SitesBLAST

M1 (= M1) modified: Initiator methionine, Removed
Y102 (= Y102) mutation to L: Retains 4% of wild-type lysine uptake activity. Increases the capacity to inhibit CadC in the presence of lysine.
W106 (= W106) mutation to L: Retains 20% of wild-type lysine uptake activity. Increases the capacity to inhibit CadC in the presence of lysine.
K163 (= K163) mutation to A: Retains 24% of wild-type lysine uptake activity. Increases the capacity to inhibit CadC in the presence of lysine.
F216 (= F215) mutation to L: Retains 13% of wild-type lysine uptake activity. Increases the capacity to inhibit CadC in the presence of lysine.
E222 (= E221) mutation to A: Abolishes lysine uptake. Strongly inhibits CadC.
E230 (= E229) mutation to V: Abolishes lysine uptake. Shows significant less inhibition of CadC.
D275 (≠ S274) Essential for the stimulus-dependent interaction with CadC; mutation to A: Retains 88% of wild-type lysine uptake activity, but can hardly inhibit CadC. Cannot interact with CadC; when associated with A-278.
D278 (= D277) Essential for the stimulus-dependent interaction with CadC; mutation to A: Retains 88% of wild-type lysine uptake activity, but can hardly inhibit CadC. Cannot interact with CadC; when associated with A-275.
E438 (≠ S436) mutation to A: Retains 14% of wild-type lysine uptake activity. Is unable to inhibit CadC.
D443 (vs. gap) mutation to A: Retains 11% of wild-type lysine uptake activity. Is unable to inhibit CadC.
D446 (= D442) mutation to A: Retains 13% of wild-type lysine uptake activity. Is unable to inhibit CadC.

P04817 Arginine permease CAN1; Canavanine resistance protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
40% identity, 100% coverage: 1:491/491 of query aligns to 71:579/590 of P04817

query
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P04817

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P113 (≠ A42) mutation to L: In CAN1-343; confers citrulline transport activity in GAP1-deleted cells.
P148 (= P77) mutation to L: In CAN1-337; confers citrulline transport activity in GAP1-deleted cells and leads to sensitivity to L-glutamic acid alpha-hydroxamate, alpha-aminoisobutyrate, 3-chloro-L-alanine, L-ethionine, L-allylglycine, and D-histidine, but not sensitivity to L-aspartic acid alpha-hydroxamate or p-fluoro-L-phenylalanine.
V149 (= V78) mutation to F: In CAN1-315; confers citrulline transport activity in GAP1-deleted cells.
S152 (= S81) mutation to F: In CAN1-342; confers citrulline transport activity in GAP1-deleted cells.
Y173 (= Y102) mutation to D: In CAN1-306; confers citrulline transport activity in GAP1-deleted cells.; mutation to H: In CAN1-327; confers citrulline transport activity in GAP1-deleted cells.
G308 (= G228) mutation to A: In CAN1-341; confers citrulline transport activity in GAP1-deleted cells.
P313 (= P233) mutation to S: In CAN1-329; confers citrulline transport activity in GAP1-deleted cells and leads to sensitivity to L-glutamic acid alpha-hydroxamate, alpha-aminoisobutyrate, 3-chloro-L-alanine, L-ethionine, L-allylglycine, and D-histidine, L-aspartic acid alpha-hydroxamate and p-fluoro-L-phenylalanine.
TS 354:355 (≠ AS 275:276) mutation Missing: In CAN1-318; confers citrulline transport activity in GAP1-deleted cells.
Y356 (≠ D277) mutation to H: In CAN1-340; confers citrulline transport activity in GAP1-deleted cells.; mutation to N: In CAN1-339; confers citrulline transport activity in GAP1-deleted cells.
W451 (= W371) mutation to C: In CAN1-328; confers citrulline transport activity in GAP1-deleted cells.; mutation to L: In CAN1-316; confers citrulline transport activity in GAP1-deleted cells.; mutation to S: In CAN1-335; confers citrulline transport activity in GAP1-deleted cells.
F461 (= F381) mutation to S: In CAN1-307; confers citrulline transport activity in GAP1-deleted cells.

Q9URZ4 Cationic amino acid transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
37% identity, 99% coverage: 4:491/491 of query aligns to 71:567/587 of Q9URZ4

query
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Q9URZ4

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Sites not aligning to the query:

29 modified: Phosphoserine
30 modified: Phosphoserine
37 modified: Phosphoserine

P19145 General amino-acid permease GAP1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
39% identity, 97% coverage: 13:489/491 of query aligns to 86:575/602 of P19145

query
sites
P19145

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I

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I

A

L

L

-

F

-

W

V

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A

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M

I

I

I

N

N

A

M

L

F

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V

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K

A

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A

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V

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F

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I

I

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F

I

A

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C

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G

A

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G

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Y

H

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D

K

P

A

G

P

A

F

F

V

A

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G

G

D

V

T

P

P

A

G

-

A

-

K

-

F

-

K

-

G

I

V

L

C

S

S

V

V

F

F

V

V

V

T

A

A

G

A

F

F

S

S

F

F

Q
x
A

G

G

T

S

E

E

L

L

V

V

G

G

I

L

T

A

A

A

G

S

E

E

S

S

A

V

T

E

P

P

E

R

K

K

S

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V

P

P

K

K

A

A

I

A

N

K

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Q

V

V

F

F

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W

R

R

I

I

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F

F

Y

Y

I

I

L

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A

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F

L

V

M

I

I

A

G

C

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L

L

I

V

P

P

Y

Y

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N

S

D

P

K

K

S

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L

L

I

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G

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A

S

S

A

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V

D

D

I

A

A

A

I

A

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S

P

P

F

F

T

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I

V

A

F

I

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K

R

T

A

H

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G

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I

A

K

A

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A

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A

P

S

S

V

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M

V

N

N

A

V

V

V

I

I

L

L

T

I

S

A

V

V

I

L

S

S

A

V

A

G

N

N

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S

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A

M

I

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Y

A

A

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C

S

S

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M

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M

Y

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S

A

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A

A

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D

Q

D

R

F

F

A

L

P

P

K

E

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I

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H

Y

T

V

T

D

K

R

N

K

G

G

V

R

P

P

L

L

R

V

A

G

Q

I

V

A

A

V

T

T

T

S

I

A

V

F

G

G

A

L

I

I

A

A

F

F

I

V

-

A

T

A

S

S

I

K

A

K

G

E

P

G

E

E

V

V

Y

F

S

N

W

W

L

L

I

L

A

A

A

L

S

S

G

G

L

L

T

S

G

S

F

L

I

F

A

T

W

W

V

G

G

G

I

I

A

C

I

I

S

C

H

H

F

I

R

R

F

F

R

R

R

K

A

A

F

L

V

A

K

A

Q

Q

G

G

H

R

Q

G

L

L

S

D

E

E

L

L

K

S

Y

F

H

K

A

S

K

P

-

T

-

G

-

V

-

W

-

G

-

S

-

Y

W

W

F

G

P

L

F

F

G

M

P

V

I

I

L

I

A

M

F

F

V

I

L

A

C

Q

I

F

L

Y

V

V

I

A

-

V

-

F

-

P

I

V

G

G

Q

D

N

S

P

P

S

S

A

A

F

E

V

G

H

F

F

F

D

E

W

-

K

-

Q

-

I

-

G

-

V

-

T

A

Y

Y

L

L

S

S

V

F

P

P

L

L

F

V

F

M

I

V

L

M

F

Y

F

I

W

G

Y

H

K

K

I

I

K

Y

Y

K

H

R

T

N

G

W

-

K

-

L

I

F

I

I

P

P

L

A

D

E

K

K

V

M

D

D

V

I

T

D

P

T

H

G

K

R

H

R

Q

E

E

V

D

D

V

L

D

D

A297 (≠ Q218) mutation to V: Impairs basic amino-acids transport and regulation by these amino-acids.

Sites not aligning to the query:

76 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

P46349 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) (see paper)
42% identity, 82% coverage: 13:417/491 of query aligns to 8:403/469 of P46349

query
sites
P46349

V

L

K

K

R

K

S

E

L

L

K

K

T

T

R

R

H

H

L

M

S

T

M

M

I

I

A

S

L

I

G

A

G

G

S

V

I

I

G

G

T

A

G

G

L

L

F

F

V

V

A
x
G

S

S

G

G

S

S

A

V

I

I

S

H

T

S

A

T

G
|
G

P

P

G

G

G

A

G

-

L

V

A

S

Y

Y

V

A

A

L

L

A

G

G

I

L

M

L

V

V

Y

I

F

F

L

I

M

M

T

R

S

M

L

L

G

G

E

E

M

M

A

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A

N

V

M

N

P

P

V

T

S

S

G

G

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S

F

F

A

S

T

Q

Y

Y

S

A

T

H

K

D

Y

A

V

I

D

G

P

P

A

W

L

A

G

G

F

F

A

T

M

I

G

G

W

W

N

L

Y

Y

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W

F

F

N

F

W

W

A

V

I

I

T

V

L

I

A

A

V

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D

E

I

A

S

I

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A

A

G

A

A

L

G

V

I

M

I

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Q

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Y

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W

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H

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D

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T

L

I

I

I

L

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I

M

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M

L

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N

A

V

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V

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K

A

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F

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A

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F

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G

F

F

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T

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F

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G

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I

F

M

A

-

P

G

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A

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V

G

G

L

F

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S

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N

F

L

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Y

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K

K

G

A

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L

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G

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A

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M

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E

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G

A

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A

A

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G

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S

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K

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I

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A

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I

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A

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P

Y

W

T

N

S

S

P

A

K

N

L

I

L

L

G

E

S

-

A

-

S

-

D

-

I

-

A

-

I

-

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S

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P

F

F

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V

L

A

V

V

F

L

E

E

R

H

A

I

G

G

L

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A

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A

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Q

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M

N

N

A

F

V

I

I

V

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L

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A

V

V

I

L

S

S

A

C

A

L

N

N

S

S

G
|
G

M

L

Y

Y

A

T

S

T

S

S

R

R

M

M

L

L

Y

Y

S

S

L

L

A

A

L

E

D

R

D

N

F

E

A

A

P

P

K

R

Y

R

F

F

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M

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S

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K

N

K

G

G

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P

P

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A

A

Q

I

V

V

A

A

T
x
G

T

T

I

F

V
x
F

G

S

A

Y

I

I

A

A

F

V

I

V

T

M

S

N

I

Y

A

F

G

S

P

P

E

D

-

T

V

V

Y

F

S

L

W

F

L

L

I

V

A

N

A

S

S

S

G

G

L

A

T

I

G

A

F

L

I

L

A

V

W

Y

V

L

G

V

I

I

A

A

I

V

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S

H

Q

F

L

R

K

F

M

R

R

R

K

A

K

F

L

V

E

K

K

Q

T

G

N

H

P

Q

E

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-

S

-

E

A

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K

K

Y

I

H

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A

M

K

W

W

L

F

F

P

P

F

F

G33 (≠ A38) mutation to D: Lack of activity.
G42 (= G47) mutation to S: Lack of activity.
G301 (= G314) mutation to V: Lack of activity.
G338 (≠ T351) mutation to E: Lack of activity.
F341 (≠ V354) mutation to S: Lack of activity.

Sites not aligning to the query:

414 G→R: Lack of activity.

P24207 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) (see 3 papers)
38% identity, 88% coverage: 1:431/491 of query aligns to 7:428/458 of P24207

query
sites
P24207

M

V

A

S

N

E

Q

D

T

T

S

A

G

S

N

N

G

Q

G

E

N

P

E

T

V

L

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H

R

R

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G

L

L

K

H

T

N

R
|
R

H

H

L

I

S

Q

M

L

I

I

A

A

L

L

G

G

S

A

I

I

G

G

T

T

G

G

L

L

F

F

V

L

A

G

S

I

G

G

S

P

A

A

I

I

S

Q

T

M

A

A

G

G

P
|
P

G

A

G

V

G

-

L

L

A

G

Y

Y

V

G

A

V

L

A

G

G

I

I

M

I

V

A

Y

F

F

L

L

I

M

M

T

R

S

Q

L

L

G

G

E

E

M

M

A

V

T

V

N

E

M

E

P

P

V

V

S

S

G

G

S

S

F
|
F

A

A

T

H

Y
x
F

S

A

T
x
Y

K

K

Y
|
Y

V
x
W

D

G

P

P

A
x
F

L

A

G

G

F
|
F

A

L

M

S

G

G

W
|
W

N

N

Y
|
Y

W
|
W

F

V

N

M

W
x
F

A

V

I

L

T

V

L

G

A

M

V

A

D
x
E

I

L

S

T

T

A

A

A

A

G

L

I

V

Y

M

M

K

Q

F

Y

W

W

L

F

P

P

N

D

V

V

P

P

G

T

W

W

I

I

W

W

S

A

T

A

I

A

I

F

L

F

V

I

M

I

I

I

F

N

M

A

I

V

N

N

A

L

L

V

T

N

V

V

K

R

A

L

F

Y

G

G

E

E

T

T

E

E

Y

F

W

W

M

F

A

A

M

L

I

I

K
|
K

V

V

V

L

T

A

V

I

I

G

F

M

L

I

I

G

V

F

G

G

F

L

A

W

T

L

I

L

F

F

G

S

I

G

M

H

G

G

H

E

A

K

T

A

G

S

L

I

S

D

N

N

F

L

T

W

Y

R

K

Y

K

G

A

G

P

F

F

F

V

A

G

T

G

G

V

W

P

N

A

G

I

L

L

I

S

L

V

S

F

L

V

A

V

V

A

I

G

M

F

F

S

S

F

F

Q

G

G

G

T

L

E
|
E

L

L

V

I

G

G

I

I

T

T

A

A

G

A

E

E

S

A

A

R

T

D

P

P

E

E

K

K

S

S

V

I

P

P

K

K

A

A

I

V

N

N

Q

Q

V

V

F

V

W

Y

R
|
R

I

I

L

L

F

F

Y

Y

I

I

L

G

A

S

I

L

F

V

V

V

I

L

A

L

C

A

L

L

I

Y

P

P

Y

W

T

V

S

E

P

V

K

K

L

-

G

-

S

-

S

S

A

N

S

S

D

-

I

-

A

-

I

-

S

S

P

P

F

F

T

V

L

M

V

I

F

F

E

H

R

N

A

L

G

D

L

S

A

N

A

V

A

A

S

S

V

A

M

L

N

N

A

F

V

V

I

I

L

L

T

V

S

A

V

S

I

L

S

S

A

V

A

Y

N

N

S

S

G

G

M

V

Y

Y

A

S

S

N

S

S

R

R

M

M

L

L

Y

F

S

G

L

L

A

S

L

V

D

Q

D

G

F

N

A

A

P

P

K

K

Y

F

F

L

E

T

H

R

T

V

T

S

K

R

N

R

G

G

V

V

P
|
P

L

I

R

N

A

S

-

L

Q

M

V

L

A

S

T

G

T

A

I

I

V

T

G

S

A

L

I

V

A

V

F

L

I

I

T

N

S

Y

I

L

A

L

G

P

P

Q

E

K

V

A

Y

F

S

G

W

L

L

L

I

M

A

A

A

L

S

V

G

V

L

A

T

T

G

L

F

L

I

L

A

N

W

W

V

I

G

M

I

I

A

C

I

L

S

A

H

H

F

L

R

R

F

F

R

R

R

A

A

A

F

M

V

R

K

R

Q

Q

G

G

H

R

Q

-

L

-

S

-

E

E

L

T

K

Q

Y

F

H

K

A

A

K

L

W

L

F

Y

P

P

F

F

G

G

P

N

I

Y

L

L

-

C

-

I

A

A

F

F

V

L

L

G

C

M

I

I

L

L

V

L

I

L

I

M

R26 (= R20) mutation R->G,S,Q: Strong decrease in phenylalanine transport activity.
P54 (= P48) mutation to A: 50% of wild-type phenylalanine transport activity.; mutation to G: No change in phenylalanine transport activity.; mutation to L: 26% of wild-type phenylalanine transport activity.
F87 (= F82) mutation to L: No effect on phenylalanine transport activity.
F90 (≠ Y85) mutation to L: 65% of wild-type phenylalanine transport activity.
Y92 (≠ T87) mutation to L: 41% of wild-type phenylalanine transport activity.
Y94 (= Y89) mutation to L: 69% of wild-type phenylalanine transport activity.
W95 (≠ V90) mutation to L: 10% of wild-type phenylalanine transport activity.
F98 (≠ A93) mutation to L: No effect on phenylalanine transport activity.
F101 (= F96) mutation to L: 38% of wild-type phenylalanine transport activity.
W105 (= W100) mutation to L: 39% of wild-type phenylalanine transport activity.
Y107 (= Y102) mutation to L: No effect on phenylalanine transport activity.
W108 (= W103) mutation to L: 71% of wild-type phenylalanine transport activity.
F111 (≠ W106) mutation to L: 60% of wild-type phenylalanine transport activity.; mutation to Y: Enables the transport of tryptophan to almost the same steady-state level as that of phenylalanine.
E118 (≠ D113) mutation E->G,L,V,N: Loss of activity.
K168 (= K163) mutation K->L,R: Strong decrease in phenylalanine transport activity.; mutation to N: Loss of activity.
E226 (= E221) mutation E->A,Q,K,R,W: Loss of activity.
R252 (= R247) mutation R->D,E,F,W,P: Loss of activity.
P341 (= P344) mutation to A: 5% of wild-type phenylalanine transport activity.; mutation P->G,Q,K,R: Loss of activity.; mutation to S: 3% of wild-type phenylalanine transport activity.; mutation to T: 17% of wild-type phenylalanine transport activity.

Sites not aligning to the query:

442 P→A: 46% of wild-type phenylalanine transport activity.; P→G: 52% of wild-type phenylalanine transport activity.; P→L: 43% of wild-type phenylalanine transport activity.

P48813 High-affinity glutamine permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
33% identity, 99% coverage: 4:491/491 of query aligns to 136:646/663 of P48813

query
sites
P48813

Q

Q

T

E

S

Q

G

E

N

Q

G

K

G

Q

N

E

E

N

V

L

K

K

R

K

S

S

L

I

K

K

T

P

R

R

H

H

L

T

S

V

M

M

I

M

A

S

L

L

G

G

G

T

S

G

I

I

G

G

T

T

G

G

L

L

F

L

V

V

A

G

S

N

G

S

S

K

A

V

I

L

S

N

T

N

A

A

G

G

P

P

G

G

G

L

L

I

A

G

Y

Y

V

A

A

I

L

M

G

G

I

S

M

C

V

V

Y

Y

F

C

L

I

M

I

T

Q

S

A

L

C

G

G

E

E

M

L

A

A

T

V

-

I

N

Y

M

S

P

D

V

L

S

I

G

G

S

G

F

F

A

N

T

T

Y

Y

S

P

T

L

K

F

Y

L

V

V

D

D

P

P

A

A

L

L

G

G

F

F

A

S

M

V

G

A

W

W

N

L

Y

F

W

C

F

L

N

Q

W

W

A

L

I

C

T

V

L

C

A

P

V

L

D

E

I

L

S

V

T

T

A

A

A

S

L

M

V

T

M

I

K

K

F

Y

W

W

L

T

P

T

N

S

V

V

P

N

G

P

W

D

I

V

W

F

S

V

T

V

I

I

I

F

L

Y

V

V

M

L

I

I

F

V

M

V

I

I

N

N

A

V

L

F

T

G

V

A

K

K

A

G

F

Y

G

A

E

E

T

A

E

D

Y

F

W

F

M

F

A

N

M

C

I

C

K

K

V

I

V

L

T

M

V

I

V

V

I

G

F

F

L

F

I

I

V

L

G

-

F

-

A

A

T

I

I

I

F

I

G

D

I

C

M

G

G

G

G

A

H

G

A

T

T

D

G

G

L

Y

S

I

N

G

F

S

T

K

Y

Y

K

W

K

R

A

D

P

P

-

G

-

A

F

F

V

R

G

G

G

D

V

T

P

P

-

I

-

Q

-

R

-

F

-

K

A

G

I

V

L

V

S

A

V

T

F

F

V

V

V

T

A

A

G

A

F

F

S

A

F

F

Q

G

G

M

T

S

E

E

L

Q

V

L

G

A

I

M

T

T

A

A

G

S

E

E

S

Q

A

S

T

N

P

P

E

R

K

K

S

A

V

I

P

P

K

S

A

A

I

A

N

K

Q

K

V

M

F

I

W

Y

R

R

I

I

L

L

L

F

F

V

Y

F

I

L

L

A

A

S

I

L

F

T

V

L

I

V

A

G

C

F

L

L

I

V

P

P

Y

Y

T

T

S

S

P

D

K

Q

L

L

G

G

S

A

A

G

S

S

D

A

I

T

A

K

I

A

S

S

P

P

F

Y

T

V

L

I

V

A

F

V

E

S

R

S

A

H

G

G

L

V

A

R

A

V

A

P

S

H

V

F

M

I

N

N

A

A

V

V

I

I

L

L

T

L

S

S

V

V

I

L

S

S

A

V

A

A

N

N

S

G

G

A

M

F

Y

Y

A

T

S

S

R

R

M

I

L

L

Y

M

S

S

L

L

A

A

L

K

D

Q

D

G

F

N

A

A

P

P

K

K

Y

C

F

F

E

D

H

Y

T

I

T

D

K

R

N

E

G

G

V

R

P

P

L

A

R

A

A

A

Q

M

V

L

A

V

T

S

T

A

I

L

V

F

G

G

A

V

I

I

A

A

F

F

I

C

T

A

S

S

I

S

A

K

G

K

P

E

E

E

-

D

V

V

Y

F

S

T

W

W

L

L

I

L

A

A

A

I

S

S

G

G

L

L

T

S

G

Q

F

L

I

F

A

T

W

W

V

I

G

T

I

I

A

C

I

L

S

S

H

H

F

I

R

R

F

F

R

R

A

A

F

M

V

K

K

V

Q

Q

G

G

H

R

Q

S

L

L

S

G

E

E

L

V

K

G

Y

Y

H

K

A

S

K

Q

W

V

F

G

P

V

F

W

G

G

P

S

I

A

L

Y

A

A

F

V

V

L

L

M

C

M

I

V

L

L

V

A

I

L

I

I

G

A

Q

Q

-

F

-

W

-

V

-

A

-

I

-

A

-

P

-

I

-

G

N

K

P

L

S

S

A

A

F

Q

V

S

H

F

F

F

D

E

W

-

K

-

Q

-

I

-

G

-

V

-

T

N

Y

Y

L

L

S

A

V

M

P

P

L

I

F

W

F

I

I

A

L

L

F

Y

F

I

W

F

Y

Y

K

K

I

V

-

W

-

K

K

K

Y

D

H

W

T

S

G

L

I

F

I

I

P

P

L

A

D

D

K

K

V

V

D

D

V

L

T

V

P

S

H

H

K

R

H

N

-

I

-

F

-

D

-

E

-

L

-

K

Q

Q

E

E

D

D

V

E

D

E

T

Y

K

K

Sites not aligning to the query:

132 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

P15993 Aromatic amino acid transport protein AroP; Aromatic amino acid:H(+) symporter AroP; General aromatic amino acid permease; General aromatic transport system from Escherichia coli (strain K12) (see paper)
38% identity, 87% coverage: 10:435/491 of query aligns to 8:424/457 of P15993

query
sites
P15993

G

G

N

E

E

Q

V

L

K

K

R

R

S

G

L

L

K

K

T

N

R

R

H

H

L

I

S

Q

M

L

I

I

A

A

L

L

G

G

S

A

I

I

G

G

T

T

G

G

L

L

F

F

V

L

A

G

S

S

G

A

S

S

A

V

I

I

S

Q

T

S

A

A

G

G

P

P

G

G

G

I

G

-

L

I

L

L

A

G

Y

Y

V

A

A

I

L

A

G

G

I

F

M

I

V

A

Y

F

F

L

L

I

M

M

T

R

S

Q

L

L

G

G

E

E

M

M

A

V

T

V

N

E

M

E

P

P

V

V

S

A

G

G

S

S

F

F

A

S

T

H

Y

F

S

A

T

Y

K

K

Y

Y

V

W

D

G

P

S

A

F

L

A

G

G

F

F

A

A

M

S

G

G

W

W

N

N

Y

Y

W

W

F

V

N

L

W
x
Y

A

V

I

L

T

V

L

A

A

M

V

A

D

E

I

L

S

T

T

A

A

V

A

G

L

K

V

Y

M

I

K

Q

F

F

W

W

L

Y

P

P

N

E

V

I

P

P

G

T

W

W

I

V

W

S

S

A

T

A

I

V

I

F

L

F

V

V

M

V

I

I

F

N

M

A

I

I

N

N

A

L

L

T

T

N

V

V

K

K

A

V

F

F

G

G

E

E

T

M

E

E

Y

F

W

W

M

F

A

A

M

I

I

I

K

K

V

V

V

I

T

A

V

V

I

A

F

M

L

I

I

I

V

F

G

G

F

G

A

W

T

L

I

L

F

F

G

S

I

G

M

N

G

G

H

P

A

Q

T

A

G

T

L

V

S

S

N

N

F

L

T

W

Y

D

K

Q

K

G

A

G

P

F

F

L

V

P

G

H

G

G

V

F

P

T

A

G

I

L

L

V

S

M

V

M

F

M

V

A

V

I

A

I

G

M

F

F

S

S

F

F

Q

G

G

G

T

L

E

E

L

L

V

V

G

G

I

I

T

T

A

A

G

A

E

E

S

A

A

D

T

N

P

P

E

E

K

Q

S

S

V

I

P

P

K

K

A

A

I

T

N

N

Q

Q

V

V

F

I

W

Y

R

R

I

I

L

L

L

I

F

F

Y

Y

I

I

L

G

A

S

I

L

F

A

V

V

I

L

A

L

C

S

L

L

I

M

P

P

Y

W

T

T

S

-

P

-

K

-

L

-

G

-

S

R

S

V

A

T

S

A

D

D

I

-

A

-

I

T

S

S

P

P

F

F

T

V

L

L

V

I

F

F

E

H

R

E

A

L

G

G

L

D

A

T

A

F

A

V

A

A

S

N

V

A

M

L

N

N

A

I

V

V

I

V

L

L

T

T

S

A

V

A

I

L

S

S

A

V

A

Y

N

N

S

S

G

C

M

V

Y

Y

A

C

S

N

S

S

R

R

M

M

L

L

Y

F

S

G

L

L

A

A

L

Q

D

Q

D

G

F

N

A

A

P

P

K

K

Y

A

F

L

E

A

H

S

T

V

T

D

K

K

N

R

G

G

V

V

P

P

L

V

R

N

A

T

Q

I

V

L

A

V

T

S

T

A

I

L

V

V

G

T

A

A

I

L

A

C

F

V

I

L

T

I

S

N

I

Y

A

L

G

A

P

P

E

E

V

S

Y

A

S

F

W

G

L

L

I

L

A

M

A

A

S

L

G

V

L

V

T

S

G

A

F

L

-

V

I

I

A

N

W

W

V

A

G

M

I

I

A

S

I

L

S

A

H

H

F

M

R

K

F

F

R

R

A

A

F

K

V

Q

K

E

Q

Q

G

G

H

-

Q

-

L

-

S

V

E

V

L

T

K

R

Y

F

H

P

A

A

K

L

W

L

F

Y

P

P

F

L

G

G

P

N

-

W

-

I

I

C

L

L

A

L

F

F

V

M

L

A

C

A

I

V

L

L

V

V

I

I

I

M

G

L

Q

M

N

T

P

P

Y103 (≠ W106) Key residue for tryptophan transport; mutation to F: Decreases tryptophan transport to less than 50% of wild-type levels and reduces the ability of tryptophan to inhibit phenylalanine transport from 95 to 62%.

Q03770 SPS-sensor component SSY1; Amino-acid permease homolog SSY1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
26% identity, 99% coverage: 3:487/491 of query aligns to 267:826/852 of Q03770

query
sites
Q03770

N

N

Q

R

T

S

S

R

G

A

N

T

G

R

G

K

N

Y

E

H

V

I

K

Q

R

R

S

K

L

L

K

K

T

V

R

R

H

H

L

I

S

Q

M

M

I

L

A

S

L

I

G

G

G

A

S

C

I

F

G

S

T

V

G

G

L

L

F

F

V

L

A

T

S

S

G

G

S

K

A

A

I

F

S

S

T

I

A

A

G

G

P

P

G

F

G

G

G

T

L

L

A

G

Y

F

V

G

A

L

L

T

G

G

I

S

M

I

V

I

Y

L

F

A

L

T

M

M

T

L

S

S

L

F

G

T

E

E

M

L

A

S

T

T

N

L

M

I

P

P

V

V

S

S

G

S

S

G

F

F

A

S

T

G

Y

L

S

A

T

S

K

R

Y

F

V

V

D

E

P

D

A

A

L

F

G

G

F

F

A

A

M

L

G

G

W

W

N

T

Y

Y

W

W

F

I

N

S

W

C

A

M

I

L

T

A

L

L

A

P

V

A

D

Q

I

V

S

S

T

S

A

S

A
x
T

L

F

V

Y

M

L

K

S

F

Y

W

Y

L

-

P

N

N

N

V

V

-

N

-

I

-

S

-

K

-

G

-

V

-

T

P

A

G

G

W

F

I

I

W

-

S

-

T

T

I

L

I

F

L

S

V

A

M

F

I

S

F

I

M

V

I

V

N

N

A

L

L

L

T

D

V

V

K

S

A

I

F

M

G

G

E

E

T

I

E

V

Y

Y

W

V

M

A

A

G

M

I

I

S

K

K

V

V

V

I

T

I

V

A

V

I

I

L

F

M

L

V

I

F

V

-

G

-

F

-

A

-

T

T

I

M

F

I

G

I

I

L

M

N

G

A

G

G

H

H

A

G

T

N

G

D

L

I

-

H

-

E

-

G

-

V

-

G

-

F

-

R

-

Y

-

W

-

D

-

S

-

K

-

S

-

V

S

R

N

N

F

L

T

T

Y

Y

-

G

-

L

-

Y

-

R

-

P

-

T

-

F

-

D

-

L

-

A

-

D

-

A

-

G

-

E

-

G

-

S

K

K

-

G

-

I

-

S

A

G

P

P

F

-

V

K

G

G

G

R

V

F

P

L

A

A

I

T

L

A

S

S

V

V

F

M

V

L

V

I

A

S

G

T

F

F

S

A

F

F

Q

S

G

G

T

V

E

E

L

M

V

T

G

F

I

L

T

A

A

S

G

G

E

E

S

A

A

I

T

N

P

P

E

R

K

K

S

T

V

I

P

P

K

S

A

A

I

T

N

K

Q

R

V

T

F

F

W

S

R

I

I

V

L

L

L

I

F

S

Y

Y

I

V

L

F

A

L

I

I

F

F

V

S

I

V

A

G

C

I

L

N

I

I

P

Y

Y

S

T

G

S

D

P

P

K

R

L

L

-

S

-

Y

-

F

-

P

-

G

-

I

-

S

-

E

-

K

-

R

-

Y

-

E

-

A

-

I

-

K

-

G

-

T

-

G

-

M

-

D

-

W

-

R

-

L

-

R

-

T

-

N

-

C

-

R

-

G

G

G

S

I

S

D

A

Y

S

R

D

Q

I

I

A

S

I

V

-

G

-

T

-

G

-

Y

-

S

S

S

P

P

F

W

T

V

L

V

V

A

F

L

E

Q

R

N

A

F

G

G

L

L

A

C

A

T

A

F

A

A

S

S

V

A

M

F

N

N

A

A

V

I

I

L

L

I

T

F

S

F

V

T

I

A

S

T

A

A

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N

I

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S

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F

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C

S

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R

M

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L

L

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Y

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A

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D

Q

D

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K

A

A

P

P

K

P

Y

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F

F

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E

H

I

T

C

T

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K

K

N

R

G

G

V

V

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P

L

Y

R

V

A

S

Q

V

V

I

A

F

T

S

I

L

V

F

G

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A

V

I

I

A

A

F

Y

I

I

T

A

-

V

S

D

I

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A

T

G

A

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I

E

E

V

N

Y

F

S

D

W

V

L

L

I

A

A

N

A

V

S

S

G

S

L

A

T

S

G

T

F

S

I

I

A

I

W

W

V

M

G

G

I

L

A

N

I

L

S

S

H

F

F

L

R

R

F

F

R

Y

A

A

F

L

V

K

K

Q

Q

R

-

K

-

D

-

I

G

S

H

R

Q

N

L

D

S

S

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S

L

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K

P

Y

Y

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K

A

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K

P

W

F

F

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A

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I

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L

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V

L

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C

C

I

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L

L

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I

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M

N

G

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Y

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P

A

N

F

F

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I

H

H

F

H

D

F

W

W

-

S

-

T

K

K

Q

A

I

F

G

F

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S

T

A

Y

Y

L

G

S

G

V

L

P

M

L

F

F

F

I

I

L

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F

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W

A

Y

Y

K

K

I

V

K

L

Y

G

H

T

T

S

G

K

I

I

I

Q

P

R

L

L

D

D

K

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V

L

D

D

V

M

T

D

P

S

H

G

K

R

H

R

Q

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D

D

T382 (≠ A118) mutation T->H,L: Constitutively active, up-regulates amino acid permease transcription in response to subthreshold concentrations of amino acids.; mutation to K: In SSY1-102; constitutively active, up-regulates amino acid permease transcription in the absence of amino-acids.; mutation to R: Constitutively active, up-regulates amino acid permease transcription in the absence of amino acids.

P76037 Putrescine importer PuuP from Escherichia coli (strain K12) (see paper)
21% identity, 98% coverage: 3:481/491 of query aligns to 8:457/461 of P76037

query
sites
P76037

N

N

Q

I

T

A

S

A

G

Q

N

P

G

G

G

K

N

T

E

R

V

L

K

R

R

K

S

S

L

L

K

K

T

L

R

W

H

Q

L

V

S

V

M

M

I

M

A

G

L

L

G

A

G

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L

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G

P

T

M

G

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L

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F

F

V

D

A

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S

F

G

G

-

I

-

V

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S

A

G

I

I

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S

T

D

A

G

G

H

-

V

P

P

G

A

G

S

G

Y

L

L

A

A

Y

L

V

A

A

G

L

-

G

-

I

-

M

-

V

V

Y

L

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F

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M

A

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G

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K

M

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N

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A

A

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Y

Y

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A

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K

K

Y

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I

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N

P

P

A

H

L

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G

G

F

F

A

M

M

V

G

G

W

W

N

S

Y

S

W

L

F

L

N

D

W
x
Y

A

L

I

F

T

L

L

P

A

M

V

I

D

N

I

V

S

L

T

L

A

A

A

K

L

I

V

Y

M

L

K

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F

A

W

L

L

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P

P

N

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V

V

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W

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W

W

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V

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V

I

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I

F

L

V

V

A

M

I

I

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F

T

M

A

I

A

N

N

A

L

L

K

T

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V

V

K

N

A

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V

G

A

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T

F

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Y

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F

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G

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A

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G

G

L

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-

N

-

F

-

T

V

Y

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K

S

K

L

A

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P

F

F

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G

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-

N

-

A

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H

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L

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P

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I

I

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A

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V

I

V

V

A

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F

F

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F

F

Q

L

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G

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D

L

A

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V

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T

I

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L

A

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T

A

P

T

D

P

A

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A

K

R

S

V

V

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K

A

A

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I

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F

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N

T

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G

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K

L

D

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I

I

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A

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F

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A

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-

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A

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I

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V

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A

A

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N

L

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A

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H

Y

A

A

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S

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R

M

L

L

L

Y

Y

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L

M

A

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L

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D

D

D

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-

V

F

F

A

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Y

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F

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Y

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