Comparing WP_053938584.1 NCBI__GCF_001294205.1:WP_053938584.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 13 hits to proteins with known functional sites (download)
P0A6L0 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Escherichia coli (strain K12) (see 2 papers)
59% identity, 98% coverage: 5:255/257 of query aligns to 3:258/259 of P0A6L0
Sites not aligning to the query:
5el1A Crystal structure of deoxyribose-phosphate aldolase from escherichia coli (k58e-y96w mutant) after acetaldehyde treatment (see paper)
60% identity, 95% coverage: 5:247/257 of query aligns to 1:248/248 of 5el1A
5ekyA Crystal structure of deoxyribose-phosphate aldolase from escherichia coli (k58e-y96w mutant) (see paper)
60% identity, 95% coverage: 5:247/257 of query aligns to 1:248/248 of 5ekyA
1jcjA Observation of covalent intermediates in an enzyme mechanism at atomic resolution (see paper)
59% identity, 96% coverage: 2:247/257 of query aligns to 1:251/252 of 1jcjA
6z9iB Escherichia coli d-2-deoxyribose-5-phosphate aldolase - n21k mutant complex with reaction products (see paper)
59% identity, 95% coverage: 5:247/257 of query aligns to 1:248/248 of 6z9iB
7p76A Re-engineered 2-deoxy-d-ribose-5-phosphate aldolase catalysing asymmetric michael addition reactions, schiff base complex with cinnamaldehyde (see paper)
57% identity, 94% coverage: 6:247/257 of query aligns to 1:247/247 of 7p76A
8forA Crystal structure of kemp eliminase ke70-core with bound transition state analogue
53% identity, 89% coverage: 6:233/257 of query aligns to 1:234/249 of 8forA
3q2dA Optimization of the in silico designed kemp eliminase ke70 by computational design and directed evolution (see paper)
52% identity, 89% coverage: 5:233/257 of query aligns to 2:232/246 of 3q2dA
Q9Y315 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Homo sapiens (Human) (see paper)
37% identity, 92% coverage: 11:247/257 of query aligns to 48:303/318 of Q9Y315
1ub3A Crystal structure of tetrameric structure of aldolase from thermus thermophilus hb8 (see paper)
36% identity, 61% coverage: 48:204/257 of query aligns to 35:185/211 of 1ub3A
Sites not aligning to the query:
3ngjD Crystal structure of a putative deoxyribose-phosphate aldolase from entamoeba histolytica
32% identity, 81% coverage: 3:209/257 of query aligns to 2:198/222 of 3ngjD
Sites not aligning to the query:
3qyqA 1.8 angstrom resolution crystal structure of a putative deoxyribose- phosphate aldolase from toxoplasma gondii me49 (see paper)
28% identity, 64% coverage: 14:178/257 of query aligns to 17:186/273 of 3qyqA
Sites not aligning to the query:
Q4ZMV1 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Pseudomonas syringae pv. syringae (strain B728a) (see paper)
35% identity, 63% coverage: 51:213/257 of query aligns to 40:201/226 of Q4ZMV1
Sites not aligning to the query:
>WP_053938584.1 NCBI__GCF_001294205.1:WP_053938584.1
MHPNQLAQAALRALHLMDLTALNDTDTHASIRALAAAANTPVGTPAALCVYAQFVQTAQA
ALTEEGLDLPVATVTNFPYGNADPEAAAAETAAAIHLGADEVDVVFPYRALLAGDAEVGR
KLVELSRAAVGDKILKVIIESGELKDPALIRQASEISIAAGAHFIKTSTGKVPVNATLEA
AEIMIQAIHDAGKPVGFKAAGGVRSAADAAAYLAIADRIMGPTWASAATFRFGASSLLGN
LLTTVGHDAGATKTSAY
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory