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Comparing WP_052306284.1 NCBI__GCF_000020045.1:WP_052306284.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
42% identity, 97% coverage: 19:584/584 of query aligns to 9:582/596 of 1t9cA
- active site: Y29 (= Y39), G31 (= G41), G32 (= G42), A33 (= A43), I34 (≠ V44), E55 (= E65), T78 (= T88), F117 (= F127), Q118 (= Q128), E119 (= E129), K167 (= K177), R227 (≠ E237), M263 (≠ L272), V290 (= V299), V406 (= V406), L431 (= L431), G432 (= G432), M434 (= M434), D459 (= D459), N486 (= N486), E488 (≠ Y488), Q489 (≠ L489), M491 (= M491), V492 (= V492), W495 (≠ L495), L517 (= L518), G522 (= G523), L523 (≠ H524), K556 (≠ P558)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G42), V107 (= V117), P108 (= P118), F117 (= F127), K167 (= K177), D288 (= D297), R289 (= R298), W495 (≠ L495)
- binding flavin-adenine dinucleotide: R157 (= R167), G216 (= G226), A217 (≠ G227), G218 (= G228), N221 (≠ A231), T243 (= T252), L244 (= L253), Q245 (≠ M254), L261 (≠ P270), M263 (≠ L272), H264 (= H273), G283 (= G292), A284 (= A293), R285 (= R294), D287 (= D296), R289 (= R298), V290 (= V299), E316 (≠ D317), V317 (≠ I318), N321 (≠ T322), G334 (= G335), D335 (= D336), A336 (≠ V337), M411 (= M411), G429 (= G429), G430 (= G430)
- binding magnesium ion: D459 (= D459), N486 (= N486), E488 (≠ Y488)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
42% identity, 97% coverage: 19:584/584 of query aligns to 9:582/596 of 1t9dA
- active site: Y29 (= Y39), G31 (= G41), G32 (= G42), A33 (= A43), I34 (≠ V44), E55 (= E65), T78 (= T88), F117 (= F127), Q118 (= Q128), E119 (= E129), K167 (= K177), R227 (≠ E237), M263 (≠ L272), V290 (= V299), V406 (= V406), L431 (= L431), G432 (= G432), M434 (= M434), D459 (= D459), N486 (= N486), E488 (≠ Y488), Q489 (≠ L489), M491 (= M491), V492 (= V492), W495 (≠ L495), L517 (= L518), G522 (= G523), L523 (≠ H524), K556 (≠ P558)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G42), A33 (= A43), V107 (= V117), P108 (= P118), F117 (= F127), K167 (= K177), M263 (≠ L272), D288 (= D297), R289 (= R298), W495 (≠ L495)
- binding flavin-adenine dinucleotide: R157 (= R167), G216 (= G226), A217 (≠ G227), G218 (= G228), N221 (≠ A231), T243 (= T252), L244 (= L253), Q245 (≠ M254), M260 (= M269), L261 (≠ P270), H264 (= H273), G283 (= G292), A284 (= A293), R285 (= R294), D287 (= D296), R289 (= R298), V290 (= V299), E316 (≠ D317), V317 (≠ I318), N321 (≠ T322), G334 (= G335), D335 (= D336), A336 (≠ V337), Q410 (= Q410), M411 (= M411), G429 (= G429), G430 (= G430)
- binding magnesium ion: D459 (= D459), N486 (= N486), E488 (≠ Y488)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E65), P81 (= P91), Q118 (= Q128), G432 (= G432), M434 (= M434), M464 (= M464)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
42% identity, 97% coverage: 19:584/584 of query aligns to 10:583/597 of 1t9aA
- active site: Y30 (= Y39), G32 (= G41), G33 (= G42), A34 (= A43), I35 (≠ V44), E56 (= E65), T79 (= T88), F118 (= F127), Q119 (= Q128), E120 (= E129), K168 (= K177), R228 (≠ E237), M264 (≠ L272), V291 (= V299), V407 (= V406), L432 (= L431), G433 (= G432), M435 (= M434), D460 (= D459), N487 (= N486), E489 (≠ Y488), Q490 (≠ L489), M492 (= M491), V493 (= V492), W496 (≠ L495), L518 (= L518), G523 (= G523), L524 (≠ H524), K557 (≠ P558)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G42), V108 (= V117), P109 (= P118), F118 (= F127), K168 (= K177), M264 (≠ L272), D289 (= D297), R290 (= R298), M492 (= M491), V493 (= V492), W496 (≠ L495)
- binding flavin-adenine dinucleotide: R158 (= R167), G217 (= G226), A218 (≠ G227), G219 (= G228), N222 (≠ A231), T244 (= T252), L245 (= L253), Q246 (≠ M254), L262 (≠ P270), M264 (≠ L272), H265 (= H273), G284 (= G292), A285 (= A293), R286 (= R294), D288 (= D296), R290 (= R298), V291 (= V299), E317 (≠ D317), V318 (≠ I318), N322 (≠ T322), G335 (= G335), D336 (= D336), A337 (≠ V337), Q411 (= Q410), M412 (= M411), G430 (= G429), G431 (= G430)
- binding magnesium ion: D460 (= D459), N487 (= N486), E489 (≠ Y488)
- binding propyl trihydrogen diphosphate: V407 (= V406), G408 (= G407), Q409 (= Q408), H410 (= H409), M435 (= M434), G459 (= G458), D460 (= D459), A461 (≠ G460), S462 (= S461), N487 (= N486), E489 (≠ Y488), Q490 (≠ L489), G491 (= G490), M492 (= M491)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G432), M435 (= M434), M465 (= M464)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
42% identity, 97% coverage: 19:584/584 of query aligns to 9:581/595 of 1t9bB
- active site: Y29 (= Y39), G31 (= G41), G32 (= G42), A33 (= A43), I34 (≠ V44), E55 (= E65), T78 (= T88), F117 (= F127), Q118 (= Q128), E119 (= E129), K167 (= K177), R226 (≠ E237), M262 (≠ L272), V289 (= V299), V405 (= V406), L430 (= L431), G431 (= G432), M433 (= M434), D458 (= D459), N485 (= N486), E487 (≠ Y488), Q488 (≠ L489), M490 (= M491), V491 (= V492), W494 (≠ L495), L516 (= L518), G521 (= G523), L522 (≠ H524), K555 (≠ P558)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V117), P108 (= P118), D287 (= D297), R288 (= R298), M490 (= M491), W494 (≠ L495)
- binding flavin-adenine dinucleotide: R157 (= R167), G215 (= G226), A216 (≠ G227), G217 (= G228), N220 (≠ A231), T242 (= T252), L243 (= L253), Q244 (≠ M254), M259 (= M269), L260 (≠ P270), M262 (≠ L272), H263 (= H273), G282 (= G292), A283 (= A293), R284 (= R294), D286 (= D296), R288 (= R298), V289 (= V299), E315 (≠ D317), V316 (≠ I318), N320 (≠ T322), G333 (= G335), D334 (= D336), A335 (≠ V337), Q409 (= Q410), M410 (= M411), G428 (= G429), G429 (= G430)
- binding magnesium ion: D458 (= D459), N485 (= N486), E487 (≠ Y488)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
42% identity, 97% coverage: 19:584/584 of query aligns to 11:585/599 of 1n0hA
- active site: Y31 (= Y39), G33 (= G41), G34 (= G42), A35 (= A43), I36 (≠ V44), E57 (= E65), T80 (= T88), F119 (= F127), Q120 (= Q128), E121 (= E129), K169 (= K177), R230 (≠ E237), M266 (≠ L272), V293 (= V299), V409 (= V406), L434 (= L431), G435 (= G432), M437 (= M434), D462 (= D459), N489 (= N486), E491 (≠ Y488), Q492 (≠ L489), M494 (= M491), V495 (= V492), W498 (≠ L495), L520 (= L518), G525 (= G523), L526 (≠ H524), K559 (≠ P558)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V406), G410 (= G407), Q411 (= Q408), H412 (= H409), G435 (= G432), M437 (= M434), G461 (= G458), D462 (= D459), A463 (≠ G460), S464 (= S461), M467 (= M464), N489 (= N486), E491 (≠ Y488), Q492 (≠ L489), G493 (= G490), V495 (= V492)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G42), A35 (= A43), V109 (= V117), P110 (= P118), F119 (= F127), K169 (= K177), M266 (≠ L272), D291 (= D297), R292 (= R298), V495 (= V492), W498 (≠ L495)
- binding flavin-adenine dinucleotide: R159 (= R167), G219 (= G226), A220 (≠ G227), G221 (= G228), N224 (≠ A231), T246 (= T252), L247 (= L253), Q248 (≠ M254), L264 (≠ P270), G265 (= G271), M266 (≠ L272), H267 (= H273), G286 (= G292), A287 (= A293), R288 (= R294), D290 (= D296), R292 (= R298), V293 (= V299), E319 (≠ D317), V320 (≠ I318), N324 (≠ T322), G337 (= G335), D338 (= D336), A339 (≠ V337), M414 (= M411), G432 (= G429), G433 (= G430)
