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Comparing WP_050462203.1 NCBI__GCF_001189915.1:WP_050462203.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q6BF17 D-galactonate dehydratase; GalD; EC 4.2.1.6 from Escherichia coli (strain K12)
37% identity, 100% coverage: 1:379/379 of query aligns to 1:382/382 of Q6BF17
- H185 (= H190) mutation H->N,Q: Loss of activity.
- H285 (= H290) mutation to N: Loss of activity.
- E310 (≠ P310) mutation to Q: Loss of activity.
3rraB Crystal structure of enolase prk14017 (target efi-500653) from ralstonia pickettii 12j with magnesium bound
38% identity, 96% coverage: 18:379/379 of query aligns to 16:375/379 of 3rraB
- active site: I35 (≠ L38), R38 (≠ K41), Y118 (= Y121), K145 (= K149), N147 (≠ Y151), E151 (≠ A155), D184 (= D188), H186 (= H190), E210 (= E214), G235 (= G239), E236 (= E240), R237 (= R241), Q257 (= Q261), D259 (= D263), H286 (= H290), P288 (= P292), E311 (≠ H316)
- binding magnesium ion: D184 (= D188), E210 (= E214), E236 (= E240)
3rcyF Crystal structure of mandelate racemase/muconate lactonizing enzyme- like protein from roseovarius sp. Tm1035
36% identity, 92% coverage: 18:364/379 of query aligns to 23:382/397 of 3rcyF
- active site: K165 (= K149), D167 (≠ Y151), R175 (vs. gap), G208 (≠ D188), H210 (= H190), E234 (= E214), G259 (= G239), E260 (= E240), Q281 (= Q261), A283 (≠ D263), H310 (= H290), A313 (≠ N293), L332 (≠ V312), E335 (= E315)
- binding magnesium ion: E234 (= E214), E260 (= E240)
- binding alpha-D-ribofuranose: R85 (= R78), P86 (≠ G79), P239 (= P219), A266 (≠ F246), E267 (≠ D247)
2o56A Crystal structure of a member of the enolase superfamily from salmonella typhimurium
33% identity, 95% coverage: 1:360/379 of query aligns to 2:386/392 of 2o56A
- active site: K165 (= K149), D167 (vs. gap), M171 (vs. gap), L186 (≠ D160), E214 (≠ D188), H216 (= H190), E240 (= E214), G265 (= G239), E266 (= E240), Q287 (= Q261), D289 (= D263), H316 (= H290), E341 (= E315), A346 (≠ E319)
- binding magnesium ion: E214 (≠ D188), E240 (= E214), E266 (= E240)
4e6mA Crystal structure of putative dehydratase protein from salmonella enterica subsp. Enterica serovar typhimurium (salmonella typhimurium)
33% identity, 94% coverage: 1:358/379 of query aligns to 2:393/401 of 4e6mA
- active site: L45 (= L38), G48 (vs. gap), K169 (= K149), D171 (≠ Y151), I175 (≠ A155), E223 (≠ D188), H225 (= H190), E249 (= E214), G274 (= G239), E275 (= E240), R276 (= R241), Q296 (= Q261), D298 (= D263), H325 (= H290), C327 (≠ P292), E350 (= E319), A355 (vs. gap)
- binding magnesium ion: E223 (≠ D188), E249 (= E214), E275 (= E240)
4ihcB Crystal structure of probable mannonate dehydratase dd703_0947 (target efi-502222) from dickeya dadantii ech703
32% identity, 100% coverage: 1:379/379 of query aligns to 2:382/395 of 4ihcB
- active site: F39 (≠ L38), R42 (≠ K41), R150 (≠ K149), Q152 (vs. gap), D201 (= D188), H203 (= H190), E227 (= E214), G252 (= G239), E253 (= E240), L254 (≠ R241), R274 (≠ Q261), H276 (≠ D263), H303 (= H290), P305 (= P292), E330 (= E315)
- binding magnesium ion: D201 (= D188), E227 (= E214), E253 (= E240)
Sites not aligning to the query:
3v3wA Crystal structure of an enolase from the soil bacterium cellvibrio japonicus (target efi-502161) with bound mg and glycerol
31% identity, 100% coverage: 1:379/379 of query aligns to 1:397/397 of 3v3wA
- active site: L36 (= L38), R39 (≠ K41), H122 (≠ N123), K144 (≠ T146), R147 (≠ K149), Q149 (vs. gap), Y159 (vs. gap), E179 (≠ L162), D205 (= D188), H207 (= H190), E231 (= E214), G256 (= G239), E257 (= E240), V258 (≠ R241), R278 (≠ Q261), T280 (≠ D263), F306 (≠ P289), H307 (= H290), G308 (≠ N291), A309 (≠ P292), E334 (= E315), W397 (= W379)
- binding magnesium ion: D205 (= D188), E231 (= E214), E257 (= E240)
2qq6B Crystal structure of mandelate racemase/muconate lactonizing enzyme- like protein from rubrobacter xylanophilus dsm 9941
34% identity, 97% coverage: 2:367/379 of query aligns to 4:393/396 of 2qq6B
- active site: P37 (= P39), G79 (= G80), D124 (≠ N123), K166 (= K149), D168 (≠ Y151), D213 (= D188), H215 (= H190), E239 (= E214), G264 (= G239), E265 (= E240), M286 (≠ Q261), D288 (= D263), H315 (= H290), N316 (= N291), E340 (= E315), D345 (≠ F323)
- binding magnesium ion: D213 (= D188), E239 (= E214), E265 (= E240), H315 (= H290)
B3PDB1 D-galactonate dehydratase family member RspA; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.8 from Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa) (see paper)
31% identity, 100% coverage: 1:379/379 of query aligns to 1:402/402 of B3PDB1
- D210 (= D188) binding Mg(2+)
- E236 (= E214) binding Mg(2+)
- E262 (= E240) binding Mg(2+)
4e4fB Crystal structure of enolase pc1_0802 (target efi-502240) from pectobacterium carotovorum subsp. Carotovorum pc1
30% identity, 100% coverage: 1:379/379 of query aligns to 2:381/381 of 4e4fB
- active site: L37 (= L38), R40 (≠ K41), R148 (≠ K149), Q150 (≠ Y151), D189 (= D188), H191 (= H190), E215 (= E214), G240 (= G239), E241 (= E240), V242 (≠ R241), R262 (≠ Q261), T264 (≠ D263), H291 (= H290), P293 (= P292), E318 (= E319), W381 (= W379)
- binding magnesium ion: D189 (= D188), E215 (= E214), E241 (= E240)
2ox4C Crystal structure of putative dehydratase from zymomonas mobilis zm4
32% identity, 96% coverage: 1:362/379 of query aligns to 2:388/397 of 2ox4C
- active site: K165 (= K149), D167 (≠ Y151), E214 (≠ D188), H216 (= H190), E240 (= E214), G265 (= G239), E266 (= E240), Q287 (= Q261), D289 (= D263), H316 (= H290), E341 (= E319)
- binding magnesium ion: E214 (≠ D188), E240 (= E214), E266 (= E240)
4k1wA Crystal structure of the a314p mutant of mannonate dehydratase from novosphingobium aromaticivorans complexed with mg and d-mannonate
31% identity, 100% coverage: 1:379/379 of query aligns to 11:395/395 of 4k1wA
- active site: G131 (≠ A122), R157 (≠ K149), Q159 (vs. gap), D203 (= D188), H205 (= H190), E229 (= E214), G254 (= G239), E255 (= E240), R276 (≠ Q261), T278 (≠ D263), H305 (= H290), E332 (= E315), W395 (= W379)
- binding d-mannonic acid: N47 (≠ P39), D203 (= D188), H205 (= H190), E255 (= E240), H305 (= H290), P307 (= P292), D309 (vs. gap), E332 (= E315), L382 (≠ I366), W395 (= W379)
- binding magnesium ion: D203 (= D188), E229 (= E214), E255 (= E240)
- binding 1,3-propandiol: W174 (≠ V159), H202 (≠ L187), Y208 (≠ L193)
3gy1B Crystal structure of putative mandelate racemase/muconate lactonizing protein from clostridium beijerinckii ncimb 8052
30% identity, 93% coverage: 3:354/379 of query aligns to 7:357/388 of 3gy1B
- active site: R152 (≠ K149), Q154 (≠ Y151), D191 (= D188), H193 (= H190), E217 (= E214), G242 (= G239), E243 (= E240), R264 (≠ Q261), H266 (≠ D263), H293 (= H290), E320 (= E315)
- binding magnesium ion: D191 (= D188), E217 (= E214), E243 (= E240)
4e5tA Crystal structure of a putative mandelate racemase/muconate lactonizing enzyme (target psi-200750) from labrenzia alexandrii dfl- 11
32% identity, 95% coverage: 1:360/379 of query aligns to 1:374/392 of 4e5tA
2qjnA Crystal structure of d-mannonate dehydratase from novosphingobium aromaticivorans complexed with mg and 2-keto-3-deoxy-d-gluconate (see paper)
30% identity, 100% coverage: 1:379/379 of query aligns to 1:385/385 of 2qjnA
- active site: G121 (≠ A122), R147 (≠ K149), Q149 (vs. gap), D193 (= D188), H195 (= H190), E219 (= E214), G244 (= G239), E245 (= E240), R266 (≠ Q261), T268 (≠ D263), H295 (= H290), E322 (= E315), W385 (= W379)
- binding 2-keto-3-deoxygluconate: N37 (≠ P39), D193 (= D188), H195 (= H190), E245 (= E240), H295 (= H290), A297 (≠ P292), D299 (vs. gap), E322 (= E315), L372 (≠ I366), W385 (= W379)
- binding magnesium ion: D193 (= D188), E219 (= E214), E245 (= E240)
2qjmA Crystal structure of the k271e mutant of mannonate dehydratase from novosphingobium aromaticivorans complexed with mg and d-mannonate (see paper)
30% identity, 100% coverage: 1:379/379 of query aligns to 1:384/384 of 2qjmA
- active site: G121 (≠ A122), R147 (≠ K149), Q149 (vs. gap), D192 (= D188), H194 (= H190), E218 (= E214), G243 (= G239), E244 (= E240), R265 (≠ Q261), T267 (≠ D263), H294 (= H290), E321 (= E315), W384 (= W379)
- binding d-mannonic acid: N37 (≠ P39), R147 (≠ K149), D192 (= D188), H194 (= H190), E244 (= E240), H294 (= H290), A296 (≠ P292), D298 (vs. gap), E321 (= E315), L371 (≠ I366), W384 (= W379)
- binding magnesium ion: D192 (= D188), E218 (= E214), E244 (= E240)
3rgtA Crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with d-arabinohydroxamate
30% identity, 98% coverage: 8:379/379 of query aligns to 6:383/383 of 3rgtA
- active site: H122 (≠ N123), R147 (≠ K149), Q149 (≠ Y151), D191 (= D188), H193 (= H190), E217 (= E214), G242 (= G239), E243 (= E240), R264 (≠ Q261), P266 (≠ D263), H293 (= H290), G294 (≠ N291), E320 (= E315), W383 (= W379)
- binding cobalt (ii) ion: D191 (= D188), E217 (= E214), E243 (= E240)
- binding (2S,3R,4R)-2,3,4,5-tetrahydroxy-N-oxo-pentanamide: N37 (≠ P39), D191 (= D188), H193 (= H190), E243 (= E240), H293 (= H290), P295 (= P292), D297 (vs. gap), E320 (= E315), W383 (= W379)
3p93C Crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with mg,d-mannonate and 2-keto-3-deoxy-d- gluconate
30% identity, 98% coverage: 8:379/379 of query aligns to 6:384/384 of 3p93C
- active site: H122 (≠ N123), R147 (≠ K149), Q149 (≠ Y151), D192 (= D188), H194 (= H190), E218 (= E214), G243 (= G239), E244 (= E240), R265 (≠ Q261), P267 (≠ D263), H294 (= H290), G295 (≠ N291), E321 (= E315), W384 (= W379)
- binding 2-keto-3-deoxygluconate: N37 (≠ P39), D192 (= D188), H194 (= H190), E244 (= E240), H294 (= H290), P296 (= P292), D298 (vs. gap), E321 (= E315), W384 (= W379)
- binding magnesium ion: D192 (= D188), E218 (= E214), E244 (= E240)
3p93A Crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with mg,d-mannonate and 2-keto-3-deoxy-d- gluconate
30% identity, 98% coverage: 8:379/379 of query aligns to 6:384/384 of 3p93A
- active site: H122 (≠ N123), R147 (≠ K149), Q149 (≠ Y151), D192 (= D188), H194 (= H190), E218 (= E214), G243 (= G239), E244 (= E240), R265 (≠ Q261), P267 (≠ D263), H294 (= H290), G295 (≠ N291), E321 (= E315), W384 (= W379)
- binding d-mannonic acid: N37 (≠ P39), D192 (= D188), H194 (= H190), E244 (= E240), H294 (= H290), P296 (= P292), D298 (vs. gap), E321 (= E315)
- binding magnesium ion: D192 (= D188), E218 (= E214), E244 (= E240)
A6M2W4 D-galactonate dehydratase family member Cbei_4837 from Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) (see paper)
29% identity, 93% coverage: 3:354/379 of query aligns to 6:371/399 of A6M2W4
- D205 (= D188) binding Mg(2+)
- E231 (= E214) binding Mg(2+)
- E257 (= E240) binding Mg(2+)
Query Sequence
>WP_050462203.1 NCBI__GCF_001189915.1:WP_050462203.1
MKITAIKAFATVSPVSDWVFVKVETDQPGLIGWGECSLPGKPNAMLGAVADLEKLVVGAD
PTNTEWCWQRMYRHAFWRGGPIQTAALSGVDIALWDIRGKLANQPVYKLMGGAVRDRIRL
YANCGLSSDPEELRRRVRHAVSLGYTAVKFYPLPAVNAVDSLATIRQVVACCEAVRDEIG
AERDFALDFHGRLSSGFAVEIESAIRHTKPLWIEEPVLPETPKALARLAEKCVIPIAVGE
RLFTRFDFREVLENEWATVIQPDVANAGGITEMMKIAAFAETYGVALAPHNPNGPVQSIA
GMHLAAALQPFVILEHRHEHHDFLEQLADNIPKVGADGYVGLPKGPGLGIHVNEEFARAN
NHGTWIPEVFRADGTIGDW
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory