SitesBLAST

Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see paper)
32% identity, 93% coverage: 3:219/233 of query aligns to 2050:2276/2435 of Q9BZC7

query
sites
Q9BZC7

L

V

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I

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E

N

N

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L

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T

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K

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Y

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R

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K

F

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E

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A

A

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D

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I

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G

G

L

L

G

G

P

V

N

N

G

G

A

A

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G

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K

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F

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M

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G

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G

M

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N

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R

F

F

Sites not aligning to the query:

271 modified: N5-methylglutamine; Q→R: Abolishes methylation by N6AMT1.

P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see 2 papers)
30% identity, 93% coverage: 3:219/233 of query aligns to 1379:1594/1704 of P34358

query
sites
P34358

L

L

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N

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T

F

F

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A

A

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D

N

N

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A

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-

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-

K

L

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Y

K1417 (= K41) mutation to R: Some cell corpses not engulfed.

Sites not aligning to the query:

126 modified: carbohydrate, N-linked (GlcNAc...) asparagine
586 K→R: Cell corpses not engulfed.
639 E→G: Cell corpses not engulfed.
1012 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1045 modified: carbohydrate, N-linked (GlcNAc...) asparagine

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
33% identity, 86% coverage: 7:207/233 of query aligns to 9:215/285 of 4yerA

query
sites
4yerA

N

N

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L

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K

F
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F

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x
F

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A

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N
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N

G
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G

A

A

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G

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K

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x
T

T
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T

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I

binding adenosine-5'-diphosphate: F14 (= F12), F17 (≠ Q15), N39 (= N37), G40 (= G38), G42 (= G40), K43 (= K41), T44 (≠ S42), T45 (= T43), T135 (≠ Q129), F136 (≠ L130), S137 (= S131)

6z4wA Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
32% identity, 93% coverage: 3:219/233 of query aligns to 4:226/230 of 6z4wA

query
sites
6z4wA

L

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K

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x
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x
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A
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A

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N

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Y

binding adenosine-5'-diphosphate: Y13 (≠ F12), T17 (≠ Q15), A19 (= A17), G40 (= G38), G42 (= G40), K43 (= K41), S44 (= S42), T45 (= T43)

A0A0H2ZM82 Cell division ATP-binding protein FtsE from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) (see paper)
32% identity, 93% coverage: 3:219/233 of query aligns to 4:226/230 of A0A0H2ZM82

query
sites
A0A0H2ZM82

L

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N

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G

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-

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N

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A

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L

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L

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A

D
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D

E
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E

P

P

T

T

N

G

G

N

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L

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N

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Q

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E

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A

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L

L

C

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S

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A

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K

N

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G

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D

E

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S

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K

G

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Y

K43 (= K41) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.
D164 (= D154) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.
E165 (= E155) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution (see paper)
31% identity, 91% coverage: 3:215/233 of query aligns to 4:226/229 of 6z67B

query
sites
6z67B

L

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A

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L

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x
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G

A

A

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G

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N

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A

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R

R

V

V

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M

E

E

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A

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A

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N

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E

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Y

binding phosphoaminophosphonic acid-adenylate ester: Y13 (≠ F12), G16 (vs. gap), A19 (= A17), S39 (≠ N37), G40 (= G38), G42 (= G40), K43 (= K41), S44 (= S42), T45 (= T43)

E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
31% identity, 87% coverage: 17:219/233 of query aligns to 2272:2480/2595 of E9Q876

query
sites
E9Q876

A

A

L

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D

N

N

N

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N

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F

Sites not aligning to the query:

1388:1461 ISMLTGLFGATAGTIFVYGKDIKTDLNTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKTQLHEEVKR→M: In a mouse model for harlequin ichthyosis (HI), smooth skin (smsk) mutant mice show a pronounced perinatal lethal skin phenotype in 25% of the offspring and newborn mutant pups die within a few hours after birth, and appear severely dehydrated with dry cracking skin. Smsk homozygous mutants embryos show a normal appearance at 14.5 dpc, but at 16.5 dpc develop a partial absence of normal skin folds around the trunk and limbs, and by 18.5 dpc develop a taut, thick skin and limb contractures.
1996 G→D: In a mouse model for harlequin ichthyosis (HI), homozygous mice are embryonic lethal but occasionally pups are found in the first few hours after birth but die and are severely dehydrated and fail to suckle normally. Homozygous pups show hallmarks of HI desease including hyperkeratosis, abnormal extracellular lipid lamellae and defects in cornified envelope processing. At 14.5 dpc and 15.5 dpc homozygous embryos appear normal; however from 16.5 dpc onwards they are characterized by an absence of normal skin folds around the trunk and limbs. As development progressed, embryos develop a taut, thick epidermis and multiple contractures affecting the limbs. Late stage embryos are smaller.

8eopA Cryo-em structure of nanodisc reconstituted human abca7 eq mutant in atp bound closed state (see paper)
28% identity, 98% coverage: 3:230/233 of query aligns to 1452:1684/1687 of 8eopA

query
sites
8eopA

L

L

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N

N

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x
Y

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A

A

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N

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G

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x
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S

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T

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N

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-

S

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L

L

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A

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F

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S

binding adenosine-5'-triphosphate: Y1461 (≠ F12), N1488 (= N37), G1489 (= G38), G1491 (= G40), K1492 (= K41), S1494 (≠ T43), Q1533 (≠ E82), T1584 (≠ Q129), S1586 (= S131)
binding magnesium ion: T1493 (≠ S42), Q1533 (≠ E82)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 659, 662, 666, 686, 687, 689, 690, 691, 692, 782, 784

O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 35 papers)
30% identity, 93% coverage: 3:219/233 of query aligns to 1912:2135/2261 of O95477

query
sites
O95477

L

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K

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A

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F

R1925 (≠ T16) to Q: in Scott syndrome; shows impaired trafficking of the mutant protein to the plasma membrane; dbSNP:rs142688906
K1952 (= K41) mutation to M: Inhibits ATPase activity; when associated with M-939. Decreases translocase activity; when associated with M-939. Does not affect protein subcellular localization in plasma membrane and endosome; when associated with M-939.
S2054 (≠ G139) modified: Phosphoserine; by PKA
R2081 (≠ I166) to W: in TGD; highly decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; loss protein subcellular localization to the plasma membrane; dbSNP:rs137854501
A2109 (= A193) to T: in a colorectal cancer sample; somatic mutation

Sites not aligning to the query:

3 modified: S-palmitoyl cysteine; C→S: Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased cholesterol efflux. Decreased phospholipid efflux. Decreased palmitoylation; when associated with S-23, S-1110 and S-1111.
23 modified: S-palmitoyl cysteine; C→S: Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased palmitoylation; when associated with S-3, S-1110 and S-1111.
74 I→C: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-371.; I→K: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with E-371.
75 modified: Disulfide link with 309
85 P → L: in FHA1; Alabama; dbSNP:rs145183203
98 modified: carbohydrate, N-linked (GlcNAc...) asparagine
100 S→C: Highly decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
210 E → D: in a colorectal cancer sample; somatic mutation
219 R → K: in dbSNP:rs2230806
230 R → C: in dbSNP:rs9282541
244 modified: carbohydrate, N-linked (GlcNAc...) asparagine
248 P → A: in dbSNP:rs142625938
255 A → T: in TGD; deficient cellular cholesterol efflux; dbSNP:rs758100110
304 V→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane; when associated with C-308.
308 V→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane; when associated with C-304.
309 modified: Disulfide link with 75
364 S → C: in dbSNP:rs775035559
371 I→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane. 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-74 or C-375.; I→E: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-74.
375 L→C: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-371.
399 V → A: in dbSNP:rs9282543
401 K → Q: in dbSNP:rs138487227
496 R → W: in dbSNP:rs147675550
568 K→A: 60-65% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane.
573 Y→F: No effect on phospholipid and cholesterol efflux and on localization to cell membrane.
581 D→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-584 and K-585.
583 F→K: 90-95% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with E-590.
584 E→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-581 and K-585.
585 D→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-581 and K-584.
590 W → S: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs137854496; W→E: 90-95% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-583.
593 F→L: Moderately decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
638 R → Q: in dbSNP:rs374190304
771 V → M: in dbSNP:rs2066718
774 T → P: in dbSNP:rs35819696; natural variant: T -> S
776 K → N: in dbSNP:rs138880920
815 E → G: in dbSNP:rs145582736
825 V → I: in dbSNP:rs2066715
883 I → M: in dbSNP:rs2066714
917 D → Y: in a colorectal cancer sample; somatic mutation
929 T → I: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; loss protein subcellular localization to the plasma membrane; dbSNP:rs1832457117
935 N → S: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs28937313
939 K→M: Inhibits ATPase activity; when associated with M-1952. Decreases translocase activity; when associated with M-1952. Does not affect protein subcellular localization in plasma membrane and endosome; when associated with M-1952.
1042 modified: Phosphoserine; by PKA
1065 natural variant: P -> S
1091 M → T: in FHA1; loss of localization to plasma membrane; decreased cholesterol efflux; decreased phospholipid efflux
1110 modified: S-palmitoyl cysteine; C→S: Decreased palmitoylation; when associated with S-3, S-23 and S-1111.
1111 modified: S-palmitoyl cysteine; C→S: Decreased palmitoylation; when associated with S-3, S-23 and S-1110.
1172 E → D: in dbSNP:rs33918808
1181 S → F: in dbSNP:rs76881554
1216 G → V: in dbSNP:rs562403512
1341 R → T: in dbSNP:rs147743782
1376 S → G: in dbSNP:rs145689805
1379 L → F: in TGD; the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane; dbSNP:rs1831213945
1407 A → T: in a colorectal cancer sample; somatic mutation; dbSNP:rs189206655
1463 modified: Disulfide link with 1477
1477 modified: Disulfide link with 1463; C → R: in TGD; loss of interaction with APOE; unable to generate APOE-containing high density lipoproteins; moderately decreased protein abundance; moderately decreased ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs137854494
1512 T→M: Moderately decreased protein abundance. Does not affect ATPase activity. Moderately decreased phospholipid translocase activity.
1555 I → T: in dbSNP:rs1997618
1587 K → R: in dbSNP:rs2230808
1611 N → D: in FHA1; deficient cellular cholesterol efflux
1615 R → Q: in dbSNP:rs1251839800
1648 L → P: in dbSNP:rs1883024
1670 A → T: in dbSNP:rs1203589782
1680 R → Q: in dbSNP:rs150125857
1704 V → D: in TGD; the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane
1731 S → C: in dbSNP:rs760507032
1897 R → W: in FHA1; uncertain significance; dbSNP:rs760768125
2150 P → L: in FHA1; moderately decreased protein abundance; does not affect ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs369098049
2163 natural variant: F -> S
2168 L → P: in dbSNP:rs2853577
2243 D → E: in dbSNP:rs34879708
2244 V → I: in dbSNP:rs144588452

8ee6A Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
28% identity, 93% coverage: 3:219/233 of query aligns to 1498:1721/1808 of 8ee6A

query
sites
8ee6A

L

L

Q

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N

N

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x
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E

E

L

M

L

Y

T

V

G

K

R

E

E

Y

H

L

L

Q

E

F

L

V

L

A

A

N

R

I

L

H

R

K

G

I

V

S

P

S

E

A

A

R

Q

V

V

D

A

E

Q

V

T

-

A

-

G

-

S

-

G

I

L

E

A

L

R

V

L

G

G

I

L

T

S

P

W

E

Y

K

A

S

D

K

R

K

P

I

A

G

G

Q

T

L

Y

S

S

K

G

G

G

Y

N

K

K

Q

R

R

K

V

L

G

A

L

T

A

A

Q

L

A

A

I

L

I

V

H

G

Q

D

P

P

D

A

L

V

I

F

L

L

D

D

E

E

P

P

T

T

N

T

G

G

L

M

D

D

P

P

N

S

Q

A

I

R

E

F

I

L

R

W

N

N

-

S

V

L

K

A

E

V

I

V

G

R

Q

E

Q

G

K

R

T

S

V

V

L

M

L

L

S

T

T

S

H

H

I

S

M

M

Q

E

E

E

V

C

E

E

A

A

L

L

C

C

S

S

R

R

V

L

I

A

L

I

I

M

H

V

K

N

G

G

N

R

I

F

L

R

Q

C

D

L

C

G

P

S

I

P

D

Q

E

H

F

L

K

K

G

G

R

R

F

F

binding phosphothiophosphoric acid-adenylate ester: Y1507 (≠ F12), A1514 (= A17), G1535 (= G38), A1536 (= A39), G1537 (= G40), K1538 (= K41), T1539 (≠ S42)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 607, 608, 633, 640, 660, 661, 663, 664, 665, 666

P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see paper)
31% identity, 93% coverage: 3:219/233 of query aligns to 1912:2135/2261 of P41233

query
sites
P41233

L

L

Q

E

I

I

I

K

N

E

L

L

T

T

K

K

K

I

F

Y

-

R

G

K

E

R

Q

K

T

P

A

A

L

V

D

D

N

R

I

I

T

C

I

I

S

G

I

I

D

P

K

P

N

G

E

E

I

C

I

F

G

G

L

L

G

G

P

V

N

N

G

G

A

A

G

G

K

K

S

S

T

T

L

T

M

F

K

K

S

M

I

L

V

T

G

G

A

D

L

T

K

P

I

V

D

T

Q

R

G

G

E

D

I

A

I

F

F

L

N

N

G

K

M

N

N

S

I

I

S

L

E

S

H

N

E

I

I

H

E

E

S

V

K

H

K

Q

K

N

I

M

G

G

F

Y

L

C

P

P

E

Q

N

F

N

D

P

A

L

I

Y

T

L

E

E

L

M

L

Y

T

V

G

K

R

E

E

Y

H

L

V

Q

E

F

F

V

F

A

A

N

L

I

L

H

R

K

G

I

V

S

P

S

E

A

K

R

E

V

V

D

G

E

K

V

V

I

G

E

E

L

W

-

A

-

I

-

R

-

K

V

L

G

G

I

L

T

V

P

K

E

Y

K

G

S

E

K

K

K

Y

I

A

G

S

Q

N

L

Y

S

S

K

G

G

G

Y

N

K

K

Q

R

R

K

V

L

G

S

L

T

A

A

Q

M

A

A

I

L

I

I

H

G

Q

G

P

P

D

P

L

V

I

F

L

L

D

D

E

E

P

P

T

T

N

T

G

G

L

M

D

D

P

P

N

K

Q

A

I

R

E

F

I

L

R

W

N

N

V

C

V

A

K

L

E

S

I

I

G

V

Q

K

Q

E

-

G

K

R

T

S

V

V

L

V

L

L

S

T

T

S

H

H

I

S

M

M

Q

E

E

E

V

C

E

E

A

A

L

L

C

C

S

T

R

R

V

M

I

A

L

I

I

M

H

V

K

N

G

G

N

R

I

F

L

R

Q

C

D

L

C

G

P

S

I

V

D

Q

E

H

F

L

K

K

G

N

R

R

F

F

Sites not aligning to the query:

489 modified: carbohydrate, N-linked (GlcNAc...) asparagine

Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see 2 papers)
28% identity, 91% coverage: 7:219/233 of query aligns to 1298:1512/1624 of Q8IUA7

query
sites
Q8IUA7

N

N

L

C

T

F

K

S

K

K

F

R

G

K

E

K

Q
x
K

T

I

A

A

L

T

D

R

N

N

I

V

T

S

I

F

S

C

I

V

D

K

K

K

N

G

E

E

I

V

I

I

G

G

L

L

G

G

P

H

N

N

G

G

A

A

G

G

K

K

S

S

T

T

L

T

M

I

K

K

S

M

I

I

V

T

G

G

A

D

L

T

K

K

I

P

D

T

Q

A

G

G

E

Q

I

V

I

I

F

L

N

K

G

G

M

S

N

G

I

G

S

G

E

-

H

-

E

-

I

-

E

E

S

P

K

L

K

G

K

F

I

L

G

G

F

Y

L

C

P

P

E

Q

N

E

N

N

P

A

L

L

Y

W

L

P

E

N

M

L

Y

T

V

V

K

R

E

Q

Y

H

L

L

Q

E

F

V

V

Y

A

A

N

A

I

V

H

K

K

G

I

L

S

R

S

K

A

G

-

D

-

A

-

M

-

I

R

A

V

I

D

T

E

R

V

L

I

V

E

D

L

A

V

L

G

K

I

L

T

Q

P

D

E

Q

K

L

S

K

K

A

K

P

I

V

G

K

Q

T

L

L

S

S

K

E

G

G

Y

I

K

K

Q

R

R

K

V

L

G

C

L

F

A

V

Q

L

A

S

I

I

I

L

H

G

Q

N

P

P

D

S

L

V

I

L

L

L

D

D

E

E

P

P

T

S

N

T

G

G

L

M

D

D

P

P

N

E

Q

G

I

Q

E

Q

I

M

R

W

N

Q

V

V

V

I

K

R

E

A

I

T

G

F

Q

R

-

N

-

T

Q

E

K

R

T

G

V

A

L

L

S

T

T

T

H

H

I

Y

M

M

Q

A

E

E

V

A

E

E

A

A

L

V

C

C

S

D

R

R

V

V

I

A

L

I

I

M

H

V

K

S

G

G

N

R

I

L

L

R

Q

C

D

I

C

G

P

S

I

I

D

Q

E

H

F

L

K

K

G

S

R

K

F

F

K1306 (≠ Q15) to T: in dbSNP:rs2302294

Sites not aligning to the query:

353 R → H: in dbSNP:rs1860447
949 modified: carbohydrate, N-linked (GlcNAc...) asparagine

7tbwA The structure of atp-bound abca1 (see paper)
31% identity, 93% coverage: 3:219/233 of query aligns to 1621:1844/1928 of 7tbwA

query
sites
7tbwA

L

L

Q

E

I

I

I

K

N

E

L

L

T

T

K

K

K

I

F
x
Y

-

R

G
x
K

E

R

Q

K

T

P

A

A

L

V

D

D

N

R

I

I

T

C

I

V

S

G

I

I

D

P

K

P

N

G

E

E

I

C

I

F

G

G

L

L

G

G

P

V

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
|
S

T
x
S

L

T

M

F

K

K

S

M

I

L

V

T

G

G

A

D

L

T

K

T

I

V

D

T

Q

R

G

G

E

D

I

A

I

F

F

L

N

N

G

K

M

N

N

S

I

I

S

L

E

S

H

N

E

I

I

H

E

E

S

V

K

H

K

Q

K

N

I

M

G

G

F

Y

L

C

P

P

E
x
Q

N

F

N

D

P

A

L

I

Y

T

L

E

E

L

M

L

Y

T

V

G

K

R

E

E

Y

H

L

V

Q

E

F

F

V

F

A

A

N

L

I

L

H

R

K

G

I

V

S

P

S

E

A

K

R

E

V

V

D

G

E

K

V

V

-

G

-

E

-

W

-

A

I

I

E

R

L

K

V

L

G

G

I

L

T

V

P

K

E

Y

K

G

S

E

K

K

K

Y

I

A

G

G

Q
x
N

L

Y

S
|
S

K
x
G

G
|
G

Y

N

K

K

Q

R

R

K

V

L

G

S

L

T

A

A

Q

M

A

A

I

L

I

I

H

G

Q

G

P

P

D

P

L

V

I

F

L

L

D

D

E
x
Q

P

P

T

T

N

T

G
|
G

L

M

D

D

P

P

N

K

Q

A

I

R

E

F

I

L

R

W

N

N

-

C

-

A

-

L

-

S

V

V

K

K

E

E

I

-

G

-

Q

-

Q

G

K

R

T

S

V

V

L

V

L

L

S

T

T

S

H
|
H

I

S

M

M

Q

E

E

E

V

C

E

E

A

A

L

L

C

C

S

T

R

R

V

M

I

A

L

I

I

M

H

V

K

N

G

G

N

R

I

F

L

R

Q

C

D

L

C

G

P

S

I

V

D

Q

E

H

F

L

K

K

G

N

R

R

F

F

binding adenosine-5'-triphosphate: Y1630 (≠ F12), K1633 (≠ G13), N1657 (= N37), G1658 (= G38), G1660 (= G40), K1661 (= K41), S1662 (= S42), S1663 (≠ T43), Q1702 (≠ E82), N1753 (≠ Q129), S1755 (= S131), G1756 (≠ K132), G1757 (= G133), Q1779 (≠ E155), G1783 (= G159), H1811 (= H186)
binding magnesium ion: S1662 (= S42),