SitesBLAST
Comparing WP_054256928.1 NCBI__GCF_001298675.1:WP_054256928.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
30% identity, 93% coverage: 9:250/260 of query aligns to 5:254/254 of 1g6hA
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
30% identity, 93% coverage: 9:249/260 of query aligns to 5:253/253 of 1g9xB
4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
32% identity, 90% coverage: 11:245/260 of query aligns to 4:234/240 of 4ymuJ
- binding adenosine-5'-triphosphate: F11 (= F18), V16 (≠ I23), S36 (≠ N43), G37 (= G44), S38 (≠ A45), G39 (= G46), K40 (= K47), S41 (= S48), T42 (= T49), E162 (= E177), H194 (= H208)
- binding magnesium ion: S41 (= S48), E162 (= E177)
Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see paper)
34% identity, 79% coverage: 24:228/260 of query aligns to 549:741/1704 of Q8R420
Sites not aligning to the query:
- 292 E→V: Knockin new born mice are healthy and survive into adulthood without overt signs of respiratory distress. Knockin mice show a severe lung phenotype that begins with alveolar inflammatory cell infiltration at the early stage of the mouse life followed by aberrant lung remodeling with characteristics of diffuse parenchymal lung disease (DPLD)- and emphysema-like alveolar disruption in older mice.
6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
30% identity, 93% coverage: 9:249/260 of query aligns to 3:235/240 of 6mjpA
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state (see paper)
30% identity, 93% coverage: 8:250/260 of query aligns to 2:235/371 of 3puyA
- binding phosphoaminophosphonic acid-adenylate ester: W12 (≠ F18), S37 (≠ N43), G38 (= G44), C39 (≠ A45), G40 (= G46), K41 (= K47), S42 (= S48), T43 (= T49), Q81 (= Q90), R128 (≠ T147), A132 (≠ N151), S134 (≠ T153), G136 (≠ A155), Q137 (≠ E156), E158 (= E177), H191 (= H208)
- binding magnesium ion: S42 (= S48), Q81 (= Q90)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3 (see paper)
30% identity, 93% coverage: 8:250/260 of query aligns to 2:235/371 of 3puxA
- binding adenosine-5'-diphosphate: W12 (≠ F18), G38 (= G44), C39 (≠ A45), G40 (= G46), K41 (= K47), S42 (= S48), T43 (= T49), R128 (≠ T147), S134 (≠ T153), Q137 (≠ E156)
- binding beryllium trifluoride ion: S37 (≠ N43), G38 (= G44), K41 (= K47), Q81 (= Q90), S134 (≠ T153), G136 (≠ A155), H191 (= H208)
- binding magnesium ion: S42 (= S48), Q81 (= Q90)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4 (see paper)
30% identity, 93% coverage: 8:250/260 of query aligns to 2:235/371 of 3puwA
- binding adenosine-5'-diphosphate: W12 (≠ F18), V17 (≠ I23), G38 (= G44), C39 (≠ A45), G40 (= G46), K41 (= K47), S42 (= S48), T43 (= T49), R128 (≠ T147), A132 (≠ N151), S134 (≠ T153), Q137 (≠ E156)
- binding tetrafluoroaluminate ion: S37 (≠ N43), G38 (= G44), K41 (= K47), Q81 (= Q90), S134 (≠ T153), G135 (≠ Y154), G136 (≠ A155), E158 (= E177), H191 (= H208)
- binding magnesium ion: S42 (= S48), Q81 (= Q90)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4 (see paper)
30% identity, 93% coverage: 8:250/260 of query aligns to 2:235/371 of 3puvA
- binding adenosine-5'-diphosphate: W12 (≠ F18), V17 (≠ I23), G38 (= G44), C39 (≠ A45), G40 (= G46), K41 (= K47), S42 (= S48), T43 (= T49), R128 (≠ T147), A132 (≠ N151), S134 (≠ T153), Q137 (≠ E156)
- binding magnesium ion: S42 (= S48), Q81 (= Q90)
P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 5 papers)
30% identity, 93% coverage: 8:250/260 of query aligns to 3:236/371 of P68187
- A85 (≠ N93) mutation to M: Suppressor of EAA loop mutations in MalFG.
- K106 (≠ N124) mutation to C: Suppressor of EAA loop mutations in MalFG.
- V114 (≠ A132) mutation to C: Suppressor of EAA loop mutations in MalFG.
- V117 (≠ L135) mutation to M: Suppressor of EAA loop mutations in MalFG.
- E119 (= E137) mutation to K: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- A124 (≠ Q142) mutation to T: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- G137 (≠ A155) mutation to A: Loss of maltose transport. Has greater ability to decrease mal gene expression than wild-type MalK.
- D158 (= D176) mutation to N: Loss of maltose transport but retains ability to repress mal genes.
- R228 (= R242) mutation to C: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
Sites not aligning to the query:
- 241 F→I: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 267 W→G: Normal maltose transport but constitutive mal gene expression.
- 278 G→P: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 282 S→L: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 284 G→S: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 302 G→D: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 308 E→Q: Maltose transport is affected but retains ability to interact with MalT.
- 322 S→F: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 340 G→A: Maltose transport is affected but retains ability to interact with MalT.
- 346 G→S: Normal maltose transport but constitutive mal gene expression.
- 355 F→Y: Maltose transport is affected but retains ability to interact with MalT.
2awnB Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
30% identity, 93% coverage: 8:250/260 of query aligns to 2:235/374 of 2awnB
1q12A Crystal structure of the atp-bound e. Coli malk (see paper)
30% identity, 93% coverage: 9:250/260 of query aligns to 1:233/367 of 1q12A
- binding adenosine-5'-triphosphate: W10 (≠ F18), S35 (≠ N43), G36 (= G44), C37 (≠ A45), G38 (= G46), K39 (= K47), S40 (= S48), T41 (= T49), R126 (≠ T147), A130 (≠ N151), S132 (≠ T153), G134 (≠ A155), Q135 (≠ E156)
P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
27% identity, 85% coverage: 9:230/260 of query aligns to 5:221/501 of P04983
- K43 (= K47) mutation to R: Loss of transport.
P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
30% identity, 93% coverage: 8:250/260 of query aligns to 3:236/369 of P19566
- L86 (≠ I94) mutation to F: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
- P160 (= P178) mutation to L: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
- D165 (≠ S183) mutation to N: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
Sites not aligning to the query:
- 306 E→K: Loss of transport. No effect on ATP-binding and ATP hydrolysis. Retains repressor activity.
4u00A Crystal structure of ttha1159 in complex with adp (see paper)
28% identity, 90% coverage: 9:242/260 of query aligns to 3:228/241 of 4u00A
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
28% identity, 86% coverage: 19:241/260 of query aligns to 16:232/353 of 1oxvD
Sites not aligning to the query:
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
28% identity, 86% coverage: 19:241/260 of query aligns to 16:232/353 of 1oxvA
Sites not aligning to the query:
1oxuA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
28% identity, 86% coverage: 19:241/260 of query aligns to 16:232/353 of 1oxuA
Sites not aligning to the query:
Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
28% identity, 86% coverage: 19:241/260 of query aligns to 16:232/353 of Q97UY8