SitesBLAST
Comparing WP_052664800.1 NCBI__GCF_000969705.1:WP_052664800.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 14 hits to proteins with known functional sites (download)
4zohB Crystal structure of glyceraldehyde oxidoreductase (see paper)
37% identity, 97% coverage: 1:284/293 of query aligns to 1:273/274 of 4zohB
- active site: Y256 (= Y267)
- binding flavin-adenine dinucleotide: R28 (≠ K29), P29 (≠ L30), A31 (= A32), G32 (= G33), G33 (= G34), H34 (= H35), S35 (= S36), L36 (= L37), H77 (≠ W78), I95 (= I101), G96 (= G102), V100 (= V106), T105 (= T111), G108 (= G114), S109 (= S115), S111 (≠ A117), A117 (= A123), D118 (= D124), L160 (= L166), V161 (≠ L167), D185 (≠ R192), F186 (≠ L193)
7dqxE Crystal structure of xanthine dehydrogenase family protein
36% identity, 98% coverage: 1:286/293 of query aligns to 1:286/293 of 7dqxE
- binding flavin-adenine dinucleotide: K29 (= K29), I30 (≠ L30), I31 (≠ L31), G33 (= G33), G34 (= G34), Q35 (≠ H35), S36 (= S36), L37 (= L37), H78 (≠ W78), I101 (= I101), A102 (≠ G102), I106 (≠ V106), G110 (= G110), T111 (= T111), G113 (= G113), G114 (= G114), S115 (= S115), A117 (= A117), A123 (= A123), E124 (≠ D124), I167 (≠ L167), Y193 (≠ L193)
1ffuC Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
41% identity, 98% coverage: 1:288/293 of query aligns to 1:287/287 of 1ffuC
- binding flavin-adenine dinucleotide: K29 (= K29), L30 (= L30), A32 (= A32), G33 (= G33), G34 (= G34), H35 (= H35), S36 (= S36), L37 (= L37), I54 (= I54), I101 (= I101), A102 (≠ G102), G110 (= G110), T111 (= T111), G114 (= G114), D115 (≠ S115), A117 (= A117), N123 (≠ A123), D124 (= D124), L161 (= L161), V166 (≠ L166), M167 (≠ L167), W193 (≠ L193)
P19920 Carbon monoxide dehydrogenase medium chain; CO dehydrogenase subunit M; CO-DH M; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
38% identity, 98% coverage: 1:286/293 of query aligns to 1:285/288 of P19920
1n5wC Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
38% identity, 98% coverage: 1:286/293 of query aligns to 1:285/287 of 1n5wC
1t3qC Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
33% identity, 96% coverage: 2:283/293 of query aligns to 3:279/285 of 1t3qC
- binding flavin-adenine dinucleotide: I29 (≠ L30), A31 (= A32), G32 (= G33), G33 (= G34), Q34 (≠ H35), S35 (= S36), L36 (= L37), V100 (≠ I101), A101 (≠ G102), V105 (= V106), T110 (= T111), G113 (= G114), S114 (= S115), A116 (= A117), A122 (= A123), E123 (≠ D124), L166 (= L167), Y190 (≠ L193)
2w54A Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde (see paper)
29% identity, 91% coverage: 11:278/293 of query aligns to 171:433/450 of 2w54A
- binding flavin-adenine dinucleotide: L189 (= L30), A191 (= A32), G192 (= G33), G193 (= G34), T194 (≠ H35), D195 (≠ S36), V196 (≠ L37), W199 (≠ P39), L213 (≠ I54), F258 (≠ I101), A259 (≠ G102), A267 (≠ G110), T268 (= T111), G271 (= G114), N272 (≠ S115), A274 (= A117), N275 (≠ H118), G280 (≠ A123), D281 (= D124), R318 (≠ L161), V324 (≠ L167), Q347 (= Q188)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 42
- binding fe2/s2 (inorganic) cluster: 38, 39, 40, 42, 44, 45, 47, 63, 103, 104, 106, 134, 135, 136
- binding {[(5aR,8R,9aR)-2-amino-4-oxo-6,7-di(sulfanyl-kappaS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(hydroxy)oxo(thioxo)molybdenum: 102, 136
1jroA Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
29% identity, 91% coverage: 11:278/293 of query aligns to 171:433/450 of 1jroA
- binding flavin-adenine dinucleotide: L189 (= L30), A191 (= A32), G192 (= G33), G193 (= G34), T194 (≠ H35), D195 (≠ S36), V196 (≠ L37), F258 (≠ I101), A259 (≠ G102), T268 (= T111), G271 (= G114), N272 (≠ S115), A274 (= A117), G280 (≠ A123), D281 (= D124), R318 (≠ L161), V324 (≠ L167)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 42, 43
- binding fe2/s2 (inorganic) cluster: 37, 38, 39, 40, 42, 44, 45, 47, 63, 103, 106, 134, 136
3hrdG Crystal structure of nicotinate dehydrogenase (see paper)
28% identity, 68% coverage: 6:203/293 of query aligns to 4:208/292 of 3hrdG
- binding flavin-adenine dinucleotide: I29 (≠ L30), A31 (= A32), G32 (= G33), G33 (= G34), T34 (≠ H35), D35 (≠ S36), F77 (≠ W78), V100 (≠ I101), G101 (= G102), I105 (≠ V106), T110 (= T111), G113 (= G114), N114 (≠ S115), S116 (≠ A117), T117 (≠ H118), G122 (≠ A123), D123 (= D124), I168 (≠ L166), M169 (≠ L167)
Q0QLF4 Nicotinate dehydrogenase FAD-subunit; NDH; Nicotinic acid hydroxylase FAD-subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
28% identity, 68% coverage: 6:203/293 of query aligns to 4:208/296 of Q0QLF4
- 29:36 (vs. 30:37, 50% identical) binding FAD
- G101 (= G102) binding FAD
- TIGGN 110:114 (≠ TIGGS 111:115) binding FAD
- D123 (= D124) binding FAD
- R160 (vs. gap) binding FAD
- M169 (≠ L167) binding FAD
- K187 (= K185) binding FAD
O33820 4-hydroxybenzoyl-CoA reductase subunit beta; 4-HBCR subunit beta; EC 1.1.7.1 from Thauera aromatica (see paper)
25% identity, 94% coverage: 6:281/293 of query aligns to 7:318/324 of O33820
- 29:36 (vs. 31:37, 38% identical) binding FAD
- T111 (= T111) binding FAD
- N115 (≠ S115) binding FAD
- Q118 (vs. gap) binding FAD
- D162 (= D124) binding FAD
- K224 (= K185) binding FAD
1rm6B Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
25% identity, 94% coverage: 6:281/293 of query aligns to 7:318/323 of 1rm6B
- binding flavin-adenine dinucleotide: P29 (vs. gap), G31 (≠ A32), A32 (≠ G33), G33 (= G34), T34 (≠ H35), D35 (≠ S36), L36 (= L37), L53 (≠ I54), V101 (≠ I101), A102 (≠ G102), A110 (≠ G110), T111 (= T111), G114 (= G114), N115 (≠ S115), C117 (vs. gap), Q118 (vs. gap), D162 (= D124), L207 (= L167), V231 (≠ S191), D232 (≠ R192), F233 (≠ L193)
- binding iron/sulfur cluster: C122 (vs. gap), F124 (vs. gap), C138 (vs. gap), C146 (vs. gap), H147 (vs. gap), V148 (vs. gap), C155 (≠ A117), Y156 (≠ H118), A157 (= A119)
Q8GUQ8 Xanthine dehydrogenase 1; AtXDH1; EC 1.17.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
26% identity, 80% coverage: 27:260/293 of query aligns to 282:529/1361 of Q8GUQ8
- W364 (vs. gap) mutation to A: Decreases activity 8-fold.
- Y421 (≠ M156) mutation to A: Decreases activity 4-fold.
Sites not aligning to the query:
- 831 E→A: Loss of activity.
- 909 R→A: Decreases activity 12-fold.
- 1297 E→A: Decreases activity 40-fold.
5y6qB Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
22% identity, 78% coverage: 28:257/293 of query aligns to 24:304/330 of 5y6qB
- binding flavin-adenine dinucleotide: I26 (≠ L30), A28 (= A32), G29 (= G33), G30 (= G34), T31 (≠ H35), T32 (≠ S36), Q33 (≠ L37), A97 (≠ I101), A98 (≠ G102), I102 (≠ V106), A106 (≠ G110), T107 (= T111), G110 (= G114), N111 (≠ S115), R113 (vs. gap), Q114 (vs. gap), G164 (vs. gap), D165 (= D124), I213 (≠ L166), I214 (≠ L167), K232 (= K185), F241 (≠ A194)
- binding iron/sulfur cluster: C118 (vs. gap), Y121 (vs. gap), C130 (vs. gap), N131 (vs. gap), C139 (vs. gap), A141 (vs. gap), C158 (vs. gap), I159 (vs. gap), A160 (vs. gap)
Query Sequence
>WP_052664800.1 NCBI__GCF_000969705.1:WP_052664800.1
MYPVAFEYVRPSSVDEARHWLVELGEDAKLLAGGHSLLPMLKLRLAAPEVLVDICDLPEL
VRIDVGADGARLGAGTTWRALLRDRSLGAAYPLIHDAVAVIGDRQVRARGTIGGSIAHAD
VAADIPAPLLALGASVEIAGDTGSRREPLDDVLVGMFETTLGEAELLTAVHIPALSSTTT
TAYVKFEQPASRLALCGVAVVIDHHPDQRLHGVRIAVTGAGDRAYRATEAEAVLEGQQPD
DQRLDAAADAARHDLSARSDVHADAVYRSHLVRVLTRRALETALARHAAQEAA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory