Comparing WP_042118777.1 NCBI__GCF_000092045.1:WP_042118777.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 5 papers)
63% identity, 97% coverage: 22:1244/1257 of query aligns to 8:1224/1227 of P13009
Sites not aligning to the query:
Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 6 papers)
56% identity, 99% coverage: 2:1244/1257 of query aligns to 5:1262/1265 of Q99707
3ivaA Structure of the b12-dependent methionine synthase (meth) c-teminal half with adohcy bound (see paper)
61% identity, 46% coverage: 666:1244/1257 of query aligns to 4:574/576 of 3ivaA
3bulA E. Coli i690c/g743c meth c-terminal fragment (649-1227) (see paper)
61% identity, 46% coverage: 666:1244/1257 of query aligns to 4:574/577 of 3bulA
4cczA Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains
56% identity, 50% coverage: 16:649/1257 of query aligns to 4:611/611 of 4cczA
8g3hA Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
35% identity, 69% coverage: 24:888/1257 of query aligns to 7:832/841 of 8g3hA
3k13C Structure of the pterin-binding domain metr of 5- methyltetrahydrofolate-homocysteine methyltransferase from bacteroides thetaiotaomicron
66% identity, 23% coverage: 366:652/1257 of query aligns to 1:286/287 of 3k13C
6bdyA Crystal structure of the meth reactivation domain bound to sinefungin (see paper)
57% identity, 26% coverage: 924:1244/1257 of query aligns to 6:324/326 of 6bdyA
1mskA Methionine synthase (activation domain) (see paper)
57% identity, 26% coverage: 924:1244/1257 of query aligns to 6:324/327 of 1mskA
1bmtA How a protein binds b12: a 3.O angstrom x-ray structure of the b12- binding domains of methionine synthase (see paper)
70% identity, 20% coverage: 666:914/1257 of query aligns to 4:246/246 of 1bmtA
8sseA Methionine synthase, c-terminal fragment, cobalamin and reactivation domains from thermus thermophilus hb8 (see paper)
31% identity, 43% coverage: 673:1212/1257 of query aligns to 4:506/507 of 8sseA
1q8jA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima (cd2+, hcy, methyltetrahydrofolate complex) (see paper)
29% identity, 47% coverage: 24:611/1257 of query aligns to 9:538/559 of 1q8jA
3bofA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima complexed with zn2+ and homocysteine (see paper)
29% identity, 47% coverage: 24:611/1257 of query aligns to 9:538/560 of 3bofA
5vooA Methionine synthase folate-binding domain with methyltetrahydrofolate from thermus thermophilus hb8 (see paper)
36% identity, 22% coverage: 372:645/1257 of query aligns to 5:273/282 of 5vooA
7xcnP Crystal structure of the mttb-mttc complex at 2.7 a resolution (see paper)
31% identity, 16% coverage: 685:890/1257 of query aligns to 20:215/215 of 7xcnP
2i2xB Crystal structure of methanol:cobalamin methyltransferase complex mtabc from methanosarcina barkeri (see paper)
33% identity, 14% coverage: 676:856/1257 of query aligns to 52:216/258 of 2i2xB
Sites not aligning to the query:
Q46EH4 Methanol--corrinoid protein; Methanol:corrinoid methyltransferase 1 subunit of 27 kDa; MT1 subunit 27 kDa from Methanosarcina barkeri (strain Fusaro / DSM 804) (see paper)
33% identity, 14% coverage: 676:856/1257 of query aligns to 52:216/258 of Q46EH4
Sites not aligning to the query:
3ezxA Structure of methanosarcina barkeri monomethylamine corrinoid protein
33% identity, 14% coverage: 674:855/1257 of query aligns to 8:185/212 of 3ezxA
Sites not aligning to the query:
4jgiB 1.5 angstrom crystal structure of a novel cobalamin-binding protein from desulfitobacterium hafniense dcb-2 (see paper)
30% identity, 13% coverage: 683:851/1257 of query aligns to 19:174/206 of 4jgiB
Sites not aligning to the query:
5dmmA Crystal structure of the homocysteine methyltransferase mmum from escherichia coli, metallated form (see paper)
26% identity, 24% coverage: 30:334/1257 of query aligns to 12:284/288 of 5dmmA
>WP_042118777.1 NCBI__GCF_000092045.1:WP_042118777.1
MFDNLFGPETGKRDGNEVFAALRKAASERILVLDGAMGTQIQGLGYDEDQFRGTRFIGCA
CHQKGNNDLLILTQPDAIEEIHYRYAKAGADILETNTFSSTRIAQADYQMEGAVYDLNKE
GAEIVRRAALRAEREDGRRRFVAGAIGPTNRTASISPDVNNPGFRAVTFDDLRSAYGEQI
DGLIDGGADIILIETIFDTLNAKAAIFACEERFEAKGVRLPVMISGTITDLSGRTLSGQT
PSAFWNSVRHANPFTIGLNCALGANAMRPHLQELSGVADTFICAYPNAGLPNEFGQYDET
PELMAAQIDSFAREGLVNIVGGCCGSTPEHIRAIAETVAKYKPRPIPEHRPFMSLSGLEP
FELTKDIPFVNVGERTNVTGSAKFRKLITNADYTAALDVARDQVENGAQVIDINMDEGLI
DSEKAMVEFLNLIAAEPDIARVPVMIDSSKFSIIESGLKRVQGKPIVNSISLKEGEENFL
AQARLLRNYGAAVVVMAFDETGQADNYDRKVEICTRAYKLLTEKIGFPPEDIIFDPNIFA
VATGIEEHNNYGVDFIEAARTIRERMPLVHISGGVSNLSFSFRGNEPVREAMHAVFLYHA
IQAGMDMGIVNAGQLAVYDNIDPELREACEDVVLNRRADGTERLLEVAERFRGAGAKEGR
VQDLSWREWSVEKRLEHALVNGITEYIEADTEEARRQAARPLHVIEGPLMAGMNVVGDLF
GSGKMFLPQVVKSARVMKQAVAVLLPYMEEEKRLNGGDDRQSAGKILMATVKGDVHDIGK
NIVGVVLACNNYEIVDLGVMVPATKILETAIAEKVDVIGLSGLITPSLDEMVHVASEMER
QGFEIPLLIGGATTSRVHTAVKIHPGYNKGQAVYVTDASRAVGVVSALLSPETRQGYVDD
IRAEYAKVAAAHARSEAEKVRLPLARARENAHKIDWSAYKPTKPEFFGTRVFEDYDLAEL
AKYIDWTPFFQTWELRGRFPAILEDEKQGEAARALWADAQAMLKKIIDEKWFRPRAVIGF
WPAGAVGDDIRLFTDESRSQELATFYTLRQQLSKRDGRANVALSDFVAPVTSGVQDYVGG
FVVTAGIEEIAIAERFERSNDDYSSILVKALADRFAEAFAERMHEQVRREYWGYASDEHL
SNEDLIGEAYAGIRPAPGYPAQPDHTEKKTLFKLLDAEKAAGVKLTESYAMWPGSSVSGL
YIGHPDSYYFGVAKVERDQVEDYAKRKGMDVSEVERWLGPVLNYVPRKADEEIDDAA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory