SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_042118350.1 NCBI__GCF_000092045.1:WP_042118350.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
35% identity, 32% coverage: 267:395/400 of query aligns to 86:214/215 of 4ymtC

query
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4ymtC

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binding arginine: N98 (≠ Y279), Y102 (≠ F283), E152 (≠ Q333), M156 (≠ L337), K158 (= K339), E159 (≠ N340), E159 (≠ N340)

Sites not aligning to the query:

binding arginine: 66, 67

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
35% identity, 32% coverage: 267:395/400 of query aligns to 86:214/214 of 4ymwC

query
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4ymwC

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binding histidine: N98 (≠ Y279), Y102 (≠ F283), E152 (≠ Q333), E159 (≠ N340)

Query Sequence

>WP_042118350.1 NCBI__GCF_000092045.1:WP_042118350.1
MTHQALDSTRLSRSGWSFQSALYDPTVRGIFFQVLTIVLLVVFVWWVAHNTAVNLARANI
ASGFGFLNGRAGFEVGQSLIAYSSDSTYGRALVVGLLNTILIAVTGIITATIIGFIVGIG
RLSRNWLIAKLCTVYVEVFRNIPPLLVIFFWYSGVLAVLPNARESLHLPLGTYLNNRGLS
FPKPIFGETFWLVGVAFVVAIIAVIATARWAHRRQAATGQPFHTIWASIGLLVGLPLITF
LLAGAPLSFDYPIAGKFNLTGGSVVGPEFMSLFLALSFYTAAFIAEIVRAGIRGVPKGQT
EAAGALGLHPSSITRLVVIPQALRIIIPPLSSQYLNLTKNSSLAIAIGFADLVAVGSTTL
NQTGQAVEVILIWMVIYLGLSVVTSLLMNWFNAKMALVER

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory