SitesBLAST

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
36% identity, 69% coverage: 1:205/298 of query aligns to 1:212/285 of 4yerA

query
sites
4yerA

M

M

E

E

T

D

I

I

L

I

T

V

V

V

T

E

N

N

L

L

T

V

K

K

F
|
F

G

G

S

D

L
x
F

I

E

A

A

V

V

N

K

D

G

L

V

S

S

F

F

T

S

I

V

E

K

K

K

G

G

N

E

V

I

Y

F

G

A

I

F

L

L

G

G

P

P

N
|
N

G
|
G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

L

I

G

H

I

M

I

L

L

T

N

T

V

L

N

K

K

P

T

T

T

S

G

G

E

K

F

A

H

-

W

W

F

V

D

A

G

G

S

H

S

D

-

V

-

L

-

K

S

E

T

P

H

R

Q

E

A

V

L

R

K

R

K

K

V

I

G

G

A

I

I

V

I

F

E

Q

R

D

P

Q

N

S

F

L

Y

D

P

R

Y

E

M

L

T

T

A

A

I

Y

Q

E

N

N

L

M

K

Y

L

I

V

H

C

G

K

K

I

I

K

Y

E

G

V

Y

S

G

E

G

T

E

K

K

I

L

E

K

K

R

L

I

-

L

-

E

-

L

E

E

L

F

V

V

G

E

L

L

D

E

R

F

K

K

H

D

S

K

K

P

F

V

R

K

T
|
T

Y
x
F

S
|
S

L

G

G

G

M

M

K

A

Q

R

R

R

L

L

A

E

I

I

A

A

S

R

A

S

L

L

L

I

N

H

D

E

P

P

E

E

I

V

L

L

I

F

L

L

D

D

E

E

P

P

T

T

N

I

G

G

L

L

D

D

P

P

Q

H

G

T

I

R

H

A

Q

H

I

M

R

W

E

E

I

Y

I

I

K

S

K

K

I

M

A

K

S

K

Q

E

-

H

G

N

T

M

T

T

I

I

L

F

L

L

A

T

S

T

H

H

L

Y

L

M

D

D

E

E

V

A

E

E

K

Q

V

L

C

A

S

D

H

R

V

V

V

A

I

I

L

I

R

D

K

H

G

G

binding adenosine-5'-diphosphate: F14 (= F14), F17 (≠ L17), N39 (= N39), G40 (= G40), G42 (= G42), K43 (= K43), T44 (≠ S44), T45 (= T45), T135 (= T129), F136 (≠ Y130), S137 (= S131)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
34% identity, 70% coverage: 4:211/298 of query aligns to 1:218/240 of 4ymuJ

query
sites
4ymuJ

I

M

L

I

T

F

V

V

T

N

N

D

L

V

T

Y

K

K

K

N

F
|
F

G

G

S

S

L

L

I

E

A
x
V

V

L

N

K

D

G

L

V

S

T

F

L

T

K

I

V

E

N

K

K

G

G

N

E

V

V

Y

V

G

V

I

I

L

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

T

L

L

L

G

R

I

C

I

I

L

N

N

L

V

L

V

E

N

E

K

P

T

T

T

K

G

G

E

E

F

V

-

F

-

I

-

D

-

G

-

V

H

K

W

I

F

N

D

N

G

G

S

K

S

V

S

N

T

I

H

N

Q

K

A

V

L

R

K

Q

K

K

V

V

G

G

A

M

I

V

I

F

E

Q

R

H

P

F

N

N

F

L

Y

F

P

P

Y

H

M

L

T

T

A

A

I

I

Q

E

N

N

L

I

K

T

L

L

V

A

-

P

C

V

K

K

I

V

K

K

E

K

V

M

S

N

E

K

T

K

K

E

I

A

E

E

K

L

-

A

-

V

-

D

-

L

L

L

E

A

L

K

V

V

G

G

L

L

D

D

R

K

K

K

H

D

S

Q

K

Y

F

P

R

I

T

K

Y

L

S

S

L

G

G

G

M

Q

K

K

Q

Q

R

R

L

L

A

A

I

I

A

A

S

R

A

A

L

L

L

A

N

M

D

Q

P

P

E

E

I

V

L

M

I

L

L

F

D

D

E
|
E

P

P

T

T

N

S

G

A

L

L

D

D

P

P

Q

E

G

M

I

V

H

K

Q

E

I

V

R

L

E

N

I

V

I

M

K

K

K

Q

I

L

A

A

S

N

Q

E

G

G

T

M

T

T

I

M

L

V

A

V

S

T

H
|
H

L

E

L

M

D

G

E

F

V

A

E

R

K

E

V

V

C

G

S

D

H

R

V

V

V

I

I

F

L

M

R

D

K

D

G

G

V

V

K

I

L

V

Y

E

S

E

G

G

binding adenosine-5'-triphosphate: F11 (= F14), V16 (≠ A19), S36 (≠ N39), G37 (= G40), S38 (= S41), G39 (= G42), K40 (= K43), S41 (= S44), T42 (= T45), E162 (= E155), H194 (= H187)
binding magnesium ion: S41 (= S44), E162 (= E155)

8k1oB Mycobacterial efflux pump, amppnp bound state (see paper)
36% identity, 69% coverage: 7:211/298 of query aligns to 8:213/215 of 8k1oB

query
sites
8k1oB

V

I

T

R

N

G

L

L

T

T

K

K

K

H

F

F

G

G

S

S

L

V

I

R

A

A

V

L

N

D

D

G

L

L

S

D

F

L

T

T

I

V

E

R

K

E

G

G

N

E

V

V

Y

H

G

G

I

F

L

L

G

G

P

P

N
|
N

G

G

S

A

G
|
G

K
|
K

S
|
S

T
|
T

T

T

L

L

G

R

I

I

I

L

L

L

N

G

V

L

V

V

N

K

K

A

T

D

T

G

G

G

E

S

F

V

H

R

W

L

F

L

D

G

G

G

S

D

S

P

S

W

T

T

-

D

-

A

-

V

-

D

-

L

H

H

Q

R

A

H

L

I

K

A

K

Y

V

V

G

P

A

G

I

D

I

V

E

-

R

-

P

-

N

T

F

L

Y

W

P

P

Y

S

M

L

T

T

A

G

I

G

Q

E

N

T

L

I

K

D

L

L

V

L

C

A

K

R

I

M

K

R

E

G

-

G

V

I

S

D

E

N

T

A

K

R

I

R

E

A

E

E

K

L

L

I

E

E

L

R

V

F

G

G

L

L

L

D

D

P

R

T

K

K

H

-

S

-

K

K

F

A

R

R

T
|
T

Y

Y

S
|
S

L

K

G

G

M

N

K

R

Q

Q

R

K

L

V

A

S

I

L

A

I

S

S

A

A

L

L

L

S

N

S

D

H

P

A

E

T

I

L

L

L

I

L

L

L

D

D

E

E

P

P

T

S

N

S

G

G

L

L

D

D

P

P

Q

L

G

M

I

E

H

N

Q

V

I

F

R

Q

E

Q

I

C

I

I

K

G

K

E

I

A

A

R

S

Q

Q

R

G

G

T

V

T

T

I

V

L

L

A

S

S

S

H

H

L

I

L

L

D

A

E

E

V

T

E

E

K

A

V

L

C

C

S

E

H

K

V

V

V

T

I

I

L

I

R

R

K

A

G

G

V

K

K

T

L

V

Y

E

S

S

G

G

binding phosphoaminophosphonic acid-adenylate ester: N40 (= N39), G43 (= G42), K44 (= K43), S45 (= S44), T46 (= T45), T131 (= T129), S133 (= S131)

8k1pB Mycobacterial efflux pump, adp+vanadate bound state
36% identity, 69% coverage: 7:211/298 of query aligns to 6:211/213 of 8k1pB

query
sites
8k1pB

V

I

T

R

N

G

L

L

T

T

K

K

K

H

F
|
F

G

G

S

S

L

V

I

R

A

A

V

L

N

D

D

G

L

L

S

D

F

L

T

T

I

V

E

R

K

E

G

G

N

E

V

V

Y

H

G

G

I

F

L

L

G

G

P

P

N
|
N

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

T

T

L

L

G

R

I

I

I

L

L

L

N

G

V

L

V

V

N

K

K

A

T

D

T

G

G

G

E

S

F

V

H

R

W

L

F

L

D

G

G

G

S

D

S

P

S

W

T

T

-

D

-

A

-

V

-

D

-

L

H

H

Q

R

A

H

L

I

K

A

K

Y

V

V

G

P

A

G

I

D

I

V

E

-

R

-

P

-

N

T

F

L

Y

W

P

P

Y

S

M

L

T

T

A

G

I

G

Q

E

N

T

L

I

K

D

L

L

V

L

C

A

K

R

I

M

K

R

E

G

-

G

V

I

S

D

E

N

T

A

K

R

I

R

E

A

E

E

K

L

L

I

E

E

L

R

V

F

G

G

L

L

L

D

D

P

R

T

K

K

H

-

S

-

K

K

F

A

R

R

T
|
T

Y

Y

S
|
S

L

K

G

G

M

N

K

R

Q

Q

R

K

L

V

A

S

I

L

A

I

S

S

A

A

L

L

L

S

N

S

D

H

P

A

E

T

I

L

L

L

I

L

L

L

D

D

E

E

P

P

T

S

N

S

G

G

L

L

D

D

P

P

Q

L

G

M

I

E

H

N

Q

V

I

F

R

Q

E

Q

I

C

I

I

K

G

K

E

I

A

A

R

S

Q

Q

R

G

G

T

V

T

T

I

V

L

L

A

S

S

S

H

H

L

I

L

L

D

A

E

E

V

T

E

E

K

A

V

L

C

C

S

E

H

K

V

V

V

T

I

I

L

I

R

R

K

A

G

G

V

K

K

T

L

V

Y

E

S

S

G

G

binding adenosine-5'-diphosphate: F13 (= F14), N38 (= N39), G39 (= G40), A40 (≠ S41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)
binding adenosine-5'-triphosphate: T129 (= T129), S131 (= S131)

3c4jA Abc protein artp in complex with atp-gamma-s
32% identity, 70% coverage: 4:211/298 of query aligns to 3:220/242 of 3c4jA

query
sites
3c4jA

I

M

L

I

T

D

V

V

T

H

N

Q

L

L

T

K

K

K

K

S

F
|
F

G

G

S

S

L

L

I

E

A
x
V

V

L

N

K

D

G

L

I

S

N

F

V

T

H

I

I

E

R

K

E

G

G

N

E

V

V

Y

V

G

V

I

V

L

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

L

L

G

R

I

C

I

L

L

N

N

L

V

L

V

E

N

D

K

F

T

D

T

E

G

G

E

E

F

I

H

-

W

I

F

I

D

D

G

G

-

I

-

N

-

L

-

K

-

A

-

K

S

D

S

T

S

N

T

L

H

N

Q

K

A

V

L

R

K

E

V

V

G

G

A

M

I

V

I

F

E

Q

R

R

P

F

N

N

F

L

Y

F

P

P

Y

H

M

M

T

T

A

V

I

L

Q

N

N

N

L

I

K

T

L

L

V

A

-

P

C

M

K

K

I

V

K

R

-

K

-

W

-

P

-

R

E

E

V

K

S

A

E

E

T

A

K

K

I

A

E

M

E

E

K

L

L

L

E

D

L

K

V

V

G

G

L

L

L

K

D

D

R

K

K

A

H

H

S

A

K

Y

F

P

R

D

T

S

Y

L

S

S

L

G

G

G

M

Q

K

A

Q

Q

R

R

L

V

A

A

I

I

A

A

S

R

A

A

L

L

L

A

N

M

D

E

P

P

E

K

I

I

L

M

I

L

L

F

D

D

E

E

P

P

T

T

N

S

G

A

L

L

D

D

P

P

Q

E

G

M

I

V

H

G

Q

E

I

V

R

L

E

S

I

V

I

M

K

K

K

Q

I

L

A

A

S

N

Q

E

G

G

T

M

T

T

I

M

L

V

A

V

S

T

H

H

L

E

L

M

D

G

E

F

V

A

E

R

K

E

V

V

C

G

S

D

H

R

V

V

V

L

I

F

L

M

R

D

K

G

G

G

V

Y

K

I

L

I

Y

E

S

E

G

G

binding phosphothiophosphoric acid-adenylate ester: F13 (= F14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), S40 (= S41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)

3c41J Abc protein artp in complex with amp-pnp/mg2+
32% identity, 70% coverage: 4:211/298 of query aligns to 3:220/242 of 3c41J

query
sites
3c41J

I

M

L

I

T

D

V

V

T

H

N

Q

L

L

T

K

K

K

K

S

F
|
F

G

G

S

S

L

L

I

E

A
x
V

V

L

N

K

D

G

L

I

S

N

F

V

T

H

I

I

E

R

K

E

G

G

N

E

V

V

Y

V

G

V

I

V

L

I

G

G

P

P

N
x
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

L

L

G

R

I

C

I

L

L

N

N

L

V

L

V

E

N

D

K

F

T

D

T

E

G

G

E

E

F

I

H

-

W

I

F

I

D

D

G

G

-

I

-

N

-

L

-

K

-

A

-

K

S

D

S

T

S

N

T

L

H

N

Q

K

A

V

L

R

K

E

V

V

G

G

A

M

I

V

I

F

E

Q

R

R

P

F

N

N

F

L

Y

F

P

P

Y

H

M

M

T

T

A

V

I

L

Q

N

N

N

L

I

K

T

L

L

V

A

-

P

C

M

K

K

I

V

K

R

-

K

-

W

-

P

-

R

E

E

V

K

S

A

E

E

T

A

K

K

I

A

E

M

E

E

K

L

L

L

E

D

L

K

V

V

G

G

L

L

L

K

D

D

R

K

K

A

H

H

S

A

K

Y

F

P

R

D

T

S

Y

L

S

S

L

G

G

G

M

Q

K

A

Q

Q

R

R

L

V

A

A

I

I

A

A

S

R

A

A

L

L

L

A

N

M

D

E

P

P

E

K

I

I

L

M

I

L

L

F

D
|
D

E

E

P

P

T

T

N

S

G

A

L

L

D

D

P

P

Q

E

G

M

I

V

H

G

Q

E

I

V

R

L

E

S

I

V

I

M

K

K

K

Q

I

L

A

A

S

N

Q

E

G

G

T

M

T

T

I

M

L

V

A

V

S

T

H

H

L

E

L

M

D

G

E

F

V

A

E

R

K

E

V

V

C

G

S

D

H

R

V

V

V

L

I

F

L

M

R

D

K

G

G

G

V

Y

K

I

L

I

Y

E

S

E

G

G

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)
binding magnesium ion: S43 (= S44), D163 (= D154)

2olkA Abc protein artp in complex with adp-beta-s
32% identity, 70% coverage: 4:211/298 of query aligns to 3:220/242 of 2olkA

query
sites
2olkA

I

M

L

I

T

D

V

V

T

H

N

Q

L

L

T

K

K

K

K

S

F
|
F

G

G

S

S

L

L

I

E

A
x
V

V

L

N

K

D

G

L

I

S

N

F

V

T

H

I

I

E

R

K

E

G

G

N

E

V

V

Y

V

G

V

I

V

L

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

L

L

G

R

I

C

I

L

L

N

N

L

V

L

V

E

N

D

K

F

T

D

T

E

G

G

E

E

F

I

H

-

W

I

F

I

D

D

G

G

-

I

-

N

-

L

-

K

-

A

-

K

S

D

S

T

S

N

T

L

H

N

Q

K

A

V

L

R

K

E

V

V

G

G

A

M

I

V

I

F

E

Q

R

R

P

F

N

N

F

L

Y

F

P

P

Y

H

M

M

T

T

A

V

I

L

Q

N

N

N

L

I

K

T

L

L

V

A

-

P

C

M

K

K

I

V

K

R

-

K

-

W

-

P

-

R

E

E

V

K

S

A

E

E

T

A

K

K

I

A

E

M

E

E

K

L

L

L

E

D

L

K

V

V

G

G

L

L

L

K

D

D

R

K

K

A

H

H

S

A

K

Y

F

P

R

D

T

S

Y

L

S

S

L

G

G

G

M

Q

K

A

Q

Q

R

R

L

V

A

A

I

I

A

A

S

R

A

A

L

L

L

A

N

M

D

E

P

P

E

K

I

I

L

M

I

L

L

F

D

D

E

E

P

P

T

T

N

S

G

A

L

L

D

D

P

P

Q

E

G

M

I

V

H

G

Q

E

I

V

R

L

E

S

I

V

I

M

K

K

K

Q

I

L

A

A

S

N

Q

E

G

G

T

M

T

T

I

M

L

V

A

V

S

T

H

H

L

E

L

M

D

G

E

F

V

A

E

R

K

E

V

V

C

G

S

D

H

R

V

V

V

L

I

F

L

M

R

D

K

G

G

G

V

Y

K

I

L

I

Y

E

S

E

G

G

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (= F14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), S40 (= S41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)

2oljA Abc protein artp in complex with adp/mg2+
32% identity, 70% coverage: 4:211/298 of query aligns to 3:220/242 of 2oljA

query
sites
2oljA

I

M

L

I

T

D

V

V

T

H

N

Q

L

L

T

K

K

K

K

S

F
|
F

G

G

S

S

L

L

I

E

A
x
V

V

L

N

K

D

G

L

I

S

N

F

V

T

H

I

I

E

R

K

E

G

G

N

E

V

V

Y

V

G

V

I

V

L

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

L

L

G

R

I

C

I

L

L

N

N

L

V

L

V

E

N

D

K

F

T

D

T

E

G

G

E

E

F

I

H

-

W

I

F

I

D

D

G

G

-

I

-

N

-

L

-

K

-

A

-

K

S

D

S

T

S

N

T

L

H

N

Q

K

A

V

L

R

K

E

V

V

G

G

A

M

I

V

I

F

E

Q

R

R

P

F

N

N

F

L

Y

F

P

P

Y

H

M

M

T

T

A

V

I

L

Q

N

N

N

L

I

K

T

L

L

V

A

-

P

C

M

K

K

I

V

K

R

-

K

-

W

-

P

-

R

E

E

V

K

S

A

E

E

T

A

K

K

I

A

E

M

E

E

K

L

L

L

E

D

L

K

V

V

G

G

L

L

L

K

D

D

R

K

K

A

H

H

S

A

K

Y

F

P

R

D

T

S

Y

L

S

S

L

G

G

G

M

Q

K

A

Q

Q

R

R

L

V

A

A

I

I

A

A

S

R

A

A

L

L

L

A

N

M

D

E

P

P

E

K

I

I

L

M

I

L

L

F

D

D

E

E

P

P

T

T

N

S

G

A

L

L

D

D

P

P

Q

E

G

M

I

V

H

G

Q

E

I

V

R

L

E

S

I

V

I

M

K

K

K

Q

I

L

A

A

S

N

Q

E

G

G

T

M

T

T

I

M

L

V

A

V

S

T

H

H

L

E

L

M

D

G

E

F

V

A

E

R

K

E

V

V

C

G

S

D

H

R

V

V

V

L

I

F

L

M

R

D

K

G

G

G

V

Y

K

I

L

I

Y

E

S

E

G

G

binding adenosine-5'-diphosphate: F13 (= F14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), S40 (= S41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
32% identity, 72% coverage: 5:219/298 of query aligns to 4:239/353 of 1oxvD

query
sites
1oxvD

L

I

T

I

V

V

T

K

N

N

L

V

T

S

K

K

K

V

F
|
F

-

K

G

G

S

K

L

V

I

V

A

A

V

L

N

D

D

N

L

V

S

N

F

I

T

N

I

I

E

E

K

N

G

G

N

E

V

R

Y

F

G

G

I

I

L

L

G

G

P

P

N
x
S

G
|
G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

T

F

L

M

G

R

I

I

L

A

N

G

V

L

V

D

N

V

K

P

T

S

T

T

G

G

E

E

F

L

H

Y

W

F

F

D

D

D

G

R

S

L

S

V

S

A

T

S

H

N

Q

G

A

K

L

L

-

I

-

V

-

P

-

E

-

D

K

R

K

K

V

I

G

G

A

M

I

V

I

F

E
x
Q

R

T

P

W

N

A

F

L

Y

Y

P

P

Y

N

M

L

T

T

A

A

I

F

Q

E

N

N

L

I

K

A

L

F

V

P

C

L

K

T

I

N

K

M

E

K

V

M

S

S

E

K

T

E

K

E

I

I

E

R

E

K

K

R

L

V

E

E

L

E

V

V

G

A

-

K

L

I

L

L

D

D

R

I

K

H

H

H

-

V

-

L

S

N

K

H

F

F

-

P

R

R

T

E

Y

L

S

S

L

G

G

G

M

Q

K

Q

Q

Q

R

R

L

V

A

A

I

L

A

A

S

R

A

A

L

L

L

V

N

K

D

D

P

P

E

S

I

L

L

L

I

L

L

L

D

D

E
|
E

P

P

T

F

N

S

G

N

L

L

D

D

P

A

Q

R

G

M

I

R

H

D

Q

S

I

A

R

R

E

A

I

L

I

V

K

K

K

E

I

V

A

Q

S

S

Q

R

-

L

G

G

T

V

T

T

I

L

L

L

L

V

A

V

S

S

H

H

L

D

L

P

D

A

E

D

V

I

E

F

K

A

V

I

C

A

S

D

H

R

V

V

V

G

I

V

L

L

R

V

K

K

G

G

V

K

-

L

-

V

-

Q

-

V

-

G

-

K

-

P

-

E

K

D

L

L

Y

Y

S

D

G

N

P

P

V

V

D

S

S

I

M

Q

L

V

A

A

S

S

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F14), S40 (≠ N39), G41 (= G40), G43 (= G42), K44 (= K43), T45 (≠ S44), T46 (= T45), Q89 (≠ E82), E166 (= E155)
binding magnesium ion: T45 (≠ S44), Q89 (≠ E82)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
32% identity, 72% coverage: 5:219/298 of query aligns to 4:239/353 of 1oxvA

query
sites
1oxvA

L

I

T

I

V

V

T

K

N

N

L

V

T

S

K

K

K

V

F
|
F

-

K

G

G

S

K

L

V

I

V

A

A

V

L

N

D

D

N

L

V

S

N

F

I

T

N

I

I

E

E

K

N

G

G

N

E

V

R

Y

F

G

G

I

I

L

L

G

G

P

P

N
x
S

G
|
G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

T

F

L

M

G

R

I

I

L

A

N

G

V

L

V

D

N

V

K

P

T

S

T

T

G

G

E

E

F

L

H

Y

W

F

F

D

D

D

G

R

S

L

S

V

S

A

T

S

H

N

Q

G

A

K

L

L

-

I

-

V

-

P

-

E

-

D

K

R

K

K

V

I

G

G

A

M

I

V

I

F

E

Q

R

T

P

W

N

A

F

L

Y

Y

P

P

Y

N

M

L

T

T

A

A

I

F

Q

E

N

N

L

I

K

A

L

F

V

P

C

L

K

T

I

N

K

M

E

K

V

M

S

S

E

K

T

E

K

E

I

I

E

R

E

K

K

R

L

V

E

E

L

E

V

V

G

A

-

K

L

I

L

L

D

D

R

I

K

H

H

H

-

V

-

L

S

N

K

H

F

F

-

P

R

R

T

E

Y

L

S

S

L

G

G

G

M

Q

K

Q

Q

Q

R

R

L

V

A

A

I

L

A

A

S

R

A

A

L

L

L

V

N

K

D

D

P

P

E

S

I

L

L

L

I

L

L

L

D

D

E
|
E

P

P

T

F

N

S

G

N

L

L

D

D

P

A

Q

R

G

M

I

R

H

D

Q

S

I

A

R

R

E

A

I

L

I

V

K

K

K

E

I

V

A

Q

S

S

Q

R

-

L

G

G

T

V

T

T

I

L

L

L

L

V

A

V

S

S

H

H

L

D

L

P

D

A

E

D

V

I

E

F

K

A

V

I

C

A

S

D

H

R

V

V

V

G

I

V

L

L

R

V

K

K

G

G

V

K

-

L

-

V

-

Q

-

V

-

G

-

K

-

P

-

E

K

D

L

L

Y

Y

S

D

G

N

P

P

V

V

D

S

S

I

M

Q

L

V

A

A

S

S

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F14), S40 (≠ N39), G41 (= G40), G43 (= G42), K44 (= K43), T45 (≠ S44), T46 (= T45), E166 (= E155)

1oxuA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
32% identity, 72% coverage: 5:219/298 of query aligns to 4:239/353 of 1oxuA

query
sites
1oxuA

L

I

T

I

V

V

T

K

N

N

L

V

T

S

K

K

K

V

F
|
F

-

K

G

G

S

K

L

V

I

V

A
|
A

V

L

N

D

D

N

L

V

S

N

F

I

T

N

I

I

E

E

K

N

G

G

N

E

V

R

Y

F

G

G

I

I

L

L

G

G

P

P

N

S

G
|
G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

T

F

L

M

G

R

I

I

L

A

N

G

V

L

V

D

N

V

K

P

T

S

T

T

G

G

E

E

F

L

H

Y

W

F

F

D

D

D

G

R

S

L

S

V

S

A

T

S

H

N

Q

G

A

K

L

L

-

I

-

V

-

P

-

E

-

D

K

R

K

K

V

I

G

G

A

M

I

V

I

F

E

Q

R

T

P

W

N

A

F

L

Y

Y

P

P

Y

N

M

L

T

T

A

A

I

F

Q

E

N

N

L

I

K

A

L

F

V

P

C

L

K

T

I

N

K

M

E

K

V

M

S

S

E

K

T

E

K

E

I

I

E

R

E

K

K

R

L

V

E

E

L

E

V

V

G

A

-

K

L

I

L

L

D

D

R

I

K

H

H

H

-

V

-

L

S

N

K

H

F

F

-

P

R

R

T

E

Y

L

S

S

L

G

G

G

M

Q

K

Q

Q

Q

R

R

L

V

A

A

I

L

A

A

S

R

A

A

L

L

L

V

N

K

D

D

P

P

E

S

I

L

L

L

I

L

L

L

D

D

E

E

P

P

T

F

N

S

G

N

L

L

D

D

P

A

Q

R

G

M

I

R

H

D

Q

S

I

A

R

R

E

A

I

L

I

V

K

K

K

E

I

V

A

Q

S

S

Q

R

-

L

G

G

T

V

T

T

I

L

L

L

L

V

A

V

S

S

H

H

L

D

L

P

D

A

E

D

V

I

E

F

K

A

V

I

C

A

S

D

H

R

V

V

V

G

I

V

L

L

R

V

K

K

G

G

V

K

-

L

-

V

-

Q

-

V

-

G

-

K

-

P

-

E

K

D

L

L

Y

Y

S

D

G

N

P

P

V

V

D

S

S

I

M

Q

L

V

A

A

S

S

binding adenosine-5'-diphosphate: F13 (= F14), A20 (= A19), G41 (= G40), G43 (= G42), K44 (= K43), T45 (≠ S44), T46 (= T45)

Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
32% identity, 72% coverage: 5:219/298 of query aligns to 4:239/353 of Q97UY8

query
sites
Q97UY8

L

I

T

I

V

V

T

K

N

N

L

V

T

S

K

K

K

V

F

F

-

K

G

G

S

K

L

V

I

V

A

A

V

L

N

D

D

N

L

V

S

N

F

I

T

N

I

I

E

E

K

N

G

G

N

E

V

R

Y

F

G

G

I

I

L

L

G

G

P

P

N

S

G

G

S

A

G

G

K

K

S

T

T

T

T

F

L

M

G

R

I

I

L

A

N

G

V

L

V

D

N

V

K

P

T

S

T

T

G

G

E

E

F

L

H

Y

W

F

F

D

D

D

G

R

S

L

S

V

S

A

T

S

H

N

Q

G

A

K

L

L

-

I

-

V

-

P

-

E

-

D

K

R

K

K

V

I

G

G

A

M

I

V

I

F

E

Q

R

T

P

W

N

A

F

L

Y

Y

P

P

Y

N

M

L

T

T

A

A

I

F

Q

E

N

N

L

I

K

A

L

F

V

P

C

L

K

T

I

N

K

M

E

K

V

M

S

S

E

K

T

E

K

E

I

I

E

R

E

K

K

R

L

V

E

E

L

E

V

V

G

A

-

K

L

I

L

L

D

D

R

I

K

H

H

H

-

V

-

L

S

N

K

H

F

F

-

P

R

R

T

E

Y

L

S
|
S

L

G

G
|
G

M

Q

K

Q

Q

Q

R

R

L

V

A

A

I

L

A

A

S

R

A

A

L

L

L

V

N

K

D

D

P

P

E

S

I

L

L

L

I

L

L

L

D

D

E
|
E

P

P

T

F

N

S

G

N

L

L

D

D

P

A

Q

R

G

M

I

R

H

D

Q

S

I

A

R

R

E

A

I

L

I

V

K

K

K

E

I

V

A

Q

S

S

Q

R

-

L

G

G

T

V

T

T

I

L

L

L

L

V

A

V

S

S

H

H

L

D

L

P

D

A

E

D

V

I

E

F

K

A

V

I

C

A

S

D

H

R

V

V

V

G

I

V

L

L

R

V

K

K

G

G

V

K

-

L

-

V

-

Q

-

V

-

G

-

K

-

P

-

E

K

D

L

L

Y

Y

S

D

G

N

P

P

V

V

D

S

S

I

M

Q

L

V

A

A

S

S

S142 (= S131) mutation to A: Decrease in ATPase activity. Can form dimers.
G144 (= G133) mutation to A: Loss of ATPase activity. Cannot form dimers. Forms an active heterodimer; when associated with A-166.
E166 (= E155) mutation to A: Loss of ATPase activity. Can form dimers in the presence of ATP-Mg(2+). Forms an active heterodimer; when associated with A-144.; mutation to Q: Strong decrease in ATPase activity. Can form dimers in the presence of ATP alone, without Mg(2+).

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
32% identity, 68% coverage: 4:205/298 of query aligns to 2:212/241 of 4u00A

query
sites
4u00A

I

I

L

I

T

R

V

I

T

R

N

N

L

L

T

H

K

K

K

W

F
|
F

G

G

S

P

L

L

I

H

A
x
V

V

L

N

K

D

G

L

I

S

H

F

L

T

E

I

V

E

A

K

P

G

G

N

E

V

K

Y

L

G

V

I

I

L

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

T

L

L

I

G

R

I

T

I

I

L

N

N

R

V

L

V

E

N

D

K

F

T

Q

T

E

G

G

E

E

F

V

H

-

W

V

F

V

D

D

G

G

-

L

S

S

S

V

S

K

T

D

H

D

Q

R

A

A

L

L

K

R

K

E

-

I

-

R

-

E

V

V

G

G

A

M

I

V

I

F

E

Q

R

Q

P

F

N

N

F

L

Y

F

P

P

Y

H

M

M

T

T

A

V

I

L

Q

E

N

N

L

V

K

T

L

L

V

A

-

P

C

M

K

R

I

V

K

R

E

R

V

W

S

P

E

R

T

E

K

K

I

A

E

E

E

K

K

K

-

A

-

L

-

E

-

L

L

L

E

E

L

R

V

V

G

G

L

I

L

L

D

D

R

Q

K

A

H

R

S

K

K

Y

F

P

R

A

T

Q

Y

L

S

S

L

G

G

G

M

Q

K

Q

Q

Q

R

R

L

V

A

A

I

I

A

A

S

R

A

A

L

L

L

A

N

M

D

E

P

P

E

K

I

I

L

M

I

L

L

F

D

D

E

E

P

P

T

T

N

S

G

A

L

L

D

D

P

P

Q

E

G

M

I

V

H

G

Q

E

I

V

R

L

E

D

I

V

I

M

K

R

K

D

I

L

A

A

S

Q

Q

G

G

G

T

M

T

T

I

M

L

V

A

V

S

T

H

H

L

E

L

M

D

G

E

F

V

A

E

R

K

E

V

V

C

A

S

D

H

R

V

V

I

F

L

M

R

D

K

G

G

G

binding adenosine-5'-diphosphate: F12 (= F14), V17 (≠ A19), S37 (≠ N39), G38 (= G40), S39 (= S41), G40 (= G42), K41 (= K43), S42 (= S44), T43 (= T45)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
32% identity, 68% coverage: 4:205/298 of query aligns to 1:217/343 of P30750

query
sites
P30750

I

M

L

I

T

K

V

L

T

S

N

N

L

I

T

T

K

K

K

V

F

F

-

H

-

Q

-

G

-

T

G

R

S

T

L

I

I

Q

A

A

V

L

N

N

D

N

L

V

S

S

F

L

T

H

I

V

E

P

K

A

G

G

N

Q

V

I

Y

Y

G

G

I

V

L

I

G

G

P

A

N
x
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

T

L

L

I

G

R

I

C

I

V

L

-

N

N

V

L

N

E

K

R

T

P

T

T

G

E

E

G

F

S

H

V

W

L

F

V

D

D

G

G

S

Q

-

E

-

L

-

T

-

L

-

S

-

E

S

S

S

E

T

L

H

T

Q

K

A

A

L

R

K

R

K

Q

V

I

G

G

A

M

I

I

I

F

E

Q

R

H

P

F

N

N

F

L

Y

L

P

S

Y

S

M

R

T

T

A

V

I

F

Q

G

N

N

L

V

K

A

L

L

V

P

C

L

K

E

I

L

-

D

-

N

-

T

-

P

K

K

E

D

V

E

S

V

E

K

T

R

K

R

I

V

E

T

E

E

K

L

L

L

E

S

L

L

V

V

G

G

L

L

L

G

D

D

R

K

K

H

H

D

S

S

K

Y

F

P

R

S

T

N

Y

L

S

S

L

G

G

G

M

Q

K

K

Q

Q

R

R

L

V

A

A

I

I

A

A

S

R

A

A

L

L

L

A

N

S

D

N

P

P

E

K

I

V

L

L

I

L

L

C

D

D

E
|
E

P

A

T

T

N

S

G

A

L

L

D

D

P

P

Q

A

G

T

I

T

H

R

Q

S

I

I

R

L

E

E

I

L

K

K

K

D

I

I

A

N

S

R

Q

R

-

L

G

G

T

L

T

T

I

I

L

L

A

I

S

T

H

H

L

E

L

M

D

D

E

V

V

V

E

K

K

R

V

I

C

C

S

D

H

C

V

V

V

A

I

V

L

I

R

S

K

N

G

G

40:46 (vs. 39:45, 71% identical) binding ATP
E166 (= E155) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 15 papers)
30% identity, 69% coverage: 1:205/298 of query aligns to 1377:1590/1704 of Q99758

query
sites
Q99758

M

L

E

H

T

T

I

P

L

L

T

I

V

I

T

K

N

E

L

L

T

S

K
|
K

K

V

F

Y

G

E

-

Q

-

R

-

V

S

P

L

L

I

L

A

A

V

V

N

D

D

R

L

L

S

S

F

L

T

A

I

V

E

Q

K

K

G

G

N

E

V

C

Y

F

G

G

I

L

L

L

G

G

P

F

N

N

G

G

S

A

G

G

K

K

S

T

T

T

L

F

G

K

I

M

I

L

L

T

N

G

V

E

N

S

K

L

T

T

T

S

G

G

E

-

F

-

H

-

W

-

F

-

D

D

G

A

S

F

S

V

S

G

T

G

H

H

Q

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A

I

L

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K

S

K

D

V

V

G

G

A

K

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Q

R

R

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I

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G

F

Y

Y

C

P

P

-

Q

-

F

-

D

-

A

-

L

-

D

Y

H

M

M

T

T

A

G

I

R

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N

M

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L

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L

M

V

Y

C

A

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I

L

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R

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G

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I

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P

E

E

T

R

K

H

I

I

E

G

E

A

K

C

L

V

E

E

-

N

-

T

L

L

V

R

G

G

L

L

D

L

R

E

K

P

H

H

S

A

K

N

-

K

-

L

F

V

R

R

T

T

Y

Y

S

S

L

G

G

G

M

N

K

K

Q

R

R

K

L

L

A

S

I

T

A

G

S

I

A

A

L

L

L

I

N

G

D

E

P

P

E

A

I

V

L

I

I

F

L

L

D

D

E

E

P

P

T

S

N

T

G

G

L

M

D

D

P

P

Q

V

G

A

I

R

H

R

Q

L

I
x
L

R

W

E

D

I

T

I

V

K

A

K

R

I

A

A

R

S

E

Q

S

G

G

T

K

T

A

I

I

L

I

A

T

S

S

H

H

L

S

L

M

D

E

E

E

V

C

E

E

K

A

V
x
L

C

C

S

T

H

R

V

L

V

A

I

I

L

M

R

V

K

Q

G

G

K1388 (= K12) to N: in SMDP3; decreases phosphatidylcholine transport; increases protein abundance; does not affect folding in the endoplasmic reticulum; decreases proteolytic processing; affects lamellar bodies development; reduces free cholesterol transport
L1553 (≠ I168) to P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; dbSNP:rs121909183
L1580 (≠ V195) to P: in SMDP3; does not affect location in intracellular vesicle membrane; does not affect proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; decreases ATP binding in vitro; affects the intracellular vesicles development; decreases phosphatidylcholine transport; mutation to A: Decreases ATP hydrolysis activity of 13% compared to the wild-type.; mutation to F: Decreases ATP hydrolysis activity of 13% compared to the wild-type.; mutation to V: Decreases ATP hydrolysis activity of 56% compared to the wild-type.

Sites not aligning to the query:

43 R → L: in SMDP3; uncertain significance
53 N→Q: Does not affect N-glycosylation. Does not affect protein expression. Does not affect lamellar body membrane location.
101 L → P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; decreases ATP binding in vitro; dbSNP:rs121909182
124 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→Q: Loss of N-glycosylation. Reduces protein expression by 50%. Affects anterograde trafficking; when associated with Q-140. Reduces protein expression by 85%; when associated with Q-140. Does not affect lamellar body membrane location.
140 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N → H: in dbSNP:rs45447801; N→Q: Loss of N-glycosylation. Reduces protein expression by 50%. Affects anterograde trafficking; when associated with Q-124. Reduces protein expression by 85%; when associated with Q-140. Does not affect lamellar body membrane location.
173:174 LK→AA: Loss of proteolytic processing.
174:175 Cleavage; by CTSL
215 Q → K: in SMDP3; loss of lamellar bodies membrane location; loss of proteolytic cleavage; increases cellular free cholesterol and phosphatidylcholine transport; loss of vesicles formation; increases free cholesterol induced cell death; loss of protein oligomerization; dbSNP:rs879159551
280 R → C: in SMDP3; uncertain significance; does not affect protein oligomerization; dbSNP:rs201299260
288 R → K: in SMDP3; uncertain significance; does not affect protein oligomerization; dbSNP:rs117603931
290 L → M: in a breast cancer sample; somatic mutation
292 E → V: in SMDP3; uncertain significance; does not affect lamellar bodies membrane location; does not affect proteolytic cleavage; affects lamellar bodies formation; does not affect cholesterol and phosphatidylcholine transport; decreases vesicles formation; does not affect free cholesterol induced cell death; dbSNP:rs149989682
568 N → D: in SMDP3; does not affect location in intracellular vesicle membrane; does not affect proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; decreases ATP binding in vitro; does not affect protein expression; does not affect multivesicular bodies and lamellar bodies location; affects multivesicular bodies and lamellar bodies development; loss of phosphatidylcholine transport; does not affect cholesterol transport; dbSNP:rs121909184
579 L → P: in SMDP3; uncertain significance
605 R → Q: in SMDP3; uncertain significance; dbSNP:rs760006956
693 S→L: Does not affect protein oligomerization.
766 P → S: in dbSNP:rs45592239
801 E → D: in a breast cancer sample; somatic mutation
945 N→Q: Does not affect lamellar body membrane location. Does not affect protein expression. Does not affect proteolytic processing.
982 L → P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; dbSNP:rs1402761450
1069 H → Q: in a breast cancer sample; somatic mutation
1076 N → K: in SMDP3; uncertain significance; dbSNP:rs2093663770
1221 G → S: in SMDP3; does not affect intracellular vesicle membrane location; does not affect proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; G→A: Decreases ATP hydrolysis activity of 15% compared to the wild-type.; G→T: Decreases ATP hydrolysis activity of 36% compared to the wild-type.; G→V: Decreases ATP hydrolysis activity of 18% compared to the wild-type.
1302 G → E: in SMDP3; uncertain significance; dbSNP:rs2093657978
1591 Q → P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; dbSNP:rs28936691

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
32% identity, 68% coverage: 4:205/298 of query aligns to 2:218/344 of 6cvlD

query
sites
6cvlD

I

M

L

I

T

K

V

L

T

S

N

N

L

I

T

T

K

K

K

V

F
|
F

-

H

-
x
Q

-

G

-

T

G

R

S

T

L
x
I

I

Q

A

A

V

L

N

N

D

N

L

V

S

S

F

L

T

H

I

V

E

P

K

A

G

G

N

Q

V

I

Y

Y

G

G

I

V

L

I

G

G

P

A

N
x
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

T

L

L

I

G

R

I

C

I

V

L

-

N

N

V

L

N

E

K

R

T

P

T

T

G

E

E

G

F

S

H

V

W

L

F

V

D

D

G

G

S

Q

-

E

-

L

-

T

-

L

-

S

-

E

S

S

S

E

T

L

H

T

Q

K

A

A

L

R

K

R

K

Q

V

I

G

G

A

M

I

I

I

F

E

Q

R

H

P

F

N

N

F

L

Y

L

P

S

Y

S

M

R

T

T

A

V

I

F

Q

G

N

N

L

V

K

A

L

L

V

P

C

L

K

E

I

L

-

D

-

N

-

T

-

P

K

K

E

D

V

E

S

V

E

K

T

R

K

R

I

V

E

T

E

E

K

L

L

L

E

S

L

L

V

V

G

G

L

L

L

G

D

D

R

K

K

H

H

D

S

S

K

Y

F

P

R

S

T
x
N

Y

L

S
|
S

L

G

G

G

M
x
Q

K

K

Q

Q

R

R

L

V

A

A

I

I

A

A

S

R

A

A

L

L

L

A

N

S

D

N

P

P

E

K

I

V

L

L

I

L

L

C

D

D

E

Q

P

A

T

T

N

S

G

A

L

L

D

D

P

P

Q

A

G

T

I

T

H

R

Q

S

I

I

R

L

E

E

I

L

K

K

K

D

I

I

A

N

S

R

Q

R

-

L

G

G

T

L

T

T

I

I

L

L

A

I

S

T

H
|
H

L

E

L

M

D

D

E

V

V

V

E

K

K

R

V

I

C

C

S

D

H

C

V

V

V

A

I

V

L

I

R

S

K

N

G

G

binding phosphothiophosphoric acid-adenylate ester: F12 (= F14), Q14 (vs. gap), I19 (≠ L17), S41 (≠ N39), G42 (= G40), A43 (≠ S41), G44 (= G42), K45 (= K43), S46 (= S44), T47 (= T45), N141 (≠ T129), S143 (= S131), Q146 (≠ M134), H200 (= H187)

Query Sequence

>WP_054559221.1 NCBI__GCF_001306415.1:WP_054559221.1
METILTVTNLTKKFGSLIAVNDLSFTIEKGNVYGILGPNGSGKSTTLGIILNVVNKTTGE
FHWFDGSSSTHQALKKVGAIIERPNFYPYMTAIQNLKLVCKIKEVSETKIEEKLELVGLL
DRKHSKFRTYSLGMKQRLAIASALLNDPEILILDEPTNGLDPQGIHQIREIIKKIASQGT
TILLASHLLDEVEKVCSHVVILRKGVKLYSGPVDSMLASHGFFELRSQQKEALLAFLRAH
HSFTKIQETDNMITAFVNQELAAEELNKALFKEGIFLSHLVKRRESLEEQFLQLTKNQ

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory