SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_048081777.1 NCBI__GCF_000745485.1:WP_048081777.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
47% identity, 98% coverage: 4:224/226 of query aligns to 1:223/232 of 1f3oA

query
sites
1f3oA

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binding adenosine-5'-diphosphate: Y11 (= Y14), G41 (= G44), G43 (= G46), K44 (= K47), S45 (= S48), T46 (= T49)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
47% identity, 98% coverage: 4:224/226 of query aligns to 1:223/230 of 1l2tA

query
sites
1l2tA

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binding adenosine-5'-triphosphate: Y11 (= Y14), S40 (= S43), G41 (= G44), S42 (= S45), G43 (= G46), K44 (= K47), S45 (= S48), T46 (= T49), F138 (≠ M142), Q145 (≠ K148), S147 (= S150), G149 (= G152), Q150 (≠ E153), H204 (= H206)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
46% identity, 98% coverage: 4:225/226 of query aligns to 3:221/226 of 5xu1B

query
sites
5xu1B

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binding magnesium ion: G45 (= G46), K46 (= K47), S47 (= S48)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
45% identity, 98% coverage: 4:224/226 of query aligns to 5:223/233 of P75957

query
sites
P75957

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G42 (= G41) mutation to D: Loss of lipoprotein release when overexpressed.

7mdyC Lolcde nucleotide-bound
45% identity, 98% coverage: 4:224/226 of query aligns to 2:220/226 of 7mdyC

query
sites
7mdyC

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binding adp orthovanadate: Y12 (= Y14), G42 (= G44), S43 (= S45), G44 (= G46), K45 (= K47), S46 (= S48), T47 (= T49), Q91 (= Q93), H138 (≠ Y144), E142 (≠ K148), S144 (= S150), G145 (= G151), G146 (= G152), E168 (= E174), N172 (= N178), H201 (= H206)
binding magnesium ion: S46 (= S48), Q91 (= Q93)

7arlD Lolcde in complex with lipoprotein and adp (see paper)
45% identity, 98% coverage: 4:224/226 of query aligns to 2:220/222 of 7arlD

query
sites
7arlD

L

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I

I

F

Y

Q

Q

T

F

F

H

N

H

L

L

L

L

P

P

A

D

L

F

T

T

V

A

R

L

D

E

N

N

V

V

E

A

F

M

P

P

M

L

R

-

N

-

L

L

N

I

G

G

S

K

K

K

K

K

M

P

N

A

K

E

S

I

S

N

R

-

I

-

K

S

K

R

A

A

E

L

E

E

C

M

I

L

E

K

I

A

V

V

G

G

L

L

G

D

D

H

R

R

M

A

D

N

Y

H

L

R

P

P

A

S

K

E

L

L

S

S

G

G

G

G

E

E

R

R

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

V

V

N

N

N

N

P

P

K

R

F

L

I

V

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

A

E

R

S

N

T

A

E

D

N

S

I

I

I

F

N

Q

L

L

L

L

H

G

E

E

V

L

N

N

Q

R

N

L

E

Q

-

G

T

T

T

A

V

F

I

L

M

V

V

V

T

T

H

H

D

D

A

L

E

Q

T

L

T

A

K

K

N

R

-

M

T

S

R

R

I

Q

M

L

K

E

I

M

R

R

D

D

G

G

K

R

I

L

binding adenosine-5'-diphosphate: G42 (= G44), G44 (= G46), K45 (= K47), S46 (= S48)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
44% identity, 98% coverage: 4:224/226 of query aligns to 4:222/229 of 7v8iD

