SitesBLAST
Comparing WP_043745687.1 NCBI__GCF_000009985.1:WP_043745687.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4ywjA Crystal structure of 4-hydroxy-tetrahydrodipicolinate reductase (htpa reductase) from pseudomonas aeruginosa
53% identity, 100% coverage: 2:265/265 of query aligns to 3:267/268 of 4ywjA
- active site: H156 (= H154), K160 (= K158)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), R12 (= R11), M13 (= M12), D35 (≠ E33), R36 (= R34), F76 (= F74), T77 (= T75), V81 (≠ A79), G99 (= G97), T101 (= T99), A124 (≠ P122), N125 (= N123), F126 (= F124), R237 (= R235), F240 (= F238)
3ijpA Crystal structure of dihydrodipicolinate reductase from bartonella henselae at 2.0a resolution (see paper)
48% identity, 100% coverage: 1:265/265 of query aligns to 2:266/266 of 3ijpA
- active site: H155 (= H154), K159 (= K158)
- binding sodium ion: I21 (≠ V20), Q22 (≠ L21), R24 (≠ A23), V27 (≠ C26)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G7), N10 (= N9), G11 (= G10), R12 (= R11), M13 (= M12), R35 (= R34), F75 (= F74), S76 (≠ T75), Q77 (≠ A76), A80 (= A79), G98 (= G97), T100 (= T99), G123 (≠ P122), N124 (= N123), M125 (≠ F124), F239 (= F238)
3ijpB Crystal structure of dihydrodipicolinate reductase from bartonella henselae at 2.0a resolution (see paper)
48% identity, 100% coverage: 1:265/265 of query aligns to 2:266/267 of 3ijpB
5temA Structure of 4-hydroxy-tetrahydrodipicolinate reductase from vibrio vulnificus with 2,6 pyridine dicarboxylic and nadh (see paper)
49% identity, 100% coverage: 1:265/265 of query aligns to 2:266/266 of 5temA
- active site: H155 (= H154), K159 (= K158)
- binding nicotinamide-adenine-dinucleotide: G8 (= G7), G11 (= G10), R12 (= R11), M13 (= M12), E34 (= E33), R35 (= R34), F75 (= F74), T76 (= T75), S80 (≠ A79), G98 (= G97), T100 (= T99), P123 (= P122), N124 (= N123), Y125 (≠ F124), F239 (= F238)
- binding pyridine-2,6-dicarboxylic acid: T100 (= T99), P123 (= P122), H156 (= H155), K159 (= K158), S164 (= S163), G165 (= G164), T166 (= T165)
5tejB Structure of 4-hydroxy-tetrahydrodipicolinate reductase from vibrio vulnificus with 2,5 furan dicarboxylic and nadh (see paper)
49% identity, 100% coverage: 1:265/265 of query aligns to 2:266/269 of 5tejB
- active site: H155 (= H154), K159 (= K158)
- binding 2,5 Furan Dicarboxylic Acid: T100 (= T99), H156 (= H155), K159 (= K158), S164 (= S163), G165 (= G164), T166 (= T165)
- binding nicotinamide-adenine-dinucleotide: G8 (= G7), G11 (= G10), R12 (= R11), M13 (= M12), E34 (= E33), R35 (= R34), F75 (= F74), T76 (= T75), S80 (≠ A79), G98 (= G97), T100 (= T99), P123 (= P122), N124 (= N123), Y125 (≠ F124), F239 (= F238)
5tejA Structure of 4-hydroxy-tetrahydrodipicolinate reductase from vibrio vulnificus with 2,5 furan dicarboxylic and nadh (see paper)
49% identity, 100% coverage: 1:265/265 of query aligns to 2:266/269 of 5tejA
- active site: H155 (= H154), K159 (= K158)
- binding nicotinamide-adenine-dinucleotide: G8 (= G7), G11 (= G10), R12 (= R11), M13 (= M12), E34 (= E33), R35 (= R34), F75 (= F74), T76 (= T75), S80 (≠ A79), G98 (= G97), T100 (= T99), P123 (= P122)
1drvA Escherichia coli dhpr/acnadh complex (see paper)
49% identity, 100% coverage: 1:265/265 of query aligns to 3:267/270 of 1drvA
- active site: H156 (= H154), K160 (= K158)
- binding 3-acetylpyridine adenine dinucleotide: G9 (= G7), G12 (= G10), R13 (= R11), M14 (= M12), E35 (= E33), F76 (= F74), T77 (= T75), R78 (≠ A76), G81 (≠ A79), G99 (= G97), A124 (≠ P122), F126 (= F124), R237 (= R235)
1druA Escherichia coli dhpr/nadh complex (see paper)
49% identity, 100% coverage: 1:265/265 of query aligns to 3:267/270 of 1druA
- active site: H156 (= H154), K160 (= K158)
- binding nicotinamide-adenine-dinucleotide: G9 (= G7), G12 (= G10), R13 (= R11), M14 (= M12), E35 (= E33), R36 (= R34), F76 (= F74), T77 (= T75), R78 (≠ A76), G81 (≠ A79), G99 (= G97), T100 (= T98), T101 (= T99), A124 (≠ P122), N125 (= N123), F126 (= F124), F240 (= F238)
1arzA Escherichia coli dihydrodipicolinate reductase in complex with nadh and 2,6 pyridine dicarboxylate (see paper)
49% identity, 100% coverage: 1:265/265 of query aligns to 3:267/270 of 1arzA
1drwA Escherichia coli dhpr/nhdh complex (see paper)
49% identity, 100% coverage: 1:265/265 of query aligns to 5:269/272 of 1drwA
- active site: H158 (= H154), K162 (= K158)
- binding nicotinamide purin-6-ol-dinucleotide: G11 (= G7), G14 (= G10), R15 (= R11), M16 (= M12), E37 (= E33), R38 (= R34), F78 (= F74), T79 (= T75), R80 (≠ A76), G101 (= G97), T102 (= T98), T103 (= T99), A126 (≠ P122), N127 (= N123), F128 (= F124), F242 (= F238)
1dihA Three-dimensional structure of e. Coli dihydrodipicolinate reductase (see paper)
49% identity, 100% coverage: 1:265/265 of query aligns to 5:269/272 of 1dihA
- active site: H158 (= H154), K162 (= K158)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G11 (= G7), G14 (= G10), R15 (= R11), M16 (= M12), R38 (= R34), F78 (= F74), T79 (= T75), R80 (≠ A76), G83 (≠ A79), G101 (= G97), T103 (= T99), N127 (= N123), F128 (= F124), R239 (= R235), F242 (= F238)
P04036 4-hydroxy-tetrahydrodipicolinate reductase; HTPA reductase; EC 1.17.1.8 from Escherichia coli (strain K12) (see 3 papers)
49% identity, 100% coverage: 1:265/265 of query aligns to 6:270/273 of P04036
- G12 (= G7) binding
- GRM 15:17 (= GRM 10:12) binding
- RM 16:17 (= RM 11:12) binding
- E38 (= E33) binding
- R39 (= R34) binding
- TR 80:81 (≠ TA 75:76) binding
- GTT 102:104 (= GTT 97:99) binding ; binding
- AANF 126:129 (≠ APNF 121:124) binding
- F129 (= F124) binding
- H159 (= H154) mutation H->A,Q: 135 to 200-fold reduction in catalytic activity.
- K163 (= K158) binding ; mutation K->A,C,Q: 625 to 830-fold reduction in catalytic activity.
- R240 (= R235) binding
- F243 (= F238) binding
1arzB Escherichia coli dihydrodipicolinate reductase in complex with nadh and 2,6 pyridine dicarboxylate (see paper)
49% identity, 100% coverage: 1:265/265 of query aligns to 2:266/269 of 1arzB
- active site: H155 (= H154), K159 (= K158)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G8 (= G7), G10 (≠ N9), G11 (= G10), R12 (= R11), M13 (= M12), E34 (= E33), F75 (= F74), T76 (= T75), R77 (≠ A76), G80 (≠ A79), H84 (= H83), G98 (= G97), T100 (= T99), A123 (≠ P122), N124 (= N123), F125 (= F124), F239 (= F238)
- binding pyridine-2,6-dicarboxylic acid: T100 (= T99), H156 (= H155), K159 (= K158), S164 (= S163), G165 (= G164), T166 (= T165), F239 (= F238)
Q9X1K8 4-hydroxy-tetrahydrodipicolinate reductase; HTPA reductase; EC 1.17.1.8 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
36% identity, 99% coverage: 1:263/265 of query aligns to 1:212/216 of Q9X1K8
1vm6B Crystal structure of dihydrodipicolinate reductase (tm1520) from thermotoga maritima at 2.27 a resolution
36% identity, 99% coverage: 1:263/265 of query aligns to 6:217/218 of 1vm6B
- active site: H132 (= H154), K136 (= K158)
- binding nicotinamide-adenine-dinucleotide: G12 (= G7), S14 (≠ N9), G15 (= G10), R16 (= R11), M17 (= M12), D37 (≠ E33), V38 (≠ R34), F53 (= F74), S54 (≠ T75), S55 (≠ A76), E57 (≠ A78), A58 (= A79), G76 (= G97), T78 (= T99), Y101 (≠ P122), N102 (= N123), F103 (= F124), F192 (= F238)
5wolA Crystal structure of dihydrodipicolinate reductase dapb from coxiella burnetii
29% identity, 99% coverage: 1:263/265 of query aligns to 2:230/230 of 5wolA
- active site: H133 (= H154), K137 (= K158)
- binding pyridine-2-carboxylic acid: P104 (= P122), T144 (= T165), K147 (≠ G168)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: N7 (≠ V6), G11 (= G10), K12 (≠ R11), M13 (= M12), G34 (≠ E33), R35 (= R34), F54 (= F74), T55 (= T75), T56 (≠ A76), S59 (≠ A79), G77 (= G97), T78 (= T98), T79 (= T99), P104 (= P122), N105 (= N123), F106 (= F124)
1p9lA Structure of m. Tuberculosis dihydrodipicolinate reductase in complex with nadh and 2,6 pdc (see paper)
31% identity, 97% coverage: 1:256/265 of query aligns to 1:234/245 of 1p9lA
- active site: H132 (= H154), K136 (= K158)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G7 (= G7), G10 (= G10), K11 (≠ R11), V12 (≠ M12), D33 (≠ I40), A34 (≠ G41), F52 (= F74), T53 (= T75), V57 (≠ A79), G75 (= G97), T77 (= T99), P103 (= P122), N104 (= N123), F105 (= F124), F217 (= F238)
- binding pyridine-2,6-dicarboxylic acid: H133 (= H155), K136 (= K158), S141 (= S163), G142 (= G164), T143 (= T165), A192 (≠ G213)
1c3vA Dihydrodipicolinate reductase from mycobacterium tuberculosis complexed with NADPH and pdc (see paper)
31% identity, 97% coverage: 1:256/265 of query aligns to 1:234/245 of 1c3vA
- active site: H132 (= H154), K136 (= K158)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: K9 (≠ N9), G10 (= G10), K11 (≠ R11), V12 (≠ M12), D33 (≠ I40), A34 (≠ G41), F52 (= F74), T53 (= T75), V57 (≠ A79), G75 (= G97), T77 (= T99), P103 (= P122), N104 (= N123), F217 (= F238)
- binding pyridine-2,6-dicarboxylic acid: T77 (= T99), N104 (= N123), K136 (= K158), S141 (= S163), G142 (= G164), T143 (= T165), A192 (≠ G213)
5ugvA Dapb from mycobacterium tuberculosis (see paper)
31% identity, 97% coverage: 1:256/265 of query aligns to 2:235/245 of 5ugvA
5tjzA Structure of 4-hydroxytetrahydrodipicolinate reductase from mycobacterium tuberculosis with NADPH and 2,6 pyridine dicarboxylic acid (see paper)
31% identity, 97% coverage: 1:256/265 of query aligns to 2:235/245 of 5tjzA
- active site: H133 (= H154), K137 (= K158)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G7), G11 (= G10), K12 (≠ R11), V13 (≠ M12), D34 (≠ I40), A35 (≠ G41), F53 (= F74), T54 (= T75), G76 (= G97), T77 (= T98), T78 (= T99), P104 (= P122), N105 (= N123), F106 (= F124), F218 (= F238)
- binding pyridine-2,6-dicarboxylic acid: T78 (= T99), P104 (= P122), H134 (= H155), K137 (= K158), S142 (= S163), G143 (= G164), T144 (= T165), A193 (≠ G213)
Query Sequence
>WP_043745687.1 NCBI__GCF_000009985.1:WP_043745687.1
MRIGIVGCNGRMGRMLMEAVLSAEGCTLSGGTERAGSEVIGLDPGTLLGRPPVGALVTAD
ARTLFQASDAVIDFTAPAATLAHAAIAAELGKVLVVGTTGLSKDDEARLAEAARSTPVVY
APNFSVGVNLLMALTERAAAILGDDYDIEIVEMHHRHKVDAPSGTALGLGRSAALGRQVA
LDSRWCKARDGHTGARPKGEIGFATLRGGDVVGDHTVMFAAEGERVELTHKASSRTVFAK
GAVRAARWATGQKPGLYSMRDVLGL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory