SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_046158296.1 NCBI__GCF_000971335.1:WP_046158296.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
34% identity, 94% coverage: 5:218/228 of query aligns to 11:213/214 of 4ymwC

query
sites
4ymwC
Y
 
Y
L
 
T
P
 
P
S
 
L
I
 
F
L
 
I
E
 
S
G
 
G
G
 
L
V
 
I
L
 
M
T
 
T
L
 
L
K
 
K
L
 
L
A
 
T
G
 
F
T
 
L
S
 
A
L
 
V
V
 
T
V
 
I
S
 
G
V
 
V
A
 
L
L
 
M
G
 
G
L
 
L
V
 
F
G
 
I
A
 
A
L
 
L
F
 
M
K
 
K
S
 
M
S
 
S
H
 
S
S
 
I
R
 
K
P
 
P
L
 
I
T
 
K
L
 
L
L
 
V
A
 
A
E
 
S
F
 
S
Y
 
Y
S
 
I
T
 
E
V
 
V
V
 
I
R
 
R
G
 
G
I
 
T
P
 
P
D
 
L
L
 
L
V
 
V
W
 
Q
M
 
L
F
 
L
L
 
L
L
 
I
F
 
Y
F
 
N
G
 
G
A
 
L
Q
 
M
M
 
Q
A
 
-
L
 
-
N
 
-
D
 
-
I
 
-
C
 
-
G
 
-
Y
 
-
F
 
F
G
 
G
W
 
M
Q
 
N
S
 
I
P
 
P
D
 
-
I
 
-
N
 
-
P
 
A
F
 
F
A
 
T
A
 
A
G
 
G
V
 
V
A
 
S
T
 
A
L
 
L
G
 
A
F
 
I
I
x
N
F
 
S
G
 
S
A
 
A
Y
|
Y
M
 
V
T
 
A
E
 
E
T
 
I
F
 
I
R
 
R
G
 
A
A
 
G
M
 
I
M
 
Q
A
 
A
V
 
V
H
 
D
K
 
P
G
 
G
Q
 
Q
M
 
N
E
 
E
A
 
A
G
 
A
L
 
R
A
 
S
Y
 
L
G
 
G
M
 
M
S
 
T
P
 
H
L
 
A
R
 
M
V
 
A
F
 
M
F
 
R
R
 
Y
I
 
V
Q
 
I
L
 
I
P
 
P
Q
 
Q
M
 
A
V
 
I
R
 
K
Y
 
N
A
 
I
L
 
L
P
 
P
S
 
A
F
 
L
S
 
G
N
 
N
N
x
E
W
 
F
L
 
I
V
 
V
L
 
M
V
 
L
K
 
K
S
x
E
T
 
S
A
 
A
L
 
I
V
 
V
S
 
S
V
 
V
I
 
I
G
 
G
L
 
F
N
 
A
D
 
D
V
 
L
M
 
T
Y
 
R
R
 
Q
A
 
A
D
 
D
A
 
I
A
 
I
K
 
Q
S
 
S
A
 
V
T
 
T
Q
 
Y
Q
 
R
P
 
Y
F
 
F
D
 
E
V
 
P
Y
 
Y
V
 
I
V
 
I
V
 
I
G
 
A
A
 
A
L
 
I
F
 
Y
L
 
F
V
 
V
V
 
M
T
 
T
G
 
L
V
 
T
S
 
F
N
 
S
L
 
K
L
 
L
L
 
L
H
 
S
W
 
L
L
 
F
E
 
E
K
 
R
R
 
R

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
34% identity, 94% coverage: 5:218/228 of query aligns to 11:213/215 of 4ymtC

query
sites
4ymtC
Y
 
Y
L
 
T
P
 
P
S
 
L
I
 
F
L
 
I
E
 
S
G
 
G
G
 
L
V
 
I
L
 
M
T
 
T
L
 
L
K
 
K
L
 
L
A
 
T
G
 
F
T
 
L
S
 
A
L
 
V
V
 
T
V
 
I
S
 
G
V
 
V
A
 
L
L
 
M
G
 
G
L
 
L
V
 
F
G
 
I
A
 
A
L
 
L
F
 
M
K
 
K
S
 
M
S
 
S
H
 
S
S
 
I
R
 
K
P
 
P
L
 
I
T
 
K
L
 
L
L
 
V
A
 
A
E
 
S
F
 
S
Y
 
Y
S
 
I
T
 
E
V
 
V
V
 
I
R
 
R
G
 
G
I
 
T
P
|
P
D
x
L
L
 
L
V
 
V
W
 
Q
M
 
L
F
 
L
L
 
L
L
 
I
F
 
Y
F
 
N
G
 
G
A
 
L
Q
 
M
M
 
Q
A
 
-
L
 
-
N
 
-
D
 
-
I
 
-
C
 
-
G
 
-
Y
 
-
F
 
F
G
 
G
W
 
M
Q
 
N
S
 
I
P
 
P
D
 
-
I
 
-
N
 
-
P
 
A
F
 
F
A
 
T
A
 
A
G
 
G
V
 
V
A
 
S
T
 
A
L
 
L
G
 
A
F
 
I
I
x
N
F
 
S
G
 
S
A
 
A
Y
|
Y
M
 
V
T
 
A
E
 
E
T
 
I
F
 
I
R
 
R
G
 
A
A
 
G
M
 
I
M
 
Q
A
 
A
V
 
V
H
 
D
K
 
P
G
 
G
Q
 
Q
M
 
N
E
 
E
A
 
A
G
 
A
L
 
R
A
 
S
Y
 
L
G
 
G
M
 
M
S
 
T
P
 
H
L
 
A
R
 
M
V
 
A
F
 
M
F
 
R
R
 
Y
I
 
V
Q
 
I
L
 
I
P
 
P
Q
 
Q
M
 
A
V
 
I
R
 
K
Y
 
N
A
 
I
L
 
L
P
 
P
S
 
A
F
 
L
S
 
G
N
 
N
N
x
E
W
 
F
L
 
I
V
 
V
L
x
M
V
 
L
K
|
K
S
x
E
T
 
S
A
 
A
L
 
I
V
 
V
S
 
S
V
 
V
I
 
I
G
 
G
L
 
F
N
 
A
D
 
D
V
 
L
M
 
T
Y
 
R
R
 
Q
A
 
A
D
 
D
A
 
I
A
 
I
K
 
Q
S
 
S
A
 
V
T
 
T
Q
 
Y
Q
 
R
P
 
Y
F
 
F
D
 
E
V
 
P
Y
 
Y
V
 
I
V
 
I
V
 
I
G
 
A
A
 
A
L
 
I
F
 
Y
L
 
F
V
 
V
V
 
M
T
 
T
G
 
L
V
 
T
S
 
F
N
 
S
L
 
K
L
 
L
L
 
L
H
 
S
W
 
L
L
 
F
E
 
E
K
 
R
R
 
R

Query Sequence

>WP_046158296.1 NCBI__GCF_000971335.1:WP_046158296.1
MLQGYLPSILEGGVLTLKLAGTSLVVSVALGLVGALFKSSHSRPLTLLAEFYSTVVRGIP
DLVWMFLLFFGAQMALNDICGYFGWQSPDINPFAAGVATLGFIFGAYMTETFRGAMMAVH
KGQMEAGLAYGMSPLRVFFRIQLPQMVRYALPSFSNNWLVLVKSTALVSVIGLNDVMYRA
DAAKSATQQPFDVYVVVGALFLVVTGVSNLLLHWLEKRYSMGAKESGL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory