SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_055442190.1 NCBI__GCF_001418105.1:WP_055442190.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6quzD Structure of atpgs-bound outward-facing tm287/288 in complex with sybody sb_tm35 (see paper)
32% identity, 73% coverage: 159:606/611 of query aligns to 130:573/574 of 6quzD

query
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6quzD

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binding phosphothiophosphoric acid-adenylate ester: Y347 (= Y374), V353 (≠ I381), G374 (= G402), S375 (≠ A403), G376 (= G404), K377 (= K405), T378 (= T406), T379 (= T407), Q419 (= Q447), D474 (≠ E507), L475 (= L508), S476 (= S509), G478 (= G511), Q479 (= Q512), H531 (= H564)
binding magnesium ion: T378 (= T406), Q419 (= Q447)

6qv0B Structure of atp-bound outward-facing tm287/288 in complex with sybody sb_tm35 (see paper)
32% identity, 73% coverage: 159:606/611 of query aligns to 126:569/570 of 6qv0B

query
sites
6qv0B

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binding adenosine-5'-triphosphate: Y343 (= Y374), V349 (≠ I381), T369 (≠ N401), S371 (≠ A403), G372 (= G404), K373 (= K405), T374 (= T406), T375 (= T407), Q415 (= Q447), D470 (≠ E507), S472 (= S509), G474 (= G511), Q475 (= Q512), H527 (= H564)
binding magnesium ion: T374 (= T406), Q415 (= Q447)

2onjA Structure of the multidrug abc transporter sav1866 from s. Aureus in complex with amp-pnp (see paper)
35% identity, 59% coverage: 247:606/611 of query aligns to 212:576/578 of 2onjA

query
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2onjA

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A

H
|
H

R

R

F

L

S

S

T

T

V

I

R

T

Q

H

A

A

D

D

R

K

I

I

L

V

V

V

L

I

E

E

E

N

G

G

R

H

V

I

L

V

E

E

M

T

G

G

T

T

H

H

E

R

E

E

L

L

M

I

K

A

N

K

Q

Q

S

G

L

A

Y

Y

A

E

D

H

L

L

F

Y

T

S

L

I

Q

Q

binding phosphoaminophosphonic acid-adenylate ester: Y349 (= Y374), I356 (= I381), S376 (≠ N401), G377 (= G402), G378 (≠ A403), G379 (= G404), K380 (= K405), S381 (≠ T406), T382 (= T407), Q422 (= Q447), K477 (≠ E507), S479 (= S509), G480 (= G510), E503 (= E533), H534 (= H564)

2hydA Multidrug abc transporter sav1866 (see paper)
35% identity, 59% coverage: 247:606/611 of query aligns to 212:576/578 of 2hydA

