Comparing WP_050460854.1 NCBI__GCF_001189915.1:WP_050460854.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4k28A 2.15 angstrom resolution crystal structure of a shikimate dehydrogenase family protein from pseudomonas putida kt2440 in complex with NAD+ (see paper)
33% identity, 96% coverage: 11:272/273 of query aligns to 2:262/266 of 4k28A
O67049 Shikimate dehydrogenase (NADP(+)); SD; SDH; EC 1.1.1.25 from Aquifex aeolicus (strain VF5) (see paper)
30% identity, 93% coverage: 9:262/273 of query aligns to 2:242/269 of O67049
2hk9A Crystal structure of shikimate dehydrogenase from aquifex aeolicus in complex with shikimate and NADP+ at 2.2 angstrom resolution (see paper)
30% identity, 93% coverage: 9:262/273 of query aligns to 2:242/269 of 2hk9A
2hk9B Crystal structure of shikimate dehydrogenase from aquifex aeolicus in complex with shikimate and NADP+ at 2.2 angstrom resolution (see paper)
30% identity, 93% coverage: 9:262/273 of query aligns to 2:242/267 of 2hk9B
Q5HNV1 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Staphylococcus epidermidis (strain ATCC 35984 / RP62A) (see paper)
26% identity, 89% coverage: 17:259/273 of query aligns to 4:236/269 of Q5HNV1
Sites not aligning to the query:
3sefC 2.4 angstrom resolution crystal structure of shikimate 5-dehydrogenase (aroe) from vibrio cholerae o1 biovar eltor str. N16961 in complex with shikimate and NADPH
32% identity, 74% coverage: 17:219/273 of query aligns to 5:196/244 of 3sefC
Sites not aligning to the query:
3pgjA 2.49 angstrom resolution crystal structure of shikimate 5- dehydrogenase (aroe) from vibrio cholerae o1 biovar eltor str. N16961 in complex with shikimate
33% identity, 74% coverage: 17:219/273 of query aligns to 5:205/272 of 3pgjA
Sites not aligning to the query:
Q9KVT3 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
33% identity, 74% coverage: 17:219/273 of query aligns to 9:209/278 of Q9KVT3
Sites not aligning to the query:
3dooA Crystal structure of shikimate dehydrogenase from staphylococcus epidermidis complexed with shikimate (see paper)
26% identity, 89% coverage: 17:259/273 of query aligns to 4:227/258 of 3dooA
Sites not aligning to the query:
3sefA 2.4 angstrom resolution crystal structure of shikimate 5-dehydrogenase (aroe) from vibrio cholerae o1 biovar eltor str. N16961 in complex with shikimate and NADPH
37% identity, 55% coverage: 70:219/273 of query aligns to 53:201/268 of 3sefA
Sites not aligning to the query:
1npdB X-ray structure of shikimate dehydrogenase complexed with NAD+ from e.Coli (ydib) northeast structural genomics research consortium (nesg) target er24 (see paper)
25% identity, 93% coverage: 8:262/273 of query aligns to 2:262/288 of 1npdB
P0A6D5 Quinate/shikimate dehydrogenase; NAD-dependent shikimate 5-dehydrogenase; EC 1.1.1.282 from Escherichia coli (strain K12) (see 4 papers)
25% identity, 93% coverage: 8:262/273 of query aligns to 2:262/288 of P0A6D5
Sites not aligning to the query:
1o9bA Quinate/shikimate dehydrogenase ydib complexed with nadh (see paper)
26% identity, 91% coverage: 14:262/273 of query aligns to 2:256/280 of 1o9bA
Q58484 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
28% identity, 93% coverage: 9:262/273 of query aligns to 2:254/282 of Q58484
1nvtB Crystal structure of shikimate dehydrogenase (aroe or mj1084) in complex with NADP+ (see paper)
30% identity, 74% coverage: 9:210/273 of query aligns to 7:205/287 of 1nvtB
Sites not aligning to the query:
1nvtA Crystal structure of shikimate dehydrogenase (aroe or mj1084) in complex with NADP+ (see paper)
30% identity, 74% coverage: 9:210/273 of query aligns to 7:205/287 of 1nvtA
Sites not aligning to the query:
1nytA Shikimate dehydrogenase aroe complexed with NADP+ (see paper)
30% identity, 83% coverage: 17:243/273 of query aligns to 5:224/271 of 1nytA
Sites not aligning to the query:
7tbvA Crystal structure of the shikimate kinase + 3-dehydroquinate dehydratase + 3-dehydroshikimate dehydrogenase domains of aro1 from candida albicans (see paper)
29% identity, 81% coverage: 18:237/273 of query aligns to 407:606/682 of 7tbvA
Sites not aligning to the query:
P15770 Shikimate dehydrogenase (NADP(+)); SD; SDH; EC 1.1.1.25 from Escherichia coli (strain K12) (see paper)
30% identity, 83% coverage: 17:243/273 of query aligns to 5:224/272 of P15770
Sites not aligning to the query:
2o7sA Crystal structure of the a. Thaliana dhq-dehydroshikimate-sdh- shikimate-NADP(h)
32% identity, 97% coverage: 7:272/273 of query aligns to 228:477/500 of 2o7sA
Sites not aligning to the query:
>WP_050460854.1 NCBI__GCF_001189915.1:WP_050460854.1
MHSSTERQITGNTRVVAIIADPIGHVRTPQAFNALMAQRAADAVMVPFNVKPEHFARFIV
AAPLIHNLAGLVVTIPYKETILAHCTELTDAAQRMGAVNIVRFGDAQDGSRSLLGGNFDG
AGFVGGLLAQGYAVQGRRVYLAGAGGAAKAIAHALAAEGIAALGIYNRSPERAEQLVREL
RQYYPQLDAHLAGAAPADYTLAINSTSLGLQSADPLPFAPDGLPAGALVAEVVMKTEITP
LLAKAGACGLAVHFGRHMLEVQIERMGQFLGLI
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory