SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_043526888.1 NCBI__GCF_000759345.1:WP_043526888.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6gwiB The crystal structure of halomonas elongata amino-transferase (see paper)
80% identity, 98% coverage: 1:450/459 of query aligns to 1:450/450 of 6gwiB

query
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6gwiB

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active site: F18 (= F18), Y149 (= Y149), D255 (= D255), K284 (= K284)
binding pyridoxal-5'-phosphate: S115 (= S115), G116 (= G116), S117 (= S117), Y149 (= Y149), H150 (= H150), G151 (= G151), E222 (= E222), D255 (= D255), V257 (= V257), I258 (= I258), K284 (= K284)

7qx0B Transaminase structure of plurienzyme (tr2e2) in complex with plp (see paper)
64% identity, 97% coverage: 2:445/459 of query aligns to 1:438/443 of 7qx0B

query
sites
7qx0B

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binding pyridoxal-5'-phosphate: S114 (= S115), G115 (= G116), S116 (= S117), Y148 (= Y149), H149 (= H150), E221 (= E222), D254 (= D255), V256 (= V257), I257 (= I258), K283 (= K284)

7qx3A Structure of the transaminase tr2e2 with eos (see paper)
65% identity, 91% coverage: 29:445/459 of query aligns to 1:417/422 of 7qx3A

query
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7qx3A

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S

S

F

V

D

K

K

N

G

G

L

L

V

V

M

M

R

R

S

A

V

V

G

G

D

G

T

T

M

M

I

I

I

I

S

S

P

P

P

P

L

L

V

V

I

L

R

S

H

R

D

E

Q

Q

V

V

D

D

E

E

L

L

V

I

A

D

L

K

A

A

W

R

Q

R

A

T

L

L

D

D

A

E

T

T

binding 2-azanylethyl hydrogen sulfate: Y121 (= Y149), A199 (= A227), K256 (= K284)

8wqjA Crystal structure of transaminase from shimia marina
56% identity, 99% coverage: 1:456/459 of query aligns to 7:458/472 of 8wqjA

query
sites
8wqjA

M

L

A

P

T

T

A

A

D

E

L

L

K

Q

A

A

L

L

D

D

S

V

A

A

H

H

H

H

L

M

H

H

P

P

F

F

T

S

D

T

Y

Q

K

N

A

D

L

F

G

N

E

D

E

T

G

G

S

A

R

R

I

V

V

I

T

T

H

Q

A

A

Q

K

G

G

I

V

Y

T

I

L

H

T

D

D

S

S

E

E

G

G

N

A

R

Q

I

I

L

L

D

D

G

A

M

M

A

A

G

G

L

L

W

W

C

C

V

V

N

N

L

I

G

G

Y

Y

G

G

R

R

A

E

E

E

L

L

V

A

E

D

A

V

A

A

S

A

A

R

Q

Q

M

M

S

R

Q

E

L

L

P

P

Y

Y

Y

Y

N

N

N

T

F

F

F

F

K

K

S

T

T

T

H

H

P

V

P

P

A

V

V

I

K

A

L

L

A

S

K

A

M

K

L

L

C

A

G

E

L

L

A

A

P

P

G

G

H

D

M

L

N

N

R

H

V

V

F

F

F

Y

T

A

G

G

S
|
S

G
|
G

S
|
S

E

E

A

A

N

N

D

D

T

T

V

N

L

M

R

R

M

L

V

V

R

R

R

H

Y

Y

W

W

E

S

L

A

K

K

G

G

Q

K

P

P

D

S

K

K

R

T

W

I

V

F

I

I

A

S

R

R

D

K

N

N

A

A

Y
|
Y

H
|
H

G
|
G

S

S

T

T

V

M

A

A

G

G

V

A

S

S

L

L

G

G

G

G

M

M

S

V

P

P

M

M

R

H

N

Q

Q

Q

G

G

G

S

P

L

L

P

V

I

P

P

D

D

I

V

A

H

H

H

I

I

R

N

Q

Q

P

P

Y

N

W

W

F

W

G

A

E

E

G

G

R

G

D

D

M

M

T

S

P

P

E

E

A

E

F

F

G

G

R

L

V

Q

C

R

A

A

A

Q

D

E

L

L

E

E

R

E

K

A

I

I

L

L

E

E

L

L

G

G

V

E

E

D

N

R

V

V

A

A

A

A

F

F

I

I

A

A

E
|
E

P

P

V

I

Q

Q

G

G

A

A

G

G

G

G

A

V

I

I

I

V

P

P

P

P

E

E

S

T

Y

Y

W

W

P

P

A

E

I

I

K

Q

A

R

I

I

L

C

D

D

K

K

Y

Y

D

E

I

I

L

L

L

L

V

I

I

A

D
|
D

E

E

V
|
V

I
|
I

C

C

G

G

F

F

G

G

R

R

L

T

G

G

E

N

W

W

F

F

G

G

S

S

Q

Q

H

T

Y

V

S

G

L

I

E

K

P

P

D

H

L

I

M

M

P

S

V

I

A

A

K
|
K

G

G

L

L

S

S

S

S

G

G

Y

Y

L

A

P

P

I

I

G

G

G

G

V

S

L

I

V

V

G

C

D

D

R

E

V

V

A

A

D

E

T

V

L

V

I

-

E

-

E

A

G

A

G

T

E

E

F

F

F

N

H

H

G

G

F
x
Y

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

V

C

A

A

C

T

A

V

V

A

A

L

L

R

E

N

N

L

L

Q

R

I

I

L

I

R

E

D

E

E

E

A

N

V

I

I

I

D

G

R

H

V

V

R

R

D

D

D

D

I

V

G

A

P

P

Y

Y

L

L

A

K

K

E

R

K

W

W

A

E

E

A

L

L

G

A

E

D

H

H

P

P

L

L

V

V

G

G

E

E

A

A

R

K

S

I

L

V

G

G

L

M

I

M

G

G

A

S

L

I

E

A

L

L

V

T

A

P

D

N

K

K

Q

E

S

T

G

R

Q

A

R

P

F

F

-

A

P

A

Q

D

A

T

F

G

A

T

V

V

G

G

N

Y

L

K

C

C

R

R

D

E

I

H

S

C

F

F

D

G

K

N

G

N

L

L

V

V

M

M

R

R

S

H

V

V

G

G

D

D

T

R

M

M

I

I

I

I

S

S

P

P

P

P

L

L

V

V

I

M

R

T

H

R

D

D

Q

E

V

V

D

D

E

T

L

L

V

I

A

E

L

R

A

A

W

T

Q

R

A

A

L

L

D

D

A

L

T

T

A

-

A

-

R

-

L

F

A

E

Q

Q

I

I

K

K

D

A

K

E

E

D

binding pyridoxal-5'-phosphate: S121 (= S115), G122 (= G116), S123 (= S117), Y155 (= Y149), H156 (= H150), G157 (= G151), E228 (= E222), D261 (= D255), V263 (= V257), I264 (= I258), K290 (= K284), Y321 (≠ F317), T322 (= T318)

7q9xAAA Probable aminotransferase
56% identity, 96% coverage: 2:443/459 of query aligns to 2:443/455 of 7q9xAAA

