SitesBLAST

Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
30% identity, 80% coverage: 8:208/250 of query aligns to 6:214/353 of Q97UY8

query
sites
Q97UY8

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N

V

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S

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K

K

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F

F

-

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G

G

K

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L

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A

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H

D

D

N

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E

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S142 (= S138) mutation to A: Decrease in ATPase activity. Can form dimers.
G144 (= G140) mutation to A: Loss of ATPase activity. Cannot form dimers. Forms an active heterodimer; when associated with A-166.
E166 (= E162) mutation to A: Loss of ATPase activity. Can form dimers in the presence of ATP-Mg(2+). Forms an active heterodimer; when associated with A-144.; mutation to Q: Strong decrease in ATPase activity. Can form dimers in the presence of ATP alone, without Mg(2+).

1vciA Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
29% identity, 82% coverage: 6:210/250 of query aligns to 7:204/353 of 1vciA

query
sites
1vciA

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V

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F
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F

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x
F

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binding adenosine-5'-triphosphate: F16 (= F15), F19 (≠ L18), S41 (≠ N40), G42 (= G41), G44 (= G43), K45 (= K44), T46 (≠ S45), T47 (= T46)

P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see 2 papers)
28% identity, 92% coverage: 8:238/250 of query aligns to 14:254/265 of P07821

query
sites
P07821

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H

K50 (= K44) mutation to Q: Lack of activity.
D172 (= D161) mutation to E: Lack of activity.
E173 (= E162) mutation to A: Lack of activity.

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
27% identity, 82% coverage: 5:209/250 of query aligns to 4:210/285 of 4yerA

query
sites
4yerA

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D

binding adenosine-5'-diphosphate: F14 (= F15), F17 (≠ L18), N39 (= N40), G40 (= G41), G42 (= G43), K43 (= K44), T44 (≠ S45), T45 (= T46), T135 (≠ E136), F136 (≠ I137), S137 (= S138)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
33% identity, 76% coverage: 5:195/250 of query aligns to 5:206/233 of P75957

query
sites
P75957

V

L

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N

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G42 (= G38) mutation to D: Loss of lipoprotein release when overexpressed.

7arlD Lolcde in complex with lipoprotein and adp (see paper)
33% identity, 76% coverage: 5:195/250 of query aligns to 2:203/222 of 7arlD

query
sites
7arlD

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D

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G

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G
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G

K
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S
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S

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T

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-

I

-

N

E

S

A

R

A

A

E

L

K

E

A

M

L

L

K

K

D

A

V

V

D

G

I

L

Y

D

K

H

L

R

R

A

D

N

R

H

Q

R

I

P

S

S

E

E

I

L

S

S

G

G

Q

E

M

R

Q

Q

R

R

V

V

F

A

I

I

A

A

R

R

S

A

I

L

V

V

R

N

E

N

P

P

K

R

L

L

L

V

I

L

M

A

D

D

E

E

P

P

M

T

A

G

S

N

I

L

D

D

P

A

E

R

M

N

Q

A

N

D

S

S

F

I

Y

F

K

Q

L

L

S

G

R

E

L

L

N

N

-

R

-

L

D

Q

K

G

M

T

T

A

I

F

I

L

L

V

I

V

S

T

H

H

D

D

V

L

binding adenosine-5'-diphosphate: G42 (= G41), G44 (= G43), K45 (= K44), S46 (= S45)

7mdyC Lolcde nucleotide-bound
33% identity, 76% coverage: 5:195/250 of query aligns to 2:203/226 of 7mdyC

query
sites
7mdyC

V

L

E

Q

I

C

S

D

N

N

V

L

S

C

K

K

K

R

F
x
Y

G

Q

K

E

L

G

S

S

V

V

-

Q

-

T

-

D

-

V

L

L

H

H

D

N

I

V

N

S

L

F

S

S

V

V

N

G

E

E

K

G

D

E

L

M

M

M

A

A

I

I

I

V

G

G

P

S

N

S

G
|
G

G
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

I

L

K

H

I

L

M

G

G

G

I

L

L

D

T

T

P

P

D

T

T

S

G

G

E

D

V

V

K

-

I

I

F

F

G

N

R

G

E

Q

P

P

K

M

-

S

-

K

-

L

-

S

-

A

-

K

-

A

-

E

-

L

K

R

S

N

R

Q

K

K

L

L

M

-

G

G

Y

F

L

I

P

Y

Q
|
Q

H

F

V

H

A

H

F

L

D

L

P

P

D

D

F

F

P

-

I

-

N

-

V

-

F

-

D

-

T

T

V

A

L

L

S

E

G

N

R

V

Y

A

H

M

G

P

L

L

F

L

K

I

G

G

Y

K

T

K

K

K

S

P

D

A

E

E

-

I

-

N

E

S

A

R

A

A

E

L

K

E

A

M

L

L

K

K

D

A

V

V

D

G

I

L

Y

D

K

H

L

R

R

A

D

N

R
x
H

Q

R

I

P

S

S

E
|
E

I

L

S
|
S

G
|
G

Q

E

M

R

Q

Q

R

R

V

V

F

A

I

I

A

A

R

R

S

A

I

L

V

V

R

N

E

N

P

P

K

R

L

L

L

V

I

L

M

A

D

D

E
|
E

P

P

M

T

A

G

S
x
N

I

L

D

D

P

A

E

R

M

N

Q

A

N

D

S

S

F

I

Y

F

K

Q

L

L

S

G

R

E

L

L

N

N

-

R

-

L

D

Q

K

G

M

T

T

A

I

F

I

L

L

V

I

V

S

T

H
|
H

D

D

V

L

binding adp orthovanadate: Y12 (≠ F15), G42 (= G41), S43 (≠ G42), G44 (= G43), K45 (= K44), S46 (= S45), T47 (= T46), Q91 (= Q81), H138 (≠ R132), E142 (= E136), S144 (= S138), G145 (= G139), G146 (= G140), E168 (= E162), N172 (≠ S166), H201 (= H193)
binding magnesium ion: S46 (= S45), Q91 (= Q81)

Query Sequence

>WP_048081113.1 NCBI__GCF_000746075.1:WP_048081113.1
MASKVVEISNVSKKFGKLSVLHDINLSVNEKDLMAIIGPNGGGKSTLIKIIMGILTPDTG
EVKIFGREPKKSRKLMGYLPQHVAFDPDFPINVFDTVLSGRYHGLFKGYTKSDEEAAEKA
LKDVDIYKLRDRQISEISGGQMQRVFIARSIVREPKLLIMDEPMASIDPEMQNSFYKLLS
RLNDKMTIILISHDVGAVSAHVDKIACLNRELFYHGPVEGSAKGLEEVYKCPLELISHGI
PHRVLGKHEK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features