query
sites
2hydA

V

V

V

V

D

K

R

S

F

F

K

A

N

I

L

E

S

D

N

N

E

E

Y

A

Y

K

N

N

L

F

N

D

K

K

K

K

-

N

-

T

-

N

-

F

-

L

-

T

L

R

A

A

V

L

K

K

R

H

S

T

A

R

L

W

-

N

G

A

F

Y

L

S

F

F

N

A

V

A

L

I

G

N

T

T

L

V

S

T

Y

D

Y

I

G

G

A

P

Y

I

V

I

F

V

I

I

-

G

-

V

-

G

I

A

Y

Y

R

L

V

A

I

I

S

S

G

G

V

S

I

I

T

T

L

V

G

G

E

T

L

L

T

A

F

A

L

F

S

V

G

G

A

Y

F

L

N

E

R

L

L

L

T

F

R

G

N

P

L

L

Q

R

D

R

F

L

F

V

S

A

K

S

F

F

T

T

R

T

I

L

T

T

E

Q

S

S

S

F

L

A

Y

S

L

M

K

D

D

R

Y

V

F

F

D

Q

F

L

L

I

D

D

I

-

S

-

I

-

A

-

P

-

S

-

H

-

K

-

E

E

D

D

M

Y

P

D

L

I

-

K

-

N

-

G

-

V

-

G

-

A

-

Q

P

P

E

I

T

E

I

I

Q

K

E

Q

G

G

-

R

F

I

E

D

F

I

K

D

N

H

V

V

H

S

F

F

A

Q

Y
|
Y

P

N

G

D

S

N

E

E

N

A

E

P

I
|
I

L

L

K

K

G

D

I

I

S

N

F

L

K

S

M

I

K

E

A

K

G

G

E

E

K

T

L

V

A

A

F

F

V

V

G

G

Q

M

N

S

G
|
G

A

G

G
|
G

K
|
K

T
x
S

T

T

L

L

T

I

K

N

L

L

L

I

L

P

R

R

F

F

Y

Y

E

D

P

V

T

T

S

S

G

G

E

Q

I

I

L

L

L

I

D

D

G

G

I

H

N

N

I

I

N

K

R

D

F

F

D

L

K

T

A

G

K

S

Y

L

Q

R

E

N

Y

Q

F

I

G

G

V

L

I

V

F

Q

Q

Q

D

D

F

N

F

I

K

L

Y

F

E

S

F

D

T

T

V

V

R

K

E

E

N

N

I

I

A

L

I

L

G

G

D

R

I

P

S

T

E

A

I

T

D

D

N

E

Q

E

S

-

K

-

I

V

E

V

N

E

A

A

A

A

E

K

L

M

S

A

L

N

A

A

N

H

E

D

V

F

V

I

Q

M

D

N

L

L

K

P

F

Q

G

G

Y

Y

D

D

Q

T

Q

E

L

V

G

G

K

E

R

R

F

-

A

-

K

-

G

G

Q

V

E
x
K

L

L

S
|
S

G

G

G

G

Q

Q

W

K

Q

Q

K

R

V

L

A

S

L

I

A

A

R

R

A

I

Y

F

M

L

K

N

D

N

A

P

K

P

V

I

M

L

I

I

L

L

D

D

E

E

P

A

T

T

S

S

A

A

L

L

D

D

A

L

K

E

A

S

E

E

S

S

E

I

V

I

F

Q

D

E

R

A

F

L

I

D

G

V

L

L

T

S

Q

K

F

D

K

R

T

T

S

T

V

L

I

I

I

V

S

A

H

H

R

R

F

L

S

S

T

T

V

I

R

T

Q

H

A

A

D

D

R

K

I

I

L

V

V

V

L

I

E

E

E

N

G

G

R

H

V

I

L

V

E

E

M

T

G

G

T

T

H

H

E

R

E

E

L

L

M

I

K

A

N

K

Q

Q

S

G

L

A

Y

Y

A

E

D

H

L

L

F

Y

T

S

L

I

Q

Q

binding adenosine-5'-diphosphate: Y349 (= Y374), I356 (= I381), G377 (= G402), G379 (= G404), K380 (= K405), S381 (≠ T406), K477 (≠ E507), S479 (= S509)

6parA Structure of a bacterial atm1-family abc exporter with mgamppnp bound (see paper)
33% identity, 53% coverage: 286:607/611 of query aligns to 261:576/578 of 6parA

query
sites
6parA

G

G

A

A

Y

M

V

A

F

W

I

T

I

V

Y

Y

R

G

V

W

I

S

S

Q

G

G

V

K

I

L

T

T

L

V

G

G

E

D

L

L

T

V

F

F

L

V

S

N

G

T

A

Y

F

L

N

T

R

Q

L

L

T

F

R

R

N

P

L

L

Q

D

D

M

F

L

F

G

S

M

K

V

F

Y

T

R

R

T

I

I

T

R

E

Q

S

G

S

L

L

I

Y

D

L

M

K

A

D

E

Y

M

F

F

D

R

F

L

L

I

D

D

I

T

S

H

I

I

A

E

P

V

S

A

H

D

K

V

E

P

D

N

M

A

P

P

L

A

P

L

E

V

T

V

I

N

Q

R

E

P

G

S

F

V

E

T

F

F

K

D

N

N

V

V

H

V

F

F

A

G

Y
|
Y

P

D

G

-

S

R

E

D

N
x
R

E

E

I
|
I

L

L

K

H

G

G

I

L

S

S

F

F

K

E

M

V

K

A

A

A

G

G

E

S

K

R

L

V

A

A

F

I

V

V

G

G

Q

P

N
x
S

G
|
G

A

A

G
|
G

K
|
K

T
x
S

T
|
T

L

I

T

A

K

R

L

L

L

L

L

F

R

R

F

F

Y

Y

E

D

P

P

T

W

S

E

G

G

E

R

I

I

L

L

L

I

D

D

G

G

I

Q

N

D

I

I

N

A

R

H

F

V

D

T

K

Q

A

T

K

S

Y

L

Q

R

E

A

Y

A

F

L

G

G

V

I

I

V

F

P

Q
|
Q

D

D

F

S

F

V

K

L

Y

F

E

N

F

D

T

T

V

I

R

G

E

Y

N

N

I

I

A

A

I

Y

G

G

D

-

I

-

S

R

E

D

I

G

D

A

N

S

Q

R

S

A

K

E

I

V

E

D

N

A

A

A

A

A

E

K

L

G

S

A

L

A

A

I

N

A

E

D

V

F

V

I

Q

A

D

R

L

L

K

P

F

Q

G

G

Y

Y

D

D

Q

T

Q

E

L

V

G

G

K

E

R

R

F

-

A

-

K

-

G

G

Q

L

E
x
K

L

L

S
|
S

G
|
G

G
|
G

Q
x
E

W

K

Q

Q

K

R

V

V

A

A

L

I

A

A

R

R

A

T

Y

L

M

V

K

K

D

N

A

P

K

P

V

I

M

L

I

L

L

F

D

D

E

E

P

A

T

T

S

S

A

A

L

L

D

D

A

T

K

R

A

T

E

E

S

Q

E

D

V

I

F

L

D

S

R

T

F

M

I

R

G

A

L

V

T

A

Q

S

F

H

K

R

T

T

S

T

V

I

I

S

I

I

S

A

H

H

R

R

F

L

S

S

T

T

V

I

R

A

Q

D

A

S

D

D

R

T

I

I

L

L

V

V

L

L

E

D

E

Q

G

G

R

R

V

L

L

A

E

E

M

Q

G

G

T

S

H

H

E

L

E

D

L

L

M

L

K

R

N

R

Q

D

S

G

L

L

Y

Y

A

A

D

E

L

M

F

W

T

A

L

R

Q

Q

A

A

binding phosphoaminophosphonic acid-adenylate ester: Y349 (= Y374), R353 (≠ N379), I355 (= I381), S375 (≠ N401), G376 (= G402), G378 (= G404), K379 (= K405), S380 (≠ T406), T381 (= T407), K476 (≠ E507), S478 (= S509), G479 (= G510), G480 (= G511), E481 (≠ Q512)
binding magnesium ion: S380 (≠ T406), Q421 (= Q447)

4mrvA Structure of a bacterial atm1-family abc transporter (see paper)
33% identity, 53% coverage: 286:607/611 of query aligns to 275:590/600 of 4mrvA

query
sites
4mrvA

G

G

A

A

Y

M

V

A

F

W

I

T

I

V

Y

Y

R

G

V

W

I

S

S

Q

G

G

V

K

I

L

T

T

L

V

G

G

E

D

L

L

T

V

F

F

L

V

S

N

G

T

A

Y

F

L

N

T

R

Q

L

L

T

F

R

R

N

P

L

L

Q
x
D

D
x
M

F
x
L

F
x
G

S
x
M

K

V

F

Y

T
x
R

R

T

I

I

T

R

E

Q

S

G

S

L

L

I

Y

D

L

M

K

A

D

E

Y

M

F

F

D

R

F

L

L

I

D

D

I

T

S

H

I

I

A

E

P

V

S

A

H

D

K

V

E

P

D

N

M

A

P

P

L

A

P

L

E

V

T

V

I

N

Q

R

E

P

G

S

F

V

E

T

F

F

K

D

N

N

V

V

H

V

F

F

A

G

Y

Y

P

D

G

-

S

R

E

D

N

R

E

E

I

I

L

L

K

H

G

G

I

L

S

S

F

F

K

E

M

V

K

A

A

A

G

G

E

S

K

R

L

V

A

A

F

I

V

V

G

G

Q

P

N
x
S

G

G

A

A

G
|
G

K

K

T
x
S

T

T

L

I

T

A

K

R

L

L

L

L

L

F

R

R

F

F

Y

Y

E

D

P

P

T

W

S

E

G

G

E

R

I

I

L

L

L

I

D

D

G

G

I

Q

N

D

I

I

N

A

R

H

F

V

D

T

K

Q

A

T

K

S

Y

L

Q

R

E

A

Y

A

F

L

G

G

V

I

I

V

F

P

Q

Q

D

D

F

S

F

V

K

L

Y

F

E

N

F

D

T

T

V

I

R

G

E

Y

N

N

I

I

A

A

I

Y

G

G

D

-

I

-

S

R

E

D

I

G

D

A

N

S

Q

R

S

A

K

E

I

V

E

D

N

A

A

A

A

A

E

K

L

G

S

A

L

A

A

I

N

A

E

D

V

F

V

I

Q

A

D

R

L

L

K

P

F

Q

G

G

Y

Y

D

D

Q

T

Q

E

L

V

G

G

K

E

R

R

F

-

A

-

K

-

G

G

Q

L

E

K

L

L

S

S

G

G

G

G

Q

E

W

K

Q

Q

K

R

V

V

A

A

L

I

A

A

R

R

A

T

Y

L

M

V

K

K

D

N

A

P

K

P

V

I

M

L

I

L

L

F

D

D

E

E

P

A

T

T

S

S

A

A

L

L

D

D

A

T

K

R

A

T

E

E

S

Q

E

D

V

I

F

L

D

S

R

T

F

M

I

R

G

A

L

V

T

A

Q

S

F

H

K

R

T

T

S

T

V

I

I

S

I

I

S

A

H

H

R

R

F

L

S

S

T

T

V

I

R

A

Q

D

A

S

D

D

R

T

I

I

L

L

V

V

L

L

E

D

E

Q

G

G

R

R

V

L

L

A

E

E

M

Q

G

G

T

S

H

H

E

L

E

D

L

L

M

L

K

R

N

R

Q

D

S

G

L

L

Y

Y

A

A

D

E

L

M

F

W

T

A

L

R

Q

Q

A

A

binding mercury bis(L-gamma-glutamyl-3-sulfido-L-alanylglycine): D309 (≠ Q320), M310 (≠ D321), L311 (≠ F322), G312 (≠ F323), M313 (≠ S324)
binding phosphate ion: M313 (≠ S324), R316 (≠ T327), S389 (≠ N401), G392 (= G404), S394 (≠ T406)

Sites not aligning to the query:

binding mercury bis(L-gamma-glutamyl-3-sulfido-L-alanylglycine): 149, 261, 262, 265

4mrsA Structure of a bacterial atm1-family abc transporter (see paper)
33% identity, 53% coverage: 286:607/611 of query aligns to 275:590/600 of 4mrsA

query
sites
4mrsA

G

G

A

A

Y

M

V

A

F

W

I

T

I

V

Y

Y

R

G

V

W

I

S

S

Q

G

G

V

K

I

L

T

T

L

V

G

G

E

D

L

L

T

V

F

F

L

V

S

N

G

T

A

Y

F

L

N

T

R

Q

L

L

T

F

R

R

N

P

L

L

Q
x
D

D
x
M

F

L

F
x
G

S
x
M

K

V

F

Y

T

R

R

T

I

I

T

R

E

Q

S

G

S

L

L

I

Y

D

L

M

K

A

D

E

Y

M

F

F

D

R

F

L

L

I

D

D

I

T

S

H

I

I

A

E

P

V

S

A

H

D

K

V

E

P

D

N

M

A

P

P

L

A

P

L

E

V

T

V

I

N

Q

R

E

P

G

S

F

V

E

T

F

F

K

D

N

N

V

V

H

V

F

F

A

G

Y

Y

P

D

G

-

S

R

E

D

N

R

E

E

I

I

L

L

K

H

G

G

I

L

S

S

F

F

K

E

M

V

K

A

A

A

G

G

E

S

K

R

L

V

A

A

F

I

V

V

G

G

Q

P

N
x
S

G

G

A

A

G
|
G

K

K

T
x
S

T

T

L

I

T

A

K

R

L

L

L

L

L

F

R

R

F

F

Y

Y

E

D

P

P

T

W

S

E

G

G

E

R

I

I

L

L

L

I

D

D

G

G

I

Q

N

D

I

I

N

A

R

H

F

V

D

T

K

Q

A

T

K

S

Y

L

Q

R

E

A

Y

A

F

L

G

G

V

I

I

V

F

P

Q

Q

D

D

F

S

F

V

K

L

Y

F

E

N

F

D

T

T

V

I

R

G

E

Y

N

N

I

I

A

A

I

Y

G

G

D

-

I

-

S

R

E

D

I

G

D

A

N

S

Q

R

S

A

K

E

I

V

E

D

N

A

A

A

A

A

E

K

L

G

S

A

L

A

A

I

N

A

E

D

V

F

V

I

Q

A

D

R

L

L

K

P

F

Q

G

G

Y

Y

D

D

Q

T

Q

E

L

V

G

G

K

E

R

R

F

-

A

-

K

-

G

G

Q

L

E

K

L

L

S

S

G

G

G

G

Q

E

W

K

Q

Q

K

R

V

V

A

A

L

I

A

A

R

R

A

T

Y

L

M

V

K

K

D

N

A

P

K

P

V

I

M

L

I

L

L

F

D

D

E

E

P

A

T

T

S

S

A

A

L

L

D

D

A

T

K

R

A

T

E

E

S

Q

E

D

V

I

F

L

D

S

R

T

F

M

I

R

G

A

L

V

T

A

Q

S

F

H

K

R

T

T

S

T

V

I

I

S

I

I

S

A

H

H

R

R

F

L

S

S

T

T

V

I

R

A

Q

D

A

S

D

D

R

T

I

I

L

L

V

V

L

L

E

D

E

Q

G

G

R

R

V

L

L

A

E

E

M

Q

G

G

T

S

H

H

E

L

E

D

L

L

M

L

K

R

N

R

Q

D

S

G

L

L

Y

Y

A

A

D

E

L

M

F

W

T

A

L

R

Q

Q

A

A

binding oxidized glutathione disulfide: D309 (≠ Q320), M310 (≠ D321), G312 (≠ F323), M313 (≠ S324)
binding phosphate ion: S389 (≠ N401), G392 (= G404), S394 (≠ T406)

Sites not aligning to the query:

binding oxidized glutathione disulfide: 142, 149, 199, 203, 261, 262, 265

4mrpA Structure of a bacterial atm1-family abc transporter (see paper)
33% identity, 53% coverage: 286:607/611 of query aligns to 275:590/600 of 4mrpA

query
sites
4mrpA

G

G

A

A

Y

M

V

A

F

W

I

T

I

V

Y

Y

R

G

V

W

I

S

S

Q

G

G

V

K

I

L

T

T

L

V

G

G

E

D

L

L

T

V

F

F

L

V

S

N

G

T

A

Y

F

L

N

T

R

Q

L

L

T

F

R

R

N

P

L

L

Q
x
D

D
x
M

F
x
L

F
x
G

S
x
M

K

V

F

Y

T

R

R

T

I

I

T

R

E

Q

S

G

S

L

L

I

Y

D

L

M

K

A

D

E

Y

M

F

F

D

R

F

L

L

I

D

D

I

T

S

H

I

I

A

E

P

V

S

A

H

D

K

V

E

P

D

N

M

A

P

P

L

A

P

L

E

V

T

V

I

N

Q

R

E

P

G

S

F

V

E

T

F

F

K

D

N

N

V

V

H

V

F

F

A

G

Y

Y

P

D

G

-

S

R

E

D

N

R

E

E

I

I

L

L

K

H

G

G

I

L

S

S

F

F

K

E

M

V

K

A

A

A

G

G

E

S

K

R

L

V

A

A

F

I

V

V

G

G

Q

P

N
x
S

G
|
G

A

A

G
|
G

K

K

T
x
S

T

T

L

I

T

A

K

R

L

L

L

L

L

F

R

R

F

F

Y

Y

E

D

P

P

T

W

S

E

G

G

E

R

I

I

L

L

L

I

D

D

G

G

I

Q

N

D

I

I

N

A

R

H

F

V

D

T

K

Q

A

T

K

S

Y

L

Q

R

E

A

Y

A

F

L

G

G

V

I

I

V

F

P

Q

Q

D

D

F

S

F

V

K

L

Y

F

E

N

F

D

T

T

V

I

R

G

E

Y

N

N

I

I

A

A

I

Y

G

G

D

-

I

-

S

R

E

D

I

G

D

A

N

S

Q

R

S

A

K

E

I

V

E

D

N

A

A

A

A

A

E

K

L

G

S

A

L

A

A

I

N

A

E

D

V

F

V

I

Q

A

D

R

L

L

K

P

F

Q

G

G

Y

Y

D

D

Q

T

Q

E

L

V

G

G

K

E

R

R

F

-

A

-

K

-

G

G

Q

L

E

K

L

L

S

S

G

G

G

G

Q

E

W

K

Q

Q

K

R

V

V

A

A

L

I

A

A

R

R

A

T

Y

L

M

V

K

K

D

N

A

P

K

P

V

I

M

L

I

L

L

F

D

D

E

E

P

A

T

T

S

S

A

A

L

L

D

D

A

T

K

R

A

T

E

E

S

Q

E

D

V

I

F

L

D

S

R

T

F

M

I

R

G

A

L

V

T

A

Q

S

F

H

K

R

T

T

S

T

V

I

I

S

I

I

S

A

H

H

R

R

F

L

S

S

T

T

V

I

R

A

Q

D

A

S

D

D

R

T

I

I

L

L

V

V

L

L

E

D

E

Q

G

G

R

R

V

L

L

A

E

E

M

Q

G

G

T

S

H

H

E

L

E

D

L

L

M

L

K

R

N

R

Q

D

S

G

L

L

Y

Y

A

A

D

E

L

M

F

W

T

A

L

R

Q

Q

A

A

binding glutathione: D309 (≠ Q320), M310 (≠ D321), M310 (≠ D321), L311 (≠ F322), G312 (≠ F323), M313 (≠ S324)
binding phosphate ion: S389 (≠ N401), G390 (= G402), G392 (= G404), S394 (≠ T406)

Sites not aligning to the query:

binding glutathione: 149, 261, 262, 265

4mrnA Structure of a bacterial atm1-family abc transporter (see paper)
33% identity, 53% coverage: 286:607/611 of query aligns to 275:590/600 of 4mrnA

query
sites
4mrnA

G

G

A

A

Y

M

V

A

F

W

I

T

I

V

Y

Y

R

G

V

W

I

S

S

Q

G

G

V

K

I

L

T

T

L

V

G

G

E

D

L

L

T

V

F

F

L

V

S

N

G

T

A

Y

F

L

N

T

R

Q

L

L

T

F

R

R

N

P

L

L

Q

D

D

M

F

L

F

G

S

M

K

V

F

Y

T

R

R

T

I

I

T

R

E

Q

S

G

S

L

L

I

Y

D

L

M

K

A

D

E

Y

M

F

F

D

R

F

L

L

I

D

D

I

T

S

H

I

I

A

E

P

V

S

A

H

D

K

V

E

P

D

N

M

A

P

P

L

A

P

L

E

V

T

V

I

N

Q

R

E

P

G

S

F

V

E

T

F

F

K

D

N

N

V

V

H

V

F

F

A

G

Y

Y

P

D

G

-

S

R

E

D

N

R

E

E

I

I

L

L

K

H

G

G

I

L

S

S

F

F

K

E

M

V

K

A

A

A

G

G

E

S

K

R

L

V

A

A

F

I

V

V

G

G

Q

P

N
x
S

G

G

A

A

G
|
G

K
|
K

T
x
S

T

T

L

I

T

A

K

R

L

L

L

L

L

F

R

R

F

F

Y

Y

E

D

P

P

T

W

S

E

G

G

E

R

I

I

L

L

L

I

D

D

G

G

I

Q

N

D

I

I

N

A

R

H

F

V

D

T

K

Q

A

T

K

S

Y

L

Q

R

E

A

Y

A

F

L

G

G

V

I

I

V

F

P

Q

Q

D

D

F

S

F

V

K

L

Y

F

E

N

F

D

T

T

V

I

R

G

E

Y

N

N

I

I

A

A

I

Y

G

G

D

-

I

-

S

R

E

D

I

G

D

A

N

S

Q

R

S

A

K

E

I

V

E

D

N

A

A

A

A

A

E

K

L

G

S

A

L

A

A

I

N

A

E

D

V

F

V

I

Q

A

D

R

L

L

K

P

F

Q

G

G

Y

Y

D

D

Q

T

Q

E

L

V

G

G

K

E

R

R

F

-

A

-

K

-

G

G

Q

L

E

K

L

L

S

S

G

G

G

G

Q

E

W

K

Q

Q

K

R

V

V

A

A

L

I

A

A

R

R

A

T

Y

L

M

V

K

K

D

N

A

P

K

P

V

I

M

L

I

L

L

F

D

D

E

E

P

A

T

T

S

S

A

A

L

L

D

D

A

T

K

R

A

T

E

E

S

Q

E

D

V

I

F

L

D

S

R

T

F

M

I

R

G

A

L

V

T

A

Q

S

F

H

K

R

T

T

S

T

V

I

I

S

I

I

S

A

H

H

R

R

F

L

S

S

T

T

V

I

R

A

Q

D

A

S

D

D

R

T

I

I

L

L

V

V

L

L

E

D

E

Q

G

G

R

R

V

L

L

A

E

E

M

Q

G

G

T

S

H

H

E

L

E

D

L

L

M

L

K

R

N

R

Q

D

S

G

L

L

Y

Y

A

A

D

E

L

M

F

W

T

A

L

R

Q

Q

A

A

binding phosphate ion: S389 (≠ N401), G392 (= G404), K393 (= K405), S394 (≠ T406)

Q2G506 ATM1-type heavy metal exporter; ATP-binding cassette transporter Atm1; NaAtm1; EC 7.-.-.- from Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199) (see paper)
33% identity, 53% coverage: 286:607/611 of query aligns to 282:597/608 of Q2G506

query
sites
Q2G506

G

G

A

A

Y

M

V

A

F

W

I

T

I

V

Y

Y

R

G

V

W

I

S

S

Q

G

G

V

K

I

L

T

T

L

V

G

G

E

D

L

L

T

V

F

F

L

V

S

N

G

T

A

Y

F

L

N

T

R

Q

L

L

T

F

R

R

N

P

L

L

Q
x
D

D
x
M

F
x
L

F
x
G

S

M

K

V

F

Y

T

R

R

T

I

I

T

R

E

Q

S

G

S

L

L

I

Y

D

L

M

K

A

D

E

Y

M

F

F

D

R

F

L

L

I

D

D

I

T

S

H

I

I

A

E

P

V

S

A

H

D

K

V

E

P

D

N

M

A

P

P

L

A

P

L

E

V

T

V

I

N

Q

R

E

P

G

S

F

V

E

T

F

F

K

D

N

N

V

V

H

V

F

F

A

G

Y

Y

P

-

G

D

S

R

E

D

N

R

E

E

I

I

L

L

K

H

G

G

I

L

S

S

F

F

K

E

M

V

K

A

A

A

G

G

E

S

K

R

L

V

A

A

F

I

V

V

G

G

Q

P

N

S

G

G

A

A

G

G

K

K

T

S

T

T

L

I

T

A

K

R

L

L

L

L

L

F

R

R

F

F

Y

Y

E

D

P

P

T

W

S

E

G

G

E

R

I

I

L

L

L

I

D

D

G

G

I

Q

N

D

I

I

N

A

R

H

F

V

D

T

K

Q

A

T

K

S

Y

L

Q

R

E

A

Y

A

F

L

G

G

V

I

I

V

F

P

Q

Q

D

D

F

S

F

V

K

L

Y

F

E

N

F

D

T

T

V

I

R

G

E

Y

N

N

I

I

A

A

I

Y

G

G

D

-

I

-

S

R

E

D

I

G

D

A

N

S

Q

R

S

A

K

E

I

V

E

D

N

A

A

A

A

A

E

K

L

G

S

A

L

A

A

I

N

A

E

D

V

F

V

I

Q

A

D

R

L

L

K

P

F

Q

G

G

Y

Y

D

D

Q

T

Q

E

L

V

G

G

K

E

R

R

F

-

A

-

K

-

G

G

Q

L

E

K

L

L

S

S

G

G

G

G

Q

E

W

K

Q

Q

K

R

V

V

A

A

L

I

A

A

R

R

A

T

Y

L

M

V

K

K

D

N

A

P

K

P

V

I

M

L

I

L

L

F

D

D

E
|
E

P

A

T

T

S

S

A

A

L

L

D

D

A

T

K

R

A

T

E

E

S

Q

E

D

V

I

F

L

D

S

R

T

F

M

I

R

G

A

L

V

T

A

Q

S

F

H

K

R

T

T

S

T

V

I

I

S

I

I

S

A

H

H

R

R

F

L

S

S

T

T

V

I

R

A

Q

D

A

S

D

D

R

T

I

I

L

L

V

V

L

L

E

D

E

Q

G

G

R

R

V

L

L

A

E

E

M

Q

G

G

T

S

H

H

E

L

E

D

L

L

M

L

K

R

N

R

Q

D

S

G

L

L

Y

Y

A

A

D

E

L

M

F

W

T

A

L

R

Q

Q

A

A

DMLG 316:319 (≠ QDFF 320:323) binding glutathione
G319 (≠ F323) mutation to L: Abolishes glutathione-dependent ATP hydrolysis.
E523 (= E533) mutation to Q: Abolishes transporter activity.

Sites not aligning to the query:

195 Y→F: Strongly increases basal rate of ATP hydrolysis.
269 N→A: Increases basal rate of ATP hydrolysis and abolishes stimulation of ATP hydrolysis by glutathione.
269:272 binding glutathione
272 Q→A: Abolishes glutathione-dependent ATP hydrolysis.

7sgrE Structure of hemolysin a secretion system hlyb/d complex (see paper)
28% identity, 95% coverage: 26:607/611 of query aligns to 137:700/700 of 7sgrE

query
sites
7sgrE

F

F

I

I

P

P

R

A

F

I

F
x
I

K

K

E

Y

I

-

W

-

K

-

T

-

N

-

K
x
R

K

K

L

I

F
|
F

L

I

-

E

-

T

-

L

-

V

L

V

S

S

A

V

F

F

C

L

R

Q

G

L

I

F

G

A

A

L

V

I

L

T

P

P

V

L

V

F

I

F

L

-

W

-

V

-

G

-

K

Q

I

V

I

V

I

M

D

D

E

K

I

V

I

L

V

V

Q

H

T

R

K

G

G

F

D

S

A

T

S

L

D

N

L

V

T

I

L

T

L

V

W

A

T

L

Y

S

V

V

A

V

I

V

E

V

F

F

G

E

L

-

I

I

I

I

L

L

S

S

D

G

L

L

V

R

S

T

R

Y

A

I

I
x
F

S

A

L

H

T

S

D

T

S

S

L

R

L

I

G

-

D

-

S

-

Y

-

S

D

I

V

D

E

S

L

S

G

V

A

R

K

I

L

I

F

K

R

K

H

T

L

N

L

Q

A

I

L

N

P

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binding [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate: I142 (≠ F31), R145 (≠ K39), F148 (= F42), F210 (≠ I105), W301 (= W215), L377 (vs. gap), I385 (= I292), W388 (vs. gap)

6pamA Structure of a bacterial atm1-family abc transporter with mgadp bound (see paper)
33% identity, 53% coverage: 286:607/611 of query aligns to 270:585/586 of 6pamA

query
sites
6pamA

G

G

A

A

Y

M

V

A

F

W

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Y

Y

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|
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G

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H

H

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L

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L

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G

L

L

Y

Y

A

A

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binding adenosine-5'-diphosphate: Y358 (= Y374), R362 (≠ N379), S384 (≠ N401), G387 (= G404), K388 (= K405), S389 (≠ T406), T390 (= T407)
binding magnesium ion: S389 (≠ T406), D510 (= D532)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 120

6panA Structure of a bacterial atm1-family abc exporter with atp bound (see paper)
33% identity, 53% coverage: 286:607/611 of query aligns to 252:567/572 of 6panA

query
sites
6panA

G

G

A

A

Y

M

V

A

F

W

I

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