SitesBLAST
Comparing WP_054255500.1 NCBI__GCF_001298675.1:WP_054255500.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see paper)
57% identity, 97% coverage: 10:434/436 of query aligns to 6:426/426 of P23893
- K265 (= K274) mutation to R: 2% of wild-type activity.
5i92F Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase (gsa) from pseudomonas aeruginosa
55% identity, 97% coverage: 10:431/436 of query aligns to 6:418/420 of 5i92F
Sites not aligning to the query:
6w80A Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from stenotrophomonas maltophilia k279a in complex with plp
55% identity, 97% coverage: 1:424/436 of query aligns to 6:419/430 of 6w80A
- active site: V26 (= V23), Y149 (= Y146), D241 (= D241), K269 (= K274)
- binding pyridoxal-5'-phosphate: S121 (= S118), G122 (= G119), T123 (= T120), Y149 (= Y146), H150 (= H147), E208 (= E208), N213 (= N213), D241 (= D241), V243 (= V243), K269 (= K274)
2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
52% identity, 97% coverage: 11:434/436 of query aligns to 9:427/427 of 2gsaB
- active site: V21 (= V23), Y144 (= Y146), E206 (= E208), D239 (= D241), M242 (= M244), K267 (= K274), A401 (= A408)
- binding pyridoxal-5'-phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K274)
2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
52% identity, 97% coverage: 11:434/436 of query aligns to 9:427/427 of 2gsaA
- active site: V21 (= V23), Y144 (= Y146), E206 (= E208), D239 (= D241), M242 (= M244), K267 (= K274), A401 (= A408)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), G146 (= G148), N211 (= N213), D239 (= D241), V241 (= V243), K267 (= K274)
3usfA Crystal structure of dava-4
52% identity, 97% coverage: 11:434/436 of query aligns to 9:427/427 of 3usfA
- active site: V21 (= V23), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K274), A401 (= A408)
- binding (4s)-4,5-diaminopentanoic acid: S23 (= S25), V25 (= V27), S157 (= S159), K267 (= K274), E400 (= E407)
- binding (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), N211 (= N213), D239 (= D241), V241 (= V243), K267 (= K274)
3fq7A Gabaculine complex of gsam (see paper)
52% identity, 97% coverage: 11:434/436 of query aligns to 9:427/427 of 3fq7A
- active site: V21 (= V23), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K274), A401 (= A408)
- binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: S23 (= S25), V25 (= V27), W61 (= W63), G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K274), G298 (= G305), T299 (= T306), E400 (= E407)
2hp2A Inter-subunit signaling in gsam (see paper)
52% identity, 97% coverage: 11:434/436 of query aligns to 9:427/427 of 2hp2A
- active site: V21 (= V23), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K274), A401 (= A408)
- binding (4s)-4,5-diaminopentanoic acid: G298 (= G305), T299 (= T306)
- binding (4r)-5-amino-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: S23 (= S25), G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K274)
- binding pyridoxal-5'-phosphate: G298 (= G305), T299 (= T306)
2hp1A Inter-subunit signaling in gsam (see paper)
52% identity, 97% coverage: 11:434/436 of query aligns to 9:427/427 of 2hp1A
- active site: V21 (= V23), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K274), A401 (= A408)
- binding (4s)-4-amino-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: S23 (= S25), V25 (= V27), W61 (= W63), S116 (= S118), G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), G146 (= G148), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K274), E400 (= E407)
2hozA Inter-subunit signaling in gsam (see paper)
52% identity, 97% coverage: 11:434/436 of query aligns to 9:427/427 of 2hozA
- active site: V21 (= V23), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K274), A401 (= A408)
- binding (4s)-4,5-diaminopentanoic acid: E141 (≠ N143), G156 (= G158), S157 (= S159), P182 (≠ E184), N368 (= N375), E370 (≠ P377), K373 (≠ L380)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), G146 (= G148), E206 (= E208), N211 (= N213), D239 (= D241), G298 (= G305), T299 (= T306)
3fqaA Gabaculien complex of gabaculine resistant gsam version (see paper)
52% identity, 97% coverage: 11:434/436 of query aligns to 8:426/426 of 3fqaA