- binding magnesium ion: D462 (= D459), N489 (= N486), E491 (≠ Y488)
- binding thiamine diphosphate: Y31 (= Y39), E57 (= E65), P83 (= P91)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
41% identity, 95% coverage: 20:576/584 of query aligns to 99:661/670 of P17597
- A122 (= A43) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L45) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E65) binding thiamine diphosphate
- S186 (= S107) binding FAD
- P197 (= P118) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ H120) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q128) binding thiamine diphosphate
- K220 (= K141) binding (R)-imazaquin
- R246 (= R167) binding (R)-imazaquin; binding FAD
- K256 (= K177) binding chlorimuron-ethyl
- G308 (= G227) binding FAD
- TL 331:332 (= TL 252:253) binding FAD
- C340 (≠ A261) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (≠ PGLH 270:273) binding FAD
- GVRFD 371:375 (≠ GARFD 292:296) binding FAD
- DR 376:377 (= DR 297:298) binding chlorimuron-ethyl
- DI 395:396 (= DI 317:318) binding FAD
- DV 414:415 (= DV 336:337) binding FAD
- QH 487:488 (= QH 408:409) binding thiamine diphosphate
- GG 508:509 (= GG 429:430) binding FAD
- GAM 511:513 (≠ GTM 432:434) binding thiamine diphosphate
- D538 (= D459) binding Mg(2+)
- DGS 538:540 (= DGS 459:461) binding thiamine diphosphate
- N565 (= N486) binding Mg(2+)
- NQHLGM 565:570 (≠ NGYLGM 486:491) binding thiamine diphosphate
- H567 (≠ Y488) binding Mg(2+)
- W574 (≠ L495) binding chlorimuron-ethyl; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ A568) binding chlorimuron-ethyl; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
42% identity, 97% coverage: 19:584/584 of query aligns to 13:593/607 of 6u9dB
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), I38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M274 (≠ L272), V301 (= V299), V417 (= V406), G443 (= G432), M445 (= M434), D470 (= D459), N497 (= N486), E499 (≠ Y488), Q500 (≠ L489), M502 (= M491), V503 (= V492), W506 (≠ L495)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G42), V111 (= V117), P112 (= P118), F121 (= F127), K171 (= K177), D299 (= D297), R300 (= R298), M502 (= M491), W506 (≠ L495)
- binding flavin-adenine dinucleotide: R161 (= R167), A228 (≠ G227), G229 (= G228), N232 (≠ A231), T254 (= T252), L255 (= L253), Q256 (≠ M254), L272 (≠ P270), M274 (≠ L272), G294 (= G292), R296 (= R294), D298 (= D296), R300 (= R298), V301 (= V299), E327 (≠ D317), V328 (≠ I318), N332 (≠ T322), D346 (= D336), A347 (≠ V337), M422 (= M411), G440 (= G429), G441 (= G430)
- binding magnesium ion: D470 (= D459), N497 (= N486)
- binding thiamine diphosphate: E59 (= E65), P85 (= P91), V417 (= V406), G418 (= G407), Q419 (= Q408), H420 (= H409), G443 (= G432), M445 (= M434), A471 (≠ G460), S472 (= S461), N497 (= N486), E499 (≠ Y488), Q500 (≠ L489), G501 (= G490), M502 (= M491), V503 (= V492)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V406), G401 (= G407), Q402 (= Q408), H403 (= H409), G426 (= G432), M428 (= M434), G452 (= G458), D453 (= D459), G454 (= G460), S455 (= S461), M458 (= M464), N480 (= N486), H482 (≠ Y488), L483 (= L489), G484 (= G490), M485 (= M491), V486 (= V492)
- binding flavin-adenine dinucleotide: R161 (= R167), G222 (= G226), G223 (= G227), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), L264 (≠ P270), M266 (≠ L272), H267 (= H273), G286 (= G292), V287 (≠ A293), R288 (= R294), D290 (= D296), R292 (= R298), V293 (= V299), D310 (= D317), I311 (= I318), D329 (= D336), V330 (= V337), M405 (= M411), G423 (= G429)
- binding magnesium ion: F370 (≠ Y376), D453 (= D459), M458 (= M464), Q461 (= Q467), N480 (= N486), H482 (≠ Y488), K533 (≠ P532)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ L272), R292 (= R298), M485 (= M491), W489 (≠ L495), S568 (≠ A568)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/582 of 5wj1A
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), S38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M266 (≠ L272), V293 (= V299), V400 (= V406), G426 (= G432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ Y488), L483 (= L489), M485 (= M491), V486 (= V492), W489 (≠ L495), H558 (≠ P558)
- binding flavin-adenine dinucleotide: R161 (= R167), G222 (= G226), G223 (= G227), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), M263 (= M269), L264 (≠ P270), G286 (= G292), R288 (= R294), V293 (= V299), D310 (= D317), I311 (= I318), D329 (= D336), V330 (= V337), M405 (= M411), G423 (= G429), G424 (= G430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ Y488)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ L272), D291 (= D297), R292 (= R298), M485 (= M491), W489 (≠ L495), S568 (≠ A568)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V406), G401 (= G407), Q402 (= Q408), H403 (= H409), M428 (= M434), D453 (= D459), G454 (= G460), S455 (= S461), M458 (= M464), N480 (= N486), H482 (≠ Y488), L483 (= L489), G484 (= G490), M485 (= M491), V486 (= V492)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/582 of 5k6tA
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), S38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M266 (≠ L272), V293 (= V299), V400 (= V406), G426 (= G432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ Y488), L483 (= L489), M485 (= M491), V486 (= V492), W489 (≠ L495), H558 (≠ P558)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H273), R292 (= R298), M485 (= M491), W489 (≠ L495), S568 (≠ A568)
- binding flavin-adenine dinucleotide: R161 (= R167), G222 (= G226), G223 (= G227), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), L264 (≠ P270), G286 (= G292), R288 (= R294), D290 (= D296), R292 (= R298), V293 (= V299), D310 (= D317), I311 (= I318), D329 (= D336), V330 (= V337), Q404 (= Q410), M405 (= M411), G423 (= G429)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ Y488)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V406), G401 (= G407), Q402 (= Q408), H403 (= H409), G426 (= G432), M428 (= M434), G452 (= G458), G454 (= G460), S455 (= S461), N480 (= N486), H482 (≠ Y488), L483 (= L489), G484 (= G490)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/582 of 5k6rA
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), S38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M266 (≠ L272), V293 (= V299), V400 (= V406), G426 (= G432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ Y488), L483 (= L489), M485 (= M491), V486 (= V492), W489 (≠ L495), H558 (≠ P558)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R298), W489 (≠ L495), S568 (≠ A568)
- binding flavin-adenine dinucleotide: R161 (= R167), G222 (= G226), G223 (= G227), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), L264 (≠ P270), M266 (≠ L272), G286 (= G292), R288 (= R294), R292 (= R298), V293 (= V299), D310 (= D317), I311 (= I318), G328 (= G335), D329 (= D336), V330 (= V337), M405 (= M411), G423 (= G429)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ Y488)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V406), G401 (= G407), Q402 (= Q408), H403 (= H409), G426 (= G432), M428 (= M434), D453 (= D459), G454 (= G460), S455 (= S461), M458 (= M464), N480 (= N486), H482 (≠ Y488), L483 (= L489), G484 (= G490), M485 (= M491), V486 (= V492)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/582 of 1z8nA
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), S38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M266 (≠ L272), V293 (= V299), V400 (= V406), G426 (= G432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ Y488), L483 (= L489), M485 (= M491), V486 (= V492), W489 (≠ L495), H558 (≠ P558)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K141), R161 (= R167), Y191 (= Y197), R194 (vs. gap), D291 (= D297), R292 (= R298), D312 (= D319), W489 (≠ L495), G569 (= G569)
- binding flavin-adenine dinucleotide: R161 (= R167), G222 (= G226), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), L264 (≠ P270), G265 (= G271), M266 (≠ L272), H267 (= H273), G286 (= G292), V287 (≠ A293), R288 (= R294), D290 (= D296), R292 (= R298), V293 (= V299), D310 (= D317), I311 (= I318), D329 (= D336), V330 (= V337), M405 (= M411), G423 (= G429), G424 (= G430)
- binding magnesium ion: D453 (= D459), N480 (= N486)
- binding thiamine diphosphate: V400 (= V406), G401 (= G407), Q402 (= Q408), H403 (= H409), G426 (= G432), M428 (= M434), G452 (= G458), G454 (= G460), S455 (= S461), N480 (= N486), H482 (≠ Y488), L483 (= L489), G484 (= G490), M485 (= M491), V486 (= V492)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/582 of 1yi1A
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), S38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M266 (≠ L272), V293 (= V299), V400 (= V406), G426 (= G432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ Y488), L483 (= L489), M485 (= M491), V486 (= V492), W489 (≠ L495), H558 (≠ P558)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D297), R292 (= R298), W489 (≠ L495), S568 (≠ A568)
- binding flavin-adenine dinucleotide: R161 (= R167), G223 (= G227), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), M263 (= M269), L264 (≠ P270), G265 (= G271), M266 (≠ L272), H267 (= H273), G286 (= G292), V287 (≠ A293), R288 (= R294), D290 (= D296), V293 (= V299), D310 (= D317), I311 (= I318), D329 (= D336), V330 (= V337), M405 (= M411), G423 (= G429), G424 (= G430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ Y488)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/582 of 1yi0A
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), S38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M266 (≠ L272), V293 (= V299), V400 (= V406), G426 (= G432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ Y488), L483 (= L489), M485 (= M491), V486 (= V492), W489 (≠ L495), H558 (≠ P558)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D297), R292 (= R298), W489 (≠ L495), S568 (≠ A568)
- binding flavin-adenine dinucleotide: R161 (= R167), G222 (= G226), G223 (= G227), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), L264 (≠ P270), G265 (= G271), M266 (≠ L272), H267 (= H273), G286 (= G292), V287 (≠ A293), R288 (= R294), D290 (= D296), R292 (= R298), V293 (= V299), D310 (= D317), I311 (= I318), G328 (= G335), D329 (= D336), V330 (= V337), M405 (= M411), G423 (= G429), G424 (= G430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ Y488)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/582 of 1yhzA
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), S38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M266 (≠ L272), V293 (= V299), V400 (= V406), G426 (= G432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ Y488), L483 (= L489), M485 (= M491), V486 (= V492), W489 (≠ L495), H558 (≠ P558)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D297), R292 (= R298), M485 (= M491), W489 (≠ L495), S568 (≠ A568)
- binding flavin-adenine dinucleotide: R161 (= R167), G223 (= G227), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), L264 (≠ P270), M266 (≠ L272), H267 (= H273), G286 (= G292), V287 (≠ A293), R288 (= R294), D290 (= D296), V293 (= V299), D310 (= D317), I311 (= I318), D329 (= D336), V330 (= V337), Q404 (= Q410), M405 (= M411), G423 (= G429), G424 (= G430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ Y488)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/582 of 1yhyA
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), S38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M266 (≠ L272), V293 (= V299), V400 (= V406), G426 (= G432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ Y488), L483 (= L489), M485 (= M491), V486 (= V492), W489 (≠ L495), H558 (≠ P558)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D297), R292 (= R298), V486 (= V492), W489 (≠ L495), S568 (≠ A568)
- binding flavin-adenine dinucleotide: R161 (= R167), G222 (= G226), G223 (= G227), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), L264 (≠ P270), G265 (= G271), M266 (≠ L272), H267 (= H273), G286 (= G292), V287 (≠ A293), R288 (= R294), D290 (= D296), V293 (= V299), D310 (= D317), I311 (= I318), D329 (= D336), V330 (= V337), Q404 (= Q410), M405 (= M411), G423 (= G429), G424 (= G430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ Y488)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/582 of 1ybhA
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), S38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M266 (≠ L272), V293 (= V299), V400 (= V406), G426 (= G432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ Y488), L483 (= L489), M485 (= M491), V486 (= V492), W489 (≠ L495), H558 (≠ P558)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (≠ L272), D291 (= D297), R292 (= R298), M485 (= M491), W489 (≠ L495), S568 (≠ A568)
- binding flavin-adenine dinucleotide: R161 (= R167), G223 (= G227), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), L264 (≠ P270), M266 (≠ L272), H267 (= H273), G286 (= G292), V287 (≠ A293), R288 (= R294), D290 (= D296), V293 (= V299), D310 (= D317), I311 (= I318), D329 (= D336), V330 (= V337), Q404 (= Q410), M405 (= M411), G423 (= G429), G424 (= G430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ Y488)
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/585 of 5k2oA
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), S38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M266 (≠ L272), V293 (= V299), V400 (= V406), G426 (= G432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ Y488), L483 (= L489), M485 (= M491), V486 (= V492), W489 (≠ L495), H558 (≠ P558)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (≠ L272), R292 (= R298), W489 (≠ L495), S568 (≠ A568)
- binding flavin-adenine dinucleotide: R161 (= R167), G222 (= G226), G223 (= G227), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), L264 (≠ P270), G286 (= G292), R288 (= R294), D290 (= D296), V293 (= V299), D310 (= D317), I311 (= I318), D329 (= D336), V330 (= V337), Q404 (= Q410), M405 (= M411), G423 (= G429)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ Y488)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V406), G401 (= G407), Q402 (= Q408), H403 (= H409), M428 (= M434), D453 (= D459), G454 (= G460), S455 (= S461), N480 (= N486), H482 (≠ Y488), L483 (= L489), G484 (= G490), M485 (= M491), V486 (= V492)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 13:576/583 of 5k3sA
- active site: Y33 (= Y39), G35 (= G41), G36 (= G42), A37 (= A43), S38 (≠ V44), E59 (= E65), T82 (= T88), F121 (= F127), Q122 (= Q128), E123 (= E129), K171 (= K177), M266 (≠ L272), V293 (= V299), V400 (= V406), G426 (= G432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ Y488), L483 (= L489), M485 (= M491), V486 (= V492), W489 (≠ L495), H558 (≠ P558)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R298), M485 (= M491), W489 (≠ L495), G569 (= G569)
- binding flavin-adenine dinucleotide: R161 (= R167), G222 (= G226), G223 (= G227), G224 (= G228), T246 (= T252), L247 (= L253), M248 (= M254), L264 (≠ P270), M266 (≠ L272), G286 (= G292), R288 (= R294), D290 (= D296), V293 (= V299), D310 (= D317), I311 (= I318), D329 (= D336), V330 (= V337), M405 (= M411), G423 (= G429)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ Y488)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V406), G401 (= G407), Q402 (= Q408), H403 (= H409), G426 (= G432), M428 (= M434), D453 (= D459), G454 (= G460), S455 (= S461), N480 (= N486), H482 (≠ Y488), L483 (= L489), G484 (= G490), M485 (= M491), V486 (= V492)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
41% identity, 96% coverage: 19:576/584 of query aligns to 12:575/582 of 3ea4A
- active site: Y32 (= Y39), G34 (= G41), G35 (= G42), A36 (= A43), S37 (≠ V44), E58 (= E65), T81 (= T88), F120 (= F127), Q121 (= Q128), E122 (= E129), K170 (= K177), M265 (≠ L272), V292 (= V299), V399 (= V406), G425 (= G432), M427 (= M434), D452 (= D459), N479 (= N486), H481 (≠ Y488), L482 (= L489), M484 (= M491), V485 (= V492), W488 (≠ L495), H557 (≠ P558)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D297), R291 (= R298), W488 (≠ L495), S567 (≠ A568)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R167), G221 (= G226), G222 (= G227), G223 (= G228), T245 (= T252), L246 (= L253), M247 (= M254), L263 (≠ P270), G264 (= G271), M265 (≠ L272), H266 (= H273), G285 (= G292), R287 (= R294), D289 (= D296), R291 (= R298), D309 (= D317), I310 (= I318), G327 (= G335), D328 (= D336), V329 (= V337), M404 (= M411), G422 (= G429)
- binding magnesium ion: D452 (= D459), N479 (= N486), H481 (≠ Y488)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V406), G400 (= G407), Q401 (= Q408), H402 (= H409), M427 (= M434), G451 (= G458), D452 (= D459), G453 (= G460), S454 (= S461), N479 (= N486), H481 (≠ Y488), L482 (= L489), G483 (= G490), M484 (= M491), V485 (= V492)
Query Sequence
>WP_052306284.1 NCBI__GCF_000020045.1:WP_052306284.1
MQQLAKAGPEALGKNGNASGAQIVLSVLRAEGVDTVWGYPGGAVLPLYDALQETVDITHL
LVRHEQAAVHAADGFARATGKVGVALVTSGPGVTNTVTGIATAYFDSIPMVVISGNVPTH
SIGTDAFQECDAVGITRSIVKHNFLVLDISQLAKTLKSAFYIARTGRPGPVLVDIPKDVL
QAKTPLSIAESVALRSYRPRTEPHVGQVRRAAEALARSRRPCILVGGGAVASAASEEIAE
LVRRLDAPVTNTLMALGAFPASDRRCLGMPGLHGTYEANLAMQHCDVLIALGARFDDRVI
GNTGEFQSDRRTIIHVDIDPATIDKRVQVDIPIVGDVKTAARAILEQLRAQRINDGNRND
WWKEIGNWREKRCLAYEPDADVIKPQFVIQQLWEATGGDAYICSDVGQHQMWAAQLYGFD
KPRRWINSGGLGTMGVGLPYAMGVKRALPDADVVAVTGDGSIQMCIQELSTCRQYDLGVK
IVSLNNGYLGMVRQLQHVNYRDRYSHSYMDALPDFVALARAYGHVGFRIERPCDVEPVLR
EALAMKQRTVFMDFAIDPSENVWPMVRAGAGLTDMLMNSRDVDR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory