SitesBLAST

Q007T0 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip; EC 1.3.5.1 from Sus scrofa (Pig) (see paper)
30% identity, 21% coverage: 22:107/407 of query aligns to 183:279/280 of Q007T0

query
sites
Q007T0

L

L

R

Y

K

E

C
|
C

V

I

H

L

C
|
C

G

A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P

P

T

S

Y

Y

Q

W

L
x
W

L

N

G

G

D

D

E

K

L

Y

D

L

G

G

P

P

R

A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

L

I

E

D

G

S

S

R

D

D

V

D

S

F

T

T

-

E

-

R

-

L

-

A

-

K

-

L

R

Q

T

D

V

P

G

F

H

S

L

L

D

Y

R

R

C
|
C

L

H

T

T

C

I

R

M

S

N

C
|
C

E

T

T

G

T

T

C
|
C

P

P

S

K

G

G

V

L

E

N

Y

P

G

G

H

K

-

A

L

I

V

A

D

E

I

I

G

K

R

K

Q

M

V

M

A

A

-

T

-

Y

-

K

E

E

Q

K

R

K

A

A

S

S

C186 (= C25) binding [4Fe-4S] cluster
C189 (= C28) binding [4Fe-4S] cluster
C192 (= C31) binding [4Fe-4S] cluster
C196 (= C35) binding [3Fe-4S] cluster
W201 (≠ L40) binding a ubiquinone
C243 (= C75) binding [3Fe-4S] cluster
C249 (= C81) binding [3Fe-4S] cluster
C253 (= C85) binding [4Fe-4S] cluster

Sites not aligning to the query:

93 binding [2Fe-2S] cluster
98 binding [2Fe-2S] cluster
101 binding [2Fe-2S] cluster
113 binding [2Fe-2S] cluster

5odcI Heterodisulfide reductase / [nife]-hydrogenase complex from methanothermococcus thermolithotrophicus at 2.3 a resolution (see paper)
30% identity, 24% coverage: 11:107/407 of query aligns to 19:109/173 of 5odcI

query
sites
5odcI

G

G

T

T

P

P

A

I

-

P

G

G

D

D

E

D

A

V

D

V

A

S

I

S

L

L

R

K

K

A

C
|
C

V
x
Y

H
x
Q

C
|
C

G
|
G

F

T

C
|
C

T

T

A

G

T

S

C
|
C

P
|
P

T

S

Y

G

Q

R

L

R

L

T

G

-

D

-

E

-

L

-

D

-

G

S

P
x
Y

R
|
R

G
x
T

R

R

I

K

Y

V

L

I

I

R

K

K

Q

A

M

L

L

L

E

G

G

M

S

D

D

D

V

V

S

L

T

D

R

S

T

-

V

-

G

D

H
x
D

L

I

D

W

R

K

C
|
C

L
x
T

T
|
T

C
|
C

R
x
Y

S

T

C
|
C

E

Y

T

E

T

R

C
|
C

P

P

S

R

G

D

V
|
V

E

K

Y

V

G

T

H

E

L

I

V

I

D

K

I

T

G

I

R

R

Q

N

V

L

A

A

E

A

Q

Q

R

K

A

G

S

N

binding magnesium ion: R53 (= R49), D73 (≠ H71)
binding iron/sulfur cluster: C34 (= C25), Y35 (≠ V26), Q36 (≠ H27), C37 (= C28), G38 (= G29), C40 (= C31), C44 (= C35), P45 (= P36), Y52 (≠ P48), T54 (≠ G50), C77 (= C75), T78 (≠ L76), T79 (= T77), C80 (= C78), Y81 (≠ R79), C83 (= C81), C87 (= C85), V91 (= V89)

Q9YHT2 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip; EC 1.3.5.1 from Gallus gallus (Chicken) (see 2 papers)
28% identity, 21% coverage: 22:105/407 of query aligns to 193:284/290 of Q9YHT2

query
sites
Q9YHT2

L

L

R

Y

K

E

C
|
C

V

I

H

L

C
|
C

G

A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P

P

T

S

Y

Y

Q

W

L
x
W

L

N

G

G

D

D

E

K

L

Y

D

L

G

G

P

P

R

A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

L

I

E

D

G

S

S

R

D

D

V

D

S

Y

T

T

-

E

-

R

-

L

-

A

-

Q

-

L

R

Q

T

D

V

P

G

F

H

S

L

L

D

Y

R

R

C
|
C

L

H

T

T

C

I

R

M

S

N

C
|
C

E

T

T

R

T

T

C
|
C

P

P

S

K

G

G

V

L

E

N

Y

P

G

G

H

K

-

A

L

I

V

A

D

E

I

I

G

K

R

K

Q

M

V

M

A

A

E

T

Q

Y

R

K

C196 (= C25) binding [4Fe-4S] cluster
C199 (= C28) binding [4Fe-4S] cluster
C202 (= C31) binding [4Fe-4S] cluster
C206 (= C35) binding [3Fe-4S] cluster
W211 (≠ L40) binding a ubiquinone
C253 (= C75) binding [3Fe-4S] cluster
C259 (= C81) binding [3Fe-4S] cluster
C263 (= C85) binding [4Fe-4S] cluster

Sites not aligning to the query:

103 binding [2Fe-2S] cluster
108 binding [2Fe-2S] cluster
111 binding [2Fe-2S] cluster
123 binding [2Fe-2S] cluster

1yq3B Avian respiratory complex ii with oxaloacetate and ubiquinone (see paper)
28% identity, 21% coverage: 22:105/407 of query aligns to 150:241/242 of 1yq3B

query
sites
1yq3B

L

L

R

Y

K

E

C
|
C

V
x
I

H
x
L

C
|
C

G
x
A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P
|
P

T

S

Y

Y

Q

W

L
x
W

L

N

G

G

D

D

E

K

L
x
Y

D

L

G

G

P
|
P

R
x
A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

L

I

E

D

G

S

S

R

D

D

V

D

S

Y

T

T

-

E

-

R

-

L

-

A

-

Q

-

L

R

Q

T

D

V

P

G

F

H

S

L

L

D

Y

R

R

C
|
C

L

H

T
|
T

C
x
I

R
x
M

S
x
N

C
|
C

E

T

T

R

T

T

C
|
C

P
|
P

S

K

G

G

V

L

E

N

Y

P

G

G

H

K

-

A

L

I

V

A

D

E

I

I

G

K

R

K

Q

M

V

M

A

A

E

T

Q

Y

R

K

binding fe3-s4 cluster: C163 (= C35), Y173 (≠ L45), P176 (= P48), C210 (= C75), T212 (= T77), I213 (≠ C78), M214 (≠ R79), N215 (≠ S80), C216 (= C81)
binding iron/sulfur cluster: C153 (= C25), I154 (≠ V26), L155 (≠ H27), C156 (= C28), A157 (≠ G29), C159 (= C31), A177 (≠ R49), C220 (= C85), P221 (= P86)
binding Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer: P164 (= P36), W168 (≠ L40), I213 (≠ C78)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 60, 61, 63, 65, 66, 67, 68, 80

6myqB Avian mitochondrial complex ii with ferulenol bound (see paper)
28% identity, 21% coverage: 22:105/407 of query aligns to 147:238/239 of 6myqB

query
sites
6myqB

L

L

R

Y

K

E

C
|
C

V
x
I

H
x
L

C
|
C

G

A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P

P

T

S

Y

Y

Q

W

L
x
W

L

N

G

G

D

D

E

K

L
x
Y

D

L

G

G

P
|
P

R
x
A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

L

I

E

D

G

S

S

R

D

D

V

D

S

Y

T

T

-

E

-

R

-

L

-

A

-

Q

-

L

R

Q

T

D

V

P

G

F

H

S

L

L

D

Y

R

R

C
|
C

L

H

T
|
T

C
x
I

R
x
M

S
x
N

C
|
C

E

T

T

R

T

T

C
|
C

P
|
P

S

K

G

G

V

L

E

N

Y

P

G

G

H

K

-

A

L

I

V

A

D

E

I

I

G

K

R

K

Q

M

V

M

A

A

E

T

Q

Y

R

K

binding 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one: W165 (≠ L40), I210 (≠ C78)
binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), N212 (≠ S80), C213 (= C81)
binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 57, 58, 60, 62, 63, 65, 77

6mysB Avian mitochondrial complex ii with atpenin a5 bound, sidechain outside (see paper)
28% identity, 21% coverage: 22:105/407 of query aligns to 148:239/240 of 6mysB

query
sites
6mysB

L

L

R

Y

K

E

C
|
C

V
x
I

H
x
L

C
|
C

G
x
A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P
|
P

T

S

Y

Y

Q

W

L
x
W

L

N

G

G

D

D

E

K

L
x
Y

D

L

G

G

P
|
P

R
x
A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

L

I

E

D

G

S

S

R

D

D

V

D

S

Y

T

T

-

E

-

R

-

L

-

A

-

Q

-

L

R

Q

T

D

V

P

G

F

H

S

L

L

D

Y

R

R

C
|
C

L
x
H

T
|
T

C
x
I

R
x
M

S
x
N

C
|
C

E

T

T

R

T

T

C
|
C

P

P

S

K

G

G

V

L

E

N

Y

P

G

G

H

K

-

A

L

I

V

A

D

E

I

I

G

K

R

K

Q

M

V

M

A

A

E

T

Q

Y

R

K

binding 3-[(2s,4s,5r)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1h)-pyridinone: P162 (= P36), W166 (≠ L40), H209 (≠ L76), I211 (≠ C78)
binding fe3-s4 cluster: C161 (= C35), Y171 (≠ L45), P174 (= P48), C208 (= C75), T210 (= T77), I211 (≠ C78), M212 (≠ R79), N213 (≠ S80), C214 (= C81)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), A155 (≠ G29), C157 (= C31), A175 (≠ R49), C218 (= C85)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 57, 58, 59, 61, 63, 64, 65, 66, 78

6myrB Avian mitochondrial complex ii with thiapronil bound (see paper)
28% identity, 21% coverage: 22:105/407 of query aligns to 148:239/240 of 6myrB

query
sites
6myrB

L

L

R

Y

K

E

C
|
C

V
x
I

H
x
L

C
|
C

G
x
A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P
|
P

T

S

Y

Y

Q

W

L
x
W

L

N

G

G

D

D

E

K

L
x
Y

D

L

G

G

P
|
P

R
x
A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

L

I

E

D

G

S

S

R

D

D

V

D

S

Y

T

T

-

E

-

R

-

L

-

A

-

Q

-

L

R

Q

T

D

V

P

G

F

H

S

L

L

D

Y

R

R

C
|
C

L
x
H

T
|
T

C
x
I

R
x
M

S
x
N

C
|
C

E

T

T

R

T

T

C
|
C

P

P

S

K

G

G

V

L

E

N

Y

P

G

G

H

K

-

A

L

I

V

A

D

E

I

I

G

K

R

K

Q

M

V

M

A

A

E

T

Q

Y

R

K

binding fe3-s4 cluster: C161 (= C35), Y171 (≠ L45), P174 (= P48), C208 (= C75), H209 (≠ L76), T210 (= T77), I211 (≠ C78), M212 (≠ R79), N213 (≠ S80), C214 (= C81)
binding thiapronil: P162 (= P36), W166 (≠ L40), H209 (≠ L76), I211 (≠ C78)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), A155 (≠ G29), C157 (= C31), A175 (≠ R49), C218 (= C85)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 58, 59, 63, 64, 65, 66, 78

6mypB Avian mitochondrial complex ii with ttfa (thenoyltrifluoroacetone) bound (see paper)
28% identity, 21% coverage: 22:105/407 of query aligns to 148:239/240 of 6mypB

query
sites
6mypB

L

L

R

Y

K

E

C
|
C

V
x
I

H
x
L

C
|
C

G
x
A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P
|
P

T

S

Y

Y

Q

W

L
x
W

L

N

G

G

D

D

E

K

L

Y

D

L

G

G

P

P

R
x
A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

L

I

E

D

G

S

S

R

D

D

V

D

S

Y

T

T

-

E

-

R

-

L

-

A

-

Q

-

L

R

Q

T

D

V

P

G

F

H

S

L

L

D

Y

R

R

C
|
C

L
x
H

T
|
T

C

I

R
x
M

S
x
N

C
|
C

E

T

T

R

T

T

C
|
C

P

P

S

K

G

G

V

L

E

N

Y

P

G

G

H

K

-

A

L

I

V

A

D

E

I

I

G

K

R

K

Q

M

V

M

A

A

E

T

Q

Y

R

K

binding fe3-s4 cluster: C161 (= C35), C208 (= C75), H209 (≠ L76), T210 (= T77), M212 (≠ R79), N213 (≠ S80), C214 (= C81)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), A155 (≠ G29), C157 (= C31), A175 (≠ R49), C218 (= C85)
binding 4,4,4-trifluoro-1-thien-2-ylbutane-1,3-dione: P162 (= P36), W166 (≠ L40), H209 (≠ L76)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 58, 59, 61, 63, 64, 65, 66, 78

6myoB Avian mitochondrial complex ii with flutolanyl bound (see paper)
28% identity, 21% coverage: 22:105/407 of query aligns to 148:239/240 of 6myoB

query
sites
6myoB

L

L

R

Y

K

E

C
|
C

V
x
I

H
x
L

C
|
C

G
x
A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P

P

T

S

Y

Y

Q

W

L
x
W

L

N

G

G

D

D

E

K

L
x
Y

D

L

G

G

P
|
P

R
x
A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

L

I

E

D

G

S

S

R

D

D

V

D

S

Y

T

T

-

E

-

R

-

L

-

A

-

Q

-

L

R

Q

T

D

V

P

G

F

H

S

L

L

D

Y

R

R

C
|
C

L
x
H

T
|
T

C
x
I

R
x
M

S
x
N

C
|
C

E

T

T

R

T

T

C
|
C

P

P

S

K

G

G

V

L

E

N

Y

P

G

G

H

K

-

A

L

I

V

A

D

E

I

I

G

K

R

K

Q

M

V

M

A

A

E

T

Q

Y

R

K

binding fe3-s4 cluster: C161 (= C35), Y171 (≠ L45), P174 (= P48), C208 (= C75), T210 (= T77), I211 (≠ C78), M212 (≠ R79), N213 (≠ S80), C214 (= C81)
binding N-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)benzamide: W166 (≠ L40), H209 (≠ L76), I211 (≠ C78)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), A155 (≠ G29), C157 (= C31), A175 (≠ R49), C218 (= C85)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 58, 59, 61, 63, 64, 65, 66, 78

2fbwB Avian respiratory complex ii with carboxin bound (see paper)
28% identity, 21% coverage: 22:105/407 of query aligns to 148:239/240 of 2fbwB

query
sites
2fbwB

L

L

R

Y

K

E

C
|
C

V
x
I

H
x
L

C
|
C

G

A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P
|
P

T

S

Y

Y

Q

W

L
x
W

L

N

G

G

D

D

E

K

L
x
Y

D

L

G

G

P
|
P

R
x
A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

L

I

E

D

G

S

S

R

D

D

V

D

S

Y

T

T

-

E

-

R

-

L

-

A

-

Q

-

L

R

Q

T

D

V

P

G

F

H

S

L

L

D

Y

R

R

C
|
C

L
x
H

T
|
T

C
x
I

R
x
M

S
x
N

C
|
C

E

T

T

R

T

T

C
|
C

P
|
P

S

K

G

G

V

L

E

N

Y

P

G

G

H

K

-

A

L

I

V

A

D

E

I

I

G

K

R

K

Q

M

V

M

A

A

E

T

Q

Y

R

K

binding 2-methyl-n-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide: P162 (= P36), W166 (≠ L40), H209 (≠ L76)
binding fe3-s4 cluster: C161 (= C35), Y171 (≠ L45), P174 (= P48), C208 (= C75), T210 (= T77), I211 (≠ C78), M212 (≠ R79), N213 (≠ S80), C214 (= C81)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), C157 (= C31), A175 (≠ R49), C218 (= C85), P219 (= P86)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 58, 59, 61, 63, 64, 65, 66, 78

3sfeB Crystal structure of porcine mitochondrial respiratory complex ii bound with oxaloacetate and thiabendazole (see paper)
28% identity, 21% coverage: 22:105/407 of query aligns to 148:239/240 of 3sfeB

query
sites
3sfeB

L

L

R

Y

K

E

C
|
C

V
x
I

H
x
L

C
|
C

G
x
A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P

P

T

S

Y

Y

Q

W

L

W

L

N

G

G

D

D

E

K

L
x
Y

D

L

G

G

P
|
P

R
x
A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

L

I

E

D

G

S

S

R

D

D

V

D

S

F

T

T

-

E

-

R

-

L

-

A

-

K

-

L

R

Q

T

D

V

P

G

F

H

S

L

L

D

Y

R

R

C
|
C

L
x
H

T
|
T

C
x
I

R
x
M

S
x
N

C
|
C

E

T

T

G

T

T

C
|
C

P
|
P

S
x
K

G

G

V
x
L

E

N

Y

P

G

G

H

K

-

A

L

I

V

A

D

E

I

I

G

K

R

K

Q

M

V

M

A

A

E

T

Q

Y

R

K

binding fe3-s4 cluster: C161 (= C35), Y171 (≠ L45), P174 (= P48), C208 (= C75), T210 (= T77), I211 (≠ C78), M212 (≠ R79), N213 (≠ S80), C214 (= C81)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), A155 (≠ G29), C157 (= C31), A175 (≠ R49), C218 (= C85), P219 (= P86), K220 (≠ S87), L222 (≠ V89)
binding 2-(1,3-thiazol-4-yl)-1h-benzimidazole: H209 (≠ L76), I211 (≠ C78)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 58, 59, 61, 63, 64, 65, 66, 78

8gs8B Cryo-em structure of the human respiratory complex ii (see paper)
29% identity, 20% coverage: 22:102/407 of query aligns to 149:237/239 of 8gs8B

query
sites
8gs8B

L

L

R

Y

K

E

C
|
C

V

I

H

L

C
|
C

G

A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P
|
P

T

S

Y

Y

Q

W

L
x
W

L

N

G

G

D

D

E

K

L
x
Y

D

L

G

G

P
|
P

R
x
A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

L

I

E

D

G

S

S

R

D

D

V

D

S

F

T

T

-

E

-

R

-

L

-

A

-

K

-

L

R

Q

T

D

V

P

G

F

H

S

L

L

D

Y

R

R

C
|
C

L
x
H

T
|
T

C
x
I

R
x
M

S
x
N

C
|
C

E

T

T

R

T

T

C
|
C

P

P

S

K

G

G

V

L

E

N

Y

P

G

G

H

K

-

A

L

I

V

A

D

E

I

I

G

K

R

K

Q

M

V

M

A

A

binding fe3-s4 cluster: C162 (= C35), Y172 (≠ L45), P175 (= P48), C209 (= C75), H210 (≠ L76), T211 (= T77), I212 (≠ C78), M213 (≠ R79), N214 (≠ S80), C215 (= C81)
binding iron/sulfur cluster: C152 (= C25), C155 (= C28), C158 (= C31), A176 (≠ R49), C219 (= C85)
binding ubiquinone-1: P163 (= P36), W167 (≠ L40), I212 (≠ C78)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 59, 60, 64, 65, 66, 67, 79

Query Sequence

>WP_047215942.1 NCBI__GCF_001931675.1:WP_047215942.1
MQTHLADFIRGTPAGDEADAILRKCVHCGFCTATCPTYQLLGDELDGPRGRIYLIKQMLE
GSDVSTRTVGHLDRCLTCRSCETTCPSGVEYGHLVDIGRQVAEQRASRPLVQRAQRKFLS
TFLPNPHLFGPALRLGQFLRPMLPRRLRRKIPLSGSSGQWPRQTHQRKMLMLAGCVQPAM
LPNINSATARVFDAVDIQLIMAPEAGCCGAIRHHLSDTAGALDDMRRNIDAWWPHLEQGV
ESIVINASGCGAMVKEYGHLLRHDSRYAARAERVAAAARDPSEILPAHAATLKQRTHRPG
NQVLAYHPPCTLQHAQQLRGEVERLLLELGVNLKPVQDSHLCCGSAGTYSLLQPELATRL
RDNKLAQCEAQRPATILSANVGCIAHLQSGTRTPVRHWIELVDSLLV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory