Comparing WP_053935922.1 NCBI__GCF_001294205.1:WP_053935922.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 5 hits to proteins with known functional sites (download)
1m2wA Pseudomonas fluorescens mannitol 2-dehydrogenase ternary complex with NAD and d-mannitol (see paper)
25% identity, 96% coverage: 18:477/477 of query aligns to 31:489/492 of 1m2wA
1lj8A Crystal structure of mannitol dehydrogenase in complex with NAD (see paper)
25% identity, 96% coverage: 18:477/477 of query aligns to 31:489/492 of 1lj8A
7rk5B Mannitol-2-dehydrogenase bound to nadh from aspergillus fumigatus
25% identity, 81% coverage: 17:401/477 of query aligns to 37:426/501 of 7rk5B
4im7A Crystal structure of fructuronate reductase (ydfi) from e. Coli cft073 (efi target efi-506389) complexed with nadh and d-mannonate
27% identity, 56% coverage: 103:370/477 of query aligns to 105:376/483 of 4im7A
Sites not aligning to the query:
P09424 Mannitol-1-phosphate 5-dehydrogenase; EC 1.1.1.17 from Escherichia coli (strain K12) (see paper)
26% identity, 48% coverage: 165:395/477 of query aligns to 117:332/382 of P09424
>WP_053935922.1 NCBI__GCF_001294205.1:WP_053935922.1
MQQLDRTQPDTSPIRFVQFGEGNFLRAFIDWQIDLLNERVGLDASVVIVRPIARPDMPLL
NTQGGVYTTLIRGLNEDGVPVKEYRQIQCVKGEVDATARWNDVLALAHVPSLRFVVSNTT
EAGICINNTDGFEDFPPSSFPAKLTRFLFERYRHFEGATDKGVVLLPCELIDHNGDALKQ
AVIHFAALWKLGDAFNGWLDSACTFCSTLVDRIVTGYPRGEIAAIEKELGYTDAFLVTAE
YFYLFVIEGPAWLADELKLAGADLNIQLVDDITPYKQRKVGVLNGGHTSMVPVALLAGLE
TVGAAMDDPLVSRFLLRTLDEEIIPALPLPRAELDPFAADVLLRFRNPYIQHRLESIALN
SWSKFAARVMPQLLQYQKTNGVLPQRLVFALAANMLLYRGLMVTLTDDPAHLAWFEDAWE
KFRTHRINFAEIAQGWLANKAVWGADLNQVPQLTESLEKTLQLIDINGVRKALLELV
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory