SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_054029547.1 NCBI__GCF_001293685.1:WP_054029547.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
67% identity, 100% coverage: 1:906/907 of query aligns to 1:906/907 of 4usaA

query
sites
4usaA

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active site: I390 (= I390), F425 (= F425), R501 (= R501), F505 (= F505), R533 (= R533), E869 (= E869), L870 (= L870)
binding bicarbonate ion: R460 (= R460), A531 (= A531), F532 (= F532), Y535 (= Y535), Q539 (= Q539)
binding fe2/s2 (inorganic) cluster: V38 (≠ I38), C40 (= C40), E41 (≠ G41), G43 (≠ A43), C45 (= C45), G46 (= G46), C48 (= C48), R58 (= R58), C60 (= C60), C100 (= C100), G101 (= G101), C103 (= C103), C137 (= C137), C139 (= C139)
binding hydrocinnamic acid: I255 (= I255), F425 (= F425), F494 (= F494), L497 (= L497), Y535 (= Y535), L626 (= L626)
binding magnesium ion: E899 (= E899), E903 (≠ A903)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q99), C139 (= C139), T420 (= T420), F421 (= F421), G422 (= G422), R533 (= R533), W650 (= W650), H653 (= H653), G654 (= G654), Q655 (= Q655), G656 (= G656), S695 (≠ A695), G696 (= G696), G697 (= G697), Q700 (≠ S700), Q701 (= Q701), C799 (≠ N799), N800 (= N800), T804 (≠ V804), Q807 (= Q807), S865 (≠ A865), G866 (= G866), V867 (= V867), G868 (= G868), E869 (= E869)

4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
67% identity, 100% coverage: 1:906/907 of query aligns to 1:906/907 of 4us9A

query
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4us9A

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H

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L

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F

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V

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H

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A

W
|
W

E

E

D

D

H
|
H

G
|
G

Q
|
Q

G
|
G

A

A

D

D

M

I

G

G

A

C

L

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G

G

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T

A

A

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N

S

S

G

G

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P

A
x
S

G
|
G

S

S

R

R

S
x
Q

Q
|
Q

V

V

V

M

T

T

G

G

N

N

A

A

I

I

K

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N

V

G

A

C

C

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N

L

L

M

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x
H

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x
C

N
|
N

K

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L

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A

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T

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D

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G

Q
|
Q

M

I

Y

Y

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G

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Q

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I

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L

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L

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S

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D

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F

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D

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K

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H

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L

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C

A

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Y

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A

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K

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I

I

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D

D

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K

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D

L

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Y

Y

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D

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G

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F

G

G

A

A

A
x
S

G
|
G

V
|
V

G
|
G

E
|
E

L
|
L

P

P

L

L

T

T

S

S

S

P

H

H

V

A

A

A

V

I

I

I

N

N

A

A

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I

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K

N

S

A

A

C

T

G

G

V

V

R
|
R

I

I

R
x
Y

H

R

L

L

P

P

A

A

L

Y

P

P

E
|
E

K

K

V

V

L

L

A
x
E

A

A

L

L

K

K

active site: I390 (= I390), F425 (= F425), R501 (= R501), F505 (= F505), R533 (= R533), E869 (= E869), L870 (= L870)
binding 3-phenylpropanal: I255 (= I255), F257 (= F257), P258 (= P258), H752 (≠ N752)
binding bicarbonate ion: R460 (= R460), L498 (= L498), A531 (= A531), F532 (= F532), Y535 (= Y535), Q539 (= Q539), R890 (= R890), Y892 (≠ R892)
binding fe2/s2 (inorganic) cluster: V38 (≠ I38), C40 (= C40), E41 (≠ G41), G43 (≠ A43), C45 (= C45), G46 (= G46), C48 (= C48), R58 (= R58), C60 (= C60), C100 (= C100), G101 (= G101), C103 (= C103), C137 (= C137), C139 (= C139)
binding magnesium ion: E899 (= E899), E903 (≠ A903)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q99), C139 (= C139), T420 (= T420), F421 (= F421), G422 (= G422), R533 (= R533), W650 (= W650), H653 (= H653), G654 (= G654), Q655 (= Q655), G656 (= G656), S695 (≠ A695), G696 (= G696), G697 (= G697), Q700 (≠ S700), Q701 (= Q701), C799 (≠ N799), N800 (= N800), T804 (≠ V804), Q807 (= Q807), S865 (≠ A865), G866 (= G866), V867 (= V867), G868 (= G868), E869 (= E869)

4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
67% identity, 100% coverage: 1:906/907 of query aligns to 1:906/907 of 4us8A

query
sites
4us8A

M

M

M

I

K

Q

R

K

T

V

L

I

H

T

V

V

N

N

G

G

V

I

P

E

R

Q

T

N

V

L

I

F

V

V

E

D

A

A

D

E

Q

A

S

L

L

L

A

S

N

D

V

V

L

L

R

R

E

Q

Q

Q

L

L

G

G

L

L

T

T

G

G

T

V

K

K

I
x
V

G

G

C
|
C

G
x
E

Q

Q

A
x
G

Q

Q

C
|
C

G
|
G

C

A

C
|
C

N

S

V

V

I

I

L

L

D

D

D

G

K

K

L

V

V

V

R
|
R

S

A

C
|
C

V

V

T

T

K

K

M

M

S

K

K

R

V

V

A

A

D

D

G

G

S

A

T

Q

V

I

I

T

T

T

V

I

E

E

G

G

I

V

G

G

N

Q

R

P

D

E

N

N

L

L

H

H

P

P

I

L

Q

Q

L

K

S

A

W

W

I

V

V

L

H

H

G

G

A

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

F

F

I

I

V

V

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S

V

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K

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L

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D

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V

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R

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D

W

W

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F

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Q

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K

H

H

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R

N

N

A

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

K

K

Q

P

L

L

V

V

D

D

A

A

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V

M

M

D

D

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K

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K

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K

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M

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L

L

A

A

L

M

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V

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Q

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A

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K

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V

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H

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A

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N

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I

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K

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G

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I

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D

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M

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V

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G

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K

N

N

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R

I

I

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G

L

L

I
|
I

T

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F

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P

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N

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K

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G

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D

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|
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|
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|
T

F
|
F

G
|
G

Y

Y

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K

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|
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|
R

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W

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D

L
|
L

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L

L

R
|
R

G

G

A

A

Q

Q

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|
F

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A
|
A

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|
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|
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|
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|
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L
|
L

D

D

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W

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D

D

H
|
H

G
|
G

Q
|
Q

G
|
G

A

A

D

D

M

I

G

G

A

C

L

V

G

G

T

T

A

A

H

H

K

E

A

A

F

L

E

R

P

P

M

M

G

G

V

V

Q

A

P

P

D

E

R

K

I

I

R

K

L

F

V

T

M

W

N

P

D

N

T

T

A

A

I

T

T

T

P

P

N

N

S

S

G

G

P
|
P

A
x
S

G
|
G

S

S

R

R

S
x
Q

Q
|
Q

V

V

V

M

T

T

G

G

N

N

A

A

I

I

K

R

N

V

G

A

C

C

E

E

M

N

L

L

M

L

A

K

A

A

M

C

R

E

K

K

P

P

D

G

G

G

T

G

Y

Y

R

Y

T

T

F

Y

A

D

E

E

M

L

E

K

A

A

E

A

N

D

L

K

P

P

V

T

S

K

Y

I

S

T

G

G

Q

N

W

W

T

T

A

A

S

S

M

G

C

A

T

T

N

H

C

C

D

D

L

A

K

V

T

T

S

G

Q

L

G

G

E

K

P

P

F

F

S

V

V

V

Y

Y

M

M

Y

Y

G

G

M

V

F

F

M

M

A

A

E

E

V

V

A

T

V

V

E

D

T

V

A

A

T

T

G

G

K

Q

T

T

V

V

E

D

G

G

F

M

T

T

A

L

I

M

S

A

D

D

V

L

G

G

S

S

I

L

N
x
C

N
|
N

K

Q

L

L

V

A

V
x
T

D

D

G

G

Q
|
Q

M

I

Y

Y

G

G

I

L

A

A

Q

Q

G

G

I

I

G

G

L

L

A

A

L

L

S

S

E

E

D

D

F

F

E

E

D

D

L

I

S

K

K

K

H

H

N

A

N

T

L

L

R

V

A

G

C

A

G

G

L

F

P

P

Y

F

A

I

K

K

M

Q

I

I

P

P

D

D

K

K

M

L

D

D

L

I

H

V

Y

Y

I

V

E

N

S

H

P

P

R

R

E

P

N

D

G

G

P

P

F

F

G

G

A

A

A
x
S

G
|
G

V
|
V

G
|
G

E
|
E

L
|
L

P

P

L

L

T

T

S

S

S

P

H

H

V

A

A

A

V

I

I

I

N

N

A

A

I

I

H

K

N

S

A

A

C

T

G

G

V

V

R

R

I

I

R

Y

H

R

L

L

P

P

A

A

L

Y

P

P

E

E

K

K

V

V

L

L

A

E

A

A

L

L

K

K

active site: I390 (= I390), F425 (= F425), R501 (= R501), F505 (= F505), R533 (= R533), E869 (= E869), L870 (= L870)
binding bicarbonate ion: R460 (= R460), L498 (= L498), A531 (= A531), F532 (= F532), Y535 (= Y535), Q539 (= Q539)
binding fe2/s2 (inorganic) cluster: V38 (≠ I38), C40 (= C40), E41 (≠ G41), G43 (≠ A43), C45 (= C45), G46 (= G46), C48 (= C48), R58 (= R58), C60 (= C60), C100 (= C100), G101 (= G101), C103 (= C103), C137 (= C137), C139 (= C139)
binding benzaldehyde: I255 (= I255), I255 (= I255), L394 (= L394), F425 (= F425), F425 (= F425), F425 (= F425), F425 (= F425), L497 (= L497), L497 (= L497), R501 (= R501), A531 (= A531), Y535 (= Y535), Y535 (= Y535), L626 (= L626), L626 (= L626), L626 (= L626), P694 (= P694), G696 (= G696), G697 (= G697)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q99), C139 (= C139), T420 (= T420), F421 (= F421), G422 (= G422), R533 (= R533), H653 (= H653), G654 (= G654), Q655 (= Q655), G656 (= G656), S695 (≠ A695), G696 (= G696), G697 (= G697), Q700 (≠ S700), Q701 (= Q701), C799 (≠ N799), N800 (= N800), T804 (≠ V804), Q807 (= Q807), S865 (≠ A865), G866 (= G866), V867 (= V867), G868 (= G868), E869 (= E869)

4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
67% identity, 100% coverage: 1:906/907 of query aligns to 1:906/907 of 4c7yA

query
sites
4c7yA

M

M

M

I

K

Q

R

K

T

V

L

I

H

T

V

V

N

N

G

G

V

I

P

E

R

Q

T

N

V

L

I

F

V

V

E

D

A

A

D

E

Q

A

S

L

L

L

A

S

N

D

V

V

L

L

R

R

E

Q

Q

Q

L

L

G

G

L

L

T

T

G

G

T

V

K

K

I

V

G

G

C
|
C

G
x
E

Q

Q

A
x
G

Q

Q

C
|
C

G
|
G

C

A

C
|
C

N

S

V

V

I

I

L

L

D

D

D

G

K

K

L

V

V

V

R
|
R

S

A

C
|
C

V

V

T

T

K

K

M

M

S

K

K

R

V

V

A

A

D

D

G

G

S

A

T

Q

V

I

I

T

T

T

V

I

E

E

G

G

I

V

G

G

N

Q

R

P

D

E

N

N

L

L

H

H

P

P

I

L

Q

Q

L

K

S

A

W

W

I

V

V

L

H

H

G

G

A

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

F

F

I

I

V

V

S

S

V

A

K

K

A

G

L

L

D

D

Q

T

N

N

P

A

N

D

P

P

T

S

R

R

E

E

D

D

V

V

R

R

E

D

W

W

F

F

Q

Q

T

K

H

H

R

R

N

N

A

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

K

K

Q

P

L

L

V

V

D

D

A

A

V

V

M

M

D

D

A

A

K

A

V

V

M

I

R

N

G

G

E

K

M

K

K

P

A

E

E

T

D

D

L

L

L

E

F

F

R

K

I

M

P

P

P

A

D

D

G

G

H

R

I

I

W

W

G

G

T

S

N

K

H

Y

P

P

R

R

P

P

S

T

A

A

V

V

A

A

K

K

V

V

T

T

G

G

T

T

L

L

D

D

Y

Y

G

G

A

A

D

D

L

L

G

G

L

L

K

K

M

M

P

P

A

A

D

G

T

T

L

L

Y

H

L

L

A

A

L

M

V

V

Q

Q

A

A

K

K

V

V

S

S

H

H

A

A

N

N

I

I

K

K

G

G

I

I

D

D

T

T

S

S

E

E

A

A

E

L

K

T

M

M

P

P

G

G

V

V

F

H

K

S

V

V

V

I

T

T

A

H

K

K

D

D

V

V

T

K

G

G

K

K

N

N

R

R

I

I

T

T

G

G

L

L

I

I

T

T

F

F

P

P

T

T

N

N

K

K

G

G

D

D

G

G

W

W

D

D

R

R

P

P

I

I

L

L

C

C

D

D

Q

E

K

K

V

V

F

F

Q

Q

Y

Y

G

G

D

D

A

C

I

I

A

A

I

L

V

V

C

C

A

A

D

D

N

S

E

E

Y

A

Q

N

A

A

R

R

R

A

A

A

E

E

K

K

V

V

K

K

V

V

D

D

L

L

E

E

L

L

P

P

A

A

Y

Y

M

M

S

S

A

G

P

P

A

A

M

A

A

A

E

E

D

D

A

A

M

I

E

E

I

I

H

H

P

P

G

G

T

T

P

P

N

N

V

V

Y

Y

F

F

E

E

L

Q

P

P

V

I

V

V

K

K

G

G

G

E

E

D

T

T

A

G

P

P

L

I

M

F

Q

A

S

S

A

A

A

D

Y

V

T

T

A

V

E

E

G

G

D

D

Y

F

Y

Y

L

V

Q

G

R

R

Q

Q

P

P

H

H

L

M

T

P

M

I

E

E

T

P

D

D

V

V

G

A

C

F

A

A

Y

Y

F

M

D

G

D

D

E

D

E

G

R

K

L

C

T

Y

I

I

H

H

S

S

K

K

S

S

I
|
I

A

G

I

V

H

H

L

L

H

H

S

L

A

Y

M

M

I

I

A

A

A

P

G

G

V

V

G

G

I

L

S

E

P

P

N

D

K

Q

L

L

R

V

L

L

V

V

Q

A

N

N

P

P

A

M

G

G

T
|
T

F
|
F

G
|
G

Y

Y

K

K

F
|
F

S

S

P

P

T

T

M

S

E

E

A

A

L

L

L

V

G

A

V

V

A

A

C

A

M

M

A

A

T

T

G

G

R

R

P

P

V

V

F

H

L

L

R

R

Y

Y

D

N

Y

Y

Q

Q

H

Q

I

Q

T

Q

Y

Y

T

T

G

G

K

K

R
|
R

S

S

P

P

F

W

W

E

M

M

K

N

V

V

K

K

Y

F

G

A

A

A

D

K

K

K

E

D

G

G

K

T

I

L

V

L

A

A

M

M

E

E

S

S

D

D

W

W

S

L

V

V

D

D

H

H

G

G

P

P

Y

Y

S

S

E

E

F

F

G

G

D

D

L

L

L
|
L

T

T

L

L

R
|
R

G

G

A

A

Q

Q

F
|
F

I

I

G

G

A

A

G

G

Y

Y

G

N

I

I

P

P

N

N

I

I

R

R

G

G

M

L

G

G

R

R

T

T

V

V

C

A

T

T

N

N

H

H

A

V

W

W

G

G

S

S

A
|
A

F

F

R
|
R

A

G

Y
|
Y

G

G

S

A

P

P

Q
|
Q

S

S

F

M

L

F

A

A

S

S

E

E

S

C

L

L

I

M

D

D

E

M

L

L

A

A

E

E

K

K

M

L

G

G

I

M

D

D

P

P

L

L

E

E

L

L

R

R

A

Y

R

K

N

N

V

A

Y

Y

R

R

P

P

G

G

D

D

T

T

T

N

P

P

T

T

G

G

Q

Q

V

E

P

P

E

E

V

V

F

F

C

S

F

L

Q

P

E

D

M

M

I

I

E

D

K

Q

L

L

R

R

P

P

I

K

Y

Y

T

Q

S

A

A

A

L

L

E

E

K

K

A

A

G

Q

Q

K

N

E

S

S

T

T

A

A

D

T

V

H

K

K

R

K

G

G

V

V

G

G

I

I

S

S

L

I

G

G

I

V

Y

Y

G

G

C

S

G

G

L

L

D

D

G

G

A

P

D

D

S

A

S

S

E

E

I

A

R

W

V

A

A

E

L

L

N

N

P

A

D

D

N

G

T

T

I

I

T

T

V

V

F

H

S

T

S

A

W
|
W

E

E

D

D

H
|
H

G
|
G

Q
|
Q

G
|
G

A

A

D

D

M

I

G

G

A

C

L

V

G

G

T

T

A

A

H

H

K

E

A

A

F

L

E

R

P

P

M

M

G

G

V

V

Q

A

P

P

D

E

R

K

I

I

R

K

L

F

V

T

M

W

N

P

D

N

T

T

A

A

I

T

T

T

P

P

N

N

S

S

G

G

P

P

A
x
S

G
|
G

S

S

R

R

S
x
Q

Q
|
Q

V

V

V

M

T

T

G

G

N

N

A

A

I

I

K

R

N

V

G

A

C

C

E

E

M

N

L

L

M

L

A

K

A

A

M

C

R

E

K

K

P

P

D

G

G

G

T

G

Y

Y

R

Y

T

T

F

Y

A

D

E

E

M

L

E

K

A

A

E

A

N

D

L

K

P

P

V

T

S

K

Y

I

S

T

G

G

Q

N

W

W

T

T

A

A

S

S

M

G

C

A

T

T

N

H

C

C

D

D

L

A

K

V

T

T

S

G

Q

L

G

G

E

K

P

P

F

F

S

V

V

V

Y

Y

M

M

Y

Y

G

G

M

V

F

F

M

M

A

A

E

E

V

V

A

T

V

V

E

D

T

V

A

A

T

T

G

G

K

Q

T

T

V

V

E

D

G

G

F

M

T

T

A

L

I

M

S

A

D

D

V

L

G

G

S

S

I

L

N
x
C

N
|
N

K

Q

L

L

V

A

V
x
T

D

D

G

G

Q
|
Q

M

I

Y

Y

G

G

I

L

A

A

Q

Q

G

G

I

I

G

G

L

L

A

A

L

L

S

S

E

E

D

D

F

F

E

E

D

D

L

I

S

K

K

K

H

H

N

A

N

T

L

L

R

V

A

G

C

A

G

G

L

F

P

P

Y

F

A

I

K

K

M

Q

I

I

P

P

D

D

K

K

M

L

D

D

L

I

H

V

Y

Y

I

V

E

N

S

H

P

P

R

R

E

P

N

D

G

G

P

P

F

F

G

G

A

A

A
x
S

G
|
G

V
|
V

G
|
G

E
|
E

L
|
L

P

P

L

L

T

T

S

S

S

P

H

H

V

A

A

A

V

I

I

I

N

N

A

A

I

I

H

K

N

S

A

A

C

T

G

G

V

V

R

R

I

I

R

Y

H

R

L

L

P

P

A

A

L

Y

P

P

E
|
E

K

K

V

V

L

L

A
x
E

A

A

L

L

K

K

active site: I390 (= I390), F425 (= F425), R501 (= R501), F505 (= F505), R533 (= R533), E869 (= E869), L870 (= L870)
binding bicarbonate ion: R460 (= R460), L498 (= L498), A531 (= A531), Y535 (= Y535), Q539 (= Q539)
binding fe2/s2 (inorganic) cluster: C40 (= C40), E41 (≠ G41), G43 (≠ A43), C45 (= C45), G46 (= G46), C48 (= C48), R58 (= R58), C60 (= C60), C100 (= C100), G101 (= G101), C103 (= C103), C137 (= C137), C139 (= C139)
binding magnesium ion: E899 (= E899), E903 (≠ A903)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q99), C139 (= C139), T420 (= T420), F421 (= F421), G422 (= G422), R533 (= R533), W650 (= W650), H653 (= H653), G654 (= G654), Q655 (= Q655), G656 (= G656), S695 (≠ A695), G696 (= G696), Q700 (≠ S700), Q701 (= Q701), C799 (≠ N799), N800 (= N800), T804 (≠ V804), Q807 (= Q807), S865 (≠ A865), G866 (= G866), V867 (= V867), G868 (= G868), E869 (= E869)
binding hydrogen peroxide: G696 (= G696), G697 (= G697), E869 (= E869)

3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
67% identity, 100% coverage: 1:906/907 of query aligns to 1:906/907 of 3fc4A

query
sites
3fc4A

M

M

M

I

K

Q

R

K

T

V

L

I

H

T

V

V

N

N

G

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