query
sites
7q9xAAA

A

T

T

T

A

S

D

Q

L

W

K

R

A

E

L

L

D

D

S

A

A

A

H

H

H

H

L

L

H

H

P

P

F

F

T

T

D

D

Y

T

K

A

A

S

L

L

G

N

E

Q

E

A

G

G

S

A

R

R

I

V

V

M

T

T

H

R

A

G

Q

E

G

G

I

V

Y

Y

I

L

H

W

D

D

S

S

E

E

G

G

N

N

R

K

I

I

L

I

D

D

G

G

M

M

A

A

G

G

L
|
L

W
|
W

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

A

K

E

D

L

F

V

A

E

E

A

A

A

A

S

R

A

R

Q

Q

M

M

S

E

Q

E

L

L

P

P

Y

F

Y

Y

N

N

N

T

F

F

F

F

K

K

S

T

T

T

H

H

P

P

P

A

A

V

V

V

K

E

L

L

A

S

K

S

M

L

L

L

C

A

G

E

L

V

A

T

P

P

G

A

H

G

M

F

N

D

R

R

V

V

F

F

F

Y

T

T

G

N

S
|
S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

V

M

L

I

R

R

M

M

V

V

R

R

R

R

Y

Y

W

W

E

D

L

V

K

Q

G

G

Q

K

P

P

D

E

K

K

R

K

W

T

V

L

I

I

A

G

R

R

D

W

N

N

A

G

Y
|
Y

H

H

G
|
G

S

S

T

T

V

I

A

G

G

G

V

A

S

S

L

L

G

G

G

G

M

M

S

K

P

Y

M

M

R

H

N

E

Q

Q

G

G

G

D

P

L

L

P

V

I

P

P

D

G

I

M

A

A

H

H

I

I

R

E

Q

Q

P

P

Y

W

W

W

F

Y

G

K

E

H

G

G

R

K

D

D

M

M

T

T

P

P

E

D

A

E

F

F

G

G

R

V

V

V

C

A

A

A

A

R

D

W

L

L

E

E

R

E

K

K

I

I

L

L

E

E

L

I

G

G

V

A

E

D

N

K

V

V

A

A

A

A

F

F

I

V

A

G

E
|
E

P

P

V

I

Q

Q

G

G

A

A

G

G

G

G

A

V

I

I

I

V

P

P

P

P

E

A

S

T

Y

Y

W

W

P

P

A

E

I

I

K

E

A

R

I

I

L

C

D

R

K

K

Y

Y

D

D

I

V

L

L

L

L

V

V

I

A

D
|
D

E

E

V
|
V

I
|
I

C

C

G

G

F

F

G

G

R

R

L

T

G

G

E

E

W

W

F

F

G

G

S

H

Q

Q

H

H

Y

F

S

G

L

F

E

Q

P

P

D

D

L

L

M

F

P

T

V

A

A

A

K
|
K

G

G

L

L

S

S

S

S

G

G

Y

Y

L

L

P

P

I

I

G

G

G

A

V

V

L

F

V

V

G

G

D

K

R

R

V

V

A

A

D

E

T

G

L

L

I

I

E

-

E

A

G

G

G

G

E

D

F

F

F

N

H

H

G

G

F
|
F

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

V

C

C

A

A

T

A

V

V

A

A

L

H

R

A

N

N

L

V

Q

A

I

A

L

L

R

R

D

D

E

E

A

G

V

I

I

V

D

Q

R

R

V

V

R

K

D

D

D

D

I

I

G

G

P

P

Y

Y

L

M

A

Q

K

K

R

R

W

W

A

R

E

E

-

T

L

F

G

S

E

R

H

F

P

E

L

H

V

V

G

D

E

D

A

V

R

R

S

G

L

V

G

G

L

M

I

V

G

Q

A

A

L

F

E

T

L

L

V

V

A

K

D

N

K

K

Q

A

S

K

G

R

Q

E

R

L

F

F

P

P

Q

D

A

F

F

G

A

E

V

I

G

G

N

T

L

L

C

C

R

R

D

D

I

I

S

F

F

F

D

R

K

N

G

N

L

L

V

I

M

M

R
|
R

S

A

V

C

G

G

D

D

T

H

M

I

I

V

I

S

S

A

P

P

P

P

L

L

V

V

I

M

R

T

H

R

D

A

Q

E

V

V

D

D

E

E

L

M

V

L

A

A

L

V

A

A

W

E

Q

R

A

C

L

L

D

E

binding (3E)-4-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}-2-oxobut-3-enoic acid: L55 (= L55), W56 (= W56), S115 (= S115), G116 (= G116), S117 (= S117), Y149 (= Y149), G151 (= G151), E222 (= E222), D255 (= D255), V257 (= V257), I258 (= I258), K284 (= K284), F316 (= F317), T317 (= T318), R412 (= R412)
binding pyridoxal-5'-phosphate: F316 (= F317), T317 (= T318)

4a6tC Crystal structure of the omega transaminase from chromobacterium violaceum in complex with plp (see paper)
56% identity, 96% coverage: 2:443/459 of query aligns to 2:443/455 of 4a6tC

query
sites
4a6tC

A

T

T

T

A

S

D

Q

L

W

K

R

A

E

L

L

D

D

S

A

A

A

H

H

H

H

L

L

H

H

P

P

F
|
F

T

T

D

D

Y

T

K

A

A

S

L

L

G

N

E

Q

E

A

G

G

S

A

R

R

I

V

V

M

T

T

H

R

A

G

Q

E

G

G

I

V

Y

Y

I

L

H

W

D

D

S

S

E

E

G

G

N

N

R

K

I

I

L

I

D

D

G

G

M

M

A

A

G

G

L

L

W

W

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

A

K

E

D

L

F

V

A

E

E

A

A

A

A

S

R

A

R

Q

Q

M

M

S

E

Q

E

L

L

P

P

Y

F

Y

Y

N

N

N

T

F

F

F

F

K

K

S

T

T

T

H

H

P

P

P

A

A

V

V

V

K

E

L

L

A

S

K

S

M

L

L

L

C

A

G

E

L

V

A

T

P

P

G

A

H

G

M

F

N

D

R

R

V

V

F

F

F

Y

T

T

G

N

S

S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

V

M

L

I

R

R

M

M

V

V

R

R

R

R

Y

Y

W

W

E

D

L

V

K

Q

G

G

Q

K

P

P

D

E

K

K

R

K

W

T

V

L

I

I

A

G

R

R

D

W

N

N

A

G

Y
|
Y

H
|
H

G
|
G

S

S

T

T

V

I

A

G

G

G

V

A

S

S

L

L

G

G

G

G

M

M

S

K

P

Y

M

M

R

H

N

E

Q

Q

G

G

G

D

P

L

L

P

V

I

P

P

D

G

I

M

A

A

H

H

I

I

R

E

Q

Q

P

P

Y

W

W

W

F

Y

G

K

E

H

G

G

R

K

D

D

M

M

T

T

P

P

E

D

A

E

F

F

G

G

R

V

V

V

C

A

A

A

A

R

D

W

L

L

E

E

R

E

K

K

I

I

L

L

E

E

L

I

G

G

V

A

E

D

N

K

V

V

A

A

A

A

F

F

I

V

A

G

E
|
E

P

P

V

I

Q

Q

G

G

A

A

G

G

G

G

A

V

I

I

I

V

P

P

P

P

E

A

S

T

Y

Y

W

W

P

P

A

E

I

I

K

E

A

R

I

I

L

C

D

R

K

K

Y

Y

D

D

I

V

L

L

L

L

V

V

I

A

D
|
D

E

E

V
|
V

I
|
I

C

C

G

G

F

F

G

G

R

R

L

T

G

G

E

E

W

W

F

F

G

G

S

H

Q

Q

H

H

Y

F

S

G

L

F

E

Q

P

P

D

D

L

L

M

F

P

T

V

A

A

A

K
|
K

G

G

L

L

S

S

S

S

G

G

Y

Y

L

L

P

P

I

I

G

G

G

A

V

V

L

F

V

V

G

G

D

K

R

R

V

V

A

A

D

E

T

G

L

L

I

I

E

-

E

A

G

G

G

G

E

D

F

F

F

N

H

H

G

G

F

F

T

T

Y

Y

S

S

G

G

H

H

P

P

V

V

C

C

A

A

T

A

V

V

A

A

L

H

R

A

N

N

L

V

Q

A

I

A

L

L

R

R

D

D

E

E

A

G

V

I

I

V

D

Q

R

R

V

V

R

K

D

D

D

D

I

I

G

G

P

P

Y

Y

L

M

A

Q

K

K

R

R

W

W

A

R

E

E

-

T

L

F

G

S

E

R

H

F

P

E

L

H

V

V

G

D

E

D

A

V

R

R

S

G

L

V

G

G

L

M

I

V

G

Q

A

A

L

F

E

T

L

L

V

V

A

K

D

N

K

K

Q

A

S

K

G

R

Q

E

R

L

F

F

P

P

Q

D

A

F

F

G

A

E

V

I

G

G

N

T

L

L

C

C

R

R

D

D

I

I

S

F

F

F

D

R

K

N

G

N

L

L

V

I

M

M

R

R

S

A

V

C

G

G

D

D

T

H

M

I

I
x
V

I

S

S

A

P

P

P

P

L

L

V

V

I

M

R

T

H

R

D

A

Q

E

V

V

D

D

E

E

L

M

V

L

A

A

L

V

A

A

W

E

Q

R

A

C

L

L

D

E

active site: F18 (= F18), Y149 (= Y149), E222 (= E222), D255 (= D255), I258 (= I258), K284 (= K284), V419 (≠ I419)
binding pyridoxal-5'-phosphate: G116 (= G116), S117 (= S117), Y149 (= Y149), H150 (= H150), G151 (= G151), E222 (= E222), D255 (= D255), V257 (= V257), I258 (= I258), K284 (= K284)

6s4gA Crystal structure of the omega transaminase from chromobacterium violaceum in complex with pmp (see paper)
56% identity, 96% coverage: 2:443/459 of query aligns to 1:442/453 of 6s4gA

query
sites
6s4gA

A

T

T

T

A

S

D

Q

L

W

K

R

A

E

L

L

D

D

S

A

A

A

H

H

H

H

L

L

H

H

P

P

F
|
F

T

T

D

D

Y

T

K

A

A

S

L

L

G

N

E

Q

E

A

G

G

S

A

R

R

I

V

V

M

T

T

H

R

A

G

Q

E

G

G

I

V

Y

Y

I

L

H

W

D

D

S

S

E

E

G

G

N

N

R

K

I

I

L

I

D

D

G

G

M

M

A

A

G

G

L

L

W

W

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

A

K

E

D

L

F

V

A

E

E

A

A

A

A

S

R

A

R

Q

Q

M

M

S

E

Q

E

L

L

P

P

Y

F

Y

Y

N

N

N

T

F

F

F

F

K

K

S

T

T

T

H

H

P

P

P

A

A

V

V

V

K

E

L

L

A

S

K

S

M

L

L

L

C

A

G

E

L

V

A

T

P

P

G

A

H

G

M

F

N

D

R

R

V

V

F

F

F

Y

T

T

G

N

S
|
S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

V

M

L

I

R

R

M

M

V

V

R

R

R

R

Y

Y

W

W

E

D

L

V

K

Q

G

G

Q

K

P

P

D

E

K

K

R

K

W

T

V

L

I

I

A

G

R

R

D

W

N

N

A

G

Y
|
Y

H
|
H

G
|
G

S

S

T

T

V

I

A

G

G

G

V

A

S

S

L

L

G

G

G

G

M

M

S

K

P

Y

M

M

R

H

N

E

Q

Q

G

G

G

D

P

L

L

P

V

I

P

P

D

G

I

M

A

A

H

H

I

I

R

E

Q

Q

P

P

Y

W

W

W

F

Y

G

K

E

H

G

G

R

K

D

D

M

M

T

T

P

P

E

D

A

E

F

F

G

G

R

V

V

V

C

A

A

A

A

R

D

W

L

L

E

E

R

E

K

K

I

I

L

L

E

E

L

I

G

G

V

A

E

D

N

K

V

V

A

A

A

A

F

F

I

V

A

G

E
|
E

P

P

V

I

Q

Q

G

G

A

A

G

G

G

G

A

V

I

I

I

V

P

P

P

P

E

A

S

T

Y

Y

W

W

P

P

A

E

I

I

K

E

A

R

I

I

L

C

D

R

K

K

Y

Y

D

D

I

V

L

L

L

L

V

V

I

A

D
|
D

E

E

V
|
V

I
|
I

C

C

G

G

F

F

G

G

R

R

L

T

G

G

E

E

W

W

F

F

G

G

S

H

Q

Q

H

H

Y

F

S

G

L

F

E

Q

P

P

D

D

L

L

M

F

P

T

V

A

A

A

K
|
K

G

G

L

L

S

S

S

S

G

G

Y

Y

L

L

P

P

I

I

G

G

G

A

V

V

L

F

V

V

G

G

D

K

R

R

V

V

A

A

D

E

T

G

L

L

I

I

E

-

E

A

G

G

G

G

E

D

F

F

F

N

H

H

G

G

F
|
F

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

V

C

C

A

A

T

A

V

V

A

A

L

H

R

A

N

N

L

V

Q

A

I

A

L

L

R

R

D

D

E

E

A

G

V

I

I

V

D

Q

R

R

V

V

R

K

D

D

D

D

I

I

G

G

P

P

Y

Y

L

M

A

Q

K

K

R

R

W

W

A

R

E

E

-

T

L

F

G

S

E

R

H

F

P

E

L

H

V

V

G

D

E

D

A

V

R

R

S

G

L

V

G

G

L

M

I

V

G

Q

A

A

L

F

E

T

L

L

V

V

A

K

D

N

K

K

Q

A

S

K

G

R

Q

E

R

L

F

F

P

P

Q

D

A

F

F

G

A

E

V

I

G

G

N

T

L

L

C

C

R

R

D

D

I

I

S

F

F

F

D

R

K

N

G

N

L

L

V

I

M

M

R

R

S

A

V

C

G

G

D

D

T

H

M

I

I

V

I

S

S

A

P

P

P

P

L

L

V

V

I

M

R

T

H

R

D

A

Q

E

V

V

D

D

E

E

L

M

V

L

A

A

L

V

A

A

W

E

Q

R

A

C

L

L

D

E

active site: F17 (= F18), Y148 (= Y149), D254 (= D255), K283 (= K284)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: S114 (= S115), G115 (= G116), S116 (= S117), Y148 (= Y149), H149 (= H150), G150 (= G151), E221 (= E222), D254 (= D255), V256 (= V257), I257 (= I258), K283 (= K284), F315 (= F317), T316 (= T318)

7ypmA Crystal structure of transaminase cc1012 complexed with plp and l- alanine (see paper)
56% identity, 96% coverage: 4:443/459 of query aligns to 4:445/454 of 7ypmA

query
sites
7ypmA

A

A

D

E

L

L

K

K

A

R

L

L

D

D

S

L

A

A

H

H

H

H

L

L

H

P

P

A

F

Q

T

A

D

D

Y

H

K

K

A

V

L

I

G

A

E

E

E

Q

G

G

-

G

S

S

R

R

I

I

V

I

T

T

H

R

A

A

Q

E

G

G

I

V

Y

Y

I

I

H

H

D

D

S

G

E

E

G

G

N

H

R

Q

I

I

L

L

D

D

G

G

M

M

A

A

G

G

L

L

W
|
W

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

A

E

E

E

L

L

V

A

E

K

A

A

A

A

S

Y

A

D

Q

Q

M

M

S

L

Q

E

L

L

P

P

Y

Y

Y

Y

N

N

N

T

F

F

F

F

K

K

S

T

T

A

H

T

P

P

P

P

A

P

V

I

K

E

L

L

A

A

K

A

M

K

L

I

C

A

G

Q

L

K

A

M

P

G

G

G

H

H

M

L

N

S

R

H

V

V

F

F

F

Y

T

N

G

S

S
|
S

G
|
G

S
|
S

E

E

A

A

N

N

D

D

T

T

V

V

L

F

R

R

M

L

V

V

R

R

R

H

Y

F

W

W

E

K

L

L

K

K

G

G

Q

E

P

P

D

S

K

R

R

T

W

V

V

F

I

I

A

S

R

R

D

W

N

N

A

A

Y
|
Y

H

H

G
|
G

S

S

T

T

V

V

A

A

G

G

V

V

S

S

L

L

G

G

G

G

M

M

S

K

P

H

M

M

R

H

N

K

Q

Q

G

G

G

D

P

L

L

P

V

I

P

A

D

G

I

V

A

E

H

H

I

V

R

M

Q

Q

P

P

Y

Y

W

Q

F

F

G

G

E

D

G

G

R

F

D

G

M

E

T

D

P

P

E

A

A

A

F

F

G

R

R

D

V

R

C

A

A

V

A

Q

D

A

L

I

E

E

R

D

K

K

I

I

L

L

E

E

L

V

G

G

V

P

E

E

N

N

V

V

A

A

A

A

F

F

I

I

A

G

E
|
E

P

P

V

V

Q

Q

G

G

A

A

G

G

G

G

A

V

I

I

I

I

P

P

P

P

E

D

S

G

Y

Y

W

W

P

P

A

A

I

V

K

E

A

A

I

L

L

C

D

R

K

K

Y

Y

D

G

I

I

L

L

L

L

V

V

I

C

D
|
D

E

E

V
|
V

I
|
I

C

C

G

G

F

F

G

G

R

R

L

L

G

G

E

Q

W

W

F

F

G

G

S

H

Q

Q

H

H

Y

Y

S

G

L

I

E

K

P

P

D

D

L

L

M

I

P

A

V

M

A

A

K
|
K

G

G

L

L

S

S

S

S

G

G

Y

Y

L

L

P

P

I

I

G

S

G

A

V

V

L

G

V

V

G

A

D

D

R

H

V

I

A

V

D

A

T

E

L

L

I

R

E

E

E

K

G

G

G

G

E

D

F

F

F

I

H

H

G

G

F

F

T

T

Y

Y

S

S

G

G

H

H

P

P

V

T

C

A

A

A

T

A

V

V

A

A

L

L

R

K

N

N

L

I

Q

E

I

I

L

M

R

E

D

R

E

E

A

G

V

L

I

V

D

E

R

R

V

T

R

R

D

D

D

E

I

T

G

G

P

P

Y

Y

L

L

A

A

K

Q

R

A

W

L

A

A

E

S

L

L

G

N

E

D

H

H

P

P

L

L

V

V

G

G

E

E

A

V

R

R

S

S

L

L

G

G

L

L

I

I

G

G

A

A

L

V

E

E

L

I

V

V

A

R

D

E

K

K

Q

G

S

T

G

N

Q

H

R

R

F

F

-

L

P

D

Q

K

A

E

F

G

A

E

V

A

G

G

N

P

L

I

C

V

R

R

D

D

I

L

S

C

F

I

D

K

K

N

G

G

L

L

V

M

M

V

R

R

S

A

V

I

G

R

D

D

T

S

M

I

I

V

I

C

S

C

P

P

P

P

L

L

V

I

I

I

R

T

H

K

D

A

Q

Q

V

I

D

D

E

E

L

L

V

V

A

G

L

I

A

I

W

R

Q

K

A

S

L

L

D

D

binding alanine: W57 (= W56), Y150 (= Y149)
binding pyridoxal-5'-phosphate: S116 (= S115), G117 (= G116), S118 (= S117), Y150 (= Y149), G152 (= G151), E223 (= E222), D256 (= D255), V258 (= V257), I259 (= I258), K285 (= K284)

7ypnD Crystal structure of transaminase cc1012 mutant m9 complexed with plp (see paper)
55% identity, 98% coverage: 4:453/459 of query aligns to 4:455/455 of 7ypnD

query
sites
7ypnD

A

A

D

E

L

L

K

K

A

R

L

L

D

D

S

L

A

A

H

H

H

H

L

L

H

P

P

A

F

F

T

A

D

D

Y

H

K

K

A

V

L

I

G

A

E

E

E

Q

G

G

-

G

S

S

R

R

I

I

V

I

T

T

H

R

A

A

Q

E

G

G

I

V

Y

Y

I

I

H

H

D

D

S

G

E

E

G

G

N

H

R

Q

I

I

L

L

D

D

G

G

M

W

A

A

G

G

L

L

W

F

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

A

E

E

E

L

L

V

A

E

K

A

A

A

A

S

Y

A

D

Q

Q

M

M

S

L

Q

E

L

L

P

P

Y

Y

Y

Y

N

N

N

T

F

F

F

F

K

K

S

T

T

A

H

T

P

P

P

P

A

P

V

I

K

E

L

L

A

A

K

A

M

K

L

I

C

A

G

Q

L

K

A

M

P

G

G

G

H

H

M

L

N

S

R

H

V

V

F

F

F

Y

T

N

G

S

S
|
S

G
|
G

S
|
S

E

E

A

A

N

N

D

D

T

T

V

V

L

F

R

R

M

L

V

V

R

R

R

H

Y

F

W

W

E

K

L

L

K

K

G

G

Q

E

P

P

D

S

K

R

R

T

W

V

V

F

I

I

A

S

R

R

D

W

N

N

A

A

Y
|
Y

H
|
H

G
|
G

S

S

T

T

V

V

A

A

G

G

V

V

S

S

L

L

G

G

G

G

M

M

S

K

P

H

M

M

R

H

N

K

Q

Q

G

G

G

D

P

L

L

P

V

I

P

A

D

G

I

V

A

E

H

H

I

V

R

M

Q

Q

P

P

Y

Y

W

Q

F

F

G

G

E

D

G

G

R

F

D

G

M

E

T

D

P

P

E

A

A

A

F

F

G

R

R

D

V

R

C

A

A

V

A

Q

D

A

L

I

E

E

R

D

K

K

I

I

L

L

E

E

L

V

G

G

V

P

E

E

N

N

V

V

A

A

A

A

F

F

I

I

A

G

E
|
E

P

P

V

V

Q

Q

G

G

A

A

G

G

G

G

A

V

I

I

I

I

P

P

P

P

E

D

S

G

Y

Y

W

W

P

P

A

A

I

V

K

E

A

A

I

L

L

C

D

R

K

K

Y

Y

D

G

I

I

L

L

L

L

V

V

I

C

D
|
D

E

E

V
|
V

I

A

C

C

G

G

F

F

G

G

R

R

L

L

G

G

E

Q

W

W

F

F

G

G

S

H

Q

Q

H

H

Y

Y

S

G

L

I

E

K

P

P

D

D

L

L

M

I

P

A

V

M

A

A

K
|
K

G

G

L

L

S

S

S

S

G

G

Y

Y

L

L

P

P

I

I

G

S

G

A

V

V

L

G

V

V

G

A

D

D

R

H

V

I

A

V

D

A

T

E

L

L

I

R

E

E

E

K

G

G

G

G

E

D

F

F

F

I

H

H

G

G

F
|
F

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

T

C

A

A

A

T

A

V

V

A

A

L

L

R

K

N

N

L

I

Q

E

I

I

L

M

R

E

D

R

E

E

A

G

V

L

I

V

D

E

R

R

V

T

R

R

D

D

D

E

I

T

G

G

P

P

Y

Y

L

L

A

A

K

Q

R

A

W

L

A

A

E

S

L

L

G

N

E

D

H

H

P

P

L

L

V

V

G

G

E

E

A

V

R

R

S

S

L

L

G

G

L

L

I

I

G

G

A

A

L

V

E

E

L

I

V

V

A

R

D

E

K

K

Q

G

S

T

G

N

Q

H

R

R

F

F

-

L

P

D

Q

K

A

E

F

G

A

E

V

A

G

G

N

P

L

I

C

V

R

R

D

D

I

L

S

C

F

I

D

K

K

N

G

G

L

L

V

M

M

V

R

R

S

A

V

I

G

R

D

D

T

S

M

I

I

V

I

C

S

C

P

P

P

P

L

L

V

I

I

I

R

T

H

K

D

A

Q

Q

V

I

D

D

E

E

L

L

V

V

A

G

L

I

A

I

W

R

Q

K

A

S

L

L

D

D

A

E

T

A

A

E

A

P

R

V

L

L

A

R

Q

A

I

L

K

K

binding pyridoxal-5'-phosphate: S116 (= S115), G117 (= G116), S118 (= S117), Y150 (= Y149), H151 (= H150), G152 (= G151), E223 (= E222), D256 (= D255), V258 (= V257), K285 (= K284), F318 (= F317), T319 (= T318)

5ti8B Crystal structure of an aspartate aminotransferase from pseudomonas (see paper)
59% identity, 91% coverage: 30:447/459 of query aligns to 1:381/384 of 5ti8B

query
sites
5ti8B

R

R

I

I

V

I

T

T

H

K

A

A

Q

E

G

G

I

V

Y

Y

I

L

H

W

D

D

S

S

E

E

G

G

N

N

R

K

I

I

L

L

D

D

G

G

M

M

A

A

G

G

L

L

W

W

C

C

V

M

N

N

L

V

G

G

Y

Y

G

G

R

R

A

K

E

E

L

L

V

A

E

E

A

V

A

A

S

Y

A

K

Q

Q

M

M

S

L

Q

E

L

L

P

P

Y

Y

Y

Y

N

N

N

L

F

F

F

F

K

Q

S

T

T

A

H

H

P

P

P

P

A

A

V

L

K

E

L

L

A

A

K

K

M

A

L

I

C
x
A

G

D

L

I

A

A

P

P

G

E

H

G

M

M

N
|
N

R

H

V

V

F

F

F

F

T

T

G

G

S

S

G

G

S

S

E

E

A

S

N

N

D

D

T

T

V

V

L

L

R

R

M

M

V

V

R

R

R

H

Y

Y

W

W

E

S

L

I

K

K

G

G

Q

K

P

P

D

Q

K

K

R

K

W

V

V

V

I

I

A

G

R

R

D

W

N

N

A

-

Y

-

H

-

G

-

S

-

T

-

V

-

A

-

G

-

V

-

S

-

L

-

G

-

G

-

M

-

S

-

P

-

M

-

R

-

N

-

Q

-

G

-

G

-

P

-

L

-

V

-

P

P

D

G

I

I

A

V

H

H

I

I

R

A

Q

Q

P

P

Y

Y

W

W

F

Y

G

G

E

E

G

G

R

G

D

D

M

M

T

S

P

A

E

E

A

E

F

F

G

G

R

V

V

W

C

A

A

A

A

E

D

Q

L

L

E

E

R

K

K

K

I

I

L

L

E

E

L

V

G

G

V

E

E

E

N

N

V

V

A

A

A

A

F

F

I

I

A

A

E
|
E

P

P

V

I

Q

Q

G

G

A

A

G

G

G

G

A

V

I

I

I

V

P

P

P

P

E

D

S

T

Y

Y

W

W

P

P

A

K

I

I

K

R

A

E

I

I

L

L

D

A

K

K

Y

Y

D

E

I

I

L

L

L

F

V

I

I

A

D
|
D

E

E

V

V

I
|
I

C

C

G

G

F

F

G

G

R

R

L

T

G

G

E

E

W

W

F

F

G

G

S

S

Q

Q

H

Y

Y

Y

S

G

L

N

E

A

P

P

D

D

L

L

M

M

P

P

V

I

A

A

K
|
K

G

G

L

L

S

T

S

S

G

G

Y

Y

L

I

P

P

I

M

G

G

G

G

V

V

L

I

V

V

G

R

D

D

R

E

V

I

A

V

D

D

T

T

L

L

I

N

E

E

E

-

G

-

G

-

E

-

F

-

F

-

H

-

G

-

F

-

T
|
T

Y

Y

S

S

G

G

H

H

P

P

V

V

C

A

A

A

T

A

V

V

A

A

L

L

R

E

N

N

L

I

Q

R

I

I

L

L

R

R

D

E

E

E

A

K

V

I

I

V

D

E

R

T

V

V

R

K

D

A

D

E

I

T

G

A

P

P

Y

Y

L

L

A

Q

K

K

R

R

W

W

A

Q

E

E

L

L

G

A

E

D

H

H

P

P

L

L

V

V

G

G

E

E

A

A

R

R

S

G

L

V

G

G

L

M

I

V

G

G

A

A

L

L

E

E

L

L

V

V

A

K

D

N

K

K

Q

K

S

T

G

R

Q

E

R

R

F

F

P

E

Q

N

A

-

F

-

A

G

V

V

G

G

N

M

L

L

C

C

R

R

D

E

I

H

S

C

F

F

D

R

K

N

G

G

L

L

V

I

M

M

R

R

S

A

V

V

G

G

D

D

T

T

M

M

I
|
I

I

I

S

S

P

P

P

P

L

L

V

V

I

I

R

T

H

K

D

P

Q

E

V

I

D

D

E

E

L

L

V

I

A

T

L

L

A

A

W

R

Q

K

A

C

L

L

D

D

A

Q

T

T

A

A

A

A

active site: E167 (= E222), D200 (= D255), I203 (= I258), K229 (= K284), T254 (= T318), I353 (= I419)
binding calcium ion: A71 (≠ C100), N79 (= N108)

4ba5A Crystal structure of omega-transaminase from chromobacterium violaceum (see paper)
56% identity, 90% coverage: 29:443/459 of query aligns to 1:415/427 of 4ba5A

query
sites
4ba5A

S

A

R

R

I

V

V

M

T

T

H

R

A

G

Q

E

G

G

I

V

Y

Y

I

L

H

W

D

D

S

S

E

E

G

G

N

N

R

K

I

I

L

I

D

D

G

G

M

M

A

A

G

G

L
|
L

W
|
W

C

C

V

V

N

N

L

V

G

G

Y

Y

G

G

R

R

A

K

E

D

L

F

V

A

E

E

A

A

A

A

S

R

A

R

Q

Q

M

M

S

E

Q

E

L

L

P

P

Y

F

Y

Y

N

N

N

T

F

F

F

F

K

K

S

T

T

T

H

H

P

P

P

A

A

V

V

V

K

E

L

L

A

S

K

S

M

L

L

L

C

A

G

E

L

V

A

T

P

P

G

A

H

G

M

F

N

D

R

R

V

V

F

F

F

Y

T

T

G

N

S

S

G
|
G

S
|
S

E

E

A

S

N

V

D

D

T

T

V

M

L

I

R

R

M

M

V

V

R

R

R

R

Y

Y

W

W

E

D

L

V

K

Q

G

G

Q

K

P

P

D

E

K

K

R

K

W

T

V

L

I

I

A

G

R

R

D

W

N

N

A

G

Y
|
Y

H
|
H

G
|
G

S

S

T

T

V

I

A

G

G

G

V

A

S

S

L