SitesBLAST
Comparing WP_044623788.1 NCBI__GCF_000940995.1:WP_044623788.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 13 hits to proteins with known functional sites (download)
7jsjA Structure of the nact-pf2 complex (see paper)
30% identity, 90% coverage: 36:459/471 of query aligns to 25:447/468 of 7jsjA
- binding sodium ion: S124 (= S154), I127 (≠ M157), S128 (= S158), N129 (= N159), G172 (= G205), T366 (≠ A373), T369 (≠ M376), S370 (= S377), N371 (≠ H378), A413 (≠ S425), T414 (= T426)
- binding (2R)-2-[2-(4-tert-butylphenyl)ethyl]-2-hydroxybutanedioic acid: N129 (= N159), T130 (= T160), T173 (= T206), G315 (≠ D323), I316 (≠ V324), N371 (≠ H378)
8r34A Cryoem structure of the symmetric pho90 dimer from yeast with substrates. (see paper)
29% identity, 85% coverage: 34:432/471 of query aligns to 47:439/485 of 8r34A
7t9gA Structure of vcindy-na+ (see paper)
34% identity, 77% coverage: 99:463/471 of query aligns to 74:443/445 of 7t9gA
6wtxA Structure of vcindy in complex with terephthalate (see paper)
34% identity, 77% coverage: 99:463/471 of query aligns to 74:443/445 of 6wtxA
- binding sodium ion: S129 (= S154), S133 (= S158), N134 (= N159), G176 (= G199), G182 (= G205), T356 (≠ A373), A359 (≠ M376), S360 (= S377), N361 (≠ H378), A403 (≠ S425)
- binding terephthalic acid: N134 (= N159), S183 (≠ T206), S360 (= S377), N361 (≠ H378), T362 (= T379), T404 (= T426)
6okzB Structure of vcindy bound to fumarate
34% identity, 77% coverage: 99:463/471 of query aligns to 73:442/444 of 6okzB
Q86YT5 Na(+)/citrate cotransporter; NaCT; Sodium-coupled citrate transporter; Sodium-dependent citrate transporter; Solute carrier family 13 member 5 from Homo sapiens (Human) (see 5 papers)
26% identity, 90% coverage: 36:459/471 of query aligns to 37:541/568 of Q86YT5
- T142 (= T160) to M: in DEE25; no loss of localization to plasma membrane; loss of function in citrate transport; dbSNP:rs761917087
- G219 (= G198) to E: loss of localization to plasma membrane; loss of function in citrate transport; dbSNP:rs150024888; to R: in DEE25; loss of function in citrate transport; loss of localization to plasma membrane; dbSNP:rs144332569
- T227 (= T206) to M: in DEE25; loss of function in citrate transport; no effect on localization to plasma membrane; dbSNP:rs587777577
- D243 (vs. gap) to N: no effect on localization to plasma membrane; no effect on its function in citrate transport; dbSNP:rs142262032
- G409 (≠ D323) mutation to Q: No effect on its function in citrate transport.
- I410 (≠ V324) mutation I->A,F: Significant loss of function in citrate transport.; mutation to V: No effect on its function in citrate transport.
- L420 (= L334) to P: loss of localization to plasma membrane; loss of function in citrate transport; dbSNP:rs150738356
- S427 (≠ T341) to L: in DEE25; loss of localization to plasma membrane; loss of function in citrate transport; dbSNP:rs548065551
- L485 (= L399) to R: no effect on localization to plasma membrane; reduced function in citrate transport; increased Km and Vmax values compared with that of wild type with citrate as substrate; dbSNP:rs148049520
- L488 (= L402) to P: in DEE25; loss of function in citrate transport; loss of localization to plasma membrane; dbSNP:rs587777578
- D524 (≠ Q442) to H: in DEE25; loss of function in citrate transport; no effect on localization to plasma membrane; dbSNP:rs863225448
Sites not aligning to the query:
- 341:568 natural variant: Missing (in DEE25; loss of localization to plasma membrane; loss of function in citrate transport)
- 562 modified: carbohydrate, N-linked (GlcNAc...) asparagine
8w6hA Nas1 with sulfate - in/in state (see paper)
25% identity, 79% coverage: 85:455/471 of query aligns to 59:436/462 of 8w6hA
8w6nB Nas1 with sulfate in in/out state (see paper)
26% identity, 79% coverage: 85:455/471 of query aligns to 60:455/481 of 8w6nB
4f35B Crystal structure of a bacterial dicarboxylate/sodium symporter (see paper)
33% identity, 77% coverage: 99:463/471 of query aligns to 73:412/414 of 4f35B
8w6nA Nas1 with sulfate in in/out state (see paper)
25% identity, 79% coverage: 85:455/471 of query aligns to 64:467/494 of 8w6nA
Q28615 Solute carrier family 13 member 2; Na(+)/dicarboxylate cotransporter 1; NaDC-1; Renal sodium/dicarboxylate cotransporter from Oryctolagus cuniculus (Rabbit) (see paper)
24% identity, 78% coverage: 90:457/471 of query aligns to 72:553/593 of Q28615