SitesBLAST
Comparing WP_049904537.1 NCBI__GCF_000336675.1:WP_049904537.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q53W83 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
41% identity, 96% coverage: 5:310/318 of query aligns to 4:301/309 of Q53W83
- GAEVN 34:38 (≠ GAETN 35:39) binding substrate
- YYR 103:105 (= YYR 105:107) binding substrate
- R167 (= R169) binding substrate
- S193 (≠ G196) binding ATP
- 219:225 (vs. 227:233, 71% identical) binding ATP
- GAGD 248:251 (= GAGD 257:260) binding ATP
- D251 (= D260) binding substrate
- N275 (= N284) binding ATP
- D287 (= D296) binding substrate
1v1aA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound 2- keto-3-deoxygluconate and adp (see paper)
41% identity, 96% coverage: 5:310/318 of query aligns to 4:301/301 of 1v1aA
- active site: G248 (= G257), A249 (= A258), G250 (= G259), D251 (= D260)
- binding adenosine-5'-diphosphate: K219 (= K227), G221 (= G229), A222 (= A230), A249 (= A258), G250 (= G259), N275 (= N284), A279 (= A288)
- binding 2-keto-3-deoxygluconate: L11 (≠ M12), G34 (= G35), A35 (= A36), N38 (= N39), Y89 (≠ M91), R105 (= R107), R167 (= R169), G248 (= G257), D251 (= D260), D287 (= D296)
1v1bA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound atp (see paper)
41% identity, 96% coverage: 5:309/318 of query aligns to 4:300/300 of 1v1bA
- active site: G248 (= G257), A249 (= A258), G250 (= G259), D251 (= D260)
- binding adenosine-5'-triphosphate: K219 (= K227), G221 (= G229), A238 (≠ G246), F239 (≠ Y247), V241 (= V249), G248 (= G257), A249 (= A258), G250 (= G259), N275 (= N284), A279 (= A288)
2dcnA Crystal structure of 2-keto-3-deoxygluconate kinase from sulfolobus tokodaii complexed with 2-keto-6-phosphogluconate (alpha-furanose form)
33% identity, 97% coverage: 3:312/318 of query aligns to 1:307/308 of 2dcnA
- active site: G252 (= G257), A253 (= A258), G254 (= G259), D255 (= D260)
- binding adenosine-5'-diphosphate: D193 (≠ G196), K223 (= K227), G225 (= G229), P226 (≠ A230), G228 (= G232), V247 (= V252), G254 (= G259), I279 (≠ N284), S282 (≠ G287), V286 (≠ T291)
- binding 6-O-phosphono-beta-D-psicofuranosonic acid: G33 (= G35), F89 (≠ M91), Y105 (= Y105), R107 (= R107), I136 (= I136), R165 (= R169), T251 (≠ V256), G252 (= G257), D255 (= D260), D291 (= D296)
2varA Crystal structure of sulfolobus solfataricus 2-keto-3-deoxygluconate kinase complexed with 2-keto-3-deoxygluconate (see paper)
31% identity, 97% coverage: 5:312/318 of query aligns to 3:309/311 of 2varA
- active site: G254 (= G257), A255 (= A258), G256 (= G259), D257 (= D260)
- binding adenosine monophosphate: G227 (= G229), G230 (= G232), M259 (≠ F262), S284 (≠ G287), I288 (≠ T291)
- binding phosphoaminophosphonic acid-adenylate ester: K225 (= K227), G227 (= G229), S228 (≠ A230), G230 (= G232), G254 (= G257), A255 (= A258), G256 (= G259), D257 (= D260), M259 (≠ F262), I281 (≠ N284), S284 (≠ G287), I288 (≠ T291)
- binding 3-deoxy-alpha-D-erythro-hex-2-ulofuranosonic acid: L10 (≠ M12), G33 (= G35), S34 (≠ A36), Y89 (≠ M91), Y105 (= Y105), R107 (= R107), I136 (= I136), R165 (= R169), G254 (= G257), D257 (= D260)
- binding 2-keto-3-deoxygluconate: G33 (= G35), S34 (≠ A36), Y89 (≠ M91), L103 (≠ V103), Y105 (= Y105), R107 (= R107), I136 (= I136), R165 (= R169), T253 (≠ V256), G254 (= G257), D257 (= D260), D293 (= D296)
Q97U29 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase; 2-dehydro-3-deoxyglucono/galactono-kinase; 2-keto-3-deoxy-galactonokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; KDGal kinase; EC 2.7.1.178 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
31% identity, 97% coverage: 5:312/318 of query aligns to 4:310/313 of Q97U29
5yggA Crystal structure of fructokinase double-mutant (t261c-h108c) from vibrio cholerae o395 in fructose, adp and potassium ion bound form (see paper)
31% identity, 97% coverage: 3:310/318 of query aligns to 6:309/310 of 5yggA
- binding adenosine-5'-diphosphate: K188 (≠ L194), T221 (≠ K227), G223 (= G229), A242 (≠ D248), V243 (= V249), F255 (= F262), N283 (= N284), G286 (= G287), A287 (= A288)
- binding beta-D-fructofuranose: D13 (≠ E10), D17 (≠ L14), G32 (= G35), A33 (= A36), F100 (≠ V103), F102 (≠ Y105), R163 (= R169), D253 (= D260)
5eynA Crystal structure of fructokinase from vibrio cholerae o395 in fructose, adp, beryllium trifluoride and calcium ion bound form
31% identity, 97% coverage: 3:310/318 of query aligns to 2:305/306 of 5eynA
- active site: G246 (= G257), A247 (= A258), G248 (= G259), D249 (= D260)
- binding adenosine-5'-diphosphate: H91 (≠ F98), T217 (≠ K227), G219 (= G229), A220 (= A230), A238 (≠ D248), V239 (= V249), T244 (≠ P255), G246 (= G257), A247 (= A258), G248 (= G259), F251 (= F262), N279 (= N284), G282 (= G287), A283 (= A288)
- binding beryllium trifluoride ion: G246 (= G257), G248 (= G259), D249 (= D260)
- binding beta-D-fructofuranose: D9 (≠ E10), D13 (≠ L14), G28 (= G35), A29 (= A36), N32 (= N39), F96 (≠ V103), F98 (≠ Y105), R159 (= R169), D249 (= D260)
Q8ZKR2 Aminoimidazole riboside kinase; AIRs kinase; EC 2.7.1.223 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
30% identity, 97% coverage: 3:310/318 of query aligns to 5:307/319 of Q8ZKR2
- D16 (≠ L14) binding 5-amino-1-(beta-D-ribosyl)imidazole
- G31 (= G35) binding 5-amino-1-(beta-D-ribosyl)imidazole
- Y101 (= Y105) binding 5-amino-1-(beta-D-ribosyl)imidazole
- R162 (= R169) binding 5-amino-1-(beta-D-ribosyl)imidazole
- A180 (≠ V187) binding K(+)
- A181 (≠ S188) binding K(+)
- A183 (≠ S190) binding K(+)
- G213 (= G220) binding K(+)
- D246 (= D254) binding K(+)
- T248 (≠ V256) binding K(+)
- D252 (= D260) binding 5-amino-1-(beta-D-ribosyl)imidazole
- A287 (= A290) binding K(+)
- A290 (≠ V293) binding K(+)
- G292 (= G295) binding K(+)
1tz3A Crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside (see paper)
29% identity, 97% coverage: 3:310/318 of query aligns to 1:296/299 of 1tz3A
- active site: C24 (≠ S32), F88 (≠ V103), G238 (= G257), A239 (= A258), G240 (= G259), D241 (= D260)
- binding 5-aminoimidazole ribonucleoside: D8 (≠ E10), S10 (≠ M12), D12 (≠ L14), G27 (= G35), L83 (≠ M91), F88 (≠ V103), Y90 (= Y105), R151 (= R169), M154 (≠ L172), D241 (= D260)
1tz6A Crystal structure of aminoimidazole riboside kinase from salmonella enterica complexed with aminoimidazole riboside and atp analog (see paper)
29% identity, 97% coverage: 3:310/318 of query aligns to 1:296/297 of 1tz6A
- active site: C24 (≠ S32), F88 (≠ V103), G238 (= G257), A239 (= A258), G240 (= G259), D241 (= D260)
- binding phosphomethylphosphonic acid adenylate ester: N149 (= N167), K176 (≠ L194), E181 (= E199), S209 (≠ K227), G211 (= G229), A212 (= A230), G214 (= G232), A239 (= A258), G240 (= G259), F243 (= F262), N270 (= N284), G273 (= G287), A274 (= A288)
- binding 5-aminoimidazole ribonucleoside: D8 (≠ E10), D12 (≠ L14), G27 (= G35), F88 (≠ V103), Y90 (= Y105), R151 (= R169), M154 (≠ L172), D241 (= D260)
3iq0B Crystal structure of a putative ribokinase ii in complex with atp and mg+2 from e.Coli
29% identity, 97% coverage: 3:310/318 of query aligns to 2:305/308 of 3iq0B
- active site: G252 (= G257), A253 (= A258), G254 (= G259), D255 (= D260)
- binding adenosine-5'-triphosphate: S192 (≠ G196), K223 (= K227), G225 (= G229), E247 (≠ R251), A253 (= A258), G254 (= G259), F257 (= F262), N279 (= N284), G282 (= G287)
3in1A Crystal structure of a putative ribokinase in complex with adp from e.Coli
28% identity, 87% coverage: 35:312/318 of query aligns to 40:310/312 of 3in1A
- active site: R106 (≠ P101), G255 (= G257), A256 (= A258), G257 (= G259), D258 (= D260)
- binding adenosine-5'-diphosphate: N194 (≠ G196), K225 (= K227), G227 (= G229), G230 (= G232), A244 (≠ G246), T253 (≠ P255), N282 (= N284), A285 (≠ G287)
4ebuA Crystal structure of a sugar kinase (target efi-502312) from oceanicola granulosus, with bound amp/adp crystal form i
31% identity, 86% coverage: 5:278/318 of query aligns to 17:283/306 of 4ebuA