SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_052368278.1 NCBI__GCF_000733765.1:WP_052368278.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 5 papers)
61% identity, 99% coverage: 15:1254/1255 of query aligns to 6:1227/1227 of P13009

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P13009

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C247 (= C254) binding Zn(2+)
C310 (= C317) binding Zn(2+); mutation C->A,S: Loss of zinc binding. Loss of catalytic activity.
C311 (= C318) binding Zn(2+); mutation C->A,S: Loss of zinc binding. Loss of catalytic activity.
E694 (= E707) binding methylcob(III)alamin
GDVHD 756:760 (= GDVHD 772:776) binding methylcob(III)alamin
D757 (= D773) mutation to E: Decreases activity by about 70%.; mutation to N: Decreases activity by about 45%.
H759 (= H775) binding axial binding residue; mutation to G: Loss of catalytic activity.
S804 (= S820) binding methylcob(III)alamin
T808 (= T824) binding methylcob(III)alamin
S810 (= S826) mutation to A: Decreases activity by about 40%.
A860 (= A876) binding methylcob(III)alamin
D946 (= D971) binding S-adenosyl-L-methionine
R1134 (= R1161) binding S-adenosyl-L-methionine
YY 1189:1190 (≠ YF 1216:1217) binding S-adenosyl-L-methionine

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 6 papers)
53% identity, 100% coverage: 1:1252/1255 of query aligns to 5:1263/1265 of Q99707

query
sites
Q99707

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D

R61 (≠ S56) natural variant: R -> K
C255 (≠ A249) to Y: in dbSNP:rs1140598
GSR 382:384 (≠ GST 374:376) binding (6S)-5,6,7,8-tetrahydrofolate
D449 (= D441) binding (6S)-5,6,7,8-tetrahydrofolate
N470 (= N462) binding (6S)-5,6,7,8-tetrahydrofolate
D537 (= D529) binding (6S)-5,6,7,8-tetrahydrofolate
N579 (= N571) binding (6S)-5,6,7,8-tetrahydrofolate
R585 (= R577) binding (6S)-5,6,7,8-tetrahydrofolate
R591 (= R583) binding (6S)-5,6,7,8-tetrahydrofolate
D919 (≠ R909) to G: in dbSNP:rs1805087
D963 (= D960) mutation to E: Decreases binding to MTRR; when associated with N-1071.
K1071 (≠ H1061) mutation to N: Decreases binding to MTRR; when associated with E-963.

3ivaA Structure of the b12-dependent methionine synthase (meth) c-teminal half with adohcy bound (see paper)
56% identity, 47% coverage: 663:1252/1255 of query aligns to 4:575/576 of 3ivaA

query
sites
3ivaA

W

W

R

R

E

S

N

W

D

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A

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D

T

Q

E

Y

F

A

I

E

E

E

Q

D

D

T

T

E

E

E

E

L

A

R

R

A

Q

E

Q

I

A

S

T

A

-

N

-

G

-

G

-

K

R

P

P

I

C

E

E

V

V

I

I

E

E

G

G

P

P

L

L

M

M

D

D

G

G

M

M

G

N

V

V

V

V

G

G

D

D

L

L

F

F

G

G

A

E

G

G

K

K

M

M

F

F

L

L

P

P

Q

Q

V

V

V

V

K

K

S

S

A

A

R

R

V

V

M

M

K

K

K

Q

A

A

V

V

A

A

Y

Y

L

L

I

E

P

P

F

F

I

I

E

E

A

A

E

S

K

K

E

E

E

Q

G

C

E

K

D

T

P

-

S

-

D

-

N

N

G

G

T

K

V

M

I

V

M

I

A

A

T

T

V

V

K

K

G

G

D
|
D

V

V

H
|
H

D

D

I

I

G
|
G

K

K

N

N

I

I

V
|
V

G

G

V

V

V

V

L

L

Q

Q

C

C

N

N

N

N

Y

Y

E

E

V

I

I

V

D

D

L

L

G

G

V

V

M

M

C

V

P

P

A

A

Q

E

K

K

I

I

L

L

D

R

A

T

A

A

K

K

E

E

H

V

D

N

A

A

D

D

I

L

I

I

G
|
G

L
|
L

S
|
S

G

G

L
|
L

I
|
I

T
|
T

P

P

S
|
S

L

L

D

D

E

E

M

M

V

V

H

N

F

V

A

A

K

K

E

E

M

M

E

E

R

R

Q

Q

G

G

L

F

D

T

I

I

P

P

L

L

L

L

I

I

G
|
G

G
|
G

A

A

T

T

T

T

S

S

R

K

A

A

H

H

T

T

A

A

V

V

K

K

I

I

E

E

P

Q

K

N

Y

Y

H

S

G

G

P

P

V

T

V

V

W

Y

V

V

K
x
Q

D
x
N

A

A

S

S

R

R

S

T

V

V

P

G

T

V

V

V

A

A

K

A

L

L

L

L

D

S

K

D

N

T

E

Q

R

R

G

D

A

D

M

F

L

V

E

A

E

R

L

T

K

R

A

K

D

E

Y

Y

E

E

K

T

L

V

R

R

E

I

R

Q

H

H

A

G

G

R

K

K

E

K

K

P

A

R

D

T

K

P

L

P

L

V

P

T

I

L

D

E

K

A

A

A

R

R

A

D

N

N

R

D

D

F

V

A

P

F

D

D

W

W

E

Q

G

A

Y

Y

E

T

P

P

P

P

V

V

P

A

Q

H

L

R

I

L

S

G

E

V

A

Q

G

E

D

V

K

E

A

A

E

S

Y

-

V

-

K

-

V

-

F

-

K

-

D

-

Y

-

P

-

L

I

T

E

E

T

L

L

R

R

E

N

C

Y

I

I

D

D

W

W

G

T

P

P

F

F

F

F

N

M

A
x
T

W

W

E

S

I

L

K

A

G

G

R

K

F

Y

P

P

D

R

V

I

L

L

N

E

N

D

P

E

A

V

S

V

G

G

E

V

T

E

A

A

R

Q

K

R

L

L

Y

F

E

K

E

D

A

A

N

N

A

D

M

M

L

L

D

D

Q

K

I

L

I

S

E

A

E

E

K

K

W

T

L

L

T

N

A

P

N

R

G

G

I

V

I

V

G

G

L

L

F

F

P

P

A

A

N

N

Q

R

V

V

D

-

N

G

E

D

D

D

I

I

A

E

V

I

Y

Y

T

R

D

D

E

E

S

T

R

R

S

T

D

H

E

V

L

I

L

N

R

V

L

S

H

H

C

H

L

L

R

R

Q

Q

Q

Q

S

T

E

E

H

-

R

K

E

T

G

G

V

F

P

A

N

N

R

Y

A

C

L

L

S

A

D

D

Y

F

V

V

A

A

P

P

A

K

E

L

T

S

G

G

L

K

K

A

D

D

Y

Y

V

I

G

G

A

A

F

F

A

A

V

V

T

T

A

G

G

G

L

L

G

E

S

E

S

D

E

A

K

L

C

A

E

D

E

A

F

F

R

E

K

A

A

Q

N

H

D

D

D

D

Y

Y

N

N

A

K

I

I

L

M

L

V

E

K

S

A

L

L

A

A

D
|
D

R

R

L

L

A

A

E
|
E

A

A

F

F

A

A

E

E

R

Y

L

L

H

H

Q

E

R

R

V

V

R

R

K

K

E

V

F

Y

W

W

G

G

Y

Y

V

A

P

P

D

N

E

E

K

N

L

L

D

S

N

N

D

E

A

E

L

L

I

I

Q

R

E

E

K

N

Y

Y

Q

Q

G

G

I

I

R
|
R

P
|
P

A
|
A

P

P

G
|
G

Y
|
Y

P

P

A
|
A

C

C

P

P

E

E

H
|
H

T

T

E

E

K

K

Q

A

A

T

I

I

W

W

D

E

L

L

L

L

D

E

V

V

E

E

N

K

N

H

T

T

G

G

M

M

Q

K

L

L

T

T

E

E

S

S

M

F

A
|
A

M
|
M

W

W

P

P

G
|
G

A

A

S

S

V
|
V

S
|
S

G

G

L

W

F

Y

F

F

A

S

H

H

P

P

D

D

S

S

R

K

Y
|
Y

F

Y

V

A

L

V

G

A

R

Q

V

I

N

Q

R

R

D

D

Q

Q

I

V

A

E

D

D

Y

Y

A

A

K

R

R

R

K

K

G

G

W

M

G

S

Q

V

R

T

E

E

A

V

E

E

R

R

W

W

L

L

S

A

P

P

N

N

L

L

A

G

Y

Y

E

D

active site: D107 (= D773), H109 (= H775), S160 (= S826)
binding cobalamin: H109 (= H775), G112 (= G778), V116 (= V782), G152 (= G818), L153 (= L819), S154 (= S820), L156 (= L822), I157 (= I823), T158 (= T824), G183 (= G849), G184 (= G850), Q208 (≠ K874), N209 (≠ D875), T303 (≠ A978), D443 (= D1120), A486 (= A1163), G488 (= G1165), Y489 (= Y1166), H495 (= H1172), A520 (= A1197), M521 (= M1198), G524 (= G1201), V527 (= V1204), S528 (= S1205)
binding s-adenosyl-l-homocysteine: E447 (= E1124), R484 (= R1161), P485 (= P1162), Y489 (= Y1166), A491 (= A1168), Y539 (= Y1216)

3bulA E. Coli i690c/g743c meth c-terminal fragment (649-1227) (see paper)
56% identity, 47% coverage: 663:1252/1255 of query aligns to 4:575/577 of 3bulA

query
sites
3bulA

W

W

R

R

E

S

N

W

D

E

A

V

R

N

E

K

R

R

I

L

K

E

H

Y

A

S

L

L

I

V

K

K

G

G

I

I

D

T

Q

E

Y

F

A

I

E

E

E

Q

D

D

T

T

E

E

E

E

L

A

R

R

A

Q

E

Q

I

A

S

T

A

-

N

-

G

-

G

-

K

R

P

P

I

C

E

E

V

V

I

I

E

E

G

G

P

P

L

L

M

M

D

D

G

G

M

M

G

N

V

V

V

V

G

G

D

D

L

L

F

F

G

G

A

E

G

G

K

K

M

M

F

F

L

L

P

P

Q

Q

V

V

V

V

K

K

S

S

A

A

R

R

V

V

M

M

K

K

K

Q

A

A

V

V

A

A

Y

Y

L

L

I

E

P

P

F

F

I

I

E

E

A

A

E

S

K

K

E

E

E

Q

G

C

E

K

D

T

P

-

S

-

D

-

N

N

G

G

T

K

V

M

I

V

M

I

A

A

T

T

V

V

K

K

G

G

D
|
D

V

V

H
|
H

D

D

I

I

G

G

K

K

N

N

I

I

V
|
V

G

G

V

V

V

V

L

L

Q

Q

C

C

N

N

N

N

Y

Y

E

E

V

I

I

V

D

D

L

L

G

G

V

V

M

M

C

V

P

P

A

A

Q

E

K

K

I

I

L

L

D

R

A

T

A

A

K

K

E

E

H

V

D

N

A

A

D

D

I

L

I

I

G
|
G

L
|
L

S
|
S

G

G

L
|
L

I
|
I

T
|
T

P

P

S
|
S

L

L

D

D

E

E

M

M

V

V

H

N

F

V

A

A

K

K

E

E

M

M

E

E

R

R

Q

Q

G

G

L

F

D

T

I

I

P

P

L

L

L

L

I

I

G
|
G

G
|
G

A

A

T

T

T

T

S

S

R

K

A

A

H

H

T

T

A

A

V

V

K

K

I

I

E

E

P

Q

K

N

Y

Y

H

S

G

G

P

P

V

T

V

V

W

Y

V

V

K
x
Q

D
x
N

A
|
A

S

S

R

R

S
x
T

V

V

P

G

T

V

V

V

A

A

K

A

L

L

L

L

D

S

K

D

N

T

E

Q

R

R

G

D

A

D

M

F

L

V

E

A

E

R

L

T

K

R

A

K

D

E

Y

Y

E

E

K

T

L

V

R

R

E

I

R

Q

H

H

A

G

G

R

K

K

E

K

K

P

A

R

D

T

K

P

L

P

L

V

P

T

I

L

D

E

K

A

A

A

R

R

A

D

N

N

R

D

D

F

V

A

P

F

D

D

W

W

E

Q

G

A

Y

Y

E

T

P

P

P

P

V

V

P

A

Q

H

L

R

I

L

S

G

E

V

A

Q

G

E

D

V

K

E

A

A

E

S

Y

-

V

-

K

-

V

-

F

-

K

-

D

-

Y

-

P

-

L

I

T

E

E

T

L

L

R

R

E

N

C

Y

I

I

D

D

W

W

G

T

P

P

F

F

F

F

N
x
M

A

T

W

W

E

S

I

L

K

A

G

G

R

K

F

Y

P

P

D

R

V

I

L

L

N

E

N

D

P

E

A

V

S

V

G

G

E

V

T

E

A

A

R

Q

K

R

L

L

Y

F

E

K

E

D

A

A

N

N

A

D

M

M

L

L

D

D

Q

K

I

L

I

S

E

A

E

E

K

K

W

T

L

L

T

N

A

P

N

R

G

G

I

V

I

V

G

G

L

L

F

F

P

P

A

A

N

N

Q

R

V

V

D

-

N

G

E

D

D

D

I

I

A

E

V

I

Y

Y

T

R

D

D

E

E

S

T

R

R

S

T

D

H

E

V

L

I

L

N

R

V

L

S

H

H

C

H

L

L

R

R

Q

Q

Q

Q

S

T

E

E

H

-

R

K

E

T

G

G

V

F

P

A

N

N

R

Y

A

C

L

L

S

A

D

D

Y

F

V

V

A

A

P

P

A

K

E

L

T

S

G

G

L

K

K

A

D

D

Y

Y

V

I

G

G

A

A

F

F

A

A

V

V

T

T

A

G

G

G

L

L

G

E

S

E

S

D

E

A

K

L

C

A

E

D

E

A

F

F

R

E

K

A

A

Q

N

H

D

D

D

D

Y

Y

N

N

A

K

I

I

L

M

L

V

E

K

S

A

L

L

A

A

D
|
D

R

R

L

L

A

A

E

E

A

A

F

F

A

A

E

E

R

Y

L

L

H

H

Q

E

R

R

V

V

R

R

K

K

E

V

F

Y

W

W

G

G

Y

Y

V

A

P

P

D

N

E

E

K

N

L

L

D

S

N

N

D

E

A

E

L

L

I

I

Q

R

E

E

K

N

Y

Y

Q

Q

G

G

I

I

R

R

P

P

A
|
A

P
|
P

G
|
G

Y
|
Y

P

P

A

A

C

C

P

P

E

E

H
|
H

T

T

E

E

K
|
K

Q

A

A

T

I

I

W

W

D

E

L

L

L

L

D

E

V

V

E

E

N

K

N

H

T

T

G

G

M

M

Q

K

L

L

T

T

E

E

S

S

M

F

A

A

M
|
M

W

W

P

P

G
|
G

A

A

S

S

V
|
V

S
|
S

G

G

L

W

F

Y

F

F

A

S

H

H

P

P

D

D

S

S

R

K

Y

Y

F

Y

V

A

L

V

G

A

R

Q

V

I

N

Q

R

R

D

D

Q

Q

I

V

A

E

D

D

Y

Y

A

A

K

R

R

R

K

K

G

G

W

M

G

S

Q

V

R

T

E

E

A

V

E

E

R

R

W

W

L

L

S

A

P

P

N

N

L

L

A

G

Y

Y

E

D

active site: D107 (= D773), H109 (= H775), S160 (= S826)
binding cobalamin: H109 (= H775), V116 (= V782), G152 (= G818), L153 (= L819), S154 (= S820), L156 (= L822), I157 (= I823), T158 (= T824), G183 (= G849), G184 (= G850), Q208 (≠ K874), N209 (≠ D875), A210 (= A876), T213 (≠ S879), M302 (≠ N977), D443 (= D1120), A486 (= A1163), P487 (= P1164), G488 (= G1165), Y489 (= Y1166), H495 (= H1172), K498 (= K1175), M521 (= M1198), G524 (= G1201), V527 (= V1204), S528 (= S1205)

4cczA Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains
55% identity, 50% coverage: 15:646/1255 of query aligns to 4:611/611 of 4cczA

query
sites
4cczA

E

D

E

E

I

I

R

N

K

A

H

I

L

L

S

Q

E

K

R

R

I

I

L

M

V

V

L

L

D

D

G

G

A

G

M

M

G

G

T

T

R

M

I

I

Q

Q

S

R

Y

E

K

K

L

L

G

-

E

E

A

E

D

H

Y

F

R

R

G

G

E

Q

R

E

F

F

K

K

D

D

W

H

E

A

S

R

D

P

L

L

A

K

G

G

N

N

N

N

D

D

L

I

L

L

V

S

L

I

T

T

Q

Q

P

P

E

D

L

V

I

I

K

Y

E

Q

V

I

H

H

G

K

A

E

Y

Y

L

L

D

L

A

A

G

-

A

-

D

D

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|
E

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|
G

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x
R

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|
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D

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V

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A

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L

I

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N

N

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K

K

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D

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E

A

A

T

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K

L

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A

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Q

binding (6s)-5,6,7,8-tetrahydrofolate: E336 (= E368), G342 (= G374), R344 (≠ T376), N430 (= N462), M458 (= M490), D497 (= D529), G536 (= G568), S538 (= S570), N539 (= N571), F542 (= F574), R545 (= R577), R551 (= R583)

8g3hA Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
36% identity, 67% coverage: 19:858/1255 of query aligns to 7:806/841 of 8g3hA

query
sites
8g3hA

K

R

H

A

L

L

S

S

E

Q

R

R

I

V

L

L

V

V

L

F

D

D

G

G

A

A

M

M

G

G

T

T

R

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I

L

Q

Q

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K

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L

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A

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D

D

Y

Y

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G

G

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E

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A

F

Y

K

Y

D

-

W

-

E

-

S

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D

-

L

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A

-

G

G

N

C

N

P

D

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L

V

L

L

V

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L

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T

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P

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V

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Y

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A

A

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G

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V

V

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N

N

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F

F

N

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D

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A

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L

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G

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A

A

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A

W

L

N

A

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A

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L

R

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H

S

A

L

E

P

P

I

L

D

A

V

V

V

G

G

L

M

N

N

C

C