query
sites
7v8iD

L

L

I

L

N

Q

G

C

N

D

E

N

L

L

W

C

K

K

T

R

Y

Y

K

Q

L

E

D

G

S

S

T

V

E

Q

V

T

H

D

A
x
V

L

L

R

H

G

N

L

V

N

S

I

F

T

S

V

V

G

G

E

E

G

G

E

E

F

M

V

M

S

A

I

I

M

V

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

L

N

H

M

L

I

L

G

G

G

G

L

L

D

D

N

T

P

P

T

T

K

S

G

G

D

D

L

V

F

I

I

F

D

N

G

G

K

Q

D

P

I

M

S

S

R

K

M

L

S

S

E

S

G

A

E

A

L

K

T

A

R

E

M

L

R

R

A

N

E

Q

K

K

I

L

G

G

F

F

I

I

F

Y

Q
|
Q

T

F

F

H

N

H

L

L

L

L

P

P

A

D

L

F

T

T

V

A

R

L

D

E

N

N

V

V

E

A

F

M

P

P

M

L

R

-

N

-

L

L

N

I

G

G

S

K

K

K

K

K

M

P

N

A

K

E

S

I

S

N

R

-

I

-

K

S

K

R

A

A

E

L

E

E

C

M

I

L

E

K

I

A

V

V

G

G

L

L

G

D

D

H

R
|
R

M

A

D

N

Y
x
H

L

R

P

P

A

S

K
x
E

L

L

S
|
S

G

G

G
|
G

E
|
E

R

R

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

V

V

N

N

N

N

P

P

K

R

F

L

I

V

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

N

L

L

D

D

S

A

E

R

S

N

T

A

E

D

N

S

I

I

I

F

N

Q

L

L

L

L

H

G

E

E

V

L

N

N

Q

R

N

L

E

Q

-

G

T

T

T

A

V

F

I

L

M

V

V

V

T

T

H
|
H

D

D

A

L

E

Q

T

L

T

A

K

K

N

R

-

M

T

S

R

R

I

Q

M

L

K

E

I

M

R

R

D

D

G

G

K

R

I

L

binding phosphoaminophosphonic acid-adenylate ester: V23 (≠ A23), S43 (= S43), G44 (= G44), G46 (= G46), K47 (= K47), S48 (= S48), T49 (= T49), Q93 (= Q93), R137 (= R141), H140 (≠ Y144), E144 (≠ K148), S146 (= S150), G148 (= G152), E149 (= E153), H203 (= H206)
binding magnesium ion: S48 (= S48), Q93 (= Q93)

9gvkD Cryo-em structure of endogenous atp-bound lolcde with lold-e171q mutations in nanodiscs (see paper)
44% identity, 98% coverage: 4:224/226 of query aligns to 3:221/226 of 9gvkD

query
sites
9gvkD

L

L

I

L

N

Q

G

C

N

D

E

N

L

L

W

C

K

K

T

R

Y
|
Y

K

Q

L

E

D

G

S

S

T

V

E

Q

V

T

H

D

A

V

L

L

R

H

G

N

L

V

N

S

I

F

T

S

V

V

G

G

E

E

G

G

E

E

F

M

V

M

S

A

I

I

M

V

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

L

N

H

M

L

I

L

G

G

G

G

L

L

D

D

N

T

P

P

T

T

K

S

G

G

D

D

L

V

F

I

I

F

D

N

G

G

K

Q

D

P

I

M

S

S

R

K

M

L

S

S

E

S

G

A

E

A

L

K

T

A

R

E

M

L

R

R

A

N

E

Q

K

K

I

L

G

G

F

F

I

I

F

Y

Q
|
Q

T

F

F

H

N

H

L

L

L

L

P

P

A

D

L

F

T

T

V

A

R

L

D

E

N

N

V

V

E

A

F

M

P

P

M

L

R

-

N

-

L

L

N

I

G

G

S

K

K

K

K

K

M

P

N

A

K

E

S

I

S

N

R

-

I

-

K

S

K

R

A

A

E

L

E

E

C

M

I

L

E

K

I

A

V

V

G

G

L

L

G

D

D

H

R
|
R

M

A

D

N

Y
x
H

L

R

P

P

A

S

K
x
E

L

L

S
|
S

G
|
G

G
|
G

E
|
E

R

R

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

V

V

N

N

N

N

P

P

K

R

F

L

I

V

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

N

L

L

D

D

S

A

E

R

S

N

T

A

E

D

N

S

I

I

I

F

N

Q

L

L

L

L

H

G

E

E

V

L

N

N

Q

R

N

L

E

Q

-

G

T

T

T

A

V

F

I

L

M

V

V

V

T

T

H

H

D

D

A

L

E

Q

T

L

T

A

K

K

N

R

-

M

T

S

R

R

I

Q

M

L

K

E

I

M

R

R

D

D

G

G

K

R

I

L

binding adenosine-5'-triphosphate: Y13 (= Y14), S42 (= S43), G43 (= G44), G45 (= G46), K46 (= K47), S47 (= S48), T48 (= T49), Q92 (= Q93), R136 (= R141), H139 (≠ Y144), E143 (≠ K148), S145 (= S150), G146 (= G151), G147 (= G152), E148 (= E153)
binding magnesium ion: S47 (= S48), Q92 (= Q93)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
41% identity, 99% coverage: 1:224/226 of query aligns to 1:221/648 of P75831

query
sites
P75831

M

M

N

T

G

P

L

L

I

L

N

E

G

L

N

K

E

D

L

I

W

R

K

R

T

S

Y

Y

K

P

L

A

D

G

S

D

T

E

E

Q

V

V

H

E

A

V

L

L

R

K

G

G

L

I

N

S

I

L

T

D

V

I

G

Y

E

A

G

G

E

E

F

M

V

V

S

A

I

I

M

V

G

G

P

A

S

S

G

G

S

S

G

G

K
|
K

S

S

T

T

L

L

L

M

N

N

M

I

I

L

G

G

G

C

L

L

D

D

N

K

P

A

T

T

K

S

G

G

D

T

L

Y

F

R

I

V

D

A

G

G

K

Q

D

D

I

V

S

A

R

T

M

L

S

D

E

A

G

D

E

A

L

L

T

A

R

Q

M

L

R

R

A

R

E

E

K

H

I

F

G

G

F

F

I

I

F

F

Q

Q

T

R

F

Y

N

H

L

L

L

L

P

S

A

H

L

L

T

T

V

A

R

E

D

Q

N

N

V

V

E

E

F

V

P

P

M

A

R

V

N

Y

L

-

N

-

G

-

S

-

K

A

K

G

M

L

N

E

K

R

S

K

S

Q

R

R

I

L

K

L

K

R

A

A

E

Q

E

E

C

L

I

L

E

Q

I

R

V

L

G

G

L

L

G

E

D

D

R

R

M

T

D

E

Y

Y

L

Y

P

P

A

A

K

Q

L

L

S

S

G

G

G

G

E

Q

R

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

V

M

N

N

N

G

P

G

K

Q

F

V

I

I

L

L

A

A

D
|
D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

S

S

E

H

S

S

T

G

E

E

N

E

I

V

I

M

N

A

L

I

L

L

H

H

E

Q

V

L

N

R

Q

D

N

R

E

G

T

H

T

T

V

V

I

I

M

I

V

V

T

T

H

H

D

D

A

P

E

Q

T

V

T

A

K

A

N

Q

T

A

-

E

R

R

I

V

M

I

K

E

I

I

R

R

D

D

G

G

K

E

I

I

K47 (= K47) mutation to L: Lack of activity.
D169 (= D173) mutation to N: Lack of activity.

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
45% identity, 90% coverage: 21:224/226 of query aligns to 20:220/615 of 5lilA

query
sites
5lilA

V

V

H

H

A
x
V

L

L

R

K

G

D

L

I

N

S

I

L

T

S

V

I

G

E

E

R

G

G

E

D

F

F

V

V

S

A

I

I

M

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

N

N

M

I

I

I

G

G

G

C

L

L

D

D

N

T

P

A

T

T

K

G

G

G

D

S

L

S

F

K

I

I

D

D

G

G

K

K

D

E

I

T

S

I

R

E

M

L

S

T

E

N

G

D

E

Q

L

L

T

S

R

D

M

L

R

R

A

S

E

Q

K

K

I

F

G

G

F

F

I

I

F

F

Q
|
Q

T

R

F

Y

N

N

L

L

L

L

P

S

A

S

L

L

T

T

V

A

R

A

D

E

N

N

V

V

E

A

F

L

P

P

M

A

R

I

N

-

L

-

N

-

G

-

S

Y

K

A

K

G

M

M

N

P

K

Q

S

S

S

Q

R

R

I

L

K

E

K

R

A

A

E

K

E

Q

C

L

I

L

E

E

I

K

V

L

G

G

L

L

G

G

D

D

R
x
K

M

W

D

Q

Y

N

L

K

P

P

A

N

K
x
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

R

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

V

M

N

N

N

G

P

G

K

E

F

I

I

I

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

S

S

E

H

S

S

T

G

E

E

N

N

I

V

I

M

N

E

L

I

L

L

H

R

E

Q

V

L

N

H

Q

E

N

E

E

G

T

H

T

T

V

I

I

I

M

M

V

V

T

T

H

H

D

D

A

K

E

H

T

I

T

A

K

A

N

S

T

A

-

N

R

R

I

I

M

I

K

E

I

I

R

K

D

D

G

G

K

E

I

I

binding adenosine-5'-triphosphate: V22 (≠ A23), S42 (= S43), G43 (= G44), G45 (= G46), K46 (= K47), S47 (= S48), T48 (= T49), Q92 (= Q93), K136 (≠ R141), Q143 (≠ K148), S145 (= S150), G147 (= G152), Q148 (≠ E153)
binding magnesium ion: S47 (= S48), Q92 (= Q93)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 13

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
45% identity, 90% coverage: 21:224/226 of query aligns to 20:220/592 of 5lj7A

query
sites
5lj7A

V

V

H

H

A
x
V

L

L

R

K

G

D

L

I

N

S

I

L

T

S

V

I

G

E

E

R

G

G

E

D

F

F

V

V

S

A

I

I

M

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

N

N

M

I

I

I

G

G

G

C

L

L

D

D

N

T

P

A

T

T

K

G

G

G

D

S

L

S

F

K

I

I

D

D

G

G

K

K

D

E

I

T

S

I

R

E

M

L

S

T

E

N

G

D

E

Q

L

L

T

S

R

D

M

L

R

R

A

S

E

Q

K

K

I

F

G

G

F

F

I

I

F

F

Q
|
Q

T

R

F

Y

N

N

L

L

L

L

P

S

A

S

L

L

T

T

V

A

R

A

D

E

N

N

V

V

E

A

F

L

P

P

M

A

R

I

N

-

L

-

N

-

G

-

S

Y

K

A

K

G

M

M

N

P

K

Q

S

S

S

Q

R

R

I

L

K

E

K

R

A

A

E

K

E

Q

C

L

I

L

E

E

I

K

V

L

G

G

L

L

G

G

D

D

R
x
K

M

W

D

Q

Y

N

L

K

P

P

A

N

K
x
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

R

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

V

M

N

N

N

G

P

G

K

E

F

I

I

I

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

S

S

E

H

S

S

T

G

E

E

N

N

I

V

I

M

N

E

L

I

L

L

H

R

E

Q

V

L

N

H

Q

E

N

E

E

G

T

H

T

T

V

I

I

I

M

M

V

V

T

T

H

H

D

D

A

K

E

H

T

I

T

A

K

A

N

S

T

A

-

N

R

R

I

I

M

I

K

E

I

I

R

K

D

D

G

G

K

E

I

I

binding adenosine-5'-triphosphate: V22 (≠ A23), S42 (= S43), G43 (= G44), G45 (= G46), K46 (= K47), S47 (= S48), T48 (= T49), Q92 (= Q93), K136 (≠ R141), Q143 (≠ K148), S145 (= S150), G147 (= G152), Q148 (≠ E153)
binding magnesium ion: S47 (= S48), Q92 (= Q93)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
45% identity, 89% coverage: 24:225/226 of query aligns to 19:217/223 of 2pclA

query
sites
2pclA

L

L

R

K

G

G

L

I

N

S

I

L

T

S

V

V

G

K

E

K

G

G

E

E

F

F

V

V

S

S

I

I

M

I

G

G

P

A

S

S

G

G

S

S

G

G

K

K

S

S

T

T

L

L

L

L

N

Y

M

I

I

L

G

G

G

L

L

L

D

D

N

A

P

P

T

T

K

E

G

G

D

K

L

V

F

F

I

L

D

E

G

G

K

K

D

E

I

V

S

D

R

Y

M

T

S

N

E

E

G

K

E

E

L

L

T

S

R

L

M

L

R

R

A

N

E

R

K

K

I

L

G

G

F

F

I

V

F

F

Q

Q

T

F

F

H

N

Y

L

L

L

I

P

P

A

E

L

L

T

T

V

A

R

L

D

E

N

N

V

V

E

I

F

V

P

P

M

M

R

L

N

K

L

M

N

G

G

K

S

P

K

K

K

K

M

E

N

A

K

K

S

-

S

-

R

-

I

-

K

E

K

R

A

G

E

E

E

Y

C

L

I

L

E

S

I

E

V

L

G

G

L

L

G

G

D

D

R

K

M

L

D

S

Y

R

L

K

P

P

A

Y

K

E

L

L

S

S

G

G

G

G

E

E

R

Q

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

V

A

N

N

N

E

P

P

K

I

F

L

I

L

L

F

A

A

D

D

E
|
E

P
|
P

T
|
T

G

G

N

N

L

L

D

D

S

S

E

A

S

N

T

T

E

K

N

R

I

V

I

M

N

D

L

I

L

F

H

L

E

K

V

I

N

N

Q

E

N

G

E

G

T

T

T

S

V

I

I

V

M

M

V

V

T
|
T

H

H

D

E

A

R

E

E

T

L

T

A

K

E

N

L

T

T

-

H

R

R

I

T

M

L

K

E

I

M

R

K

D

D

G

G

K

K

I

V

A

V

binding magnesium ion: E165 (= E174), P166 (= P175), T167 (= T176), T196 (= T205)

8g4cB Bceabs atpgs high res tm (see paper)
40% identity, 98% coverage: 4:224/226 of query aligns to 3:221/248 of 8g4cB

query
sites
8g4cB

L

I

I

L

N

E

G

A

N

N

E

K

L

I

W

R

K

K

T

S

Y
|
Y

-

G

-

N

K

K

L

L

D

N

S

K

T

Q

E

E

V

V

H

-

A

-

L

L

R

K

G

G

L

I

N

D

I

I

T

H

V

I

G

E

E

K

G

G

E

E

F

F

V

V

S

S

I

I

M

M

G

G

P

A

S
|
S

G

G

S
|
S

G

G

K

K

S
x
T

T

T

L

L

L

L

N

N

M

V

I

L

G

S

G

S

L

I

D

D

N

Q

P

V

T

S

K

H

G

G

D

T

L

I

F

H

I

I

D

N

G

G

K

N

D

D

I

M

S

T

R

A

M

M

S

K

E

E

G

K

E

Q

L

L

T

A

R

E

M

F

R

R

A

K

E

Q

K

H

I

L

G

G

F

F

I

I

F

F

Q

Q

T

D

F

Y

N

N

L

L

L

L

P

D

A

T

L

L

T

T

V

V

R

K

D

E

N

N

V

I

E

L

F

L

P

P

M

L

R

-

N

-

L

-

N

-

G

S

S

I

K

T

K

K

M

L

N

S

K

K

S

K

S

E

R

A

I

N

K

R

K

K

A

F

E

E

E

E

C

V

I

A

E

K

I

E

V

L

G

G

L

I

G

Y

D

E

R

L

M

R

D

D

Y

K

L

Y

P

P

A

N

K

E

L

I

S

S

G

G

G

G

E

Q

R

K

Q

Q

R

R

V

T

A

S

V

A

A

G

R

R

A

A

L

F

V

I

N

H

N

D

P

P

K

S

F

I

I

I

L

F

A

A

D
|
D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

S

S

E

K

S

S

T

A

E

S

N

D

I

L

I

L

N

N

L

K

L

L

H

S

E

Q

V

L

N

N

Q

Q

N

K

E

R

-

N

T

A

T

T

V

I

I

I

M

M

V

V

T

T

H

H

D

D

-

P

A

V

E

A

T

A

T

S

K

Y

N

C

T

G

R

R

I

V

M

I

K

F

I

I

R

K

D

D

G

G

K

Q

I

M

binding phosphothiophosphoric acid-adenylate ester: Y13 (= Y14), S42 (= S43), S44 (= S45), T47 (≠ S48), D168 (= D173)

7tchB Bceab e169q variant atp-bound conformation (see paper)
40% identity, 98% coverage: 4:224/226 of query aligns to 2:220/245 of 7tchB

query
sites
7tchB

L

I

I

L

N

E

G

A

N

N

E

K

L

I

W

R

K

K

T

S

Y
|
Y

-

G

-

N

K

K

L

L

D

N

S

K

T
x
Q

E

E

V
|
V

H

-

A

-

L

L

R

K

G

G

L

I

N

D

I

I

T

H

V

I

G

E

E

K

G

G

E

E

F

F

V

V

S

S

I

I

M

M

G

G

P

A

S
|
S

G
|
G

S
|
S

G

G

K
|
K

S
x
T

T

T

L

L

L

L

N

N

M

V

I

L

G

S

G

S

L

I

D

D

N

Q

P

V

T

S

K

H

G

G

D

T

L

I

F

H

I

I

D

N

G

G

K

N

D

D

I

M

S

T

R

A

M

M

S

K

E

E

G

K

E

Q

L

L

T

A

R

E

M

F

R

R

A

K

E

Q

K

H

I

L

G

G

F

F

I

I

F

F

Q

Q

T

D

F

Y

N

N

L

L

L

L

P

D

A

T

L

L

T

T

V

V

R

K

D

E

N

N

V

I

E

L

F

L

P

P

M

L

R

-

N

-

L

-

N

-

G

S

S

I

K

T

K

K

M

L

N

S

K

K

S

K

S

E

R

A

I

N

K

R

K

K

A

F

E

E

E

E

C

V

I

A

E

K

I

E

V

L

G

G

L

I

G

Y

D

E

R

L

M

R

D

D

Y

K

L

Y

P

P

A

N

K
x
E

L

I

S

S

G
|
G

G
|
G

E

Q

R

K

Q

Q

R

R

V

T

A

S

V

A

A

G

R

R

A

A

L

F

V

I

N

H

N

D

P

P

K

S

F

I

I

I

L

F

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

S

S

E

K

S

S

T

A

E

S

N

D

I

L

I

L

N

N

L

K

L

L

H

S

E

Q

V

L

N

N

Q

Q

N

K

E

R

-

N

T

A

T

T

V

I

I

I

M

M

V

V

T

T

H

H

D

D

-

P

A

V

E

A

T

A

T

S

K

Y

N

C

T

G

R

R

I

V

M

I

K

F

I

I

R

K

D

D

G

G

K

Q

I

M

binding adenosine-5'-triphosphate: Y12 (= Y14), Q19 (≠ T19), V21 (= V21), S41 (= S43), G42 (= G44), S43 (= S45), K45 (= K47), T46 (≠ S48), E142 (≠ K148), G145 (= G151), G146 (= G152)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
40% identity, 99% coverage: 2:224/226 of query aligns to 2:221/650 of 5ws4A

query
sites
5ws4A

N

Q

G

A

L

L

I

L

N

E

G

V

N

S

E

N

L

L

W

V

K

R

T

E

Y

F

K

P

L

A

D

G

S

E

T

S

E

T

V

I

H

Q

A

I

L

L

R

K

G

G

L

I

N

D

I

L

T

T

V

I

G

Y

E

E

G

G

E

E

F

L

V

V

S

A

I

I

M

V

G

G

P

Q

S
|
S

G
|
G

S

S

G

G

K

K

S
|
S

T

T

L

L

L

M

N

N

M

I

I

L

G

G

G

C

L

L

D

D

N

R

P

P

T

T

K

S

G

G

D

S

L

Y

F

K

I

V

D

N

G

G

K

Q

D

E

I

T

S

G

R

K

M

L

S

E

E

P

G

D

E

Q

L

L

T

A

R

Q

M

L

R

R

A

R

E

E

K

Y

I

F

G

G

F

F

I

I

F

F

Q

Q

T

R

F

Y

N

H

L

L

L

L

P

G

A

D

L

L

T

S

V

A

R

E

D

G

N

N

V

V

E

E

F

V

P

P

M

A

R

V

N

-

L

-

N

-

G

-

S

Y

K

A

K

G

M

V

N

T

K

P

S

A

S

D

R

R

I

K

K

Q

K

R

A

A

E

T

E

A

C

L

I

L

E

T

I

E

V

L

G

G

L

L

G

G

D

T

R

K

M

T

D

Q

Y

N

L

R

P

P

A

S

K

Q

L

L

S

S

G

G

G

G

E

Q

R

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

V

M

N

N

N

G

P

G

K

D

F

V

I

I

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

S

S

E

H

S

S

T

G

E

V

N

E

I

V

I

M

N

R

L

I

L

L

H

R

E

E

V

L

N

N

Q

A

N

A

E

G

T

H

T

T

V

I

I

I

M

L

V

V

T

T

H

H

D

D

A

M

E

Q

T

V

T

A

K

K

N

N

-

A

T

T

R

R

I

I

M

I

K

E

I

I

R

S

D

D

G

G

K

E

I

I

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S43), G44 (= G44), S48 (= S48)

A5U7B7 Cell division ATP-binding protein FtsE from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) (see 2 papers)
41% identity, 94% coverage: 4:215/226 of query aligns to 1:205/229 of A5U7B7

query
sites
A5U7B7

L

M

I

I

N

T

G

L

N

D

E

H

L

V

W

T

K

K

T

Q

Y

Y

K

K

L

-

D

-

S

S

T

S

E

A

V

R

H

P

A

A

L

L

R

D

G

D

L

I

N

N

I

V

T

K

V

I

G

D

E

K

G

G

E

E

F

F

V

V

S

F

I

L

M

I

G

G

P

P

S

S

G

G

S

S

G

G

K
|
K

S

S

T

T

L

F

L

M

N

R

M

L

I

L

G

L

G

A

L

A

D

E

N

T

P

P

T

T

K

S

G

G

D

D

L

V

F

R

I

V

D

S

G

K

K

F

D

H

I

V

S

N

R

K

M

L

S

R

E

G

G

R

E

H

L

V

T

P

R

K

M

L

R

R

A

-

E

Q

K

V

I

I

G

G

F
x
C

I

V

F

F

Q

Q

T

D

F

F

N

R

L

L

L

L

P

Q

A

Q

L

K

T

T

V

V

R

Y

D

D

N

N

V

V

E

A

F

F

P

A

M

L

R

E

N

V

L

I

N

G

G

-

S

-

K

K

K

R

M

T

N

D

K

A

S

I

S

N

R

R

I

V

K

-

K

-

A

V

E

P

E

E

C

V

I

L

E

E

I

T

V

V

G

G

L

L

G

S

D

G

R

K

M

A

D

N

Y

R

L

L

P

P

A

D

K

E

L

L

S

S

G

G

G

G

E

E

R

Q

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

F

V

V

N

N

N

R

P

P

K

L

F

V

I

L

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

P

E

E

S

T

T

S

E

R

N

D

I

I

I

M

N

D

L

L

L

L

H

E

E

R

V

I

N

N

Q

R

N

T

E

G

T

T

T

T

V

V

I

L

M

M

V

A

T

T

H

H

D

D

A

H

E

H

T

I

T

V

K

D

N

S

T

M

R

R

K42 (= K47) mutation to R: Does not bind ATP. Does not affect dimerization.
C84 (≠ F90) mutation to A: Does not affect ATPase activity.

8iddA Cryo-em structure of mycobacterium tuberculosis atp bound ftsex/ripc complex in peptidisc (see paper)
41% identity, 94% coverage: 4:215/226 of query aligns to 2:206/225 of 8iddA

query
sites
8iddA

L

M

I

I

N

T

G

L

N

D

E

H

L

V

W

T

K

K

T

Q

Y
|
Y

K

K

L

-

D

-

S

S

T

S

E

A

V

R

H

P

A

A

L

L

R

D

G

D

L

I

N

N

I

V

T

K

V

I

G

D

E

K

G

G

E

E

F

F

V

V

S

F

I

L

M

I

G

G

P

P

S
|
S

G

G

S

S

G
|
G

K
|
K

S
|
S

T

T

L

F

L

M

N

R

M

L

I

L

G

L

G

A

L

A

D

E

N

T

P

P

T

T

K

S

G

G

D

D

L

V

F

R

I

V

D

S

G

K

K

F

D

H

I

V

S

N

R

K

M

L

S

R

E

G

G

R

E

H

L

V

T

P

R

K

M

L

R

R

A

-

E

Q

K

V

I

I

G

G

F

C

I

V

F

F

Q

Q

T

D

F

F

N

R

L

L

L

L

P

Q

A

Q

L

K

T

T

V

V

R

Y

D

D

N

N

V

V

E

A

F

F

P

A

M

L

R

E

N

V

L

I

N

G

G

-

S

-

K

K

K

R

M

T

N

D

K

A

S

I

S

N

R

R

I

V

K

-

K

-

A

V

E

P

E

E

C

V

I

L

E

E

I

T

V

V

G

G

L

L

G

S

D

G

R

K

M

A

D

N

Y

R

L

L

P

P

A

D

K

E

L

L

S

S

G

G

G

G

E

E

R

Q

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

F

V

V

N

N

N

R

P

P

K

L

F

V

I

L

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

P

E

E

S

T

T

S

E

R

N

D

I

I

I

M

N

D

L

L

L

L

H

E

E

R

V

I

N

N

Q

R

N

T

E

G

T

T

T

T

V

V

I

L

M

M

V

A

T

T

H

H

D

D

A

H

E

H

T

I

T

V

K

D

N

S

T

M

R

R

binding adenosine-5'-triphosphate: Y12 (= Y14), S39 (= S43), G42 (= G46), K43 (= K47), S44 (= S48)

8igqA Cryo-em structure of mycobacterium tuberculosis adp bound ftsex/ripc complex in peptidisc (see paper)
41% identity, 94% coverage: 4:215/226 of query aligns to 2:206/227 of 8igqA

query
sites
8igqA

L

M

I

I

N

T

G

L

N

D

E

H

L

V

W

T

K

K

T

Q

Y
|
Y

K

K

L

-

D

-

S

S

T

S

E

A

V

R

H

P

A

A

L

L

R

D

G

D

L

I

N

N

I

V

T

K

V

I

G

D

E

K

G

G

E

E

F

F

V

V

S

F

I

L

M

I

G

G

P

P

S

S

G
|
G

S
|
S

G

G

K
|
K

S
|
S

T

T

L

F

L

M

N

R

M

L

I

L

G

L

G

A

L

A

D

E

N

T

P

P

T

T

K

S

G

G

D

D

L

V

F

R

I

V

D

S

G

K

K

F

D

H

I

V

S

N

R

K

M

L

S

R

E

G

G

R

E

H

L

V

T

P

R

K

M

L

R

R

A

-

E

Q

K

V

I

I

G

G

F

C

I

V

F

F

Q

Q

T

D

F

F

N

R

L

L

L

L

P

Q

A

Q

L

K

T

T

V

V

R

Y

D

D

N

N

V

V

E

A

F

F

P

A

M

L

R

E

N

V

L

I

N

G

G

-

S

-

K

K

K

R

M

T

N

D

K

A

S

I

S

N

R

R

I

V

K

-

K

-

A

V

E

P

E

E

C

V

I

L

E

E

I

T

V

V

G

G

L

L

G

S

D

G

R

K

M

A

D

N

Y

R

L

L

P

P

A

D

K

E

L

L

S

S

G

G

G

G

E

E

R

Q

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

F

V

V

N

N

N

R

P

P

K

L

F

V

I

L

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

P

E

E

S

T

T

S

E

R

N

D

I

I

I

M

N

D

L

L

L

L

H

E

E

R

V

I

N

N

Q

R

N

T

E

G

T

T

T

T

V

V

I

L

M

M

V

A

T

T

H

H

D

D

A

H

E

H

T

I

T

V

K

D

N

S

T

M

R

R

binding adenosine-5'-diphosphate: Y12 (= Y14), G40 (= G44), S41 (= S45), K43 (= K47), S44 (= S48)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
39% identity, 92% coverage: 4:212/226 of query aligns to 1:205/343 of P30750

query
sites
P30750

L

M

I

I

N

K

G

L

N

S

E

N

L

I

W

T

K

K

T

V

Y

F

K

H

L

Q

D

G

S

T

T

R

E

T

V

I

H

Q

A

A

L

L

R

N

G

N

L

V

N

S

I

L

T

H

V

V

G

P

E

A

G

G

E

Q

F

I

V

Y

S

G

I

V

M

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

N

R

M

C

I

V

G

N

G

L

L

L

D

E

N

R

P

P

T

T

K

E

G

G

D

S

L

V

F

L

I

V

D

D

G

G

K

Q

D

E

I

L

S

T

R

T

M

L

S

S

E

E

G

S

E

E

L

L

T

T

R

K

M

A

R

R

A

-

E

R

K

Q

I

I

G

G

F

M

I

I

F

F

Q

Q

T

H

F

F

N

N

L

L

L

L

P

S

A

S

L

R

T

T

V

V

R

F

D

G

N

N

V

V

E

A

F

L

P

P

M

L

R

E

N

L

L

D

N

N

G

T

S

P

K

K

K

D

M

E

N

V

K

K

S

-

S

-

R

-

I

-

K

R

K

R

A

V

E

T

E

E

C

L

I

L

E

S

I

L

V

V

G

G

L

L

G

G

D

D

R

K

M

H

D

D

Y

S

L

Y

P

P

A

S

K

N

L

L

S

S

G

G

G

G

E

Q

R

K

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

V

A

N

S

N

N

P

P

K

K

F

V

I

L

L

L

A

C

D

D

E
|
E

P

A

T

T

G

S

N

A

L

L

D

D

S

P

E

A

S

T

T

T

E

R

N

S

I

I

I

L

N

E

L

L

L

L

H

K

E

D

V

I

N

N

Q

R

N

R

E

L

-

G

T

L

T

T

V

I

I

L

M

L

V

I

T

T

H

H

D

E

A

M

E

D

T

V

T

V

K

K

40:46 (vs. 43:49, 86% identical) binding ATP
E166 (= E174) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
38% identity, 92% coverage: 4:212/226 of query aligns to 2:206/344 of 6cvlD

query
sites
6cvlD

L

M

I

I

N

K

G

L

N

S

E

N

L

I

W

T

K

K

T

V

Y
x
F

K

H

L
x
Q

D

G

S

T

T

R

E

T

V
x
I

H

Q

A

A

L

L

R

N

G

N

L

V

N

S

I

L

T

H

V

V

G

P

E

A

G

G

E

Q

F

I

V

Y

S

G

I

V

M

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

N

R

M

C

I

V

G

N

G

L

L

L

D

E

N

R

P

P

T

T

K

E

G

G

D

S

L

V

F

L

I

V

D

D

G

G

K

Q

D

E

I

L

S

T

R

T

M

L

S

S

E

E

G

S

E

E

L

L

T

T

R

K

M

A

R

R

A

-

E

R

K

Q

I

I

G

G

F

M

I

I

F

F

Q

Q

T

H

F

F

N

N

L

L

L

L

P

S

A

S

L

R

T

T

V

V

R

F

D

G

N

N

V

V

E

A

F

L

P

P

M

L

R

E

N

L

L

D

N

N

G

T

S

P

K

K

K

D

M

E

N

V

K

K

S

-

S

-

R

-

I

-

K

R

K

R

A

V

E

T

E

E

C

L

I

L

E

S

I

L

V

V

G

G

L

L

G

G

D

D

R

K

M

H

D

D

Y

S

L

Y

P

P

A

S

K
x
N

L

L

S
|
S

G

G

G

G

E
x
Q

R

K

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

V

A

N

S

N

N

P

P

K

K

F

V

I

L

L

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

L

L

D

D

S

P

E

A

S

T

T

T

E

R

N

S

I

I

I

L

N

E

L

L

L

L

H

K

E

D

V

I

N

N

Q

R

N

R

E

L

-

G

T

L

T

T

V

I

I

L

M

L

V

I

T

T

H
|
H

D

E

A

M

E

D

T

V

T

V

K

K

binding phosphothiophosphoric acid-adenylate ester: F12 (≠ Y14), Q14 (≠ L16), I19 (≠ V21), S41 (= S43), G42 (= G44), A43 (≠ S45), G44 (= G46), K45 (= K47), S46 (= S48), T47 (= T49), N141 (≠ K148), S143 (= S150), Q146 (≠ E153), H200 (= H206)

Query Sequence

>WP_048081777.1 NCBI__GCF_000745485.1:WP_048081777.1
MNGLINGNELWKTYKLDSTEVHALRGLNITVGEGEFVSIMGPSGSGKSTLLNMIGGLDNP
TKGDLFIDGKDISRMSEGELTRMRAEKIGFIFQTFNLLPALTVRDNVEFPMRNLNGSKKM
NKSSRIKKAEECIEIVGLGDRMDYLPAKLSGGERQRVAVARALVNNPKFILADEPTGNLD
SESTENIINLLHEVNQNETTVIMVTHDAETTKNTRIMKIRDGKIAE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory