SitesBLAST

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
34% identity, 92% coverage: 1:235/256 of query aligns to 1:223/285 of 4yerA

query
sites
4yerA

M

M

G

E

D

D

D

I

L

I

I

V

V

V

E

E

T

-

R

-

S

N

L

L

T

V

K

K

E

K

F
|
F

K

G

G

D

F
|
F

V

E

A

A

V

V

S

K

D

G

V

V

N

S

L

F

K

S

V

V

R

K

H

G

T

E

I

I

H

F

A

A

L

F

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

I

N

H

L

M

V

L

T

T

K

T

F

L

L

L

T

K

P

P

T

T

R

S

G

G

Q

K

I

A

L

W

F

V

N

A

G

G

N

H

D

D

I

V

T

L

H

-

T

K

Q

E

P

P

A

R

A

E

I

V

A

R

R

R

Q

K

-

I

G

G

M

I

V

V

R

-

S

-

F

F

Q

Q

I

D

S

Q

A

S

V

L

F

D

G

R

H

E

L

L

T

T

V

A

L

Y

E

E

N

N

V

M

R

Y

V

I

A

-

L

-

Q

-

R

-

K

-

Q

H

G

G

K

K

S

I

F

Y

Q

G

F

Y

W

-

R

-

S

G

G

G

E

E

C

-

L

-

N

-

E

K

L

L

N

K

A

K

R

R

A

I

E

L

E

E

L

L

I

L

E

E

A

F

V

V

G

E

V

L

A

L

E

E

Y

F

R

K

D

D

T

K

P

P

A

V

G

K

E
x
T

L
x
F

S
|
S

Y

G

G

G

R

M

K

A

R

R

A

R

L

L

E

E

I

I

A

A

T

R

T

S

L

L

A

I

L

H

D

E

P

P

E

E

M

V

L

L

L

F

L

L

D

D

E

E

P

P

M

T

A

I

G

G

M

L

G

D

T

P

E

H

D

T

V

R

R

A

R

H

T

M

A

W

E

E

L

Y

I

I

R

S

R

K

V

M

A

K

-

E

-

H

N

N

R

M

T

T

I

I

L

F

M

L

V

T

E

T

H

H

N

Y

L

M

S

D

V

E

V

A

A

E

D

Q

L

L

S

A

D

D

T

R

I

V

T

A

V

I

L

I

K

D

L

H

G

G

R

K

V

I

L

I

A

A

E

L

G

G

S

T

Y

P

A

T

E

E

I

L

binding adenosine-5'-diphosphate: F14 (= F16), F17 (= F19), N39 (= N41), G40 (= G42), G42 (= G44), K43 (= K45), T44 (= T46), T45 (= T47), T135 (≠ E149), F136 (≠ L150), S137 (= S151)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
32% identity, 93% coverage: 10:247/256 of query aligns to 6:235/235 of 6mhzA

query
sites
6mhzA

R

K

S

N

L

L

T

A

K

K

E

A

F
x
Y

K

K

G

G

F

R

V

R

A

V

V

V

S

E

D

D

V

V

N

S

L

L

K

T

V

V

R

N

R

S

H

G

T

E

I

I

H

V

A

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

N

Y

L

M

V

V

T

V

K

G

F

I

L

V

T

P

P

R

T

D

R

A

G

G

Q

N

I

I

L

I

F

I

N

D

G

D

N

D

D

D

I

I

T

S

H

L

T

L

Q

P

P

L

A

H

A

A

I

R

A

A

R

R

Q

R

G

G

M

I

V

G

R

Y

S

L

F

P

Q
|
Q

I

E

S

A

A

S

V

I

F

F

G

R

H

R

L

L

T

S

V

V

L

Y

E

D

N

N

V

L

R

M

V

A

A

V

L

L

Q

Q

R

I

K

R

Q

D

G

D

K

L

S

S

F

A

Q

E

F

-

W

-

R

-

S

-

G

-

E

-

C

-

L

-

N

-

E

Q

L

R

N

E

A

D

R

R

A

A

E

N

E

E

L

L

I

M

E

E

A

E

V

F

G

H

V

I

A

E

E

H

Y

L

R

R

D

D

T

S

P

M

A

G

G

Q

E
x
S

L

L

S
|
S

Y
x
G

G
|
G

R

E

K

R

R

R

A

R

L

V

E

E

I

I

A

A

T

R

T

A

L

L

A

A

L

A

D

N

P

P

E

K

M

F

L

I

L

L

D

D

E
|
E

P

P

M

F

A

A

G
|
G

-

V

-

D

-

P

M

I

G

S

T

V

E

I

D

D

V

I

R

K

R

R

T

I

A

I

E

E

L

H

I

L

R

R

R

-

V

-

A

D

A

S

N

G

R

L

T

G

I

V

L

L

M

I

V

T

E

D

H
|
H

N

N

L

V

S

R

V

E

V

T

A

L

D

A

L

V

S

C

D

E

T

R

I

A

T

Y

V

I

L

V

K

S

L

Q

G

G

R

H

V

L

L

I

A

A

E

H

G

G

S

T

Y

P

A

T

E

E

I

I

T

L

D

Q

N

D

P

E

E

H

V

V

V

K

E

R

A

V

Y

Y

M

L

G

G

binding adp orthovanadate: Y12 (≠ F16), N37 (= N41), G38 (= G42), G40 (= G44), K41 (= K45), T42 (= T46), T43 (= T47), Q84 (= Q88), S136 (≠ E149), S138 (= S151), G139 (≠ Y152), G140 (= G153), E162 (= E175), G166 (= G179), H194 (= H206)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
32% identity, 93% coverage: 10:247/256 of query aligns to 6:235/238 of 6s8nB

query
sites
6s8nB

R

K

S

N

L

L

T

A

K

K

E

A

F

Y

K

K

G

G

F

R

V

R

A

V

V

V

S

E

D

D

V

V

N

S

L

L

K

T

V

V

R

N

R

S

H

G

T

E

I

I

H

V

A

G

L

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

C

T

F

F

N

Y

L

M

V

V

T

V

K

G

F

I

L

V

T

P

P

R

T

D

R

A

G

G

Q

N

I

I

L

I

F

I

N

D

G

D

N

D

D

D

I

I

T

S

H

L

T

L

Q

P

P

L

A

H

A

A

I

R

A

A

R

R

Q

R

G

G

M

I

V

G

R

Y

S

L

F

P

Q

Q

I

E

S

A

A

S

V

I

F

F

G
x
R

H

R

L

L

T

S

V

V

L

Y

E

D

N

N

V

L

R

M

V

A

A

V

L

L

Q

Q

R

I

K

R

Q

D

G

D

K

L

S

S

F

A

Q

E

F

-

W

-

R

-

S

-

G

-

E

-

C

-

L

-

N

-

E

Q

L

R

N

E

A

D

R

R

A

A

E

N

E

E

L

L

I

M

E

E

A

E

V

F

G

H

V

I

A

E

E

H

Y

L

R

R

D

D

T

S

P
x
M

A
x
G

G
x
Q

E

S

L

L

S

S

Y

G

G

G

R

E

K

R

R

R

A

R

L

V

E

E

I

I

A

A

T

R

T

A

L

L

A

A

L

A

D

N

P

P

E

K

M

F

L

I

L

L

D

D

E

E

P

P

M

F

A

A

G

G

-

V

-

D

-

P

M

I

G

S

T

V

E

I

D

D

V

I

R

K

R

R

T

I

A

I

E

E

L

H

I

L

R

R

R

-

V

-

A

D

A

S

N

G

R

L

T

G

I

V

L

L

M

I

V

T

E

D

H

H

N

N

L

V

S

R

V

E

V

T

A

L

D

A

L

V

S

C

D

E

T

R

I

A

T

Y

V

I

L

V

K

S

L

Q

G

G

R

H

V

L

L

I

A

A

E

H

G

G

S

T

Y

P

A

T

E

E

I

I

T

L

D

Q

N

D

P

E

E

H

V

V

V

K

E

R

A

V

Y

Y

M

L

G

G

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ G94), M133 (≠ P146), G134 (≠ A147), Q135 (≠ G148)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
32% identity, 93% coverage: 10:247/256 of query aligns to 6:235/238 of 6s8gA

query
sites
6s8gA

R

K

S

N

L

L

T

A

K

K

E

A

F
x
Y

K

K

G

G

F
x
R

V

R

A

V

V

V

S

E

D

D

V

V

N

S

L

L

K

T

V

V

R

N

R

S

H

G

T

E

I

I

H

V

A

G

L

L

I

L

G

G

P

P

N
|
N

G

G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

N

Y

L

M

V

V

T

V

K

G

F

I

L

V

T

P

P

R

T

D

R

A

G

G

Q

N

I

I

L

I

F

I

N

D

G

D

N

D

D

D

I

I

T

S

H

L

T

L

Q

P

P

L

A

H

A

A

I

R

A

A

R

R

Q

R

G

G

M

I

V

G

R

Y

S

L

F

P

Q
|
Q

I

E

S

A

A

S

V

I

F

F

G

R

H

R

L

L

T

S

V

V

L

Y

E

D

N

N

V

L

R

M

V

A

A

V

L

L

Q

Q

R

I

K

R

Q

D

G

D

K

L

S

S

F

A

Q

E

F

-

W

-

R

-

S

-

G

-

E

-

C

-

L

-

N

-

E

Q

L

R

N

E

A

D

R

R

A

A

E

N

E

E

L

L

I

M

E

E

A

E

V

F

G

H

V

I

A

E

E

H

Y

L

R

R

D

D

T

S

P

M

A

G

G

Q

E
x
S

L

L

S
|
S

Y

G

G

G

R
x
E

K

R

R

R

A

R

L

V

E

E

I

I

A

A

T

R

T

A

L

L

A

A

L

A

D

N

P

P

E

K

M

F

L

I

L

L

D

D

E

E

P

P

M

F

A

A

G

G

-

V

-

D

-

P

M

I

G

S

T

V

E

I

D

D

V

I

R

K

R

R

T

I

A

I

E

E

L

H

I

L

R

R

R

-

V

-

A

D

A

S

N

G

R

L

T

G

I

V

L

L

M

I

V

T

E

D

H

H

N

N

L

V

S

R

V

E

V

T

A

L

D

A

L

V

S

C

D

E

T

R

I

A

T

Y

V

I

L

V

K

S

L

Q

G

G

R

H

V

L

L

I

A

A

E

H

G

G

S

T

Y

P

A

T

E

E

I

I

T

L

D

Q

N

D

P

E

E

H

V

V

V

K

E

R

A

V

Y

Y

M

L

G

G

binding phosphoaminophosphonic acid-adenylate ester: Y12 (≠ F16), R15 (≠ F19), N37 (= N41), G40 (= G44), K41 (= K45), T42 (= T46), T43 (= T47), Q84 (= Q88), S136 (≠ E149), S138 (= S151), E141 (≠ R154)

6mbnA Lptb e163q in complex with atp (see paper)
32% identity, 93% coverage: 10:247/256 of query aligns to 7:236/241 of 6mbnA

query
sites
6mbnA

R

K

S

N

L

L

T

A

K

K

E

A

F
x
Y

K

K

G

G

F
x
R

V

R

A
x
V

V

V

S

E

D

D

V

V

N

S

L

L

K

T

V

V

R

N

R

S

H

G

T

E

I

I

H

V

A

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

N

Y

L

M

V

V

T

V

K

G

F

I

L

V

T

P

P

R

T

D

R

A

G

G

Q

N

I

I

L

I

F

I

N

D

G

D

N

D

D

D

I

I

T

S

H

L

T

L

Q

P

P

L

A

H

A

A

I

R

A

A

R

R

Q

R

G

G

M

I

V

G

R

Y

S

L

F

P

Q

Q

I

E

S

A

A

S

V

I

F

F

G

R

H

R

L

L

T

S

V

V

L

Y

E

D

N

N

V

L

R

M

V

A

A

V

L

L

Q

Q

R

I

K

R

Q

D

G

D

K

L

S

S

F

A

Q

E

F

-

W

-

R

-

S

-

G

-

E

-

C

-

L

-

N

-

E

Q

L

R

N

E

A

D

R

R

A

A

E

N

E

E

L

L

I

M

E

E

A

E

V

F

G

H

V

I

A

E

E

H

Y

L

R

R

D

D

T

S

P

M

A

G

G

Q

E

S

L

L

S

S

Y

G

G

G

R

E

K

R

R

R

A

R

L

V

E

E

I

I

A

A

T

R

T

A

L

L

A

A

L

A

D

N

P

P

E

K

M

F

L

I

L

L

D

D

E

Q

P

P

M

F

A

A

G

G

-

V

-

D

-

P

M

I

G

S

T

V

E

I

D

D

V

I

R

K

R

R

T

I

A

I

E

E

L

H

I

L

R

R

R

-

V

-

A

D

A

S

N

G

R

L

T

G

I

V

L

L

M

I

V

T

E

D

H
|
H

N

N

L

V

S

R

V

E

V

T

A

L

D

A

L

V

S

C

D

E

T

R

I

A

T

Y

V

I

L

V

K

S

L

Q

G

G

R

H

V

L

L

I

A

A

E

H

G

G

S

T

Y

P

A

T

E

E

I

I

T

L

D

Q

N

D

P

E

E

H

V

V

V

K

E

R

A

V

Y

Y

M

L

G

G

binding adenosine-5'-triphosphate: Y13 (≠ F16), R16 (≠ F19), V18 (≠ A21), N38 (= N41), G39 (= G42), G41 (= G44), K42 (= K45), T43 (= T46), T44 (= T47), H195 (= H206)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
32% identity, 93% coverage: 10:246/256 of query aligns to 6:234/234 of 6b89A

query
sites
6b89A

R

K

S

N

L

L

T

A

K

K

E

A

F
x
Y

K

K

G

G

F
x
R

V

R

A
x
V

V

V

S

E

D

D

V

V

N

S

L

L

K

T

V

V

R

N

R

S

H

G

T

E

I

I

H

V

A

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

N

Y

L

M

V

V

T

V

K

G

F

I

L

V

T

P

P

R

T

D

R

A

G

G

Q

N

I

I

L

I

F

I

N

D

G

D

N

D

D

D

I

I

T

S

H

L

T

L

Q

P

P
x
L

A
x
H

A

A

I

R

A

A

R

R

Q

R

G

G

M

I

V

G

R

Y

S

L

F
x
P

Q
|
Q

I

E

S
x
A

A
x
S

V

I

F
|
F

G
x
R

H
x
R

L
|
L

T

S

V

V

L

Y

E

D

N

N

V

L

R

M

V

A

A
x
V

L

L

Q

Q

R

I

K

R

Q

D

G

D

K

L

S

S

F

A

Q

E

F

-

W

-

R

-

S

-

G

-

E

-

C

-

L

-

N

-

E

Q

L

R

N

E

A

D

R

R

A

A

E

N

E

E

L

L

I

M

E

E

A

E

V

F

G

H

V

I

A

E

E

H

Y

L

R

R

D

D

T

S

P

M

A

G

G
x
Q

E

S

L

L

S

S

Y

G

G

G

R

E

K

R

R

R

A

R

L

V

E

E

I

I

A

A

T
x
R

T

A

L

L

A

A

L

A

D

N

P

P

E

K

M

F

L

I

L

L

D

D

E

E

P

P

M

F

A

A

G

G

-

V

-

D

-

P

M

I

G

S

T

V

E

I

D

D

V

I

R

K

R

R

T

I

A

I

E

E

L

H

I

L

R

R

R

-

V

-

A

D

A

S

N

G

R

L

T

G

I

V

L

L

M

I

V

T

E

D

H

H

N

N

L

V

S

R

V

E

V

T

A

L

D

A

L

V

S

C

D

E

T

R

I

A

T

Y

V

I

L

V

K

S

L

Q

G

G

R

H

V

L

L

I

A

A

E

H

G

G

S

T

Y

P

A

T

E

E

I

I

T

L

D

Q

N

D

P

E

E

H

V

V

V

K

E

R

A

V

Y

Y

M

L

binding adenosine-5'-diphosphate: Y12 (≠ F16), R15 (≠ F19), V17 (≠ A21), N37 (= N41), G38 (= G42), G40 (= G44), K41 (= K45), T42 (= T46), T43 (= T47)
binding magnesium ion: T42 (= T46), Q84 (= Q88)
binding novobiocin: L71 (≠ P75), H72 (≠ A76), P83 (≠ F87), A86 (≠ S90), S87 (≠ A91), F89 (= F93), R90 (≠ G94), R91 (≠ H95), L92 (= L96), V101 (≠ A105), Q135 (≠ G148), R149 (≠ T162)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
32% identity, 93% coverage: 10:246/256 of query aligns to 6:234/234 of 4p31A

query
sites
4p31A

R

K

S

N

L

L

T

A

K

K

E

A

F
x
Y

K

K

G

G

F
x
R

V

R

A
x
V

V

V

S

E

D

D

V

V

N

S

L

L

K

T

V

V

R

N

R

S

H

G

T

E

I

I

H

V

A

G

L

L

I

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

N

Y

L

M

V

V

T

V

K

G

F

I

L

V

T

P

P

R

T

D

R

A

G

G

Q

N

I

I

L

I

F

I

N

D

G

D

N

D

D

D

I

I

T

S

H

L

T

L

Q

P

P

L

A

H

A

A

I

R

A

A

R

R

Q

R

G

G

M

I

V

G

R

Y

S

L

F

P

Q
|
Q

I

E

S

A

A

S

V

I

F

F

G

R

H

R

L

L

T

S

V

V

L

Y

E

D

N

N

V

L

R

M

V

A

A

V

L

L

Q

Q

R

I

K

R

Q

D

G

D

K

L

S

S

F

A

Q

E

F

-

W

-

R

-

S

-

G

-

E

-

C

-

L

-

N

-

E

Q

L

R

N

E

A

D

R

R

A

A

E

N

E

E

L

L

I

M

E

E

A

E

V

F

G

H

V

I

A

E

E

H

Y

L

R

R

D

D

T

S

P

M

A

G

G

Q

E

S

L

L

S

S

Y

G

G

G

R

E

K

R

R

R

A

R

L

V

E

E

I

I

A

A

T

R

T

A

L

L

A

A

L

A

D

N

P

P

E

K

M

F

L

I

L

L

D

D

E

E

P

P

M

F

A

A

G

G

-

V

-

D

-

P

M

I

G

S

T

V

E

I

D

D

V

I

R

K

R

R

T

I

A

I

E

E

L

H

I

L

R

R

R

-

V

-

A

D

A

S

N

G

R

L

T

G

I

V

L

L

M

I

V

T

E

D

H

H

N

N

L

V

S

R

V

E

V

T

A

L

D

A

L

V

S

C

D

E

T

R

I

A

T

Y

V

I

L

V

K

S

L

Q

G

G

R

H

V

L

L

I

A

A

E

H

G

G

S

T

Y

P

A

T

E

E

I

I

T

L

D

Q

N

D

P

E

E

H

V

V

V

K

E

R

A

V

Y

Y

M

L

binding adenosine-5'-diphosphate: Y12 (≠ F16), R15 (≠ F19), V17 (≠ A21), G38 (= G42), G40 (= G44), K41 (= K45), T42 (= T46), T43 (= T47)
binding magnesium ion: T42 (= T46), Q84 (= Q88)

P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 43 papers)
31% identity, 88% coverage: 7:231/256 of query aligns to 929:1143/2273 of P78363

query
sites
P78363

V
|
V

E
x
C

T
x
V

R
x
K

S
x
N

L
|
L

T
x
V

K
|
K

E
x
I

F
|
F

K
x
E

-
x
P

-
x
C

G
|
G

F
x
R

V
x
P

A
|
A

V
|
V

S
x
D

D
x
R

V
x
L

N
|
N

L
x
I

K
x
T

V
x
F

R
x
Y

R
x
E

H
x
N

T
x
Q

I
|
I

H
x
T

A
|
A

L
x
F

I
x
L

G
|
G

P
x
H

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

C
x
T

F
x
L

N
x
S

L
x
I

V
x
L

T
|
T

K
x
G

F
x
L

L
|
L

T
x
P

P
|
P

T
|
T

R
x
S

G
|
G

Q
x
T

I
x
V

L
|
L

F
x
V

N
x
G

G
|
G

N
x
R

D
|
D

I
|
I

T
x
E

H
x
T

T
x
S

Q
x
L

P
x
D

A
|
A

A
x
V

I

-

A

-

R
|
R

Q
|
Q

G
x
S

M
x
L

V
x
G

R
x
M

S
x
C

F
x
P

Q
|
Q

I
x
H

S
x
N

A
x
I

V
x
L

F
|
F

G
x
H

H
|
H

L
|
L

T
|
T

V
|
V

L
x
A

E
|
E

N
x
H

V
x
M

R
x
L

V
x
F

A
x
Y

L
x
A

Q
|
Q

R
x
L

K
|
K

Q

-

G

-

K

-

S

-

F

-

Q

-

F

-

W

-

R

-

S

-

G
|
G

E
x
K

C
x
S

L
x
Q

N
x
E

E
|
E

L
x
A

N
x
Q

A
x
L

R
x
E

A
x
M

E
|
E

E
x
A

L
x
M

I
x
L

E
|
E

A
x
D

V
x
T

G
|
G

V
x
L

A
x
H

E
x
H

Y
x
K

R
|
R

D
x
N

T
x
E

P
x
E

A
|
A

G
x
Q

E
x
D

L
|
L

S
|
S

Y
x
G

G
|
G

R
x
M

K
x
Q

R
|
R

A
x
K

L
|
L

E
x
S

I
x
V

A
|
A

T
x
I

T
x
A

L
x
F

A
x
V

L
x
G

D
|
D

P
x
A

E
x
K

M
x
V

L
x
V

L
x
I

L
|
L

D
|
D

E
|
E

P
|
P

M
x
T

A
x
S

G
|
G

M
x
V

G
x
D

T
x
P

E
x
Y

D
x
S

V
x
R

R
|
R

R
x
S

T
x
I

A
x
W

E
x
D

L
|
L

I
x
L

R
x
L

R
x
K

V
x
Y

A
x
R

A
x
S

N
x
G

R
|
R

T
|
T

I
|
I

L
x
I

M
|
M

V
x
S

E
x
T

H
|
H

N
x
H

L
x
M

S
x
D

V
x
E

V
x
A

A
x
D

D
x
L

L
|
L

S
x
G

D
|
D

T
x
R

I
|
I

T
x
A

V
x
I

L
x
I

K
x
A

L
x
Q

G
|
G

R
|
R

V
x
L

L
x
Y

A
x
C

E
x
S

G
|
G

S
x
T

P940 (vs. gap) mutation to R: Decreases 11-cis-Retinal binding affinity by 50%.
R943 (≠ F19) to Q: risk factor for STGD1; risk factor for ARMD2; decreases 11-cis-Retinal binding affinity by 100-fold; dbSNP:rs1801581; to W: in STGD1 and FFM; dbSNP:rs61749446
Y954 (≠ R30) to D: in STGD1; uncertain significance; dbSNP:rs61749447
T959 (≠ H35) to I: in STGD1; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs61752409
963:970 (vs. 39:46, 88% identical) binding
N965 (= N41) to S: in STGD1; reduced retinal-stimulated ATP hydrolysis; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; decreases about 60% the N-retinylidene-phosphatidylethanolamine transfer activity; stimulates modestly the retinal-stimulated ATPase activity; does not affect ATP-independent N-retinylidene-phosphatidylethanolamine binding; does not affect ATP-dependent release of N-retinylidene-phosphatidylethanolamine; significantly reduces phosphatidylethanolamine flippase activity; dbSNP:rs201471607; to Y: in STGD1; uncertain significance
G966 (= G42) mutation to D: Abolishes basal and retinal-stimulated ATP hydrolysis.
K969 (= K45) mutation to M: Abolishes basal and retinal-stimulated ATP hydrolysis.; mutation to M: Inhibits ATPase activity; when associated with M-1978. Decreases translocase activity; when associated with M-1978. Does not affect protein subcellular localization in endoplasmic reticulum; when associated with M-1978. Loss of ATP-dependent all-trans-retinal transport; when associated with M-1978. Loss in N-retinylidene-PE transfer activity. Inhibits ATPase activity with increasing retinal concentration. Does not affect N-retinylidene-PE binding. Impairs ATP-dependent release of N-retinylidene-PE. Significantly reduces PE flippase activity.
T970 (= T46) to P: in STGD1; uncertain significance; dbSNP:rs1570377849
T971 (= T47) to N: in STGD1; highly reduced ATP-binding capacity; abolishes retinal-stimulated ATP hydrolysis; dbSNP:rs61749450
T972 (≠ C48) to N: in STGD1; uncertain significance; dbSNP:rs61749451
L973 (≠ F49) to S: in STGD1; uncertain significance
T977 (= T53) to P: in STGD1; uncertain significance
G978 (≠ K54) to D: in STGD1; uncertain significance; dbSNP:rs61749453
G991 (= G67) to R: in FFM and STGD1; dbSNP:rs61749455
E1022 (= E100) to G: in STGD1; uncertain significance; to K: in STGD1; uncertain significance; dbSNP:rs61749459
A1038 (≠ L126) to V: in STGD1, FFM and CORD3; frequent mutation; reduced ATP-binding and retinal-stimulated ATP hydrolysis; decreases solubility at 70%; does not affect intracellular vesicle localization; significantly reduces substrate binding in the absence of ATP; reduces basal ATPase activity; dbSNP:rs61751374
G1050 (= G138) to D: in STGD1; uncertain significance; dbSNP:rs61750062
K1054 (≠ Y142) binding
S1071 (≠ E159) to L: in STGD1; reduced ATP-binding capacity; dbSNP:rs61750065
I1074 (≠ T162) to L: in STGD1; uncertain significance
G1078 (≠ L166) to E: in STGD1; uncertain significance
E1087 (= E175) mutation to Q: Does not affect protein folding; when associated with Q-2096. Loss of ATPase activity; when associated with Q-2096.
G1091 (= G179) to E: in FFM and STGD1; decreases solubilized at 70%; does not affect intracellular vesicle localization; does not affect substrate binding; drastically reduces basal ATPase activity with little or no substrate stimulation; dbSNP:rs61752417
P1094 (≠ T182) to T: in STGD1; uncertain significance
R1097 (≠ V185) to S: in STGD1; uncertain significance
R1098 (= R186) to C: in STGD1; uncertain significance; dbSNP:rs756840095
S1099 (≠ R187) to P: in STGD1; uncertain significance; dbSNP:rs61750119
D1102 (≠ E190) to Y: in dbSNP:rs138641544
R1108 (≠ A196) to C: in STGD1 and FFM; reduced ATP-binding capacity; dbSNP:rs61750120
E1122 (≠ V210) to K: in STGD1 and CORD3; dbSNP:rs61751399
R1129 (≠ T217) to C: in STGD1; may predispose to develop retinal toxicity after treatment with chloroquine and hydroxychloroquine; dbSNP:rs779426136; to L: in ARMD2 and STGD1; also found in patients with fundus flavimaculatus; reduced ATP-binding capacity; dbSNP:rs1801269
I1130 (= I218) to T: in STGD1; uncertain significance; dbSNP:rs1064793010
C1140 (≠ A228) to W: in STGD1; uncertain significance

Sites not aligning to the query:

14 N → K: in STGD1; uncertain significance
18 R → P: in STGD1; uncertain significance
21:2273 natural variant: Missing (in STGD1; uncertain significance)
24 R → H: in STGD1; uncertain significance; dbSNP:rs62645958
53:2273 natural variant: Missing (in CORD3; uncertain significance; dbSNP:rs764744217)
54 modified: Disulfide link with 81
55 H → R: in CORD3; uncertain significance
63 S → P: in CORD3; uncertain significance
65 G → E: in STGD1 and CORD3; dbSNP:rs62654395
72 G → R: in STGD1; does not affect intracellular vesicle localization; does not affect solubility; significantly reduces N-Ret-PE binding; drastically reduces basal ATPase activity with little or no all trans retinal stimulation; dbSNP:rs61751412; G → V: in STGD1; uncertain significance
75 modified: Disulfide link with 324
81 modified: Disulfide link with 54
89:2273 natural variant: Missing (in STGD1; uncertain significance)
96 N → H: in STGD1; uncertain significance; dbSNP:rs61748529; N → K: in STGD1; uncertain significance; dbSNP:rs886039297
97 Y → C: in STGD1; uncertain significance; dbSNP:rs755691060
98 modified: carbohydrate, N-linked (GlcNAc...) asparagine
100 S → P: in STGD1; highly decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs61748530
107:2273 natural variant: Missing (in CORD3; uncertain significance; dbSNP:rs765429911)
108 D → V: in STGD1; uncertain significance
143 P → L: in STGD1; uncertain significance; dbSNP:rs62646860
172 G → S: in STGD1; uncertain significance; dbSNP:rs61748532
184 S → F: in STGD1; uncertain significance; S → R: in STGD1; uncertain significance
185:2273 natural variant: Missing (in STGD1; uncertain significance)
206 S → R: in STGD1; reduced basal and retinal-stimulated ATP-hydrolysis; dbSNP:rs61748536
212 R → C: in STGD1 and CORD3; common mutation in southern Europe; reduced ATP-binding capacity; dbSNP:rs61750200; R → H: in dbSNP:rs6657239
218:2273 natural variant: Missing (in CORD3; uncertain significance)
219:2273 natural variant: Missing (found in a patient with chorioretinal atrophy; uncertain significance)
223 K → Q: in STGD1; uncertain significance; dbSNP:rs147619585
224 T → M: in a breast cancer sample; somatic mutation; dbSNP:rs373540612
240 I → R: in STGD1; uncertain significance; dbSNP:rs1553195472
241 E → D: in STGD1; uncertain significance
245:2273 natural variant: Missing (in STGD1; uncertain significance)
246 A → T: in STGD1; uncertain significance
290 R → W: in STGD1; uncertain significance; dbSNP:rs781716640
291 P → L: in STGD1; uncertain significance; dbSNP:rs190540405
320 S → C: in CORD3; uncertain significance
324 modified: Disulfide link with 75
326:2273 natural variant: Missing (in STGD1; uncertain significance; dbSNP:rs747540967)
339:2273 natural variant: Missing (in CORD3; uncertain significance)
345 Y → S: in STGD1; uncertain significance
370 modified: Disulfide link with 519
407 A → V: in STGD1 and CORD3; dbSNP:rs61751264
410 I → T: in STGD1; uncertain significance
415 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N → K: in STGD1; uncertain significance
418 F → S: in STGD1; uncertain significance; dbSNP:rs794726979
423 H → R: in dbSNP:rs3112831
424 V → A: in STGD1 and RP19; uncertain significance
431:2273 natural variant: Missing (in STGD1; uncertain significance)
440 Y → C: in CORD3; uncertain significance; dbSNP:rs770439859
444 modified: carbohydrate, N-linked (GlcNAc...) asparagine
455 L → M: in RP19; uncertain significance; dbSNP:rs764170051
471 E → K: in ARMD2 and STGD1; uncertain significance; ATP-binding capacity and retinal stimulation as in wild-type; dbSNP:rs1800548
498 D → E: in STGD1; uncertain significance
504 modified: carbohydrate, N-linked (GlcNAc...) asparagine
508 R → C: in STGD1; uncertain significance; dbSNP:rs138157885
511 R → C: in STGD1; uncertain significance; dbSNP:rs752786160
519 modified: Disulfide link with 370; C → R: in STGD1; uncertain significance; dbSNP:rs1224959251
533:2273 natural variant: Missing (in STGD1; uncertain significance)
541 L → P: in STGD1, FFM and CORD3; reduced ATP-binding capacity; abolishes retinal-stimulated ATP hydrolysis; does not affect solubility; does not affect intracellular vesicle localization; significantly reduces substrate binding; drastically reduces basal ATPase activity with little or no substrate stimulation; dbSNP:rs61751392
548 W → R: in STGD1; uncertain significance
552 V → I: in RP19; uncertain significance; dbSNP:rs145525174
572:2273 natural variant: Missing (in STGD1; uncertain significance)
576 D → H: found in a patient with pattern dystrophy; uncertain significance; dbSNP:rs374224955
593 P → L: in STGD1; uncertain significance
603 Y → C: in STGD1; uncertain significance
605:2273 natural variant: Missing (in CORD3; uncertain significance)
608 F → I: in STGD1; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs61752398
616 E → K: in STGD1; uncertain significance; dbSNP:rs1557787473
636 Q → K: in CORD3; uncertain significance
639:2273 natural variant: Missing (in STGD1; uncertain significance)
640 P → L: in STGD1; uncertain significance; dbSNP:rs760790294
641 modified: Disulfide link with 1490, Interchain; C → S: in STGD1; uncertain significance; dbSNP:rs61749416
643 V → G: in CORD3; uncertain significance; dbSNP:rs61754024
653 R → C: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; very low substrate binding; dbSNP:rs61749420; R → H: in STGD1; uncertain significance; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; very low substrate binding; dbSNP:rs141823837
661 L → R: in CORD3; uncertain significance; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding
681:2273 natural variant: Missing (found in a patient with macular dystrophy; uncertain significance)
686 L → S: in STGD1; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding; dbSNP:rs61752402
690 G → V: in STGD1; uncertain significance; severely decreases solubility; loss of cytoplasmic vesicle localization; very low substrate binding
700:2273 natural variant: Missing (in STGD1; uncertain significance)
716 T → M: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; decreases N-Ret-PE binding in the range of 40-70%; dbSNP:rs61749426
754 F → S: in STGD1; uncertain significance
764 C → Y: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; decreases N-Ret-PE binding in the range of 40-70%; dbSNP:rs61749428
765 S → N: in STGD1; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding; dbSNP:rs61749429; S → R: in STGD1; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding; dbSNP:rs61752404
767 V → D: in STGD1; also found in a patient with macular dystrophy; severely decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; severely decreases N-Ret-PE-stimulated ATPase activity; very low substrate binding; dbSNP:rs61751395
779:2273 natural variant: Missing (in STGD1; uncertain significance)
782:2273 natural variant: Missing (in STGD1; uncertain significance)
797 L → P: in STGD1; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding; dbSNP:rs61749432
808:2273 natural variant: Missing (in STGD1; uncertain significance)
816 G → V: in STGD1; uncertain significance
818 G → E: in STGD1; reduced ATP-binding capacity; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; very low substrate binding; dbSNP:rs61750202
821 W → R: in STGD1; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; very low substrate binding; dbSNP:rs61749433
824 I → T: in STGD1; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; very low substrate binding
840 M → R: in STGD1; uncertain significance; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding
846 D → H: severely decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; severely decreases N-Ret-PE-stimulated ATPase activity; very low substrate binding; dbSNP:rs61754027
849 V → A: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; decreases N-Ret-PE binding in the range of 40-70%; dbSNP:rs61749435
851 G → D: in STGD1; highly reduced ATP-binding capacity; severely decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; very low substrate binding; dbSNP:rs61749436
854 A → T: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; decreases N-Ret-PE binding in the range of 40-70%; dbSNP:rs61749437
863 G → A: in STGD1, FFM and CORD3; also found in a patient with bull's eye maculopathy; mild alteration probably leading to disease phenotype only in combination with a more severe allele; frequent mutation in northern Europe in linkage disequilibrium with the polymorphic variant Q-943; reduced ATP-binding capacity and retinal-stimulated ATP hydrolysis; significantly attenuates 11-cis-retinal binding; decreases about 80% the N-retinylidene-phosphatidylethanolamine transport activity; stimulates modestely the retinal-stimulated ATPase activity; does not affect ATP-independent N-retinylidene-phosphatidylethanolamine binding. Does not affect ATP-dependent release of N-retinylidene-phosphatidylethanolamine; significantly reduces phosphatidylethanolamine flippase activity; dbSNP:rs76157638; natural variant: Missing (in STGD1 and CORD3; reduced ATP-binding capacity and retinal-stimulated ATP hydrolysis)
876:2273 natural variant: Missing (in STGD1; uncertain significance)
901 T → A: in dbSNP:rs61754030
914 natural variant: H -> R
1029:2273 natural variant: Missing (in STGD1; uncertain significance)
1099:2273 natural variant: Missing (in STGD1; uncertain significance)
1145 L → H: in CORD3; uncertain significance
1148 natural variant: K -> T
1159 L → S: in STGD1; uncertain significance; dbSNP:rs1340749727
1161 R → H: in STGD1; uncertain significance; dbSNP:rs768278935
1177:2273 natural variant: Missing (in STGD1; uncertain significance)
1183 G → C: in CORD3; uncertain significance; dbSNP:rs75267647
1201 L → R: in STGD1; may predispose to develop retinal toxicity after treatment with chloroquine and hydroxychloroquine; dbSNP:rs61750126
1203 G → E: in CORD3; uncertain significance; dbSNP:rs146786552; G → R: in STGD1; uncertain significance
1204 D → N: in STGD1; uncertain significance; dbSNP:rs61750127
1209 M → T: in dbSNP:rs76258939
1253 T → M: in FFM; uncertain significance; dbSNP:rs61752424
1300 R → Q: in STGD1; uncertain significance; dbSNP:rs61750129
1300:2273 natural variant: Missing (in STGD1; uncertain significance; dbSNP:rs61752427)
1314 P → T: in dbSNP:rs61754041
1332:2273 natural variant: Missing (in STGD1; uncertain significance)
1357 A→T: Decreases solubility at 50%. Loss of intracellular vesicle localization. Does not affect substrate binding. Reduces basal ATPase activity.
1368 R → C: in CORD3; uncertain significance; dbSNP:rs1183074086
1371 K → N: in STGD1; uncertain significance
1380 P → L: in STGD1; also found in a patient with chorioretinal atrophy; reduced ATP-binding capacity; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; dbSNP:rs61750130
1399 E → K: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; increases N-Ret-PE binding; dbSNP:rs62642573
1408 W → L: in STGD1; does not affect secondary structure; decreases structural flexibility; significantly decreases all-trans-retinal binding; dbSNP:rs61750134; W → R: in STGD1; reduced retinal-stimulated ATP hydrolysis; dbSNP:rs61750135
1408:2273 natural variant: Missing (in STGD1; uncertain significance)
1416 natural variant: Missing (in STGD1; uncertain significance)
1428 T → M: in dbSNP:rs1800549
1442 N → K: in STGD1; uncertain significance; dbSNP:rs762150575
1443 R → H: in STGD1; loss of the majority of alpha-helical secondary structure; does not bind all-trans-retinal; does not affect conformational change; dbSNP:rs61750142
1444 modified: Disulfide link with 1455
1453:2273 natural variant: Missing (in STGD1; uncertain significance)
1455 modified: Disulfide link with 1444
1461:2273 natural variant: Missing (in STGD1; uncertain significance)
1469 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1479:2273 natural variant: Missing (in STGD1 and CORD3; uncertain significance; dbSNP:rs61752434)
1484 P → S: in STGD1; uncertain significance
1488 modified: Disulfide link with 1502; C → R: in STGD1 and FFM; also found in a patient with chorioretinal atrophy; reduced retinal-stimulated ATP hydrolysis; does not affect secondary structure; oss of structural flexibility; significantly decreases all-trans-retinal binding; dbSNP:rs61750146
1490 modified: Disulfide link with 641, Interchain; C → Y: in STGD1 and CORD3; reduced retinal-stimulated ATP hydrolysis; dbSNP:rs61751402
1502 modified: Disulfide link with 1488; C→R: Moderately decreased protein abundance. Moderately decreased ATPase activity. Moderately decreased phospholipid translocase activity.
1503 P → L: in STGD1; uncertain significance
1511 P → H: in STGD1; uncertain significance; dbSNP:rs886046564
1512 P → R: in STGD1; uncertain significance; dbSNP:rs61750150
1526 T → M: in STGD1; also found in a patient with chorioretinal atrophy; reduced retinal-stimulated ATP hydrolysis; dbSNP:rs61750152
1529 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1537 T → M: in STGD1; moderately decreased protein abundance; moderately decreased ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs62642575
1551 natural variant: Missing (in STGD1; uncertain significance)
1556 R → T: in STGD1; uncertain significance
1557 Y → C: found in a patient with chorioretinal atrophy; uncertain significance; dbSNP:rs1401716074
1562 I → T: in STGD1, FFM, ARMD2 and CORD3; uncertain significance; dbSNP:rs1762111
1572 T → M: in dbSNP:rs185093512
1588 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1591 G → R: in STGD1; uncertain significance; also found in a patient with macular dystrophy; uncertain significance; dbSNP:rs113106943
1598 A → D: in CORD3 and STGD1; uncertain significance; dbSNP:rs61750155
1618:2273 natural variant: Missing
1623 G → V: in dbSNP:rs1571257969
1637 A → T: in dbSNP:rs61754056
1640 R → Q: in STGD1, FFM and CORD3; dbSNP:rs61751403; R → W: in STGD1 and CORD3; dbSNP:rs61751404
1650:2273 natural variant: Missing (in CORD3; uncertain significance)
1652:2273 natural variant: Missing (in STGD1 and FFM; uncertain significance)
1662 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1681:1685 natural variant: Missing (in STGD1; highly reduced ATP-binding capacity)
1696 S → N: in STGD1; uncertain significance; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; increases N-Ret-PE binding; dbSNP:rs61750564
1703 Q → E: in STGD1; uncertain significance; does not affect solubility; does not affect location in cytoplasmic vesicle;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; dbSNP:rs61750565; Q → K: in STGD1; moderately decreases solubility; loss of cytoplasmic vesicle localization;decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity
1705 R → L: in STGD1; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; dbSNP:rs61753021; R → Q: in STGD1; uncertain significance; dbSNP:rs61753021
1724:2273 natural variant: Missing (in STGD1; uncertain significance)
1754 Y → D: in STGD1; uncertain significance
1761:1763 natural variant: Missing (in STGD1; highly reduced ATP-binding capacity)
1762 A → D: in STGD1; uncertain significance; dbSNP:rs121909206
1773 A → E: found in a patient with chorioretinal atrophy; uncertain significance; severely decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; A → V: in STGD1; uncertain significance; severely decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; loss of N-Ret-PE-induced stimulation in ATPase activity; dbSNP:rs760549861
1775 I → N: in STGD1; uncertain significance; dbSNP:rs771742619
1779 Y → H: in STGD1; uncertain significance
1779:2273 natural variant: Missing (in STGD1; uncertain significance)
1794 A → D: in STGD1; also found in a patient with bull's eye maculopathy; uncertain significance; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; severely decreases N-Ret-PE-stimulated ATPase activity; dbSNP:rs61751406; A → P: in STGD1; uncertain significance; loss of cytoplasmic vesicle localization; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; decreases solubility below 50%; significantly reduces N-Ret-PE binding in the absence of ATP; dbSNP:rs1571252997
1805 N → D: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; dbSNP:rs61753029
1817 natural variant: E -> D
1838 H → D: in STGD1; uncertain significance; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; decreases modestly N-Ret-PE-stimulated ATPase; dbSNP:rs62642562; H → N: in STGD1; uncertain significance; does not affect solubility; does not affect location in cytoplasmic vesicle; decreases basal ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; dbSNP:rs62642562; H → Y: in STGD1; moderately decreases solubility; loss of cytoplasmic vesicle localization; decreases basal ATPase activity below 50%; severely decreases N-Ret-PE-stimulated ATPase activity; dbSNP:rs62642562; H→R: Severely decreases solubility. Loss of cytoplasmic vesicle localization. Decreases basal ATPase activity below 50%. Loss of N-Ret-PE-induced stimulation in ATPase activity.
1843 R → W: in STGD1; does not affect solubility; does not affect location in cytoplasmic vesicle; decreases ATPase activity between 50% and 80%; decreases modestly N-Ret-PE-stimulated ATPase; does not affect N-Ret-PE binding; dbSNP:rs62642576
1868 N → I: risk factor for STGD1; slightly reduced retinal-stimulated ATP hydrolysis; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; does not affect N-Ret-PE binding; dbSNP:rs1801466
1882 M → I: in CORD3; uncertain significance; dbSNP:rs752160946
1886 G → E: in STGD1; highly reduced ATP-binding capacity; dbSNP:rs62642579
1898 R → C: does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; dbSNP:rs201357151; R → H: in STGD1 and ARMD2; does not affect solubility; does not affect location in cytoplasmic vesicle; does not affect both basal and N-Ret-PE-stimulated ATPase activity; Increases N-Ret-PE binding; dbSNP:rs1800552
1921 V → G: in STGD1; uncertain significance
1940 L → P: in STGD1 and FFM; dbSNP:rs61753033
1942 E → Q: in STGD1; uncertain significance; dbSNP:rs760353830
1948 P → L: in dbSNP:rs56142141; natural variant: P -> S
1961 G → E: in STGD1, FFM and CORD3; risk factor for ARMD2; also found in patients with cone dystrophy and with macular dystrophy; inhibition of ATP hydrolysis by retinal; dbSNP:rs1800553; G → R: in STGD1; uncertain significance; dbSNP:rs142253670
1970 L → F: in ARMD2, FFM and STGD1; also found in a patient with cone dystrophy; dbSNP:rs28938473
1971 L → R: in FFM; highly reduced ATP-binding capacity; abolishes basal and retinal-stimulated ATP hydrolysis; dbSNP:rs61753034
1972:1980 binding
1975 G→D: Inhibition of retinal-stimulated ATP hydrolysis.
1977 G → S: in STGD1 and ARMD2; highly reduced ATP-binding capacity; inhibition of ATP hydrolysis by retinal; dbSNP:rs61750639
1978 K→M: Inhibits ATPase activity; when associated with M-969. Decreases translocase activity; when associated with M-969. Does not affect protein subcellular localization in endoplasmic reticulum; when associated with M-969. Loss of ATP-dependent all-trans-retinal transport; when associated with M-1978. Loss in N-retinylidene-PE transfer activity. Inhibits ATPase activity with increasing retinal concentration. Does not affect ATP-independent N-retinylidene-PE binding. Does not affect ATP-dependent of N-retinylidene-PE release. Significantly reduces PE flippase activity. Inhibition of retinal-stimulated ATP hydrolysis.
2017 C → Y: in STGD1; uncertain significance
2023 I → T: in STGD1; uncertain significance; dbSNP:rs150633517
2027 L → F: in STGD1 and FFM; also found in a patient with chorioretinal atrophy; highly reduced ATP-binding capacity; dbSNP:rs61751408
2030 R → Q: in STGD1 and FFM; dbSNP:rs61750641
2030:2273 natural variant: Missing (in STGD1 and CORD3; uncertain significance; dbSNP:rs61751383)
2032 H → R: in STGD1; uncertain significance; dbSNP:rs1242866408
2033 L → R: in STGD1; uncertain significance; dbSNP:rs1553186896
2038 R → W: in STGD1; highly reduced ATP-binding capacity; dbSNP:rs61750643
2040 R → Q: in STGD1; uncertain significance; dbSNP:rs148460146
2040:2273 natural variant: Missing (in STGD1; uncertain significance; also found in a patient with chorioretinal atrophy; uncertain significance; dbSNP:rs61753038)
2042 V → G: in STGD1; uncertain significance
2043 P → S: in CORD3; uncertain significance; dbSNP:rs763230559
2050 V → L: in STGD1 and CORD3; may act as a modifier of macular dystrophy in patients who also have a Trp-172 mutation in PRPH2; dbSNP:rs41292677
2059 natural variant: G -> A
2064 A → T: in STGD1; uncertain significance; dbSNP:rs61753040
2073:2074 binding
2074 G → V: in STGD1; uncertain significance; dbSNP:rs367839100
2077 R → W: in STGD1; highly reduced ATP-binding capacity; decreases solubility at 50 %; loss of intracellular vesicle localization; drastically reduced basal activity with little or no substrate stimulation; dbSNP:rs61750645
2078 K → E: in STGD1; uncertain significance
2096 E → K: in STGD1; inhibition of ATP hydrolysis by retinal; dbSNP:rs61750646; E→Q: Does not affect protein folding; when associated with Q-1087. Loss of ATPase activity; when associated with Q-1087.
2097 P → S: in STGD1; uncertain significance; dbSNP:rs1166357291
2106 R → C: in STGD1 and FFM; reduced ATP-binding capacity; dbSNP:rs61750648
2107 R → C: in STGD1; uncertain significance; dbSNP:rs2297669; R → H: in STGD1 and CORD3; may predispose to develop retinal toxicity after treatment with chloroquine and hydroxychloroquine; dbSNP:rs62642564; R→P: Highly decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
2131 E → K: in STGD1; uncertain significance; dbSNP:rs61750652
2140 L → Q: in STGD1; uncertain significance; dbSNP:rs774475956
2150 C → Y: in STGD1 and CORD3; dbSNP:rs61751384
2177 D → N: in CORD3, ARMD2 and STGD1; uncertain significance; increased retinal-stimulated ATP hydrolysis; dbSNP:rs1800555
2180 P→L: Does not affect protein abundance. Does not affect ATPase activity. Moderately decreased phospholipid translocase activity.
2188 F → S: in STGD1; uncertain significance; dbSNP:rs61750658
2216 A → V: in dbSNP:rs886044763
2221 L → P: in STGD1; uncertain significance
2237 T → P: in STGD1; uncertain significance
2244:2249 Essential for ATP binding and ATPase activity
2255 S → I: in dbSNP:rs6666652

8f5bA Human abca4 structure in complex with amp-pnp
31% identity, 88% coverage: 7:231/256 of query aligns to 721:935/1924 of 8f5bA

query
sites
8f5bA

V

V

E

C

T

V

R

K

S

N

L

L

T

V

K

K

E

I

F

F

K

E

-

P

-

C

G

G

F

R

V

P

A

A

V

V

S

D

D

R

V

L

N

N

L

I

K

T

V

F

R

Y

R

E

H

N

T

Q

I

I

H

T

A

A

L

F

I

L

G

G

P

H

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

L

N

S

L

I

V

L

T

T

K

G

F

L

L

L

T

P

P

P

T

T

R

S

G

G

Q

T

I

V

L

L

F

V

N

G

G

G

N

R

D

D

I

I

T

E

H

T

T

S

Q

L

P

D

A

A

A

V

I

-

A

-

R

R

Q

Q

G

S

M

L

V

G

R

M

S

C

F

P

Q
|
Q

I

H

S

N

A

I

V

L

F

F

G

H

H

H

L

L

T

T

V

V

L

A

E

E

N

H

V

M

R

L

V

F

A

Y

L

A

Q

Q

R

L

K

K

Q

-

G

-

K

-

S

-

F

-

Q

-

F

-

W

-

R

-

S

-

G

G

E

K

C

S

L

Q

N

E

E

E

L

A

N

Q

A

L

R

E

A

M

E

E

E

A

L

M

I

L

E

E

A

D

V

T

G

G

V

L

A

H

E

H

Y

K

R

R

D

N

T

E

P

E

A

A

G

Q

E
x
D

L

L

S

S

Y

G

G

G

R

M

K

Q

R

R

A

K

L

L

E

S

I

V

A

A

T

I

T

A

L

F

A

V

L

G

D

D

P

A

E

K

M

V

L

V

L

I

L

L

D

D

E

E

P

P

M

T

A

S

G

G

M

V

G

D

T

P

E

Y

D

S

V

R

R

R

R

S

T

I

A

W

E

D

L

L

I

L

R

L

R

K

V

Y

A

R

A

S

N

G

R

R

T

T

I

I

L

I

M

M

V

S

E

T

H

H

N

H

L

M

S

D

V

E

V

A

A

D

D

L

L

L

S

G

D

D

T

R

I

I

T

A

V

I

L

I

K

A

L

Q

G

G

R

R

V

L

L

Y

A

C

E

S

G

G

S

T

binding phosphoaminophosphonic acid-adenylate ester: N757 (= N41), G758 (= G42), G760 (= G44), K761 (= K45), T762 (= T46), T763 (= T47), Q802 (= Q88), D853 (≠ E149)
binding magnesium ion: T762 (= T46), Q802 (= Q88)

Sites not aligning to the query:

binding phosphoaminophosphonic acid-adenylate ester: 1652, 1653, 1654, 1655, 1656, 1657, 1697, 1748, 1750
binding magnesium ion: 1657, 1697

7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation (see paper)
32% identity, 94% coverage: 6:245/256 of query aligns to 4:231/263 of 7d0aB

query
sites
7d0aB

I

L

V

I

E

E

T

V

R

K

S

N

L

L

T

S

K

F

E

N

F

R

K

G

G

E

F

R

V

V

A

I

V

Y

S

D

D

N

V

I

N

S

L

L

K

N

V

I

R

R

H

G

T

Q

I

I

H

T

A

A

L

I

I

M

G

G

P

P

N
x
S

G

G

A
x
T

G
|
G

K
|
K

T

T

C

L

F

L

N

R

L

L

V

I

T

G

K

G

F

Q

L

L

T

V

P

P

T

D

R

Q

G

G

Q

E

I

V

L

L

F

L

N

D

G

G

N

K

D

D

I

I

T

A

H

Q

T

M

Q

S

P

R

-

Q

-

E

-

L

-

F

A

A

I

R

A

A

R

R

Q

M

G

G

M

M

V

L

R

-

S

-

F

F

Q

Q

I

S

S

G

A

A

V

L

F

F

G

T

H

D

L

M

T

S

V

V

L

Y

E

E

N

N

V

V

R

A

V

F

A

P

L

I

Q

-

R

R

K

A

Q

H

G

T

K

K

S

-

F

-

Q

-

F

-

W

-

R

L

S

S

G

E

E

N

C

L

L

I

N

A

E

E

L

L

N

V

A

A

R

L

A

K

E

-

L

-

I

L

E

E

A

S

V

V

G

G

V

L

A

R

E

G

Y

T

R

E

D

Q

T

L

P

M

A

P

G

T

E
|
E

L

L

S
|
S

Y

G

G

G

R
x
M

K

N

R

R

A

R

L

V

E

A

I

L

A

A

T

R

T

A

L

I

A

A

L

L

D

D

P

P

E

D

M

L

L

I

L

M

L

Y

D

D

E

E

P

P

M

F

A

A

G

G

M

Q

G

D

T

P

E

I

D

V

V

K

R

G

R

V

T

L

A

T

E

R

L

L

I

I

R

R

-

S

-

L

R

R

V

E

A

A

A

L

N

D

R

L

T

T

I

T

L

I

M

I

V

V

E

S

H

H

N

D

L

V

S

P

V

E

V

T

A

L

D

S

L

I

S

A

D

D

T

Y

I

I

T

Y

V

V

L

V

K

A

L

E

G

G

R

K

V

I

L

Q

A

G

E

E

G

G

S

T

Y

-

A

-

E

-

I

-

T

-

D

-

N

-

P

P

E

E

V

E

V

L

E

Q

A

A

Y

Y

binding adenosine-5'-diphosphate: S39 (≠ N41), T41 (≠ A43), G42 (= G44), K43 (= K45), E140 (= E149), S142 (= S151), M145 (≠ R154)

7d08B Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
32% identity, 94% coverage: 6:245/256 of query aligns to 4:231/263 of 7d08B

query
sites
7d08B

I

L

V

I

E

E

T

V

R

K

S

N

L

L

T

S

K

F

E

N

F
x
R

K

G

G

E

F
x
R

V

V

A

I

V

Y

S

D

D

N

V

I

N

S

L

L

K

N

V

I

R

R

H

G

T

Q

I

I

H

T

A

A

L

I

I

M

G

G

P

P

N

S

G
|
G

A
x
T

G

G

K
|
K

T
|
T

C

L

F

L

N

R

L

L

V

I

T

G

K

G

F

Q

L

L

T

V

P

P

T

D

R

Q

G

G

Q

E

I

V

L

L

F

L

N

D

G

G

N

K

D

D

I

I

T

A

H

Q

T

M

Q

S

P

R

-

Q

-

E

-

L

-

F

A

A

I

R

A

A

R

R

Q

M

G

G

M

M

V

L

R

-

S

-

F

F

Q

Q

I

S

S

G

A

A

V

L

F

F

G

T

H

D

L

M

T

S

V

V

L

Y

E

E

N

N

V

V

R

A

V

F

A

P

L

I

Q

-

R

R

K

A

Q

H

G

T

K

K

S

-

F

-

Q

-

F

-

W

-

R

L

S

S

G

E

E

N

C

L

L

I

N

A

E

E

L

L

N

V

A

A

R

L

A

K

E

-

L

-

I

L

E

E

A

S

V

V

G

G

V

L

A

R

E

G

Y

T

R

E

D

Q

T

L

P

M

A

P

G

T

E

E

L

L

S

S

Y

G

G

G

R

M

K

N

R

R

A

R

L

V

E

A

I

L

A

A

T

R

T

A

L

I

A

A

L

L

D

D

P

P

E

D

M

L

L

I

L

M

L

Y

D

D

E
|
E

P

P

M

F

A

A

G

G

M

Q

G

D

T

P

E

I

D

V

V

K

R

G

R

V

T

L

A

T

E

R

L

L

I

I

R

R

-

S

-

L

R

R

V

E

A

A

A

L

N

D

R

L

T

T

I

T

L

I

M

I

V

V

E

S

H

H

N

D

L

V

S

P

V

E

V

T

A

L

D

S

L

I

S

A

D

D

T

Y

I

I

T

Y

V

V

L

V

K

A

L

E

G

G

R

K

V

I

L

Q

A

G

E

E

G

G

S

T

Y

-

A

-

E

-

I

-

T

-

D

-

N

-

P

P

E

E

V

E

V

L

E

Q

A

A

Y

Y

binding adenosine-5'-triphosphate: R14 (≠ F16), R17 (≠ F19), G40 (= G42), T41 (≠ A43), K43 (= K45), T44 (= T46), T45 (= T47), E166 (= E175)

6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp (see paper)
32% identity, 94% coverage: 6:245/256 of query aligns to 2:229/253 of 6z5uK

query
sites
6z5uK

I

L

V

I

E

E

T

V

R

K

S

N

L

L

T

S

K

F

E

N

F
x
R

K

G

G

E

F

R

V

V

A

I

V

Y

S

D

D

N

V

I

N

S

L

L

K

N

V

I

R

R

H

G

T

Q

I

I

H

T

A

A

L

I

I

M

G

G

P

P

N
x
S

G
|
G

A

T

G
|
G

K
|
K

T
|
T

C

L

F

L

N

R

L

L

V

I

T

G

K

G

F

Q

L

L

T

V

P

P

T

D

R

Q

G

G

Q

E

I

V

L

L

F

L

N

D

G

G

N

K

D

D

I

I

T

A

H

Q

T

M

Q

S

P

R

-

Q

-

E

-

L

-

F

A

A

I

R

A

A

R

R

Q

M

G

G

M

M

V

L

R

-

S

-

F

F

Q
|
Q

I

S

S

G

A

A

V

L

F

F

G

T

H

D

L

M

T

S

V

V

L

Y

E

E

N

N

V

V

R

A

V

F

A

P

L

I

Q

-

R

R

K

A

Q

H

G

T

K

K

S

-

F

-

Q

-

F

-

W

-

R

L

S

S

G

E

E

N

C

L

L

I

N

A

E

E

L

L

N

V

A

A

R

L

A

K

E

-

L

-

I

L

E

E

A

S

V

V

G

G

V

L

A

R

E

G

Y

T

R

E

D

Q

T

L

P

M

A

P

G

T

E

E

L

L

S

S

Y

G

G

G

R

M

K

N

R

R

A

R

L

V

E

A

I

L

A

A

T

R

T

A

L

I

A

A

L

L

D

D

P

P

E

D

M

L

L

I

L

M

L

Y

D

D

E
|
E

P

P

M

F

A

A

G

G

M

Q

G

D

T

P

E

I

D

V

V

K

R

G

R

V

T

L

A

T

E

R

L

L

I

I

R

R

-

S

-

L

R

R

V

E

A

A

A

L

N

D

R

L

T

T

I

T

L

I

M

I

V

V

E

S

H
|
H

N

D

L

V

S

P

V

E

V

T

A

L

D

S

L

I

S

A

D

D

T

Y

I

I

T

Y

V

V

L

V

K

A

L

E

G

G

R

K

V

I

L

Q

A

G

E

E

G

G

S

T

Y

-

A

-

E

-

I

-

T

-

D

-

N

-

P

P

E

E

V

E

V

L

E

Q

A

A

Y

Y

binding phosphoaminophosphonic acid-adenylate ester: R12 (≠ F16), S37 (≠ N41), G38 (= G42), G40 (= G44), K41 (= K45), T42 (= T46), T43 (= T47), Q86 (= Q88), E164 (= E175), H197 (= H206)
binding magnesium ion: Q86 (= Q88), E164 (= E175)

7e7oA Cryo-em structure of human abca4 in nrpe-bound state (see paper)
31% identity, 83% coverage: 20:231/256 of query aligns to 823:1022/2003 of 7e7oA

query
sites
7e7oA

V

I

A

A

V

V

S

D

D

R

V

L

N

N

L

I

K

T

V

F

R

Y

R

E

H

N

T

Q

I

I

H

T

A

A

L

F

I

L

G

G

P

H

N

N

G

G

A

A

G

G

K

K

T

T

C

T

F

L

N

S

L

I

V

L

T

T

K

G

F

L

L

L

T

P

P

P

T

T

R

S

G

G

Q

T

I

V

L

L

F

V

N

G

G

G

N

R

D

D

I

I

T

E

H

T

T

S

Q

L

P

D

A

A

A

V

I

-

A

-

R

R

Q

Q

G

S

M

L

V

G

R

M

S

C

F

P

Q

Q

I

H

S

N

A

I

V

L

F

F

G

H

H

H

L

L

T

T

V

V

L

A

E

E

N

H

V

M

R

L

V

F

A

Y

L

A

Q

Q

R

L

K

K

Q

-

G

-

K

-

S

-

F

-

Q

-

F

-

W

-

R

-

S

-

G

G

E

K

C

S

L

Q

N

E

E

E

L

A

N

Q

A

L

R

E

A

M

E

E

E

A

L

M

I

L

E

E

A

D

V

T

G

G

V

L

A

H

E

H

Y

K

R

R

D

N

T

E

P

E

A

A

G

Q

E

D

L

L

S

S

Y

G

G

G

R

M

K

Q

R

R

A

K

L

L

E

S

I

V

A

A

T

I

T

A

L

F

A

V

L

G

D

D

P

A

E

K

M

V

L

V

L

I

L

L

D

D

E

E

P

P

M

T

A

S

G

G

M

V

G

D

T

P

E

Y

D

S

V

R

R

R

R

S

T

I

A

W

E

D

L

L

I

L

R

L

R

K

V

Y

A

R

A

S

N

G

R

R

T

T

I

I

L

I

M

M

V

S

E

T

H

H

N

H

L

M

S

D

V

E

V

A

A

D

D

L

L

L

S

G

D

D

T

R

I

I

T

A

V

I

L

I

K

A

L

Q

G

G

R

R

V

L

L

Y

A

C

E

S

G

G

S

T

Sites not aligning to the query:

binding [(2S)-3-[2-[(E)-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenylidene]amino]ethoxy-oxidanyl-phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxy-propyl] (Z)-octadec-9-enoate: 285, 290, 526, 527, 589, 592, 1454

7lkpA Structure of atp-free human abca4 (see paper)
31% identity, 84% coverage: 17:231/256 of query aligns to 744:946/1941 of 7lkpA

query
sites
7lkpA

K

K

G

N

F

L

V

V

A

K

V

I

S

D

D

R

V

L

N

N

L

I

K

T

V

F

R

Y

R

E

H

N

T

Q

I

I

H

T

A

A

L

F

I

L

G

G

P

H

N

N

G

G

A

A

G

G

K

K

T

T

C

T

F

L

N

S

L

I

V

L

T

T

K

G

F

L

L

L

T

P

P

P

T

T

R

S

G

G

Q

T

I

V

L

L

F

V

N

G

G

G

N

R

D

D

I

I

T

E

H

T

T

S

Q

L

P

D

A

A

A

V

I

-

A

-

R

R

Q

Q

G

S

M

L

V

G

R

M

S

C

F

P

Q

Q

I

H

S

N

A

I

V

L

F

F

G
x
H

H

H

L

L

T

T

V

V

L

A

E

E

N

H

V

M

R

L

V

F

A

Y

L

A

Q

Q

R

L

K

K

Q

-

G

-

K

-

S

-

F

-

Q

-

F

-

W

-

R

-

S

-

G

G

E

K

C

S

L

Q

N

E

E

E

L

A

N

Q

A

L

R

E

A

M

E

E

E

A

L

M

I

L

E

E

A

D

V

T

G

G

V

L

A

H

E

H

Y

K

R

R

D

N

T

E

P

E

A

A

G
x
Q

E

D

L

L

S

S

Y

G

G

G

R

M

K

Q

R

R

A

K

L

L

E

S

I

V

A

A

T

I

T

A

L

F

A

V

L

G

D

D

P

A

E

K

M

V

L

V

L

I

L

L

D

D

E

E

P

P

M

T

A

S

G

G

M

V

G

D

T

P

E

Y

D

S

V

R

R

R

R

S

T

I

A

W

E

D

L

L

I

L

R

L

R

K

V

Y

A

R

A

S

N

G

R

R

T

T

I

I

L

I

M

M

V

S

E

T

H

H

N

H

L

M

S

D

V

E

V

A

A

D

D

L

L

L

S

G

D

D

T

R

I

I

T

A

V

I

L

I

K

A

L

Q

G

G

R

R

V

L

L

Y

A

C

E

S

G

G

S

T

binding Digitonin: H819 (≠ G94), Q863 (≠ G148)

Sites not aligning to the query:

binding Digitonin: 522, 526, 530, 533, 616
binding cholesterol: 9, 10, 13, 617, 1073, 1074, 1076, 1402, 1436, 1487, 1492, 1495, 1496, 1499, 1603

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
32% identity, 92% coverage: 10:245/256 of query aligns to 6:233/233 of 6b8bA

query
sites
6b8bA

R

K

S

N

L

L

T

A

K

K

E

A

F
x
Y

K

K

G

G

F
x
R

V

R

A
x
V

V

V

S

E

D

D

V

V

N

S

L

L

K

T

V

V

R

N

R

S

H

G

T

E

I

I

H

V

A

G

L

L

I

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

N

Y

L

M

V

V

T

V

K

G

F

I

L

V

T

P

P

R

T

D

R

A

G

G

Q

N

I

I

L

I

F

I

N

D

G

D

N

D

D

D

I

I

T

S

H

L

T

L

Q

P

P

L

A

H

A

A

I

R

A

A

R

R

Q

R

G

G

M

I

V

G

R

Y

S

L

F

P

Q

Q

I

E

S

A

A

S

V

I

F
|
F

G
x
R

H
x
R

L

L

T

S

V

V

L

Y

E

D

N

N

V

L

R

M

V

A

A

V

L

L

Q

Q

R

I

K

R

Q

D

G

D

K

L

S

S

F

A

Q

E

F

-

W

-

R

-

S

-

G

-

E

-

C

-

L

-

N

-

E

Q

L

R

N

E

A

D

R

R

A

A

E

N

E

E

L

L

I

M

E

E

A

E

V

F

G

H

V

I

A

E

E

H

Y

L

R

R

D

D

T

S

P

M

A

G

G

Q

E

S

L

L

S

S

Y

G

G

G

R

E

K

R

R

R

A

R

L

V

E

E

I

I

A

A

T

R

T

A

L

L

A

A

L

A

D

N

P

P

E

K

M

F

L

I

L

L

D

D

E

E

P

P

M

F

A

A

G

G

-

V

-

D

-

P

M

I

G

S

T

V

E

I

D

D

V

I

R

K

R

R

T

I

A

I

E

E

L

H

I

L

R

R

R

-

V

-

A

D

A

S

N

G

R

L

T

G

I

V

L

L

M

I

V

T

E

D

H

H

N

N

L

V

S

R

V

E

V

T

A

L

D

A

L

V

S

C

D

E

T

R

I

A

T

Y

V

I

L

V

K

S

L

Q

G

G

R

H

V

L

L

I

A

A

E

H

G

G

S

T

Y

P

A

T

E

E

I

I

T

L

D

Q

N

D

P

E

E

H

V

V

V

K

E

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (≠ F16), R15 (≠ F19), V17 (≠ A21), G38 (= G42), G40 (= G44), K41 (= K45), T42 (= T46), T43 (= T47)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F93), R90 (≠ G94), R91 (≠ H95)

Query Sequence

>WP_043744331.1 NCBI__GCF_000009985.1:WP_043744331.1
MGDDLIVETRSLTKEFKGFVAVSDVNLKVRRHTIHALIGPNGAGKTTCFNLVTKFLTPTR
GQILFNGNDITHTQPAAIARQGMVRSFQISAVFGHLTVLENVRVALQRKQGKSFQFWRSG
ECLNELNARAEELIEAVGVAEYRDTPAGELSYGRKRALEIATTLALDPEMLLLDEPMAGM
GTEDVRRTAELIRRVAANRTILMVEHNLSVVADLSDTITVLKLGRVLAEGSYAEITDNPE
VVEAYMGAGHGGAGHG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory