SitesBLAST
Comparing WP_051244599.1 NCBI__GCF_000430725.1:WP_051244599.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound (see paper)
34% identity, 90% coverage: 13:421/454 of query aligns to 7:422/425 of 6zgbA
6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis) (see paper)
34% identity, 90% coverage: 13:421/454 of query aligns to 6:421/424 of 6zl4A
- binding decyl-beta-d-maltopyranoside: L191 (≠ G198), G195 (≠ M202), R282 (≠ K289)
- binding (2~{S},3~{S})-2-azanyl-3-[[4-[2-(4-methoxyphenyl)hydrazinyl]phenyl]methoxy]butanedioic acid: R271 (≠ A278), S272 (= S279), S273 (≠ T280), M307 (≠ P313), T310 (= T316), G353 (= G359), A354 (= A360), R394 (= R394), T395 (≠ A395)
Sites not aligning to the query:
5e9sA Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
34% identity, 90% coverage: 13:421/454 of query aligns to 9:424/427 of 5e9sA
- binding aspartic acid: R274 (≠ A278), S275 (= S279), S276 (≠ T280), T313 (= T316), G353 (= G356), V354 (= V357), A357 (= A360), G358 (= G361), D394 (≠ N391), R397 (= R394), T398 (≠ A395)
- binding decyl-beta-d-maltopyranoside: L194 (≠ G198), G198 (≠ M202), Y202 (≠ L206)
- binding sodium ion: Y87 (≠ F90), T90 (≠ L93), S91 (= S94), S276 (≠ T280), G305 (= G308), A306 (≠ Y309), T307 (= T310), N309 (= N312), N309 (= N312), M310 (≠ P313), D311 (= D314), S348 (= S351), I349 (≠ K352), G350 (= G353), T351 (≠ S354), N401 (= N398), V402 (≠ L399), D405 (≠ N402)
6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor (see paper)
34% identity, 90% coverage: 13:421/454 of query aligns to 9:424/426 of 6xwnB
O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 3 papers)
32% identity, 89% coverage: 13:418/454 of query aligns to 11:421/425 of O59010
- S65 (≠ T65) mutation to V: Strongly decreased chloride conductance.
- R276 (≠ A278) mutation to S: Increased rate of aspartate transport; when associated with R-395.
- RSS 276:278 (≠ AST 278:280) binding L-aspartate
- M311 (≠ P313) mutation to A: Decreased dependence of aspartate binding on Na(+) concentration.
- T314 (= T316) binding L-aspartate
- V355 (= V357) binding L-aspartate
- D394 (≠ N391) binding L-aspartate
- M395 (≠ E392) mutation to R: Increased rate of aspartate transport; when associated with S-276.
- R397 (= R394) mutation to A: Strongly decreased affinity for aspartate.
- N401 (= N398) binding L-aspartate
- D405 (≠ N402) mutation to N: Strongly decreased affinity for aspartate.
2nwwA Crystal structure of gltph in complex with tboa (see paper)
32% identity, 88% coverage: 13:413/454 of query aligns to 2:407/407 of 2nwwA
6x15A Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
32% identity, 89% coverage: 13:414/454 of query aligns to 11:417/419 of 6x15A
- binding [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate: F46 (≠ L46), F46 (≠ L46), P75 (≠ D75), L91 (≠ V92), F95 (≠ L96), L130 (≠ A140), I133 (≠ F143), I159 (≠ V169), Y167 (vs. gap), K196 (≠ G198), G200 (≠ M202), I207 (= I209), F210 (= F212), L250 (≠ V252), I262 (≠ L264), M269 (≠ L271), T334 (≠ S336), V335 (≠ L337), G336 (≠ S338), T340 (≠ V342), L343 (≠ S345), M399 (≠ I396)
- binding aspartic acid: S277 (= S279), S278 (≠ T280), T314 (= T316), G354 (= G356), A358 (= A360), G359 (= G361), D394 (≠ N391), R397 (= R394), T398 (≠ A395)
- binding sodium ion: Y89 (≠ F90), T92 (≠ L93), S93 (= S94), G306 (= G308), T308 (= T310), N310 (= N312), N310 (= N312), M311 (≠ P313), D312 (= D314), S349 (= S351), I350 (≠ K352), T352 (≠ S354), N401 (= N398), V402 (≠ L399), D405 (≠ N402)
Sites not aligning to the query:
6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate (see paper)
33% identity, 90% coverage: 13:421/454 of query aligns to 2:413/416 of 6r7rA
- binding d-aspartic acid: R263 (≠ A278), S265 (≠ T280), M299 (≠ P313), T302 (= T316), T340 (≠ S354), G342 (= G356), V343 (= V357), G347 (= G361), D383 (≠ N391), R386 (= R394), T387 (≠ A395), N390 (= N398)
- binding decyl-beta-d-maltopyranoside: H23 (= H34), V212 (≠ M227), A216 (≠ G231)
6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa (see paper)
31% identity, 88% coverage: 13:413/454 of query aligns to 8:413/413 of 6x14A
- binding [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate: G66 (= G69), V83 (≠ L87), I157 (≠ L170), Y164 (vs. gap), K193 (≠ G198), T305 (= T310), I306 (≠ F311), I347 (≠ K352)
- binding (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid: I13 (≠ L18), M199 (= M204), S275 (≠ T280), T311 (= T316), G356 (= G361), L384 (= L384), D391 (≠ N391), R394 (= R394)
Sites not aligning to the query:
6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine (see paper)
32% identity, 89% coverage: 13:414/454 of query aligns to 3:409/409 of 6bavA
6bauA Crystal structure of gltph r397c in complex with l-cysteine (see paper)
31% identity, 88% coverage: 13:413/454 of query aligns to 3:408/408 of 6bauA