SitesBLAST
Comparing WP_052669195.1 NCBI__GCF_000969705.1:WP_052669195.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t47A Structure of fe2-hppd bound to ntbc (see paper)
57% identity, 96% coverage: 10:364/368 of query aligns to 3:362/362 of 1t47A
- binding fe (ii) ion: H172 (= H174), H255 (= H257), E334 (= E336)
- binding 2-{hydroxy[2-nitro-4-(trifluoromethyl)phenyl]methylene}cyclohexane-1,3-dione: H172 (= H174), S215 (= S217), P228 (= P230), H255 (= H257), F321 (= F323), E334 (= E336), F344 (= F346), G345 (= G347), N348 (= N350), F349 (= F351), L352 (= L354)
5ec3A Structural insight into the catalyitc mechanism of human 4- hydroxyphenylpyruvate dioxygenase
47% identity, 96% coverage: 15:368/368 of query aligns to 11:373/376 of 5ec3A
P32755 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein; EC 1.13.11.27 from Rattus norvegicus (Rat) (see 2 papers)
47% identity, 96% coverage: 15:368/368 of query aligns to 19:381/393 of P32755
- H183 (= H174) binding Fe cation
- H266 (= H257) binding Fe cation
- E349 (= E336) binding Fe cation
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylthreonine
8im2A Crystal structure of human hppd complexed with ntbc (see paper)
47% identity, 96% coverage: 15:367/368 of query aligns to 13:374/374 of 8im2A
- binding cobalt (ii) ion: H177 (= H174), H260 (= H257), E343 (= E336)
- binding 2-{hydroxy[2-nitro-4-(trifluoromethyl)phenyl]methylene}cyclohexane-1,3-dione: P233 (= P230), N235 (= N232), H260 (= H257), F330 (= F323), F341 (= F334), F353 (= F346), N357 (= N350), F358 (= F351), L361 (= L354)
8im3A Crystal structure of human hppd complexed with compound a10 (see paper)
47% identity, 95% coverage: 15:362/368 of query aligns to 13:369/371 of 8im3A
- binding [1,3-diethyl-2,2-bis(oxidanylidene)-2$l^{6},1,3-benzothiadiazol-5-yl]-(1-methyl-5-oxidanyl-pyrazol-4-yl)methanone: H177 (= H174), P233 (= P230), Q245 (= Q242), F330 (= F323), F341 (= F334), E343 (= E336), F353 (= F346), G354 (= G347), N357 (= N350), F358 (= F351), L361 (= L354)
- binding cobalt (ii) ion: H177 (= H174), H260 (= H257), E343 (= E336)
8jbwA Crystal structure of zthppd-(+)-usnic acid complex (see paper)
44% identity, 96% coverage: 13:365/368 of query aligns to 5:364/364 of 8jbwA
- binding (9bR)-2,6-diethanoyl-8,9b-dimethyl-3,7,9-tris(oxidanyl)dibenzofuran-1-one: M196 (= M184), I220 (= I208), F224 (≠ Y212), H252 (= H257)
- binding cobalt (ii) ion: H186 (= H174), H252 (= H257), Q320 (= Q321), E335 (= E336)
1sqiA Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
44% identity, 92% coverage: 15:353/368 of query aligns to 12:343/343 of 1sqiA
- binding (1-tert-butyl-5-hydroxy-1h-pyrazol-4-yl)[6-(methylsulfonyl)-4'-methoxy-2-methyl-1,1'-biphenyl-3-yl]methanone: P221 (= P230), Q228 (= Q242), H243 (= H257), F313 (= F323), F324 (= F334), E326 (= E336), F336 (= F346), N340 (= N350), F341 (= F351)
- binding fe (iii) ion: H176 (= H174), H243 (= H257), E326 (= E336)
1sqiB Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
44% identity, 92% coverage: 15:353/368 of query aligns to 13:342/342 of 1sqiB
- binding (1-tert-butyl-5-hydroxy-1h-pyrazol-4-yl)[6-(methylsulfonyl)-4'-methoxy-2-methyl-1,1'-biphenyl-3-yl]methanone: P220 (= P230), N222 (= N232), Q227 (= Q242), H242 (= H257), L299 (= L310), F312 (= F323), F323 (= F334), E325 (= E336), F335 (= F346), N339 (= N350), F340 (= F351)
- binding fe (iii) ion: H177 (= H174), H242 (= H257), E325 (= E336)
Q02110 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Sus scrofa (Pig) (see paper)
43% identity, 96% coverage: 15:368/368 of query aligns to 19:381/393 of Q02110
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylthreonine
7x8iA Crystal structure of athppd-shikonin complex (see paper)
37% identity, 95% coverage: 12:359/368 of query aligns to 10:376/380 of 7x8iA
- binding cobalt (ii) ion: H186 (= H174), H259 (= H257), E345 (= E336)
- binding 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione: L216 (= L215), Q244 (= Q242), H259 (= H257), F332 (= F323), F343 (= F334), F363 (vs. gap), F368 (= F351)
7x64A Crystal structure of athppd-y18027 complex (see paper)
37% identity, 95% coverage: 12:359/368 of query aligns to 10:376/380 of 7x64A
- binding 1,5-dimethyl-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-3-(phenylmethyl)quinazoline-2,4-dione: H186 (= H174), S218 (= S217), P231 (= P230), R241 (≠ K239), Q244 (= Q242), H259 (= H257), F332 (= F323), F363 (vs. gap), G364 (= G347), N367 (= N350), F368 (= F351)
- binding cobalt (ii) ion: H186 (= H174), H259 (= H257), E345 (= E336)
7x5sA Crystal structure of athppd-y14157 complex
37% identity, 95% coverage: 12:359/368 of query aligns to 10:376/380 of 7x5sA
- binding 2-methyl-4-(2-nitro-4-piperidin-1-yl-phenyl)carbonyl-5-phenyl-1H-pyrazol-3-one: H186 (= H174), P231 (= P230), H259 (= H257), F332 (= F323), F343 (= F334), F363 (vs. gap), K365 (≠ V348), N367 (= N350), F368 (= F351)
- binding cobalt (ii) ion: H186 (= H174), H259 (= H257), E345 (= E336)
7ezqA Complex structure of athppd with inhibitor y15832
37% identity, 95% coverage: 12:359/368 of query aligns to 10:376/382 of 7ezqA
- binding 6-(1,3-dimethyl-5-oxidanyl-pyrazol-4-yl)carbonyl-1,5-dimethyl-3-(2-methylphenyl)quinazoline-2,4-dione: H186 (= H174), P231 (= P230), Q244 (= Q242), H259 (= H257), F332 (= F323), E345 (= E336), F363 (vs. gap), G364 (= G347), N367 (= N350), F368 (= F351), L371 (= L354)
- binding cobalt (ii) ion: H186 (= H174), H259 (= H257), E345 (= E336)
8hxgA Crystal structure of athppd-y14116 complex
37% identity, 95% coverage: 12:359/368 of query aligns to 10:376/380 of 8hxgA
- binding cobalt (ii) ion: H186 (= H174), H259 (= H257), E345 (= E336)
- binding (1S,2R,3R)-2-[(S)-(2-methoxy-8-methyl-quinolin-3-yl)-oxidanyl-methyl]-6,6-dimethyl-cyclohex-4-ene-1,3-diol: P231 (= P230), H259 (= H257), F332 (= F323), F343 (= F334), F363 (vs. gap), N367 (= N350), F368 (= F351)
8hx4A Crystal structure of athppd-y18549 complex
37% identity, 95% coverage: 12:359/368 of query aligns to 10:376/382 of 8hx4A
- binding cobalt (ii) ion: H186 (= H174), H259 (= H257), E345 (= E336)
- binding 6-[(R)-[(2R,6R)-2,6-bis(oxidanyl)cyclohexyl]-oxidanyl-methyl]-3-(4,6-dimethylpyrimidin-2-yl)-1,5-dimethyl-quinazoline-2,4-dione: H186 (= H174), S218 (= S217), P231 (= P230), H259 (= H257), F332 (= F323), E345 (= E336), F363 (vs. gap), N367 (= N350), F368 (= F351)
7x67A Crystal structure of athppd-y18406 complex (see paper)
37% identity, 95% coverage: 12:359/368 of query aligns to 10:376/380 of 7x67A
- binding 1,5-dimethyl-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-3-(3-phenylpropyl)quinazoline-2,4-dione: H186 (= H174), S218 (= S217), Q244 (= Q242), H259 (= H257), F332 (= F323), F363 (vs. gap), N367 (= N350), F368 (= F351)
- binding cobalt (ii) ion: H186 (= H174), H259 (= H257), E345 (= E336)
7cqrA Complex structure of hppd with y16550
37% identity, 95% coverage: 12:359/368 of query aligns to 10:376/380 of 7cqrA
- binding cobalt (ii) ion: H186 (= H174), H259 (= H257), E345 (= E336)
- binding 3-(3-chlorophenyl)-6-[(2,5-dimethyl-3-oxidanylidene-1~{H}-pyrazol-4-yl)carbonyl]-1,5-dimethyl-quinazoline-2,4-dione: H186 (= H174), P231 (= P230), Q244 (= Q242), H259 (= H257), F332 (= F323), E345 (= E336), F363 (vs. gap), N367 (= N350), F368 (= F351)
6jx9A Structure of y17107 complexed hppd (see paper)
37% identity, 95% coverage: 12:359/368 of query aligns to 10:376/380 of 6jx9A
- binding cobalt (ii) ion: H186 (= H174), H259 (= H257), E345 (= E336)
- binding 5-[(~{Z})-(1,3-dimethyl-5-oxidanylidene-pyrazol-4-ylidene)-oxidanyl-methyl]-2-(phenylmethyl)isoindole-1,3-dione: H186 (= H174), P231 (= P230), H259 (= H257), M286 (≠ L280), F332 (= F323), E345 (= E336), F363 (vs. gap), F368 (= F351)
P93836 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
37% identity, 95% coverage: 12:359/368 of query aligns to 44:432/445 of P93836
- H226 (= H174) binding Fe cation
- H308 (= H257) binding Fe cation
- E394 (= E336) binding Fe cation
8wqmA Complex structure of athppd with atovaquone
37% identity, 95% coverage: 12:359/368 of query aligns to 10:377/383 of 8wqmA
- binding 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione: H186 (= H174), S219 (= S217), H260 (= H257), F333 (= F323), F364 (vs. gap), G365 (= G347), N368 (= N350), F369 (= F351)
- binding cobalt (ii) ion: H186 (= H174), H260 (= H257), E346 (= E336)
Query Sequence
>WP_052669195.1 NCBI__GCF_000969705.1:WP_052669195.1
MDDHDARRDLPLKGYDAIEFWVGNAKQAAHFYRTAFGFKLVGYAGPETGVRDRASYVLQQ
RSIRFVLTTGLTADHEVTRHQAVHGDGVRDVAFRVPAAEEAFRMAVERGATPFTEPEVVE
DEHGKVVRAAIRAYGDTIHTFVQRDDYSGVYLPGYQAVDADPLARPVGLSAIDHVVCNVE
EGEMDTWARFYERIMGFSQLRHFDDEAISTEYTALMSKVLWDGHGRIKLPINEPAEGKKK
SQIDEYLQYYGSPGVQHLALSTGDIVATVRQLRDNGVSFLTVPDEYYLGAKERVGEVDES
WDDLQELGILVDRDDEGYLLQIFTEPVEDRPTVFYEVIERHGAMGFGVGNFKALFESIER
AQERRGNL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory