SitesBLAST

P0AAJ3 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit; Anaerobic formate dehydrogenase iron-sulfur subunit; Formate dehydrogenase-N subunit beta; FDH-N subunit beta from Escherichia coli (strain K12) (see paper)
35% identity, 56% coverage: 56:127/128 of query aligns to 110:187/294 of P0AAJ3

query
sites
P0AAJ3

K

K

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C112 (≠ L58) binding
C133 (= C79) binding
C136 (= C82) binding
C139 (= C85) binding
C143 (= C89) binding
C160 (≠ W100) binding
C163 (= C103) binding
C175 (= C115) binding
C179 (= C119) binding

Sites not aligning to the query:

39 binding
42 binding
45 binding
49 binding
100 binding
103 binding
108 binding

7q4vF Electron bifurcating hydrogenase - hydabc from a. Woodii (see paper)
33% identity, 62% coverage: 46:124/128 of query aligns to 391:467/470 of 7q4vF

query
sites
7q4vF

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binding iron/sulfur cluster: F415 (≠ R70), I417 (= I72), C422 (= C79), G424 (≠ E81), C425 (= C82), G426 (= G83), I427 (≠ A84), C428 (= C85), C432 (= C89), P433 (= P90), I437 (≠ Y94), Y445 (≠ L102), C452 (= C109), K454 (≠ Q111), C455 (= C112), G456 (= G113), A457 (≠ M114), C458 (= C115), C462 (= C119), P463 (= P120), I467 (≠ L124)
binding zinc ion: H398 (≠ R53), C404 (≠ E59), C409 (≠ I64)

Sites not aligning to the query:

binding flavin mononucleotide: 37, 39, 67, 158, 159, 160, 375
binding nicotinamide-adenine-dinucleotide: 40, 43, 48, 177, 180, 297
binding iron/sulfur cluster: 327, 328, 329, 330, 331, 334, 373, 374
binding zinc ion: 311

7q4vB Electron bifurcating hydrogenase - hydabc from a. Woodii (see paper)
33% identity, 62% coverage: 46:124/128 of query aligns to 520:596/599 of 7q4vB

query
sites
7q4vB

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binding iron/sulfur cluster: F544 (≠ R70), C551 (= C79), K552 (≠ V80), G553 (≠ E81), C554 (= C82), G555 (= G83), I556 (≠ A84), C557 (= C85), C561 (= C89), P562 (= P90), Y574 (≠ L102), C581 (= C109), K583 (≠ Q111), C584 (= C112), G585 (= G113), A586 (≠ M114), C587 (= C115), C591 (= C119), F593 (≠ H121), S595 (≠ A123)
binding zinc ion: H527 (≠ R53), C533 (≠ E59)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 11, 16, 48, 49, 51, 52
binding flavin mononucleotide: 166, 168, 196, 198, 284, 287, 288, 289, 324
binding iron/sulfur cluster: 457, 458, 459, 460, 463, 503, 506
binding zinc ion: 440

8a5eB Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from acetobacterium woodii in the reduced state (see paper)
33% identity, 62% coverage: 46:124/128 of query aligns to 368:444/447 of 8a5eB

query
sites
8a5eB

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binding iron/sulfur cluster: F392 (≠ R70), C399 (= C79), G401 (≠ E81), C402 (= C82), G403 (= G83), C405 (= C85), C409 (= C89), P410 (= P90), I414 (≠ Y94), C429 (= C109), K431 (≠ Q111), C432 (= C112), G433 (= G113), C435 (= C115), C439 (= C119), P440 (= P120), I444 (≠ L124)
binding zinc ion: H375 (≠ R53), C381 (≠ E59), C386 (≠ I64)

Sites not aligning to the query:

binding flavin mononucleotide: 14, 16, 44, 135, 137, 171, 172, 352
binding 1,4-dihydronicotinamide adenine dinucleotide: 16, 17, 20, 25, 28, 49, 154, 157, 250
binding iron/sulfur cluster: 151, 305, 306, 307, 308, 311, 351, 354
binding zinc ion: 288

7bkdA Formate dehydrogenase - heterodisulfide reductase - formylmethanofuran dehydrogenase complex from methanospirillum hungatei (heterodislfide reductase core and mobile arm in conformational state 1, composite structure) (see paper)
39% identity, 40% coverage: 76:126/128 of query aligns to 593:646/664 of 7bkdA

query
sites
7bkdA

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binding iron/sulfur cluster: C596 (= C79), A597 (≠ V80), C599 (= C82), G600 (= G83), C602 (= C85), C606 (= C89), L611 (≠ Y94), C629 (= C109), K630 (≠ I110), C632 (= C112), G633 (= G113), C635 (= C115), C639 (= C119), I644 (≠ L124)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 149, 150, 152, 153, 173, 174, 180, 181, 185, 188, 189, 339, 340, 341, 342, 368, 419, 422, 552, 557, 559
binding iron/sulfur cluster: 10, 12, 45, 69, 70, 257, 259, 260, 261, 263, 267, 268, 284, 285, 297, 304, 305, 306, 307, 308, 310, 314, 319, 397, 398, 412, 413, 414, 416, 417, 444

7bkcK Formate dehydrogenase - heterodisulfide reductase - formylmethanofuran dehydrogenase complex from methanospirillum hungatei (dimeric, composite structure) (see paper)
40% identity, 41% coverage: 75:126/128 of query aligns to 32:94/321 of 7bkcK

query
sites
7bkcK

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binding iron/sulfur cluster: C36 (= C79), T37 (≠ V80), C39 (= C82), C42 (= C85), C46 (= C89), P47 (= P90), I51 (≠ Y94), C77 (= C109), S78 (≠ I110), Y79 (≠ Q111), C80 (= C112), G81 (= G113), C83 (= C115), C87 (= C119), L92 (= L124)

Sites not aligning to the query:

binding iron/sulfur cluster: 119, 124, 125, 127, 130, 134, 135, 139, 178, 183, 184, 185, 186, 187, 189, 193, 194, 198, 208, 215, 216, 219, 221, 222, 226, 257, 258, 259, 260, 261, 263, 267, 268

1clfA Clostridium pasteurianum ferredoxin (see paper)
41% identity, 40% coverage: 73:123/128 of query aligns to 2:51/55 of 1clfA

query
sites
1clfA

H

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binding iron/sulfur cluster: I4 (≠ D75), C8 (= C79), V9 (= V80), C11 (= C82), G12 (= G83), A13 (= A84), C14 (= C85), C18 (= C89), P19 (= P90), V20 (≠ M91), F30 (≠ S101), C37 (= C109), I38 (= I110), C40 (= C112), N42 (≠ M114), C43 (= C115), C47 (= C119), A51 (= A123)

P00195 Ferredoxin from Clostridium pasteurianum (see 2 papers)
41% identity, 40% coverage: 73:123/128 of query aligns to 3:52/56 of P00195

query
sites
P00195

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C9 (= C79) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

7p8nB Tmhydabc- t. Maritima hydrogenase with bridge closed (see paper)
34% identity, 37% coverage: 79:125/128 of query aligns to 567:613/613 of 7p8nB

query
sites
7p8nB

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binding iron/sulfur cluster: C567 (= C79), C570 (= C82), G571 (= G83), C573 (= C85), C577 (= C89), Y590 (≠ L102), I592 (≠ V104), C597 (= C109), K599 (≠ Q111), C600 (= C112), G601 (= G113), C603 (= C115), C607 (= C119)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 31, 33, 34, 36, 67, 68, 69, 70, 71
binding flavin mononucleotide: 185, 186, 187, 213, 215, 216, 217, 301, 304, 305, 306, 340, 341, 521, 522
binding iron/sulfur cluster: 320, 473, 474, 475, 476, 477, 480, 519, 520, 522, 523, 560
binding zinc ion: 457, 544, 549, 554

7bkbK Formate dehydrogenase - heterodisulfide reductase - formylmethanofuran dehydrogenase complex from methanospirillum hungatei (hexameric, composite structure) (see paper)
40% identity, 41% coverage: 75:126/128 of query aligns to 32:94/386 of 7bkbK

query
sites
7bkbK

D

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binding iron/sulfur cluster: C36 (= C79), T37 (≠ V80), C39 (= C82), C42 (= C85), C46 (= C89), P47 (= P90), I51 (≠ Y94), C77 (= C109), S78 (≠ I110), Y79 (≠ Q111), C80 (= C112), G81 (= G113), C83 (= C115), C87 (= C119), L92 (= L124)

Sites not aligning to the query:

binding iron/sulfur cluster: 119, 124, 125, 127, 130, 134, 139, 173, 174, 175, 176, 179, 183, 186, 211, 212, 214, 215, 217, 221, 222, 241, 248, 249, 251, 254, 258, 259, 263, 265, 273, 280, 281, 284, 286, 287, 291, 322, 323, 324, 325, 326, 328, 332, 333

P00219 Zinc-containing ferredoxin from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
29% identity, 73% coverage: 34:126/128 of query aligns to 1:100/103 of P00219

query
sites
P00219

N

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K29 (≠ A63) modified: N6-methyllysine

8a8oD Paps reductase from methanothermococcus thermolithotrophicus refined to 1.45 a (see paper)
38% identity, 40% coverage: 76:126/128 of query aligns to 6:57/102 of 8a8oD

query
sites
8a8oD

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L

M

binding iron/sulfur cluster: C9 (= C79), I10 (≠ V80), G11 (≠ E81), C12 (= C82), G13 (= G83), C15 (= C85), C19 (= C89), P20 (= P90), S32 (= S101), C40 (= C109), W41 (≠ I110), D42 (≠ Q111), C43 (= C112), A44 (≠ G113), C46 (= C115), C50 (= C119), I55 (≠ L124)

Sites not aligning to the query:

binding iron/sulfur cluster: 2

5t61L Tungsten formylmethanofuran dehydrogenase subunit fwdF (see paper)
39% identity, 41% coverage: 75:126/128 of query aligns to 266:324/348 of 5t61L

query
sites
5t61L

D

D

E

Q

E

D

E

T

C
|
C

V

Q

E
x
A

C
|
C

G
x
E

A

T

C
|
C

I

V

S

M

V

V

C
|
C

P
|
P

M

C

N

N

V
|
V

Y

L

S

S

F

F

-

P

-

K

-

P

-

E

-

K

-

P

-

G

D

E

E

K

T

T

W

T

S

K

L

L

C

H

V

K

D

D

E

E

K

R

K

F

C
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C

I
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I

Q
x
Y

C
|
C

G
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G

M

A

C
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C

I

E

K

R

M

S

C
|
C

P

P

H

V

G

T

A

A

L

I

K

T

L

V

binding iron/sulfur cluster: C270 (= C79), A272 (≠ E81), C273 (= C82), E274 (≠ G83), C276 (= C85), C280 (= C89), P281 (= P90), V284 (= V93), C307 (= C109), I308 (= I110), Y309 (≠ Q111), C310 (= C112), G311 (= G113), C313 (= C115), C317 (= C119)

Sites not aligning to the query:

binding iron/sulfur cluster: 30, 31, 32, 33, 34, 36, 40, 41, 70, 71, 72, 73, 74, 76, 80, 85, 114, 117, 118, 120, 124, 129, 146, 153, 156, 159, 163, 164, 168, 186, 193, 195, 196, 197, 199, 203, 204, 208, 212, 215, 238, 239, 240, 241, 242, 244, 248, 249

3egwB The crystal structure of the narghi mutant narh - c16a
32% identity, 67% coverage: 36:121/128 of query aligns to 146:229/509 of 3egwB

query
sites
3egwB

D

D

S

D

T

L

Y

G

G

G

E

E

L

F

I

D

A

K

D

L

V

A

K

K

D

D

S

K

R

N

F

F

A

D

R

N

I

I

K

Q

K

K

A

A

L

M

E

Y

S

S

R

Q

G

F

A

E

I

N

V

T

A

F

I

M

L

M

D

Y

R

L

P
|
P

I

-

H

-

R

R

D

L

E
x
C

E
|
E

E
x
H

C
|
C

V

L

E

N

C

-

G
x
P

A

A

C
|
C

I

V

S

A

V

T

C
|
C

P

P

M
x
S

N

G

-

A

V
x
I

Y

Y

S

K

F

R

D

E

E

E

T

D

W

G

S

I

L

V

C

L

V

I

D

D

E

Q

K

D

K

K

C
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C

I
x
R

Q
x
G

C
x
W

G
x
R

M

M

C
|
C

I

I

K

T

M

G

C
|
C

P

P

H

Y

binding fe3-s4 cluster: P181 (= P71), C196 (= C89), S198 (≠ M91), I201 (≠ V93), C217 (= C109), R218 (≠ I110), G219 (≠ Q111), W220 (≠ C112), R221 (≠ G113), C223 (= C115)
binding protoporphyrin ix containing fe: W220 (≠ C112), R221 (≠ G113)
binding iron/sulfur cluster: C184 (≠ E76), E185 (= E77), H186 (≠ E78), C187 (= C79), P190 (≠ G83), C192 (= C85), C227 (= C119)

Sites not aligning to the query:

binding fe3-s4 cluster: 17, 18, 19, 20, 22, 241, 263, 265, 268
binding protoporphyrin ix containing fe: 88, 89
binding iron/sulfur cluster: 26, 30, 41, 42, 232, 243, 244, 246, 247, 257, 259

P11349 Respiratory nitrate reductase 1 beta chain; Nitrate reductase A subunit beta; Quinol-nitrate oxidoreductase subunit beta; EC 1.7.5.1 from Escherichia coli (strain K12) (see 2 papers)
32% identity, 67% coverage: 36:121/128 of query aligns to 146:229/512 of P11349

query
sites
P11349

D

D

S

D

T

L

Y

G

G

G

E

E

L

F

I

D

A

K

D

L

V

A

K

K

D

D

S

K

R

N

F

F

A

D

R

N

I

I

K

Q

K

K

A

A

L

M

E

Y

S

S

R

Q

G

F

A

E

I

N

V

T

A

F

I

M

L

M

D

Y

R

L

P

P

I

-

H

-

R

R

D

L

E
x
C

E

E

E

H

C
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C

V

L

E

N

C

-

G

P

A

A

C
|
C

I

V

S

A

V

T

C
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C

P

P

M

S

N

G

-

A

V

I

Y

Y

S

K

F

R

D

E

E

E

T

D

W

G

S

I

L

V

C

L

V

I

D

D

E

Q

K

D

K

K

C
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C

I

R

Q

G

C

W

G

R

M

M

C
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C

I

I

K

T

M

G

C
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C

P

P

H

Y

C184 (≠ E76) binding
C187 (= C79) binding
C192 (= C85) binding
C196 (= C89) binding
C217 (= C109) binding
C223 (= C115) binding
C227 (= C119) binding

Sites not aligning to the query:

16 binding
19 binding
22 binding
26 binding
244 binding
247 binding
259 binding
263 binding

6x6uB Wor5 from pyrococcus furiosus, taurine-bound (see paper)
47% identity, 33% coverage: 79:120/128 of query aligns to 52:96/167 of 6x6uB

query
sites
6x6uB

C
|
C

V
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V

E

Q

C
|
C

G

P

-

D

-

Y

A
x
P

C
|
C

I

V

S

N

V

A

C
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C

P
|
P

M

T

N

N

V

A

Y
x
L

S

S

F

V

D

D

E

E

-

K

T

T

W

G

S

A

L

V

C

V

V

V

D

N

E

E

K

E

K

K

C
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C

I
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I

Q
x
T

C
|
C

G
|
G

M

A

C
|
C

I

V

K

L

M

A

C
|
C

P

P

binding iron/sulfur cluster: C52 (= C79), V53 (= V80), C55 (= C82), P59 (≠ A84), C60 (= C85), C64 (= C89), P65 (= P90), L69 (≠ Y94), C85 (= C109), I86 (= I110), T87 (≠ Q111), C88 (= C112), G89 (= G113), C91 (= C115), C95 (= C119)

Sites not aligning to the query:

binding phosphate ion: 10, 128, 130, 161, 162
binding iron/sulfur cluster: 12, 13, 15, 16, 18, 22, 26, 36, 37, 39, 100, 112, 113, 114, 115, 119, 121, 125, 130, 133

8oh5C Cryo-em structure of the electron bifurcating transhydrogenase stnabc complex from sporomusa ovata (state 2) (see paper)
35% identity, 41% coverage: 72:123/128 of query aligns to 606:670/1172 of 8oh5C

query
sites
8oh5C

I

I

H

E

R

R

D

N

E

P

E

D

E

K

C
|
C

V
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V

E
x
L

C
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C

G
|
G

A

L

C
|
C

I

V

S

R

V

V

C
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C

P

D

M

E

N

V

V

V

Y

G

S

A

-

T

-

A

-

I

-

G

-

L

-

V

-

G

-

R

-

G

F

F

D

D

E

S

T

V

-
x
I

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M

-

P

-

E

W

F

S

K

L

L

C

P

V

L

D

S

E

E

K

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K

A

C
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C

I
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I

Q
x
S

C
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C

G
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G

M

Q

C
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C

I

V

K

D

M

V

C
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C

P

P

H

T

G
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G

A
|
A

binding iron/sulfur cluster: C613 (= C79), V614 (= V80), L615 (≠ E81), C616 (= C82), G617 (= G83), C619 (= C85), C623 (= C89), I643 (vs. gap), C656 (= C109), I657 (= I110), S658 (≠ Q111), C659 (= C112), G660 (= G113), C662 (= C115), C666 (= C119), G669 (= G122), A670 (= A123)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 199, 201, 202, 203, 222, 223, 229, 230, 235, 239, 264, 265, 285, 288, 332, 471, 477, 479
binding fe2/s2 (inorganic) cluster: 36, 45, 47, 48, 50, 64
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: 330, 331, 332, 333, 353, 354, 355, 432, 433, 434, 477
binding iron/sulfur cluster: 96, 98, 100, 102, 104, 108, 147, 149, 151, 155, 156, 164, 170, 480, 562, 563, 565, 567, 573, 692, 694, 695, 699, 725, 727, 728, 853

7z0sF Structure of the escherichia coli formate hydrogenlyase complex (anaerobic preparation, without formate dehydrogenase h) (see paper)
27% identity, 61% coverage: 51:128/128 of query aligns to 1:93/164 of 7z0sF

query
sites
7z0sF

F

F

A

T

R

F

I

I

K

K

A

V

L

I

E

K

S

T

R

G

G

T

A

A

I

T

V

S

A

S

I

Y

L

P

D

L

R

E

P

P

I

I

H

A

R

V

D

D

E

K

-

N

-

F

-

R

-

G

-

K

-

P

-

E

-

Q

-

N

-

P

E

Q

C
|
C

V
x
I

E

G

C
|
C

G
x
A

A
|
A

C
|
C

I

V

S

N

V

A

C
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C

P
|
P

M

S

N

N

V
x
A

Y
x
L

S

T

F

V

D

E

E

T

-

D

-

L

-

A

-

T

-

G

-

E

-

L

T

A

W
|
W

S

E

L
x
F

C

N

V

L

D

G

E

H

K

-

C
|
C

I
|
I

Q
x
F

C
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C

G
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G

M

R

C
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C

I

E

K

E

M

V

C
|
C

P
|
P

H

T

G

A

A
|
A

L
x
I

K

K

L

L

G

S

E

Q

binding iron/sulfur cluster: C39 (= C79), I40 (≠ V80), C42 (= C82), A43 (≠ G83), A44 (= A84), C45 (= C85), C49 (= C89), P50 (= P90), A53 (≠ V93), L54 (≠ Y94), W67 (= W100), F69 (≠ L102), C74 (= C109), I75 (= I110), F76 (≠ Q111), C77 (= C112), G78 (= G113), C80 (= C115), C84 (= C119), P85 (= P120), A88 (= A123), I89 (≠ L124)

Sites not aligning to the query:

binding fe (iii) ion: 116, 119, 154, 157

Query Sequence

>WP_048065229.1 NCBI__GCF_000007345.1:WP_048065229.1
MKIKICIPTERIQNPIISETIVETGILLNIMVANIDSTYGELIADVKDSRFARIKKALES
RGAIVAILDRPIHRDEEECVECGACISVCPMNVYSFDETWSLCVDEKKCIQCGMCIKMCP
HGALKLGE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory