SitesBLAST
Comparing WP_057507173.1 NCBI__GCF_001431535.1:WP_057507173.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 13 hits to proteins with known functional sites (download)
5g5gB Escherichia coli periplasmic aldehyde oxidase (see paper)
48% identity, 91% coverage: 13:336/355 of query aligns to 5:314/316 of 5g5gB
- binding flavin-adenine dinucleotide: K26 (≠ Q36), F27 (≠ P37), A29 (= A39), G30 (= G40), G31 (= G41), T32 (= T42), N33 (= N43), L34 (= L44), G98 (≠ A108), A99 (= A109), L103 (≠ I113), A107 (= A117), T108 (≠ S118), A110 (≠ G120), G111 (= G121), N112 (= N122), L114 (= L124), Q115 (= Q125), S163 (= S173), D164 (= D174), L212 (= L221), I213 (= I222), F239 (= F250)
- binding iron/sulfur cluster: C119 (= C129), C129 (= C139), N130 (= N140), K131 (= K141), C138 (= C148), H148 (= H158), C157 (= C167), I158 (= I168), A159 (= A169)
P77324 Aldehyde oxidoreductase FAD-binding subunit PaoB; EC 1.2.99.6 from Escherichia coli (strain K12) (see paper)
48% identity, 91% coverage: 13:336/355 of query aligns to 5:314/318 of P77324
- 26:34 (vs. 36:44, 78% identical) binding
- T108 (≠ S118) binding
- C119 (= C129) binding
- C129 (= C139) binding
- C138 (= C148) binding
- C157 (= C167) binding
- D164 (= D174) binding
- I213 (= I222) binding
- K230 (= K241) binding
5y6qB Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
44% identity, 85% coverage: 36:338/355 of query aligns to 25:328/330 of 5y6qB
- binding flavin-adenine dinucleotide: I26 (≠ P37), A28 (= A39), G29 (= G40), G30 (= G41), T31 (= T42), T32 (≠ N43), Q33 (≠ L44), A97 (= A108), A98 (= A109), I102 (= I113), A106 (= A117), T107 (≠ S118), G110 (= G121), N111 (= N122), R113 (≠ L124), Q114 (= Q125), G164 (≠ S173), D165 (= D174), I213 (≠ L221), I214 (= I222), K232 (= K241), F241 (= F250)
- binding iron/sulfur cluster: C118 (= C129), Y121 (≠ F132), C130 (= C139), N131 (= N140), C139 (= C148), A141 (= A150), C158 (= C167), I159 (= I168), A160 (= A169)
1rm6B Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
34% identity, 80% coverage: 16:300/355 of query aligns to 11:281/323 of 1rm6B
- binding flavin-adenine dinucleotide: P29 (= P37), G31 (≠ A39), A32 (≠ G40), G33 (= G41), T34 (= T42), D35 (≠ N43), L36 (= L44), L53 (≠ I61), V101 (≠ A108), A102 (= A109), A110 (= A117), T111 (≠ S118), G114 (= G121), N115 (= N122), C117 (≠ L124), Q118 (= Q125), D162 (= D174), L207 (≠ I222), V231 (≠ Y248), D232 (≠ A249), F233 (= F250)
- binding iron/sulfur cluster: C122 (= C129), F124 (= F132), C138 (= C148), C146 (≠ Y157), H147 (= H158), V148 (≠ A159), C155 (= C167), Y156 (≠ I168), A157 (= A169)
O33820 4-hydroxybenzoyl-CoA reductase subunit beta; 4-HBCR subunit beta; EC 1.1.7.1 from Thauera aromatica (see paper)
34% identity, 80% coverage: 16:300/355 of query aligns to 11:281/324 of O33820
- 29:36 (vs. 37:44, 50% identical) binding
- T111 (≠ S118) binding
- N115 (= N122) binding
- Q118 (= Q125) binding
- D162 (= D174) binding
- K224 (= K241) binding
Q0QLF4 Nicotinate dehydrogenase FAD-subunit; NDH; Nicotinic acid hydroxylase FAD-subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
26% identity, 80% coverage: 11:294/355 of query aligns to 9:240/296 of Q0QLF4
- 29:36 (vs. 37:44, 75% identical) binding
- G101 (≠ A109) binding
- TIGGN 110:114 (≠ SNGGN 118:122) binding
- D123 (= D174) binding
- R160 (≠ D213) binding
- M169 (≠ I222) binding
- K187 (= K241) binding
3hrdG Crystal structure of nicotinate dehydrogenase (see paper)
26% identity, 80% coverage: 11:294/355 of query aligns to 9:240/292 of 3hrdG
- binding flavin-adenine dinucleotide: I29 (≠ P37), A31 (= A39), G32 (= G40), G33 (= G41), T34 (= T42), D35 (≠ N43), F77 (≠ N85), V100 (≠ A108), G101 (≠ A109), I105 (= I113), T110 (≠ S118), G113 (= G121), N114 (= N122), S116 (≠ G147), T117 (≠ C148), G122 (= G153), D123 (= D174), I168 (≠ L221), M169 (≠ I222)
4zohB Crystal structure of glyceraldehyde oxidoreductase (see paper)
27% identity, 84% coverage: 36:334/355 of query aligns to 28:274/274 of 4zohB
- active site: Y256 (≠ F320)
- binding flavin-adenine dinucleotide: R28 (≠ Q36), P29 (= P37), A31 (= A39), G32 (= G40), G33 (= G41), H34 (≠ T42), S35 (≠ N43), L36 (= L44), H77 (≠ Y90), I95 (≠ A108), G96 (≠ A109), V100 (≠ I113), T105 (≠ S118), G108 (= G121), S109 (≠ N122), S111 (≠ E165), A117 (vs. gap), D118 (= D174), L160 (= L221), V161 (≠ I222), D185 (≠ A249), F186 (= F250)
7dqxE Crystal structure of xanthine dehydrogenase family protein
27% identity, 79% coverage: 14:294/355 of query aligns to 8:237/293 of 7dqxE
- binding flavin-adenine dinucleotide: K29 (≠ Q36), I30 (≠ P37), I31 (= I38), G33 (= G40), G34 (= G41), Q35 (≠ T42), S36 (≠ N43), L37 (= L44), H78 (≠ N85), I101 (≠ A108), A102 (= A109), I106 (= I113), G110 (≠ A117), T111 (≠ S118), G113 (= G120), G114 (= G121), S115 (≠ N122), A117 (≠ L124), A123 (≠ S173), E124 (≠ D174), I167 (= I222), Y193 (≠ F250)
1t3qC Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
26% identity, 93% coverage: 13:341/355 of query aligns to 7:284/285 of 1t3qC
- binding flavin-adenine dinucleotide: I29 (= I35), A31 (= A39), G32 (= G40), G33 (= G41), Q34 (≠ T42), S35 (≠ N43), L36 (= L44), V100 (≠ A108), A101 (= A109), V105 (≠ I113), T110 (≠ S118), G113 (= G121), S114 (≠ N122), A116 (≠ L124), A122 (= A163), E123 (≠ D174), L166 (≠ I222), Y190 (≠ F250)
1ffuC Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
37% identity, 32% coverage: 9:123/355 of query aligns to 1:116/287 of 1ffuC
- binding flavin-adenine dinucleotide: K29 (≠ Q36), L30 (≠ P37), A32 (= A39), G33 (= G40), G34 (= G41), H35 (≠ T42), S36 (≠ N43), L37 (= L44), I54 (= I61), I101 (≠ A108), A102 (= A109), G110 (≠ A117), T111 (≠ S118), G114 (= G121), D115 (≠ N122)
Sites not aligning to the query:
1n5wC Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
25% identity, 91% coverage: 9:332/355 of query aligns to 1:282/287 of 1n5wC
P19920 Carbon monoxide dehydrogenase medium chain; CO dehydrogenase subunit M; CO-DH M; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
25% identity, 91% coverage: 9:332/355 of query aligns to 1:282/288 of P19920
Query Sequence
>WP_057507173.1 NCBI__GCF_001431535.1:WP_057507173.1
MDTRHGAGMIPATYERAASLQHALQQLASASARPIQPIAGGTNLLDLMKLQLTQPSGLLD
INALPLDTITGTEEGGLQLGATARNADTAYHPLVEREYPLLSAAILAAASPQIRNMASNG
GNLLQRTRCTYFYDRATPCNKREPGSGCSAVGGLTKYHAILGASEHCIATHPSDMCVALA
ALDATVHVASLRGTRAIPFSAFHRLPGDQPEQDSTLAADELITHLTLPPAGRFAAHSAYL
KIRERLSYAFALVSVAAALEIGPDGRIVDARLALGSVAHKPWRSTEAEQRLIGSLPDAAA
FDSAAERLLEGAQSQGQNAFKIPLARRAVVRALQAATEGTIDNRGGRRGQPEHAA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory