SitesBLAST

M1 (= M1) modified: Initiator methionine, Removed
C2 (= C2) mutation C->A,S: Loss of glutamine-dependent activity but no effect on ammonia-dependent asparagine synthetase activity.
H30 (= H34) mutation to A: 4,5-fold decrease in glutamine affinity.
D34 (= D38) mutation D->N,E: Little effect on the kinetic properties.
H81 (= H87) mutation to A: 5-fold decrease in glutamine affinity.
A105 (≠ C112) mutation to H: Little effect on the kinetic properties.
E349 (= E382) mutation E->A,Q: Loss of glutamine- and ammonia-dependent synthetase activity, but still exhibits glutaminase activity.; mutation to D: 5-fold increase in affinity for aspartate when assaying both the glutamine- and ammonia-dependent synthetase reactions, and 2-fold decrease in kcat for these reactions. Modifies the product glutamate/asparagine stoichiometry.

1ct9A Crystal structure of asparagine synthetase b from escherichia coli (see paper)
27% identity, 83% coverage: 26:537/615 of query aligns to 21:433/497 of 1ct9A

query
sites
1ct9A

V

L

Q

E

M

L

H

S

E

R

T

L

L

M

K

R

H

H

R

R

G

G

P

P

D

D

Q

W

A

S

M

G

I

I

D

Y

L

A

Q

S

P

D

H

N

V

A

G

I

L

L

S

A

H

H

A

E

R
|
R

L
|
L

S

S

I
|
I

R
x
V

D

D

L

V

K

N

S

A

G

G

I

A

Q

Q

P

P

M

L

T

Y

R

N

T

-

F

-

H

Q

G

Q

K

K

T

T

C

H

S

V

I

L

V

A

Y

V

N
|
N

G
|
G

E
|
E

I

I

Y

Y

N

N

H

H

R

Q

E

A

L

L

L

R

P

A

E

E

L

Y

Q

-

A

G

A

D

G

R

Y

Y

R

Q

F

F

T

Q

T

T

T

G

S

S

D
|
D

T

C

E

E

I

V

I

I

L

L

C

A

A

L

Y

Y

M

Q

H

E

F

K

G

G

K

P

N

E

F

F

V

L

E

D

K

D

L

L

N

Q

G

G

I

M

F

F

A

A

F

F

A

A

I

L

W

Y

D

D

D

S

T

E

T

K

R

D

E

A

L

Y

L

L

L

I

Y

G

R

R

D

D

R

H

A

L

G

G

T

I

K

I

P

P

L

L

F

Y

-

M

-

G

Y

Y

T

D

Q

E

T

H

G

G

S

Q

S

L

F

Y

V

V

F

-

G

A

S

S

E

E

P

M

K

K

A

A

L

L

F

-

C

-

H

-

P

-

D

-

V

-

T

-

P

-

S

-

I

-

D

-

K

-

N

-

S

-

L

-

Q

-

E

-

I

-

L

-

A

-

V

V

G

P

P

V

A

C

R

R

T

T

Y

-

G

-

N

-

G

-

V

-

F

-

T

-

G

-

V

I

K

K

E

E

V

F

M

P

P

A

G

G

H

S

Y

Y

H

-

I

L

F

W

C

S

P

Q

D

D

G

G

Q

E

H

I

D

R

I

S

L

Y

Y

Y

W

-

D

-

L

-

P

-

C

-

R

-

E

-

H

H

K

R

D

D

-

W

-

F

S

D

Y

Y

A

D

Q

A

T

V

V

K

Q

D

T

N

V

V

S

T

-

D

-

K

-

N

-

E

-

L

-

R

F

Q

L

A

V

L

R

E

D

D

T

S

V

V

E

K

R

S

Q

H

M

L

V

M

S

S

D

D

V

V

P

P

V

Y

C

G

T

V

F
x
L

L
|
L

S
|
S

G

G

I

L

D

D

S
|
S

S

S

I

I

V

I

T

S

A

A

L

I

A

T

A

K

R

K

H

Y

M

A

Q

-

K

-

E

-

G

-

K

-

I

-

L

L

N

H

T

S

F

F

S
x
A

F
x
V

D

G

F

L

S

P

E

G

N

S

E

P

K

-

Y

-

F

-

K

-

S

-

N

-

A

-

F

-

Q

-

P

-

E

-

R

-

D
|
D

L

L

P

K

Y

A

V

A

N

Q

R

E

M

V

L

A

Q

N

Y

H

C

L

K

G

T

T

S

V

H

H

T

H

Y

E

L

I

E

H

C

F

S

T

Q

V

E

Q

A

E

L

G

F

L

A

D

A

A

L

I

S

R

D

D

A

V

V

I

T

Y

A

H

K

I

D

E

L

T

P

Y

G

D

M

V

T
|
T

D

T

V

I

D
x
R

A

A

S

S

L

T

-

P

L

M

Y

Y

F

L

C
x
M

S

S

E

R

V

K

A

I

K

K

H

A

N

M

-

G

-

I

K

K

V

M

T

V

L

L

T
x
S

G
|
G

E
|
E

C

G

A

S

D

D

E

E

I

V

F

F

G

G

Y

Y

P

L

W

Y

F

F

Y

H

R

K

P

A

E

-

L

-

M

-

N

-

R

-

D

-

G

-

F

-

P

-

W

-

S

-

A

-

D

-

P

P

A

N

A

A

R

K

T

-

S

E

I

L

L

H

S

E

D

E

D

T

V

V

L

R

R

K

T

L

L

L

D

A

L

L

A

H

E
x
M

Y

Y

S

D

H

C

A

A

R

R

Y

A

E

N

E

K

T

A

L

M

S

S

H

-

V

-

P

-

H

-

L

-

D

-

G

-

E

-

S

-

P

-

E

-

A

-

R

-

D

-

I

-

G

-

Y

-

L

-

N

-

I

-

K

A

W

W

F

-

M

-

Q

-

T

-

L

-

D

-

R

-

M

-

D

-

R

-

T

-

S

-

M

-

Y

-

S

-

S

G

L

V

E

E

A

A

R

R

V

V

P

P

F

F

A

L

D

D

H

K

R

K

I

F

M

L

E

D

Y

V

V

A

F

M

N

R

V

I

P

N

W

P

Q

Q

M

D

K

K

Y

M

R

C

N

K

G

-

V

M

E

E

K

K

S

H

L

I

L

L

R

R

D

E

A

C

C

F

A

E

D

A

L

Y

L

L

P

P

R

A

E

S

L

V

L

A

W

W

R

R

K

Q

K

K

S

E

P

Q

Y

F

active site: L50 (= L55), N74 (= N81), G75 (= G82), T305 (= T358), R308 (≠ D361), E332 (= E382), M366 (≠ E430)
binding adenosine monophosphate: L232 (≠ F267), L233 (= L268), S234 (= S269), S239 (= S274), A255 (≠ S296), V256 (≠ F297), D263 (= D316), M316 (≠ C368), S330 (≠ T380), G331 (= G381), E332 (= E382)
binding glutamine: R49 (= R54), L50 (= L55), I52 (= I57), V53 (≠ R58), N74 (= N81), G75 (= G82), E76 (= E83), D98 (= D106)

Sites not aligning to the query:

active site: 1
binding glutamine: 1

P08243 Asparagine synthetase [glutamine-hydrolyzing]; Cell cycle control protein TS11; Glutamine-dependent asparagine synthetase; EC 6.3.5.4 from Homo sapiens (Human) (see 7 papers)
26% identity, 82% coverage: 32:537/615 of query aligns to 24:470/561 of P08243

query
sites
P08243

L

I

K

A

H

H

R

R

G

G

P

P

D

D

Q

A

-

F

-

R

-

F

A

E

M

N

I

V

D

N

L

G

Q

Y

P

T

H

N

V

C

G

C

L

F

S

G

H

F

A

H

R

R

L

L

S

A

I

V

R

V

D

D

L

P

K

L

S

F

G

G

I

M

Q

Q

P

P

M

I

T

-

R

R

T

V

F

K

H

K

G

Y

K

P

T

Y

C

L

S

W

I

L

V

C

Y

Y

N

N

G

G

E

E

I

I

Y

Y

N

N

H

H

R

K

E

K

L

M

L

Q

P

Q

E

H

L

F

Q

E

A

-

G

-

Y

F

R

E

F

Y

T

Q

T

T

T

K

S

V

D

D

T

G

E

E

I

I

L

L

C

H

A

L

Y

Y

M

D

H

K

F

G

G

G

-

I

K

E

N

Q

F

T

V

I

E

C

K

M

L

L

N

D

G

G

I

V

F

F

A

A

F

F

A

V

I

L

W

L

D

D

D

T

T

A

T

N

R

K

E

K

L

V

L

F

L

L

Y

G

R

R

D

D

R

T

A

Y

G

G

T

V

K

R

P

P

L

L

F

F

Y

K

T

A

Q

M

T

T

G

E

S

D

S

G

F

F

V

L

-

A

F

V

G

C

S

S

E

E

P

A

K

K

A

G

L

L

F

V

C

T

H

L

P

-

D

-

V

-

T

-

P

-

S

-

I

-

D

-

K

K

N

H

S

S

L

A

Q

T

E

P

I

F

L

L

A

K

V

V

G

E

P

P

A

-

R

-

T

-

Y

-

G

-

N

-

G

-

V

-

F

-

T

-

G

-

V

-

K

-

E

-

V

F

M

L

P

P

G

G

H

H

Y

Y

H

E

I

V

-

L

-

D

F

L

C

K

P

P

D

N

G

G

Q

K

H

V

D

A

I

S

L

V

Y

E

W

M

-

V

-

K

-

Y

-

H

-

C

-

R

D

D

L
x
V

P

P

C

L

R

H

E

A

H

L

K

Y

D

D

S

N

Y

V

A

E

Q

K

-

L

-

F

-

P

-

G

-

F

T

E

V

I

Q

E

T

T

V

V

S

K

-

N

-

L

-

R

F

I

L

L

V

F

R

N

D

N

T

A

V

V

E

K

R

K

Q

R

M

L

V

M

S

T

D

D

V

R

P

R

V

I

C

G

T

C

F

L

L

L

S

S

G

G

I

L

D

D

S

S

I

L

V

V

T

A

A

A

L

T

A

L

R

K

H

Q

M

L

Q

-

K

K

E

E

G

A

K

Q

I

V

-

Q

-

Y

-

P

L

L

N

Q

T

T

F

F

S

A

F

I

D

G

F

M

S

E

E

D

N

S

E

P

K

-

Y

-

F

-

K

-

S

-

N

-

A

-

F

-

Q

-

P

-

E

-

R

-

D

D

L

L

P

L

Y

A

V

A

N

R

R

K

M

V

L

A

Q

D

Y

H

C

I

K

G

T

S

S

E

H

H

T

Y

Y

E

L

V

E

L

C

F

S

N

Q

S

E

E

A

E

L

G

F

I

A

Q

A

A

L

L

S

D

D

E

A

V

V

I

T

F

A

S

K

L

D

E

L

T

P

Y

G

D

M

I

T

T

D

T

V

V

D

R

A

A

S

S

L

V

-

G

L

M

Y

Y

F

L

C

I

S

S

E

K

V

Y

A

I

K

R

H

K

N

N

K

T

-

D

-

S

-

V

V

V

T

I

L
x
F

T

S

G

G

E

E

C

G

A

S

D

D

E

E

I

L

F

T

G

Q

G

G

Y

Y

P

I

W

Y

F

F

Y

H

R

K

P

-

E

-

L

-

M

-

N

-

R

-

D

-

G

-

F

-

P

-

W

-

S

-

A

-

D

-

P

-

A

-

R

-

T

-

S

-

I

-

L

-

S

-

D

-

V

-

L

-

R

-

T

-

L

-

D

-

L

-

A

-

E

-

Y

-

S

-

H

-

A

-

R

-

Y

-

E

-

T

-

L

-

S

-

H

-

V

-

P

-

H

-

L

-

D

-

G

A

E

P

S

S

P

P

E

E

E

K

A

A

R

E

D

S

I

E

G

R

Y

L

L

L

N

R

I

E

K

L

W

Y

F

L

M

F

Q

D

T

V

L

L

L

-

D

-

R

R

M

A

D

D

R

R

T

T

S

T

M

A

Y

A

S

H

S

G

L

L

E

E

A

L

R

R

V

V

P

P

F

F

A

L

D

D

H

H

R

R

I

F

M

S

E

S

Y

Y

V

Y

F

L

N

S

V

L

P

P

W

P

Q

E

M

M

K

R

Y

I

-

P

R

K

N

N

G

G

V

I

E

E

K

K

S

H

L

L

R

R

D

E

A

T

C

F

A

E

D

D

-

S

-

N

L

L

L

I

P

P

R

K

E

E

L

I

L

L

W

W

R

R

K

P

K

K

S

E

P

A

Y

F

V210 (≠ L230) to E: in dbSNP:rs1049674
F362 (≠ L379) to V: in ASNSD; dramatic reduction in protein abundance; dbSNP:rs398122973

Sites not aligning to the query:

2 active site, For GATase activity; C→A: Loss of the glutamine-dependent asparagine synthetase activity, while the ammonia-dependent activity remained unaffected.
6 A → E: in ASNSD; dramatic reduction in protein abundance; dbSNP:rs398122975
550 R → C: in ASNSD; increases level of protein abundance; dbSNP:rs398122974

6gq3A Human asparagine synthetase (asns) in complex with 6-diazo-5-oxo-l- norleucine (don) at 1.85 a resolution (see paper)
26% identity, 81% coverage: 32:532/615 of query aligns to 23:452/509 of 6gq3A

query
sites
6gq3A

L

I

K

A

H

H

R

R

G

G

P

P

D

D

Q

A

-

F

-

R

-

F

A

E

M

N

I

V

D

N

L

G

Q

Y

P

T

H

N

V

C

G

C

L

F

S

G

H

F

A

H

R
|
R

L
|
L

S

A

I
x
V

R
x
V

D

D

L

P

K

L

S

F

G

G

I

M

Q

Q

P

P

M

I

T

-

R

R

T

V

F

K

H

K

G

Y

K

P

T

Y

C

L

S

W

I

L

V

C

Y
|
Y

N
|
N

G
|
G

E
|
E

I

I

Y

Y

N

N

H

H

R

K

E

K

L

M

L

Q

P

Q

E

H

L

F

Q

E

A

-

G

-

Y

F

R

E

F

Y

T

Q

T

T

T

K

S
x
V

D
|
D

T

G

E

E

I

I

L

L

C

H

A

L

Y

Y

M

D

H

K

F

G

G

G

-

I

K

E

N

Q

F

T

V

I

E

C

K

M

L

L

N

D

G

G

I

V

F

F

A

A

F

F

A

V

I

L

W

L

D

D

D

T

T

A

T

N

R

K

E

K

L

V

L

F

L

L

Y

G

R

R

D

D

R

T

A

Y

G

G

T

V

K

R

P

P

L

L

F

F

Y

K

T

A

Q

M

T

T

G

E

S

D

S

G

F

F

V

L

-

A

F

V

G

C

S

S

E

E

P

A

K

K

A

G

L

L

F

V

C

T

H

L

P

-

D

-

V

-

T

-

P

-

S

-

I

-

D

-

K

K

N

H

S

S

L

A

Q

T

E

P

I

F

L

L

A

K

V

V

G

E

P

P

A

-

R

-

T

-

Y

-

G

-

N

-

G

-

V

-

F

-

T

-

G

-

V

-

K

-

E

-

V

F

M

L

P

P

G

G

H

H

Y

Y

H

E

I

V

F

L

C

D

P

L

D

K

G

P

Q

N

H

G

D

K

I

V

L

A

Y

S

W

V

D

E

L

M

P

V

C

K

R

Y

E

H

H

H

-

C

K

R

D

D

S

V

Y

F

-

P

-

G

-

F

-

E

A

I

Q

E

T

T

V

V

Q

K

-

N

T

N

V

L

S

R

F

I

L

L

V

F

R

N

D

N

T

A

V

V

E

K

R

K

Q

R

M

L

V

M

S

T

D

D

V

R

P

R

V

I

C

G

T

C

F

L

L

L

S

S

G

G

I

L

D

D

S

S

I

L

V

V

T

A

A

A

L

T

A

L

R

K

H

Q

M

L

Q

-

K

K

E

E

G

A

K

Q

I

V

-

Q

-

Y

-

P

L

L

N

Q

T

T

F

F

S

A

F

I

D

G

F

M

S

E

E

D

N

S

E

P

K

-

Y

-

F

-

K

-

S

-

N

-

A

-

F

-

Q

-

P

-

E

-

R

-

D

D

L

L

P

L

Y

A

V

A

N

R

R

K

M

V

L

A

Q

D

Y

H

C

I

K

G

T

S

S

E

H

H

T

Y

Y

E

L

V

E

L

C

F

S

N

Q

S

E

E

A

E

L

G

F

I

A

Q

A

A

L

L

S

D

D

E

A

V

V

I

T

F

A

S

K

L

D

E

L

T

P

Y

G

D

M

I

T
|
T

D

T

V

V

D
x
R

A

A

S

S

L

V

-

G

L

M

Y

Y

F

L

C

I

S

S

E

K

V

Y

A

I

K

R

H

K

N

N

K

T

-

D

-

S

-

V

V

V

T

I

L

F

T

S

G

G

E

E

C

G

A

S

D

D

E

E

I

L

F

T

G

Q

G

G

Y

Y

P

I

W

Y

F

F

Y

H

R

K

P

-

E

-

L

-

M

-

N

-

R

-

D

-

G

-

F

-

P

-

W

-

S

-

A

-

D

-

P

-

A

-

R

-

T

-

S

-

I

-

L

-

S

-

D

-

V

-

L

-

R

-

T

-

L

-

D

-

L

-

A

-

E

-

Y

-

S

-

H

-

A

-

R

-

Y

-

E

-

T

-

L

-

S

-

H

-

V

-

P

-

H

-

L

-

D

-

G

A

E

P

S

S

P

P

E

E

E

K

A

A

R

E

D

S

I

E

G

R

Y

L

L

L

N

R

I

E

K

L

W

Y

F

L

M

F

Q

D

T

V

L

L

L

-

D

-

R

R

M

A

D

D

R

R

T

T

S

T

M

A

Y

A

S

H

S

G

L

L

E

E

A

L

R

R

V

V

P

P

F

F

A

L

D

D

H

H

R

R

I

F

M

S

E

S

Y

Y

V

Y

F

L

N

S

V

L

P

P

W

P

Q

E

M

M

K

R

Y

I

-

P

R

K

N

N

G

G

V

I

E

E

K

K

S

H

L

L

R

R

D

E

A

T

C

F

A

E

D

D

-

S

-

N

L

L

L

I

P

P

R

K

E

E

L

I

L

L

W

W

R

R

active site: L49 (= L55), N74 (= N81), G75 (= G82), T324 (= T358), R327 (≠ D361)
binding 5-oxo-l-norleucine: R48 (= R54), V51 (≠ I57), V52 (≠ R58), Y73 (= Y80), N74 (= N81), G75 (= G82), E76 (= E83), V95 (≠ S105), D96 (= D106)

Sites not aligning to the query:

active site: 4
binding 5-oxo-l-norleucine: 1

P78753 Probable asparagine synthetase [glutamine-hydrolyzing]; Glutamine-dependent asparagine synthetase; EC 6.3.5.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
27% identity, 83% coverage: 26:537/615 of query aligns to 22:468/557 of P78753

query
sites
P78753

V

L

Q

H

M

L

H

S

E

K

T

Q

L

L

K

R

H

H

R

R

G

G

P

P

D

D

Q

W

A

S

M

G

I

K

D

A

L

I

Q

R

P

N

H

Q

V

T

G

I

L

L

S

C

H

H

A

E

R

R

L

L

S

A

I

I

R

V

D

G

L

V

K

E

S

S

G

G

I

A

Q

Q

P

P

M

L

T

V

R

-

T

S

F

D

H

D

G

G

K

K

T

L

C

V

S

L

I

T

V

V

Y

-

N

N

G

G

E

E

I

I

Y

Y

N

N

H

H

R

L

E

K

L

L

L

R

P

E

E

N

L

L

Q

K

A

G

A

-

G

N

Y

Y

R

K

F

F

T

K

T

T

T

Y

S

S

D

D

T

C

E

E

I

V

I

I

L

L

C

Y

A

L

Y

Y

M

R

H

E

F

H

G

G

K

P

N

A

F

C

V

A

E

N

K

M

L

L

N

D

G

G

I

M

F

F

A

S

F

W

A

V

I

L

W

Y

D

D

D

Q

T

D

T

K

R

D

E

K

L

V

L

A

Y

A

R

R

D

D

R

P

A

I

G

G

T

I

K

T

P

T

L

L

-

Y

-

Q

-

G

F

F

Y

S

T

S

Q

D

T

S

G

P

S

D

S

T

F

A

V

Y

F

F

G

A

S

S

E

E

P

L

K

K

A

A

L

L

F

H

C

-

H

-

P

-

D

-

V

-

T

-

P

P

S

V

I

C

D

D

K

K

N

-

S

-

L

-

Q

-

E

-

I

I

L

I

A

A

V

F

G

P

P

P

A

G

R

H

T

Y

Y

Y

G

D

N

S

G

E

V

T

F

K

T

Q

G

T

V

V

K

R

E

Y

V

F

M

K

P

P

G

S

H

-

Y

-

H

-

I

-

F

-

C

-

P

-

D

-

G

-

Q

-

H

-

D

-

I

-

L

-

Y

W

W

W

D

D

L

-

P

-

C

-

R

-

E

E

H

N

K

K

-

I

D

P

S

S

Y

N

A

P

Q

V

T

D

V

Y

Q

K

T

L

V

L

S

R

F

E

L

T

V

L

R

E

D

A

T

S

V

V

E

R

R

K

Q

R

M

L

V

M

S

A

D

E

V

V

P

P

V

Y

C

G

T

V

F

L

L

L

S

S

G

G

I

L

D

D

S

S

I

L

V

I

T

A

A

S

L

I

A

A

R

R

H

E

M

T

Q

E

K

K

E

L

G

A

K

N

I

S

L

T

N

S

T

Q

F

-

S

S

F

E

D

E

F

A

S

R

E

T

N

I

E

T

K

A

Y

W

F

P

K

K

S

L

N

H

A

S

F

F

Q

A

-

I

-

G

-

L

-

P

P

G

E

S

R

P

D

D

L

L

P

L

Y

A

V

A

N

R

R

K

M

V

L

A

Q

D

Y

F

C

L

K

H

T

T

S

F

H

H

T

H

Y

E

L

H

E

T

C

F

S

T

Q

I

E

D

A

E

L

G

F

L

A

D

A

A

L

L

S

R

D

D

A

V

V

I

T

Y

A

H

K

L

D

E

L

T

P

Y

G

D

M

V

T

T

D

T

V

I

D

R

A

A

S

S

L

T

-

P

L

M

Y

Y

F

L

C

L

S

S

E

R

V

K

A

I

K

K

H

A

N

Q

-

G

-

V

K

K

V

M

T

V

L

L

T

S

G

G

E

E

C

G

A

S

D

D

E

E

I

I

F

F

G

G

Y

Y

P

L

W

Y

F

F

Y

-

R

-

P

-

E

-

L

-

M

-

N

-

R

-

D

-

G

-

F

-

P

-

W

-

S

-

A

G

D

N

P

A

A

P

A

S

R

R

T

E

S

A

I

F

L

H

S

S

D

E

D

C

V

V

L

R

R

R

T

V

L

K

D

N

L

L

A

-

E

-

Y

-

S

-

H

-

A

-

R

-

Y

-

E

-

T

-

L

-

S

-

H

-

V

-

P

-

H

H

L

L

D
x
S

G

D

E

-

S

-

P

-

E

-

A

-

R

-

D

-

I

-

G

-

Y

-

L

-

N

-

I

-

K

-

W

-

F

-

M

-

Q

-

T

-

L

-

L

C

D

L

R

R

M

A

D

N

R

K

T

S

S

T

M

M

Y

A

S

W

S

G

L

L

E

E

A

A

R

R

V

V

P

P

F

F

A

L

D

D

H

K

R

D

I

F

M

L

E

E

Y

V

V

A

F

L

N

N

V

I

-

D

P

P

W

E

Q

E

M

K

K

M

Y

Y

R

I

N

N

G

G

-

R

V

K

E

E

K

K

S

Y

L

I

L

L

R

R

D

K

A

A

-

F

-

D

-

T

-

H

-

D

-

S

C

L

A

Q

D

P

L

Y

L

L

P

P

R

Q

E

D

L

I

L

L

W

W

R

R

K

Q

K

K

S

E

P

Q

Y

F

S391 (≠ D447) modified: Phosphoserine

Sites not aligning to the query:

489 modified: Phosphoserine

1jgtB Crystal structure of beta-lactam synthetase (see paper)
24% identity, 53% coverage: 65:390/615 of query aligns to 57:353/500 of 1jgtB

query
sites
1jgtB

Q

R

P

A

M

V

T

A

R

R

T

S

F

L

H

T

G

G

K

A

T

P

C

T

S

T

I

A

V

V

Y

L

N
x
A

G
|
G

E

E

I

I

Y

Y

N

N

H

R

R

D

E

E

L

L

P

S

E

V

L

L

Q

P

A

A

A

G

G

-

Y

-

R

-

F

P

T

A

T

P

T

E

S

G

D

D

T

A

E

E

I

L

I

V

L

L

C

R

A

L

Y

L

M

E

H

R

F

Y

G

D

K

L

N

H

F

A

V

F

E

R

K

L

L

V

N

N

G

G

I

R

F

F

A

A

F

T

A

V

I

V

W

R

D

-

T

T

T

G

R

D

E

R

L

V

L

L

Y

A

R

T

D

D

R

H

A

A

G

G

T

S

K

V

P

P

L

L

F

Y

Y

T

T

C

Q

V

T

A

G

P

S

G

S

E

F

V

V

R

F

A

G

S

S

T

E

E

P

A

K

K

A

A

L

L

F

A

C

A

H

H

-

R

-

D

P

P

D

K

V

G

T

F

P

P

S

L

I

A

D

D

K

A

N

R

S

R

L

V

Q

A

E

G

I

L

L

T

A

G

V

V

-

Y

-

Q

G

V

P

P

A

A

R

G

T

A

Y

V

-

M

-

D

-

I

-

D

-

L

G

G

N

S

G

G

V

T

F

A

T

V

G

T

V

H

K

R

E

T

V

W

M

T

P

P

G

G

H

L

Y

S

H

R

I

R

F

I

C

L

P

P

D

E

G

G

Q

E

H

-

D

-

I

-

L

-

Y

-

W

-

D

-

L

-

P

-

C

-

R

-

E

-

H

-

K

-

D

-

S

-

Y

-

A

-

Q

A

T

V

V

A

Q

A

T

V

V

R

S

A

F

A

L

L

V

E

R

K

D

A

T

V

V

A

E

Q

R

R

Q

V

M

T

V

P

S

G

D

D

V

T

P

P

V

L

C

V

T

-

F
x
V

L
|
L

S
|
S

G

G

G
|
G

I
|
I

D
|
D

S
|
S

S

S

I

G

V

V

T

A

A

A

L

C

A

A

A

H

R

R

H

A

M

A

Q

G

K

E

E

-

G

-

K

-

I

-

L

L

N

D

T

T

F

V

S
|
S

F
x
M

D

G

F

T

S

D

E

T

N

S

E

N

K

E

Y

F

F

R

K

E

S

A

N

R

A

A

F

-

Q

-

P

-

E

-

R

-

D

-

L

-

P

-

Y

-

V

-

N

-

R

-

M

V

L

V

Q

D

Y

H

C

L

K

R

T

T

S

R

H

H

T

R

Y

E

L

I

E

T

C

I

S

P

Q

T

E

T

A

E

L

L

F

L

A

A

A

Q

L

L

S

P

D

Y

A

A

V

V

T

W

A

A

K

S

D

E

L

S

-

V

-

D

P

P

G
x
D

M

I

T

I

D

E

V
x
Y

D

L

A

L

S

P

L
|
L

L

T

Y

A

F

L

C

Y

S

R

E

A

V

L

A

D

K

G

H

P

N

E

K

R

V

R

T

I

L

L

T

T

G
|
G

E
x
Y

C
x
G

A

A

D
|
D

E
x
I

I

P

F

L

G

G

active site: A73 (≠ N81), G74 (= G82), D319 (≠ G356), Y345 (≠ E382)
binding diphosphomethylphosphonic acid adenosyl ester: V244 (≠ F267), L245 (= L268), S246 (= S269), G248 (= G271), I249 (= I272), D250 (= D273), S251 (= S274), S269 (= S296), M270 (≠ F297), L327 (= L364), G344 (= G381), Y345 (≠ E382), D348 (= D385)
binding n2-(carboxyethyl)-l-arginine: Y323 (≠ V360), Y345 (≠ E382), G346 (≠ C383), D348 (= D385), I349 (≠ E386)
binding magnesium ion: D250 (= D273), D348 (= D385)

Sites not aligning to the query:

active site: 379, 440
binding diphosphomethylphosphonic acid adenosyl ester: 420, 440
binding n2-(carboxyethyl)-l-arginine: 354, 370, 379

1mbzA Beta-lactam synthetase with trapped intermediate (see paper)
24% identity, 53% coverage: 65:390/615 of query aligns to 53:345/496 of 1mbzA

query
sites
1mbzA

Q

R

P

A

M

V

T

A

R

R

T

S

F

L

H

T

G

G

K

A

T

P

C

T

S

T

I

A

V

V

Y

L

N
x
A

G
|
G

E

E

I

I

Y

Y

N

N

H

R

R

D

E

E

L

L

P

S

E

V

L

L

Q

P

A

A

A

G

G

-

Y

-

R

-

F

P

T

A

T

P

T

E

S

G

D

D

T

A

E

E

I

L

I

V

L

L

C

R

A

L

Y

L

M

E

H

R

F

Y

G

D

K

L

N

H

F

A

V

F

E

R

K

L

L

V

N

N

G

G

I

R

F

F

A

A

F

T

A

V

I

V

W

R

D

-

T

T

T

G

R

D

E

R

L

V

L

L

Y

A

R

T

D

D

R

H

A

A

G

G

T

S

K

V

P

P

L

L

F

Y

Y

T

T

C

Q

V

T

A

G

P

S

G

S

E

F

V

V

R

F

A

G

S

S

T

E

E

P

A

K

K

A

A

L

L

F

A

C

A

H

H

P

G

D

-

V

-

T

F

P

P

S

L

I

A

D

D

K

A

N

R

S

R

L

V

Q

A

E

G

I

L

L

T

A

G

V

V

-

Y

-

Q

G

V

P

P

A

A

R

G

T

A

Y

V

-

M

-

D

-

I

-

D

-

L

G

G

N

S

G

G

V

T

F

A

T

V

G

T

V

H

K

R

E

T

V

W

M

T

P

P

G

G

H

L

Y

S

H

R

I

R

F

I

C

L

P

P

D

E

G

G

Q

E

H

-

D

-

I

-

L

-

Y

-

W

-

D

-

L

-

P

-

C

-

R

-

E

-

H

-

K

-

D

-

S

-

Y

-

A

-

Q

A

T

V

V

A

Q

A

T

V

V

R

S

A

F

A

L

L

V

E

R

K

D

A

T

V

V

A

E

Q

R

R

Q

V

M

T

V

P

S

G

D

D

V

T

P

P

V

L

C

V

T

-

F
x
V

L
|
L

S
|
S

G

G

G
|
G

I

I

D
|
D

S
|
S

S

S

I

G

V

V

T

A

A

A

L

C

A

A

A

H

R

R

H

A

M

A

Q

G

K

E

E

-

G

-

K

-

I

-

L

L

N

D

T

T

F

V

S
|
S

F
x
M

D

G

F

T

S

D

E

T

N

S

E

N

K

E

Y

F

F

R

K

E

S

A

N

R

A

A

F

-

Q

-

P

-

E

-

R

-

D

-

L

-

P

-

Y

-

V

-

N

-

R

-

M

V

L

V

Q

D

Y

H

C

L

K

R

T

T

S

R

H

H

T

R

Y

E

L

I

E

T

C

I

S

P

Q

T

E

T

A

E

L

L

F

L

A

A

A

Q

L

L

S

P

D

Y

A

A

V

V

T

W

A

A

K

S

D

E

L

S

-

V

-

D

P

P

G
x
D

M

I

T

I

D

E

V
x
Y

D

L

A

L

S

P

L
|
L

L

T

Y

A

F

L

C

Y

S

R

E

A

V

L

A

D

K

G

H

P

N

E

K

R

V

R

T

I

L

L

T

T

G
|
G

E
x
Y

C
x
G

A

A

D
|
D

E
x
I

I

P

F

L

G

G

active site: A69 (≠ N81), G70 (= G82), D311 (≠ G356), Y337 (≠ E382)
binding arginine-n-methylcarbonyl phosphoric acid 5'-adenosine ester: V236 (≠ F267), L237 (= L268), S238 (= S269), S243 (= S274), S261 (= S296), M262 (≠ F297), Y315 (≠ V360), L319 (= L364), G336 (= G381), Y337 (≠ E382), G338 (≠ C383), D340 (= D385), I341 (≠ E386)
binding magnesium ion: D242 (= D273), D340 (= D385)
binding pyrophosphate 2-: S238 (= S269), G240 (= G271), D242 (= D273), S243 (= S274), D340 (= D385)

Sites not aligning to the query:

active site: 371, 432
binding arginine-n-methylcarbonyl phosphoric acid 5'-adenosine ester: 362, 371, 432, 434, 435
binding pyrophosphate 2-: 412, 432, 433

1mc1A Beta-lactam synthetase with product (dgpc), amp and ppi (see paper)
24% identity, 53% coverage: 65:390/615 of query aligns to 49:340/491 of 1mc1A

query
sites
1mc1A

Q

R

P

A

M

V

T

A

R

R

T

S

F

L

H

T

G

G

K

A

T

P

C

T

S

T

I

A

V

V

Y

L

N
x
A

G
|
G

E

E

I

I

Y

Y

N

N

H

R

R

D

E

E

L

L

P

S

E

V

L

L

Q

P

A

A

A

G

G

-

Y

-

R

-

F

P

T

A

T

P

T

E

S

G

D

D

T

A

E

E

I

L

I

V

L

L

C

R

A

L

Y

L

M

E

H

R

F

Y

G

D

K

L

N

H

F

A

V

F

E

R

K

L

L

V

N

N

G

G

I

R

F

F

A

A

F

T

A

V

I

V

W

R

D

-

T

T

T

G

R

D

E

R

L

V

L

L

Y

A

R

T

D

D

R

H

A

A

G

G

T

S

K

V

P

P

L

L

F

Y

Y

T

T

C

Q

V

T

A

G

P

S

G

S

E

F

V

V

R

F

A

G

S

S

T

E

E

P

A

K

K

A

A

L

L

F

A

C

A

H

G

P

F

D

P

V

L

T

A

P

D

S

A

I

R

D

R

K

V

N

A

S

G

L

L

Q

T

E

G

I

V

L

Y

A

Q

V

V

G

-

P

P

A

A

R

G

T

A

Y

V

-

M

-

D

-

I

-

D

-

L

G

G

N

S

G

G

V

T

F

A

T

V

G

T

V

H

K

R

E

T

V

W

M

T

P

P

G

G

H

L

Y

S

H

R

I

R

F

I

C

L

P

P

D

E

G

G

Q

E

H

-

D

-

I

-

L

-

Y

-

W

-

D

-

L

-

P

-

C

-

R

-

E

-

H

-

K

-

D

-

S

-

Y

-

A

-

Q

A

T

V

V

A

Q

A

T

V

V

R

S

A

F

A

L

L

V

E

R

K

D

A

T

V

V

A

E

Q

R

R

Q

V

M

T

V

P

S

G

D

D

V

T

P

P

V

L

C

V

T

-

F
x
V

L

L

S
|
S

G

G

G
|
G

I

I

D
|
D

S
|
S

S

S

I

G

V

V

T

A

A

A

L

C

A

A

A

H

R

R

H

A

M

A

Q

G

K

E

E

-

G

-

K

-

I

-

L

L

N

D

T

T

F

V

S
|
S

F
x
M

D

G

F

T

S

D

E

T

N

S

E

N

K

E

Y

F

F

R

K

E

S

A

N

R

A

A

F

-

Q

-

P

-

E

-

R

-

D

-

L

-

P

-

Y

-

V

-

N

-

R

-

M

V

L

V

Q

D

Y

H

C

L

K

R

T

T

S

R

H

H

T

R

Y

E

L

I

E

T

C

I

S

P

Q

T

E

T

A

E

L

L

F

L

A

A

A

Q

L

L

S

P

D

Y

A

A

V

V

T

W

A

A

K

S

D

E

L

S

-

V

-

D

P

P

G
x
D

M

I

T

I

D

E

V
x
Y

D

L

A

L

S

P

L

L

L

T

Y

A

F

L

C

Y

S

R

E

A

V

L

A

D

K

G

H

P

N

E

K

R

V

R

T

I

L

L

T

T

G
|
G

E
x
Y

C
x
G

A

A

D
|
D

E
x
I

I

P

F

L

G

G

active site: A65 (≠ N81), G66 (= G82), D306 (≠ G356), Y332 (≠ E382)
binding adenosine monophosphate: V231 (≠ F267), S233 (= S269), S238 (= S274), S256 (= S296), M257 (≠ F297), G331 (= G381)
binding magnesium ion: D237 (= D273), D335 (= D385)
binding deoxyguanidinoproclavaminic acid: Y310 (≠ V360), Y332 (≠ E382), G333 (≠ C383), I336 (≠ E386)
binding pyrophosphate 2-: S233 (= S269), G235 (= G271), D237 (= D273), S238 (= S274), D335 (= D385)

Sites not aligning to the query:

active site: 366, 427
binding adenosine monophosphate: 427, 430
binding deoxyguanidinoproclavaminic acid: 357, 366, 427
binding pyrophosphate 2-: 407, 427, 428

1ao0A Glutamine phosphoribosylpyrophosphate (prpp) amidotransferase from b. Subtilis complexed with adp and gmp (see paper)
29% identity, 17% coverage: 64:170/615 of query aligns to 80:193/455 of 1ao0A

query
sites
1ao0A

I

V

Q

Q

P

P

M

L

T

L

-

F

R

R

T

S

F

Q

H

N

G

N

K

G

T

S

C

L

S

A

I

L

V

A

Y

H

N
|
N

G
|
G

E

N

I

L

Y

V

N

N

H

A

R

T

E

Q

L

L

L

K

P

Q

E

Q

L

L

Q

E

A

N

A

Q

G

G

Y

S

R

I

F

F

T

Q

T

T

T

S

S

S

D

D

T

T

E

E

I

V

I

L

L

A

C

H

A

L

Y

I

M

K

H

R

F

S

G

G

-

H

-

F

-

T

-

L

-

K

-

D

-

Q

-

I

K

K

N

N

F

S

V

L

E

S

K

M

L

L

N

K

G

G

I

A

F

Y

A

A

F

F

A

L

I

I

W

M

D

T

D

E

T

T

T

-

R

-

E

E

L

M

L

I

L

V

Y

A

R

L

D

D

R

P

A

N

G

G

T

L

K

R

P

P

L

L

F

S

Y

I

T

G

Q

M

T

M

G

G

S

D

S

A

F

Y

V

V

F

V

G

A

S

S

E

E

P

T

K

C

A

A

active site: N98 (= N81), G99 (= G82)

Sites not aligning to the query:

active site: 1, 27, 238, 296, 301, 311, 419
binding guanosine-5'-monophosphate: 234, 238, 279, 341, 342, 343, 345, 346, 347, 348, 349
binding adenosine-5'-diphosphate: 25, 238, 240, 241, 242, 277, 278, 279, 300, 301, 301, 303
binding magnesium ion: 279, 341, 342
binding iron/sulfur cluster: 232, 233, 234, 378, 380, 433, 436

P00497 Amidophosphoribosyltransferase; ATase; Glutamine phosphoribosylpyrophosphate amidotransferase; GPATase; EC 2.4.2.14 from Bacillus subtilis (strain 168) (see 5 papers)
29% identity, 17% coverage: 64:170/615 of query aligns to 95:208/476 of P00497

query
sites
P00497

I

V

Q

Q

P

P

M

L

T

L

-

F

R

R

T

S

F

Q

H

N

G

N

K

G

T

S

C

L

S

A

I

L

V

A

Y

H

N

N

G

G

E

N

I

L

Y

V

N

N

H

A

R

T

E

Q

L

L

L

K

P

Q

E

Q

L

L

Q

E

A

N

A

Q

G

G

Y

S

R

I

F

F

T

Q

T

T

T

S

S

S

D

D

T

T

E

E

I

V

I

L

L

A

C

H

A

L

Y

I

M

K

H

R

F

S

G

G

-

H

-

F

-

T

-

L

-

K

-

D

-

Q

-

I

K

K

N

N

F

S

V

L

E

S

K

M

L

L

N

K

G

G

I

A

F

Y

A

A

F

F

A

L

I

I

W

M

D

T

D

E

T

T

T

-

R

-

E

E

L

M

L

I

L

V

Y

A

R

L

D

D

R

P

A

N

G

G

T

L

K

R

P

P

L

L

F

S

Y

I

T

G

Q

M

T

M

G

G

S

D

S

A

F

Y

V

V

F

V

G

A

S

S

E

E

P

T

K

C

A

A

Sites not aligning to the query:

1:11 modified: propeptide
12 active site, Nucleophile; C→F: Loss of enzyme activity and N-terminal processing.
247 binding [4Fe-4S] cluster
294 binding Mg(2+)
356 binding Mg(2+)
357 binding Mg(2+)
393 binding [4Fe-4S] cluster
394 F→V: Partial loss of activity.
442 D→S: Partial loss of activity.
448 binding [4Fe-4S] cluster; C→S: Loss of activity.
451 binding [4Fe-4S] cluster; C→S: Loss of activity.
452 F→C: Lethal.

1gph1 Structure of the allosteric regulatory enzyme of purine biosynthesis (see paper)
29% identity, 17% coverage: 64:170/615 of query aligns to 84:197/465 of 1gph1

query
sites
1gph1

I

V

Q

Q

P

P

M

L

T

L

-

F

R

R

T

S

F

Q

H

N

G

N

K

G

T

S

C

L

S

A

I

L

V

A

Y

H

N

N

G

G

E

N

I

L

Y

V

N

N

H

A

R

T

E

Q

L

L

L

K

P

Q

E

Q

L

L

Q

E

A

N

A

Q

G

G

Y

S

R

I

F

F

T

Q

T

T

T

S

S

S

D

D

T

T

E

E

I

V

I

L

L

A

C

H

A

L

Y

I

M

K

H

R

F

S

G

G

-

H

-

F

-

T

-

L

-

K

-

D

-

Q

-

I

K

K

N

N

F

S

V

L

E

S

K

M

L

L

N

K

G

G

I

A

F

Y

A

A

F

F

A

L

I

I

W

M

D

T

D

E

T

T

T

-

R

-

E

E

L

M

L

I

L

V

Y

A

R

L

D

D

R

P

A

N

G

G

T

L

K

R

P

P

L

L

F

S

Y

I

T

G

Q

M

T

M

G

G

S

D

S

A

F

Y

V

V

F

V

G

A

S

S

E

E

P

T

K

C

A

A

Sites not aligning to the query:

active site: 300, 305, 315, 423
binding adenosine monophosphate: 242, 242, 244, 245, 246, 282, 283, 283, 304, 305, 307, 345, 346, 347, 349, 350, 353, 388
binding iron/sulfur cluster: 236, 237, 382, 384, 388, 437, 440

Q9STG9 Amidophosphoribosyltransferase 2, chloroplastic; AtATase2; AtPURF2; PRPP2; Glutamine phosphoribosylpyrophosphate amidotransferase 2; AtGPRAT2; Protein CHLOROPLAST IMPORT APPARATUS 1; Protein DIFFERENTIAL DEVELOPMENT OF VASCULAR ASSOCIATED CELLS; EC 2.4.2.14 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
27% identity, 20% coverage: 48:171/615 of query aligns to 153:285/561 of Q9STG9

query
sites
Q9STG9

V

I

G

A

L

I

S

G

H

H

A

V

R

R

L

Y

S

S

I

T

-

A

-

G

R

S

D

S

L

M

K

L

S

K

G

N

I

V

Q

Q

P

P

M

F

T

V

R

A

T

G

F

Y

H

R

G

F

K

G

T

S

C

V

S

G

I

V

V

A

Y
x
H

N

N

G

G

E

N

I

L

Y

V

N

N

H

Y

R

T

E

K

L

L

L

R

P

A

E

D

L

L

Q

E

A

E

A

N

G

G

Y

S

R

I

F

F

T

N

T

T

T

S

S

S

D

D

T

T

E

E

I

V

L

L

-

H

C

L

A

I

Y

A

M

I

H

S

F

K

G

A

K

R

N

P

F

F

-

F

-

M

-

R

-

I

-

V

-

D

-

A

V

C

E

E

K

K

L

L

N

Q

G

G

I

A

F

Y

A

S

F

M

A

V

I

F

W

V

D

-

T

T

T

E

R

D

E

K

L

L

L

V

L

A

Y

V

R

R

D

D

R

P

A

H

G

G

T

F

K
x
R

P
|
P

L

L

F

V

Y

M

T

G

-

R

Q

R

T

S

G

N

S

G

S

A

F

V

V

V

F

F

G

A

S

S

E

E

P

T

K

C

A

A

L

L

H187 (≠ Y80) mutation to T: In cia1-2; small plants with white leaves showing an irregular mosaic of green sectors.
R264 (≠ K151) mutation to K: Strong resistance to the bleaching herbicides DAS073 and DAS734.
P265 (= P152) mutation to S: Low resistance to the bleaching herbicides DAS073 and DAS734; when associated with F-494.

Sites not aligning to the query:

371 G→S: Low resistance to the bleaching herbicides DAS073 and DAS734.
476 P→S: Resistance to the bleaching herbicides DAS073 and DAS734.
494 Y→F: Low resistance to the bleaching herbicides DAS073 and DAS734; when associated with S-265.

6lbpA Structure of the glutamine phosphoribosylpyrophosphate amidotransferase from arabidopsis thaliana (see paper)
27% identity, 20% coverage: 48:171/615 of query aligns to 67:199/460 of 6lbpA

query
sites
6lbpA

V

I

G

A

L

I

S

G

H

H

A

V

R

R

L

Y

S

S

I

T

-

A

-

G

R

S

D

S

L

M

K

L

S

K

G

N

I

V

Q

Q

P

P

M

F

T

V

R

A

T

G

F

Y

H

R

G

F

K

G

T

S

C

V

S

G

I

V

V

A

Y

H

N
|
N

G
|
G

E

N

I

L

Y

V

N

N

H

Y

R

T

E

K

L

L

L

R

P

A

E

D

L

L

Q

E

A

E

A

N

G

G

Y

S

R

I

F

F

T

N

T

T

T

S

S

S

D

D

T

T

E

E

I

V

L

L

-

H

C

L

A

I

Y

A

M

I

H

S

F

K

G

A

K

R

N

P

F

F

-

F

-

M

-

R

-

I

-

V

-

D

-

A

V

C

E

E

K

K

L

L

N

Q

G

G

I

A

F

Y

A

S

F

M

A

V

I

F

W

V

D

-

T

T

T

E

R

D

E

K

L

L

L

V

L

A

Y

V

R

R

D

D

R

P

A

H

G

G

T

F

K

R

P

P

L

L

F

V

Y

M

T

G

-

R

Q

R

T

S

G

N

S

G

S

A

F

V

V

V

F

F

G

A

S

S

E

E

P

T

K

C

A

A

L

L

active site: N102 (= N81), G103 (= G82)

Sites not aligning to the query:

active site: 1, 27, 243, 301, 306, 316, 424
binding iron/sulfur cluster: 237, 239, 383, 385, 434, 436, 437

Query Sequence

>WP_055067462.1 NCBI__GCF_001406815.1:WP_055067462.1
MCGISGFCDFSLNYYDKKTFWETILVQMHETLKHRGPDQAMIDLQPHVGLSHARLSIRDL
KSGIQPMTRTFHGKTCSIVYNGEIYNHRELLPELQAAGYRFTTTSDTEIILCAYMHFGKN
FVEKLNGIFAFAIWDDTTRELLLYRDRAGTKPLFYTQTGSSFVFGSEPKALFCHPDVTPS
IDKNSLQEILAVGPARTYGNGVFTGVKEVMPGHYHIFCPDGQHDILYWDLPCREHKDSYA
QTVQTVSFLVRDTVERQMVSDVPVCTFLSGGIDSSIVTALAARHMQKEGKILNTFSFDFS
ENEKYFKSNAFQPERDLPYVNRMLQYCKTSHTYLECSQEALFAALSDAVTAKDLPGMTDV
DASLLYFCSEVAKHNKVTLTGECADEIFGGYPWFYRPELMNRDGFPWSADPAARTSILSD
DVLRTLDLAEYSHARYEETLSHVPHLDGESPEEARRRDIGYLNIKWFMQTLLDRMDRTSM
YSSLEARVPFADHRIMEYVFNVPWQMKYRNGVEKSLLRDACADLLPRELLWRKKSPYPKT
YHPAYEQMLIRRMREILNDPNSPVLPLLDRSKTEAFLAAPKELGKPWFGQLMAGPQLIAY
FIQINTWMQIYHLSI

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory