Comparing WP_042445810.1 NCBI__GCF_000010725.1:WP_042445810.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q88JU3 3-dehydroshikimate dehydratase; DSD; EC 4.2.1.118 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
55% identity, 98% coverage: 8:630/637 of query aligns to 1:629/635 of Q88JU3
5hmqD Xylose isomerase-like tim barrel/4-hydroxyphenylpyruvate dioxygenase fusion protein
54% identity, 97% coverage: 8:627/637 of query aligns to 3:623/624 of 5hmqD
1cjxA Crystal structure of pseudomonas fluorescens hppd (see paper)
31% identity, 51% coverage: 284:606/637 of query aligns to 4:325/352 of 1cjxA
Sites not aligning to the query:
7xntA Crystal structure of pfhppd-y13161 complex
31% identity, 51% coverage: 284:606/637 of query aligns to 7:321/341 of 7xntA
Sites not aligning to the query:
7x8eA Crystal structure of pfhppd-y13287 complex
32% identity, 51% coverage: 284:606/637 of query aligns to 6:317/341 of 7x8eA
Sites not aligning to the query:
7xntC Crystal structure of pfhppd-y13161 complex
31% identity, 51% coverage: 284:606/637 of query aligns to 6:305/320 of 7xntC
Sites not aligning to the query:
O52791 4-hydroxymandelate synthase; HMS; HmaS; 4-hydroxyphenylpyruvate dioxygenase II; EC 1.13.11.46 from Amycolatopsis orientalis (Nocardia orientalis) (see paper)
28% identity, 47% coverage: 317:615/637 of query aligns to 32:334/357 of O52791
2r5vA Hydroxymandelate synthase crystal structure (see paper)
28% identity, 47% coverage: 317:615/637 of query aligns to 31:332/346 of 2r5vA
Sites not aligning to the query:
1t47A Structure of fe2-hppd bound to ntbc (see paper)
30% identity, 27% coverage: 433:606/637 of query aligns to 160:340/362 of 1t47A
Sites not aligning to the query:
3zgjB S221m v223f y359a mutant of 4-hydroxymandelate synthase from streptomyces coelicolor (see paper)
29% identity, 50% coverage: 308:628/637 of query aligns to 23:341/343 of 3zgjB
5ec3A Structural insight into the catalyitc mechanism of human 4- hydroxyphenylpyruvate dioxygenase
26% identity, 45% coverage: 329:615/637 of query aligns to 55:355/376 of 5ec3A
8im3A Crystal structure of human hppd complexed with compound a10 (see paper)
26% identity, 45% coverage: 329:615/637 of query aligns to 57:357/371 of 8im3A
Sites not aligning to the query:
8im2A Crystal structure of human hppd complexed with ntbc (see paper)
26% identity, 45% coverage: 329:615/637 of query aligns to 57:357/374 of 8im2A
Sites not aligning to the query:
P32755 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein; EC 1.13.11.27 from Rattus norvegicus (Rat) (see 2 papers)
23% identity, 45% coverage: 329:615/637 of query aligns to 63:363/393 of P32755
Sites not aligning to the query:
Q02110 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Sus scrofa (Pig) (see paper)
24% identity, 43% coverage: 342:615/637 of query aligns to 79:363/393 of Q02110
Sites not aligning to the query:
7yvvA Acmp1, r-4-hydroxymandelate synthase
31% identity, 30% coverage: 425:615/637 of query aligns to 138:322/335 of 7yvvA
1sqiA Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
24% identity, 45% coverage: 329:615/637 of query aligns to 56:340/343 of 1sqiA
Sites not aligning to the query:
1sqiB Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
24% identity, 45% coverage: 329:615/637 of query aligns to 57:339/342 of 1sqiB
Sites not aligning to the query:
1i6nA 1.8 a crystal structure of ioli protein with a binding zinc atom (see paper)
24% identity, 40% coverage: 13:267/637 of query aligns to 8:263/278 of 1i6nA
5ywkA Crystal structure of arabidopsis thaliana hppd complexed with benquitrione-methyl (see paper)
30% identity, 18% coverage: 495:610/637 of query aligns to 226:350/372 of 5ywkA
Sites not aligning to the query:
>WP_042445810.1 NCBI__GCF_000010725.1:WP_042445810.1
MPSSAFTFKKSIATVSLSGTLPEKLEAAAAIGFDGVEIFENDLLTFDGSPADVRRIAESL
GLEITIFQPFRDFEAMPDPIRVRNLDRAERKFDVMQELGTDLVLVCSNVQPAAIDDPARA
AADLAEMAERARRRGLRIGYEALAWGRHVNRWRQAWDIVQRADHPALGLIVDSFHTLALD
DDPSGIAELPGERIFFVQLADAPKLSMDVLSWSRHFRNFPGQGQLPVQGFVDAVLASGYR
GPLSLEIFNDEFRAAPARLTALDGLRSLIHAEAEAGFGPGLPAPPVCQGVEFLEFAVDAA
ARDRLSALLASLGFHHAGRHRSKDVDLYRQGGVNLVLNSEEDSAASEHFQMHGPSVCAMA
FTVDDAARTIARAEALRCVLWRERVGDGERRIPALRAPDGTLIYLVDDKEARRSIWEDDF
HLFPAEEPATSGEPPLLGIDHVAQALPFGRMDSFVLFYRAVFGFVPESLWELPDPYGLIR
SRALVSPDAEPGRGVRLPLNISESRRTATGRFVSATAGAGVHHIAFAASDAAALVGERLA
AGAPFLPIPANYYDDLAVKHPLDDAALEALKQRELLYDRDDQGDFLHAYTDSFADRFFFE
MVERRGGYRQFGAVNAAVRMAVQAQLREGARPEFLLD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory