see paper)
45% identity, 96% coverage: 14:390/391 of query aligns to 13:387/388 of 3swoA
- active site: L135 (= L137), T136 (= T138), A246 (= A249), E367 (= E370), K379 (≠ R382)
- binding dihydroflavine-adenine dinucleotide: F133 (= F135), L135 (= L137), T136 (= T138), G141 (= G143), S142 (= S144), W166 (= W168), I167 (= I169), T168 (= T170), R272 (= R275), V274 (≠ Q277), F275 (= F278), L279 (= L282), Y282 (≠ N285), T340 (≠ D343), L341 (≠ M344), G344 (= G347), I347 (= I350), T365 (= T368), Y366 (= Y369), T369 (= T372), E371 (≠ D374), M372 (≠ V375)
2ix5A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 in complex with acetoacetyl-coa (see paper)
35% identity, 99% coverage: 5:390/391 of query aligns to 33:412/415 of 2ix5A
- active site: L158 (= L137), T159 (= T138), S271 (≠ A249), E392 (= E370), R404 (= R382)
- binding acetoacetyl-coenzyme a: S165 (= S144), A167 (≠ P146), S168 (≠ G147), F261 (≠ L239), L268 (= L246), R272 (= R250), E392 (= E370), G393 (= G371), R404 (= R382)
- binding flavin-adenine dinucleotide: L158 (= L137), T159 (= T138), G164 (= G143), S165 (= S144), W189 (= W168), N239 (≠ T217), R297 (= R275), F300 (= F278), L304 (= L282), F307 (≠ N285), L309 (= L287), N310 (≠ I288), E365 (≠ D343), L366 (≠ M344), G368 (= G346), G369 (= G347), Y391 (= Y369), T394 (= T372), D396 (= D374), I397 (≠ V375)
Q96329 Acyl-coenzyme A oxidase 4, peroxisomal; AOX 4; G6p; Short-chain acyl-CoA oxidase; AtCX4; AtG6; SAOX; EC 1.3.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
35% identity, 99% coverage: 5:390/391 of query aligns to 49:428/436 of Q96329